Latest preprint reviews

  1. Spatial and temporal coordination of Duox/TrpA1/Dh31 and IMD pathways is required for the efficient elimination of pathogenic bacteria in the intestine of Drosophila larvae

    This article has 7 authors:
    1. Fatima Tleiss
    2. Martina Montanari
    3. Olivier Pierre
    4. Julien Royet
    5. Dani Osman
    6. Armel Gallet
    7. C. Léopold Kurz
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This article describes a novel mechanism allowing the insect Drosophila to combat pathogenic enteric pathogens while preserving the beneficial indigenous microbiota. The authors provide compelling evidence that oral infection of Drosophila larvae by pathogenic bacteria activate a valve that traps the intruders in the anterior midgut, allowing them to be killed by antimicrobial peptides. This important work substantially advances our understanding of pathogen clearance in the insect gut.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  2. Sub-type specific connectivity between CA3 pyramidal neurons may underlie their sequential activation during sharp waves

    This article has 10 authors:
    1. Rosanna P. Sammons
    2. Stefano Masserini
    3. Laura Moreno-Velasquez
    4. Verjinia D. Metodieva
    5. Gaspar Cano
    6. Andrea Sannio
    7. Marta Orlando
    8. Nikolaus Maier
    9. Richard Kempter
    10. Dietmar Schmitz
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study represents valuable findings on the asymmetric connectivity pattern of two different types of CA3 pyramidal cell types showing that while athorny cells receive strong inputs from all other cell types, thorny cells receive weaker inputs from athorny neurons. Computational modeling is used to evaluate the impact of this connectivity scheme on the sequential activation of different cell types during sharp wave ripples. The experimental evidence supporting the authors' claims is solid, although improvements to the modelling aspect of the study would strengthen the study.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Local, calcium- and reward-based synaptic learning rule that enhances dendritic nonlinearities can solve the nonlinear feature binding problem

    This article has 4 authors:
    1. Zahra Khodadadi
    2. Daniel Trpevski
    3. Robert Lindroos
    4. Jeanette Hellgren Kotaleski
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This computational modeling study builds on multiple previous lines of experimental and theoretical research to investigate how a single neuron can solve a nonlinear pattern classification task. The study presents valuable insights that the location of synapses on dendritic branches, as well as synaptic plasticity of excitatory and inhibitory synapses, influences the ability of a neuron to discriminate combinations of sensory stimuli. However, the evidence presented is incomplete - the major conclusions are only partially supported by the data presented, and there are identified gaps between the supporting evidence and the major conclusions.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  4. Noisy neuronal populations effectively encode sound localization in the dorsal inferior colliculus of awake mice

    This article has 4 authors:
    1. Juan C. Boffi
    2. Brice Bathellier
    3. Hiroki Asari
    4. Robert Prevedel
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The paper reports the important discovery that the mouse dorsal inferior colliculus, an auditory midbrain area, encodes sound location. The evidence supporting the claims is solid, although how the encoding of sound source position in this area relates to localization behaviors in engaged mice remains unclear. The observations described should be of interest to auditory researchers studying the neural mechanisms of sound localization.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  5. Skeletal Muscle Satellite Cells Co-Opt the Tenogenic Gene Scleraxis to Instruct Regeneration

    This article has 5 authors:
    1. Yun Bai
    2. Tyler Harvey
    3. Minjie Hu
    4. Colin Bilyou
    5. Chen-Ming Fan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript reports an important finding that the transcription factor Scleraxis regulates regenerative myogenesis by controlling the proliferation and differentiation of muscle stem cells. The evidence presented is compelling and supports the conclusions and the mechanisms by which this gene regulates satellite cell function. These data will be of interest to developmental, transcriptional, and stem cell biologists.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  6. SLC35G1: A highly chloride-sensitive transporter responsible for the basolateral membrane transport in intestinal citrate absorption

    This article has 10 authors:
    1. Yoshihisa Mimura
    2. Tomoya Yasujima
    3. Katsuhisa Inoue
    4. Shogo Akino
    5. Chitaka Namba
    6. Hiroyuki Kusuhara
    7. Yutaro Sekiguchi
    8. Kinya Ohta
    9. Takahiro Yamashiro
    10. Hiroaki Yuasa
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This work identifies the molecular function of an orphan human transporter, SLC35G1, providing convincing but incomplete evidence that this protein is involved in intestinal citrate absorption. This work provides important insight into transporter function and human physiology.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Formation of multinucleated osteoclasts depends on an oxidized species of cell surface associated La protein

    This article has 6 authors:
    1. Evgenia Leikina
    2. Jarred M. Whitlock
    3. Kamran Melikov
    4. Wendy Zhang
    5. Michael P. Bachmann
    6. Leonid V. Chernomordik
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript provides an important advance in our understanding of the molecular events that promote osteoclast fusion. Compelling data support the conclusion that an oxidized form of the ubiquitous protein La promotes osteoclast fusion following enrichment at the cell surface of osteoclast progenitors. These data improve our understanding of the processes that regulate bone resorption and will be of broad interest to researchers in the fields of cell biology and musculoskeletal physiology.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  8. Temporally controlled nervous system-to-gut signaling bidirectionally regulates longevity in C. elegans

    This article has 5 authors:
    1. Lingxiu Xu
    2. Chengxuan Han
    3. Lei Chun
    4. X.Z. Shawn Xu
    5. Jianfeng Liu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study reports that the timing of 'brain-to-gut' signaling influences the lifespan of the C. elegans model. The main finding, that modulating the same neurotransmitter, Acetylcholine, at different ages elicits lifespan shortening - or extending - effects utilizing different receptors, is important and of broad interest to the longevity field as recognized by all the reviewers. The data is largely consistent with the authors' model, but the strength of the evidence is incomplete. The study requires several rigorous experiments detailed by the reviewers to substantiate the main conclusions.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  9. ScRNA-seq and scATAC-seq reveal that sertoli cell mediate spermatogenesis disorders through stage-specific communications in non-obstructive azoospermia

    This article has 6 authors:
    1. Shimin Wang
    2. Hongxian Wang
    3. Bicheng Jin
    4. Hongli Yan
    5. Qingliang Zheng
    6. Dong Zhao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides valuable scRNA-seq and scATAC-seq data for testicular tissues from patients with spermatogenesis disorders. By examining the transcriptomic and epigenetic changes in Sertoli cells, the authors uncovered key regulatory mechanisms underlying male infertility and identified potential therapeutic targets. While some of the cellular profiling results are convincing, the analyses for differential profiling of NOA cases and epigenomics data remain incomplete in their current form.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. The Drosophila EcR-Hippo component Taiman promotes epithelial cell fitness by control of the Dally-like glypican and Wg gradient

    This article has 3 authors:
    1. Colby K. Schweibenz
    2. Victoria C. Placentra
    3. Kenneth H. Moberg
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The authors study how cells with lower levels of the conserved steroid hormone signaling component Taiman (tai) are out-competed by neighboring wild-type cells with higher fitness in Drosophila imaginal discs. The findings are useful since they uncover an unexpected link between tai and Wingless signaling in cell competition. The evidence however is incomplete, since the tai loss-of-clone phenotype is based on one allele and the mechanism involved in cell competition through Dlp and Wg lacks adequate supporting data.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
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