eLife

Latest preprint reviews

1. Eleven key measures for monitoring general practice clinical activity during COVID-19: A retrospective cohort study using 48 million adults’ primary care records in England through OpenSAFELY

   This article has 48 authors:

   1. Louis Fisher
   2. Helen J Curtis
   3. Richard Croker
   4. Milan Wiedemann
   5. Victoria Speed
   6. Christopher Wood
   7. Andrew Brown
   8. Lisa EM Hopcroft
   9. Rose Higgins
   10. Jon Massey
   11. Peter Inglesby
   12. Caroline E Morton
   13. Alex J Walker
   14. Jessica Morley
   15. Amir Mehrkar
   16. Seb Bacon
   17. George Hickman
   18. Orla Macdonald
   19. Tom Lewis
   20. Marion Wood
   21. Martin Myers
   22. Miriam Samuel
   23. Robin Conibere
   24. Wasim Baqir
   25. Harpreet Sood
   26. Charles Drury
   27. Kiren Collison
   28. Chris Bates
   29. David Evans
   30. Iain Dillingham
   31. Tom Ward
   32. Simon Davy
   33. Rebecca M Smith
   34. William Hulme
   35. Amelia Green
   36. John Parry
   37. Frank Hester
   38. Sam Harper
   39. Jonathan Cockburn
   40. Shaun O'Hanlon
   41. Alex Eavis
   42. Richard Jarvis
   43. Dima Avramov
   44. Paul Griffiths
   45. Aaron Fowles
   46. Nasreen Parkes
   47. Brian MacKenna
   48. Ben Goldacre

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper presents an important effort to develop an open source software framework for monitoring trends and variations in healthcare over time in England. They demonstrate a compelling example of how this system can track key health care indicators over the course of the COVID-19 pandemic. The paper will likely be mainly of interest to stakeholders in England, but could inspire the creation of similar systems in other countries.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2023.03.16.532958

3. We couldn't get details of this article at this time:
   10.1101/2023.04.21.537850

4. We couldn't get details of this article at this time:
   10.1101/2023.03.16.532873

5. Multiple dynamic interactions from basal ganglia direct and indirect pathways mediate action selection

   This article has 2 authors:

   1. Hao Li
   2. Xin Jin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this valuable manuscript Li & Jin record from the substantial nigra and dorsal striatum to identify subpopulations of neurons with activity that reflects different dynamics during action selection, and then use optogenetics in transgenic mice to selectively inhibit or excite D1- and D2- expressing spiny projection neurons in the striatum, demonstrating a causal role for each in action selection in an opposing manner. They provide solid evidence for the argument that their findings cannot be explained by current models and propose a new 'triple control' model instead, with one direct and two indirect pathways, although direct evidence for a second indirect pathway is still lacking. These findings will be of broad interest to neuroscientists across multiple subfields.

   Reviewed by eLife

6. Hippocampal remapping induced by new behavior is mediated by spatial context

   This article has 2 authors:

   1. Samuel J. Levy
   2. Michael E. Hasselmo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The formation of the place cell map in the hippocampus is foundational to many models and is thought to form a substrate onto which memories can be structured. This paper presents an important new observation to our understanding of place cell formation - namely that task learning changes or interferes with the process of place cell map stabilization. Reviewers found that there was incomplete evidence for this result, however, in this version of the manuscript because of a confound between the duration of experience in an environment and task-specific learning.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2023.01.31.526541

8. Structural rather than catalytic role for mitochondrial respiratory chain supercomplexes

   This article has 6 authors:

   1. Michele Brischigliaro
   2. Alfredo Cabrera-Orefice
   3. Susanne Arnold
   4. Carlo Viscomi
   5. Massimo Zeviani
   6. Erika Fernández-Vizarra

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable findings on the organization of respiratory chain complexes in mitochondria. It provides solid evidence that respiratory supercomplex formation in the fruit fly does not impact respiratory function, suggesting the role of these complexes is structural, rather than catalytic. However, whether the conclusions extend to other species requires further evidence. This manuscript will be of broad interest to the field of mitochondrial bioenergetics.

   Reviewed by eLife

9. We couldn't get details of this article at this time:
   10.1101/2023.04.04.535507

10. σ28-dependent small RNA regulation of flagella biosynthesis

    This article has 7 authors:

    1. Sahar Melamed
    2. Aixia Zhang
    3. Michal Jarnik
    4. Joshua Mills
    5. Aviezer Silverman
    6. Hongen Zhang
    7. Gisela Storz

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This article provides important findings on how bacteria use small RNAs to regulate flagellar expression with implications for multiple fields. The data supporting the conclusions are convincing with a large amount of data that include results from phenotypic analyses, genomics approaches as well as in-vitro and in-vivo target identification and validation methods. This study on the varied effects of three sRNAs (UhpU, FliX and MotR) is of broad interest to RNA biochemists and microbiologists.

    Reviewed by eLife