eLife

Latest preprint reviews

1. Agonist efficiency links binding and gating in a nicotinic receptor

   This article has 2 authors:

   1. Dinesh C Indurthi
   2. Anthony Auerbach

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable work investigates the fundamental concept of how the energy of agonist binding is converted into the energy of the conformational change that opens the pore of a ligand-gated ion channel. The conclusions are based on analysis of solid data in terms of a mechanistic model, but adequate statistical analysis is lacking and the uniqueness of the proposed model is not discussed. The findings will be interesting to biophysicists working on ligand-gated ion channels and, more generally, to enzymologists focused on allosteric enzyme regulation.

   Reviewed by eLife

2. Large-scale neural dynamics in a shared low-dimensional state space reflect cognitive and attentional dynamics

   This article has 3 authors:

   1. Hayoung Song
   2. Won Mok Shim
   3. Monica D Rosenberg

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study examines the distribution of four states of brain activity across a variety of cognitive conditions, linking systems neuroscience with cognition and behavior. The work is convincing, using null models and replication in independent datasets to support their findings.

   Reviewed by eLife

3. Low-level repressive histone marks fine-tune gene transcription in neural stem cells

   This article has 9 authors:

   1. Arjun Rajan
   2. Lucas Anhezini
   3. Noemi Rives-Quinto
   4. Jay Y Chhabra
   5. Megan C Neville
   6. Elizabeth D Larson
   7. Stephen F Goodwin
   8. Melissa M Harrison
   9. Cheng-Yu Lee

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important work shows how a transcription factor, fruitless isoform C, fine-tunes the expression of stemness genes to maintain proper stem-cell identity during neurogenesis in Drosophila. The rationale of the work is well-thought-out, conclusions are supported by compelling evidence, and experiments are performed in a rigorous manner, although additional statistics would improve the conclusions. Overall, this work will be of interest to those working on chromatin regulation, transcription regulation, and stem-cell biology.

   Reviewed by eLife

4. Meta-analysis reveals glucocorticoid levels reflect variation in metabolic rate, not ‘stress’

   This article has 2 authors:

   1. Blanca Jimeno
   2. Simon Verhulst

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work presents a fundamental meta-analysis on the causes of glucocorticoid variations in birds and mammals. It provides convincing evidence that an increase in metabolic rates increases glucocorticoid concentrations. The work will be of broad interest to animal physiologists.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.1101/761346

6. We couldn't get details of this article at this time:
   10.1101/2022.10.28.514230

7. We couldn't get details of this article at this time:
   10.1101/2023.01.17.524456

8. Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function

   This article has 32 authors:

   1. Denis Dacheux
   2. Guillaume Martinez
   3. Christine E Broster Reix
   4. Julie Beurois
   5. Patrick Lores
   6. Magamba Tounkara
   7. Jean-William Dupuy
   8. Derrick Roy Robinson
   9. Corinne Loeuillet
   10. Emeline Lambert
   11. Zeina Wehbe
   12. Jessica Escoffier
   13. Amir Amiri-Yekta
   14. Abbas Daneshipour
   15. Seyedeh-Hanieh Hosseini
   16. Raoudha Zouari
   17. Selima Fourati Ben Mustapha
   18. Lazhar Halouani
   19. Xiaohui Jiang
   20. Ying Shen
   21. Chunyu Liu
   22. Nicolas Thierry-Mieg
   23. Amandine Septier
   24. Marie Bidart
   25. Véronique Satre
   26. Caroline Cazin
   27. Zine Eddine Kherraf
   28. Christophe Arnoult
   29. Pierre F Ray
   30. Aminata Toure
   31. Mélanie Bonhivers
   32. Charles Coutton

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study reports the physiological role of ZMYND21 in the regulation of sperm flagellar development and male fertility. The data supporting the conclusion are solid, although the inclusion of more patients and ultrastructural studies would have further strengthened the study. This work will be of interest to clinicians and researchers who work on either sperm biology or ciliopathy due to cilial defects.

   Reviewed by eLife

9. We couldn't get details of this article at this time:
   10.1101/2022.04.14.22272888

10. Microplastics are present in women’s and cows’ follicular fluid and polystyrene microplastics compromise bovine oocyte function in vitro

    This article has 9 authors:

    1. Nicole Grechi
    2. Roksan Franko
    3. Roshini Rajaraman
    4. Jan B. Stöckl
    5. Tom Trapphoff
    6. Stefan Dieterle
    7. Thomas Fröhlich
    8. Michael J. Noonan
    9. Marcia de A. M. M. Ferraz

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This manuscript represents a valuable study showing that microplastics indeed accumulate in both bovine and human ovarian follicular fluid. It also presented data that direct exposure of bovine eggs to polystyrene, a microplastic commonly found in follicular fluid, negatively affects oocyte maturation, probably through the downregulation of key proteins involved in oxidative stress, DNA damage, apoptosis, and oocyte maturation. Despite the solid supporting evidence, inclusion of the demographics and reasons for assisted reproduction of the human subjects used, as well as the details on quality control for proteomic analyses would further strengthen the study. The work will be of interest to reproductive toxicologists, regulatory scientists and reproductive health care professionals.

    Reviewed by eLife