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  1. Reinforcement learning for closed-loop optimisation of spatiotemporal stimulation in patterned neuronal networks

    1. Benedikt Maurer
    2. Vaiva Vasiliauskaitė
    3. Julian Hengsteler
    4. Gino Cathomen
    5. Tobias Ruff
    6. Cedric Schmid
    7. János Vörös
    8. Stephan J. Ihle

    • Curated by eLife

      eLife Assessment

      This study presents an open-source reinforcement learning framework for the real-time, closed-loop optimization of spatiotemporal electrical stimulation in engineered neuronal networks. Using single-spike-resolution activity as continuous feedback, the authors provide solid evidence that their platform can identify stimulation patterns that drive specific activity motifs within a structurally constrained four-node circuit. While this reproducible system offers a valuable and accessible tool for interacting with biological neural networks in an adaptive manner, further validation is needed to determine how well these stimulation strategies generalize to larger, unstructured, or more conventional network architectures.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  4. Top-down processing alone activates the early somatosensory nuclei

    1. Paige Howell
    2. Lynn Farner
    3. Finn Rabe
    4. Tim Emmenegger
    5. Maryam Seif
    6. Patrick Freund
    7. Nicole Wenderoth
    8. Sanne Kikkert

    • Curated by eLife

      eLife Assessment

      This important study provides convincing evidence that somatosensory relay nuclei remain engaged during attempted hand movements following chronic cervical spinal cord injury, including in individuals with severe motor impairment. The combination of functional and quantitative MRI with physiological controls supports the main findings and may have implications that are of importance in understanding sensorimotor processing after spinal cord injury. However, the interpretation of this activity as specifically reflecting top-down, and particularly corticocuneate, signaling may be overstated. The origin and anatomical route of the observed activity appears to remain less firmly established.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity
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