Latest preprint reviews

  1. RGS10 deficiency facilitates distant metastasis by inducing epithelial–mesenchymal transition in breast cancer

    This article has 9 authors:
    1. Yang Liu
    2. Yi Jiang
    3. Peng Qiu
    4. Tie Ma
    5. Jiawen Bu
    6. Yueting Hu
    7. Ming Jin
    8. Tong Zhu
    9. Xi Gu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable finding on the mechanism to promote distant metastasis in breast cancer. The evidence supporting the claims of the authors is convincing. The work will be of interest to medical biologists working on breast cancer.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  2. Dual Targeting of Histone Deacetylases and MYC as Potential Treatment Strategy for H3-K27M Pediatric Gliomas

    This article has 11 authors:
    1. Danielle Algranati
    2. Roni Oren
    3. Bareket Dassa
    4. Liat Fellus-Alyagor
    5. Alexander Plotnikov
    6. Haim Barr
    7. Alon Harmelin
    8. Nir London
    9. Guy Ron
    10. Noa Furth
    11. Efrat Shema
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is valuable work showing that a combination of drugs can reduce growth of Diffuse midline gliomas (clinically classified as DMG, H3 K27M-mutant) when applied in vitro and in tumor xenografts in mice. It is a significant first step towards understanding how these drugs work, and provides convincing results to encourage future pre-clinical studies. Further rationale on how doses for specific drugs were chosen, directly demonstrating a survival benefit, or implicating the Pin1 pathway components mechanistically, would make the manuscript stronger.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  3. Released Bacterial ATP Shapes Local and Systemic Inflammation during Abdominal Sepsis

    This article has 9 authors:
    1. Daniel Spari
    2. Annina Schmid
    3. Daniel Sanchez-Taltavull
    4. Shaira Murugan
    5. Keely Keller
    6. Nadia Ennaciri
    7. Lilian Salm
    8. Deborah Stroka
    9. Guido Beldi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This fundamental study advances our understanding of the role of bacterial derived extracellular ATP in the pathogenesis of sepsis. The evidence supporting the conclusions is solid, particularly with the analysis of E. coli mutants to address different aspects of bacterial release of ATP. The work will be of broad interest to researchers on microbiology and infectious diseases.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  4. N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine

    This article has 12 authors:
    1. Chuchu Wang
    2. Chunyu Zhao
    3. Xiao Hu
    4. Jiali Qiang
    5. Zhenying Liu
    6. Jinge Gu
    7. Shengnan Zhang
    8. Dan Li
    9. Yaoyang Zhang
    10. Jacqueline Burré
    11. Jiajie Diao
    12. Cong Liu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this useful study, the authors show that N-acetylation of synuclein increases clustering of synaptic vesicles in vitro and that this effect is mediated by enhanced interaction with lysophosphatidylcholine. While the evidence for enhanced clustering is largely solid, the biological significance remains unclear.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  5. Saccharomyces cerevisiae Rev7 regulates DSB repair pathway choice through binding and blocking Mre11 nuclease and Rad50 ATPase activities

    This article has 4 authors:
    1. Sugith Badugu
    2. Kshitiza M. Dhyani
    3. Manoj Thakur
    4. Kalappa Muniyappa
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript reports important data on the interaction of Rev7 with the Rad50-Mre11-Xrs2 complex in budding yeast providing evidence that a 42 amino acid region of Rev7 is necessary and sufficient for interaction. Rev7 is found to inhibit the Rad50 ATPase and the Mre11 nuclease activities, with the exception of the ssDNA exonuclease activity. Overall, the study is incomplete: controls are lacking, there is little evidence to support the conclusion about DSB repair pathway usage, and the work on the role of Mre11 in G4 metabolism is underdeveloped.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  6. De novo -designed minibinders expand the synthetic biology sensing repertoire

    This article has 6 authors:
    1. Zara Y. Weinberg
    2. Sarah S. Soliman
    3. Matthew S. Kim
    4. Irene P. Chen
    5. Melanie Ott
    6. Hana El-Samad
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a useful investigation to test de novo-designed mini binders against the Spike protein of SARS-CoV-2 within two classes of synthetic receptors (SNIPRs and CARs). The methods and evidence supporting the focused claims are very solid, although the small-scale nature of the investigation (number of modifications, number of minibinders, etc.) makes it difficult to determine how generalizable these results and potential design principles are. This work will be of interest to synthetic biologists and cell engineers as a starting point for systematic, larger-scale analysis and optimization of synthetic receptor designs for cellular therapy and other applications.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  7. Lack of evidence supporting transgenerational effects of non-transmitted paternal alleles on the murine transcriptome

    This article has 3 authors:
    1. Rodrigo Gularte-Mérida
    2. Carole Charlier
    3. Michel Georges
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important article presents the results of a large screen for non-genetic transgenerational effects that may influence gene expression and other phenotypes in mice. An extraordinary amount of mouse breeding, phenotyping, and RNA sequencing data provide compelling evidence that, for the phenotypes and genomic regions interrogated in these mouse strains, non-genetic transgenerational effects of appreciable magnitude are likely to be extremely rare. This paper will be of broad interest to geneticists and of particular interest to those studying epigenetic inheritance.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  8. Endocannabinoids and their receptors modulate endometriosis pathogenesis and immune response

    This article has 8 authors:
    1. Chandrakant Tayade
    2. Harshavardhan Lingegowda
    3. Katherine Zutautas
    4. Yuhong Wei
    5. Priyanka Yolmo
    6. Danielle Sisnett
    7. Alison McCallion
    8. Madhuri Koti
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Using new cannabinoid receptor (CNR1 and CNR2) knockout mouse models, this important paper shows how dysregulation of the endocannabinoid system is involved in endometriosis progression. The transcriptomic evidence is solid, but a major limitation of the work is the absence of detailed measurements of lesion size and burden by histopathology.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. FoxO factors are essential for maintaining organ homeostasis by acting as stress sensors in airway epithelial cells

    This article has 19 authors:
    1. Karin Uliczka
    2. Judith Bossen
    3. Ulrich M. Zissler
    4. Christine Fink
    5. Xiao Niu
    6. Mario Pieper
    7. Ruben D. Prange
    8. Christina Vock
    9. Christina Wagner
    10. Mirjam Knop
    11. Ahmed Abdelsadik
    12. Sören Franzenburg
    13. Iris Bruchhaus
    14. Michael Wegmann
    15. Carsten B. Schmidt-Weber
    16. Peter König
    17. Petra Pfefferle
    18. Holger Heine
    19. Thomas Roeder
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study investigates, from Drosophila to mammals, the role of the Forkhead box O (FoxO) transcription factors in airway epithelial cells' response to stressors including hypoxia, temperature variations, and oxidative stress. The findings suggest a conserved role of FoxO in maintaining airway homeostasis across species. However, limitations in the specificity and concerns with the loss-of-function experiments render the evidence presented incomplete. Nonetheless, this study highlights FoxO's potential relevance in respiratory diseases like asthma and offers insights into potential therapeutic targets for conditions affecting airway health.

    Reviewed by eLife

    This article has 2 evaluationsAppears in 2 listsLatest version Latest activity
  10. De novo variants in PLCG1 are associated with hearing impairment, ocular pathology, and cardiac defects

    This article has 23 authors:
    1. Mengqi Ma
    2. Yiming Zheng
    3. Shenzhao Lu
    4. Xueyang Pan
    5. Kim C. Worley
    6. Lindsay C. Burrage
    7. Lauren S. Blieden
    8. Aimee Allworth
    9. Wei-Liang Chen
    10. Giuseppe Merla
    11. Barbara Mandriani
    12. Jill A. Rosenfeld
    13. David Li-Kroeger
    14. Debdeep Dutta
    15. Shinya Yamamoto
    16. Michael F. Wangler
    17. Undiagnosed Diseases Network
    18. Ian A. Glass
    19. Sam Strohbehn
    20. Elizabeth Blue
    21. Paolo Prontera
    22. Seema R. Lalani
    23. Hugo J. Bellen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study reveals how Drosophila may be used to investigate the role of missense variants in the gene PLCG1 related to human disease in case studies. The evidence that most of these variants have a gain-of-function effect in the fly is convincing and supportive of their pathogenic effect. With some additional control experiments to assess overexpression toxicity, this work would be of relevance to human and Drosophila geneticists alike.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
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