eLife

Latest preprint reviews

1. High Cognitive Violation of Expectations is Compromised in Cerebellar Ataxia

   This article has 3 authors:

   1. Leonardo Daniel A
   2. Eli Vakil
   3. William Saban

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable investigation provides new and solid evidence for a specific cognitive deficit in cerebellar degeneration patients. The authors use three tasks that modulate complexity and error presence to show specific slowing of reaction times in the presence of errors but not with task complexity. While the authors interpret these findings as indicating that the cerebellum is required for the processing of violations of expectations, the exact patterns of results may suggest alternative interpretations. Nonetheless, the work provides a new, invaluable data point in describing the cognitive contribution of cerebellar processing.

   Reviewed by eLife

2. Cancer-immune coevolution dictated by antigenic mutation accumulation

   This article has 3 authors:

   1. Long Wang
   2. Christo Morison
   3. Weini Huang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work presents a stochastic branching process model of tumour-immune coevolution, incorporating stochastic antigenic mutation accumulation and escape within the cancer cell population. They then used this model to investigate how tumour-immune interactions influence tumour outcome and the summary statistics of sequencing data of bulk and single-cell sequencing of a tumour. The evidence is currently incomplete: statistical comparisons between the observed mutational burden distribution and theoretical predictions in the absence of immune selection should be carried out. Conclusions should be tested extensively for robustness/sensitivity to parameters.

   Reviewed by eLife

3. Interdigitating Modules for Visual Processing During Locomotion and Rest in Mouse V1

   This article has 5 authors:

   1. Andrew M Meier
   2. Rinaldo D D’Souza
   3. Weiqing Ji
   4. Edward B Han
   5. Andreas Burkhalter

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study shows that locomotion-related modulations in the mouse visual cortex are not uniform but primarily affect neurons in muscarinic receptor-negative patches, which receive projections from specific cortical areas. While the evidence is mostly solid, some uncertainties remain regarding the link between anatomical data and functional measurements. The study should be of interest to neuroscientists interested in state modulation of cortical function.

   Reviewed by eLife

4. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2401.07227v2

5. Neuropeptidergic circuit modulation of developmental sleep in Drosophila

   This article has 5 authors:

   1. Chikayo Hemmi
   2. Kenichi Ishii
   3. Mana Motoyoshi
   4. Masato Tsuji
   5. Kazuo Emoto

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study investigates an emerging research field: the interaction between sleep and development. The authors use Drosophila larvae sleep as a study model and provide valuable insight into how neuropeptide circuitry controls larvae sleep. By using a broad range of behaviour and imaging methods and analysis, the authors conclude a sleep regulatory neural pathway of Hugin-PK2-Dilps in the Drosophila neurosecretory centre IPC. However, the evidence that supports this pathway is incomplete - in particular, the methodology in sleep measurement and the specificity at each step of the Hugin-PK2-Dilps pathway require further clarifying experiments or explanation.

   Reviewed by eLife

6. Secreted small RNAs of Naegleria fowleri are biomarkers for diagnosis of primary amoebic meningoencephalitis

   This article has 5 authors:

   1. A. Cassiopeia Russell
   2. Joseph Dainis
   3. Jose Alexander
   4. Ibne Karim M. Ali
   5. Dennis E. Kyle

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper presents a method for detecting Naegleria fowleri infection, which is almost always fatal, using small RNA from blood. This could be an important advance since early detection might improve treatment outcomes. The mouse work is methodologically solid, but only a very small number of human samples were available for human validation.

   Reviewed by eLife

7. Quantifying the shape of cells - from Minkowski tensors to p-atic order

   This article has 7 authors:

   1. Lea Happel
   2. Griseldis Oberschelp
   3. Valeriia Grudtsyna
   4. Harish P Jain
   5. Rastko Sknepnek
   6. Amin Doostmohammadi
   7. Axel Voigt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper introduces an important theoretical method for characterizing symmetries of cells in biological tissues by capturing their real shape, and it sets results in contrast to related methods. The robustness of the paper's method to correctly capture dynamic and geometric changes that the cells may undergo is determined by convincing computational models, but the experimental support is incomplete and would benefit from better experimental imaging with higher quality and extended analysis. This would not only support the advantage of this method, but also strengthen its application to biological systems.

   Reviewed by eLife

8. Differential spatial regulation and activation of integrin nanoclusters inside focal adhesions

   This article has 4 authors:

   1. Sarah Keary
   2. Nicolas Mateos
   3. Felix Campelo
   4. Maria F Garcia-Parajo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this manuscript, the authors analyse the nanoscale localisation of α5β1 and αVβ3 integrins in integrin adhesion complexes (IAC) by dual-colour STORM and assess the spatial organisation at the nano and mesoscale of their main adaptors (paxillin, talin and vinculin). This is an important work that provides detailed analyses that reveal how elements of these complex structures are really organised at the nanoscale, an essential perspective for a better understanding of how IACs function and regulate mechanotransduction processes. The evidence presented is solid, with super-resolution imaging experiments conducted using a single, validated methodology and subsequent computational modelling that enabled a quantitative assessment of the resulting data.

   Reviewed by eLife

9. Nim1-related kinases regulate septin organization and cytokinesis by modulating Hof1 at the cell division site

   This article has 7 authors:

   1. Bindu Bhojappa
   2. Anubhav Dhar
   3. Bagyashree VT
   4. Jayanti Kumari
   5. Freya Cardozo
   6. Vaseef Rizvi
   7. Saravanan Palani

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study determines the functional requirements for localization and activity of S. cerevisiae septin-associated kinases using in vivo imaging, in vitro and in vivo protein-protein interaction assays, and an instructive in vivo "tethering" approach. In addition to confirming previous results, the study offers evidence that the septin-associated kinases may directly interact with the contractile ring machinery. Although the experiments appear to have been conducted correctly, the quantitative analysis of some experiments is incomplete and should be improved to strengthen the conclusions.

   Reviewed by eLife

10. Neural signatures of model-based and model-free reinforcement learning across prefrontal cortex and striatum

    This article has 6 authors:

    1. Bruno Miranda
    2. James L Butler
    3. W M Nishantha Malalasekera
    4. Timothy EJ Behrens
    5. Peter Dayan
    6. Steven W Kennerley

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important study presents single-unit activity collected during model-based (MB) and model-free (MF) reinforcement learning in non-human primates. The dataset was carefully collected, and the statistical analyses, including the modeling, are rigorous. The evidence convincingly supports different roles for particular cortical and subcortical areas in representing key variables during reinforcement learning.

    Reviewed by eLife