Latest preprint reviews

1. T-follicular helper cells are epigenetically poised to transdifferentiate into T-regulatory type-1 cells

   This article has 8 authors:

   1. Josep Garnica
   2. Patricia Sole
   3. Jun Yamanouchi
   4. Joel Moro
   5. Debajyoti Mondal
   6. Cesar Fandos
   7. Pau Serra
   8. Pere Santamaria

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides important information on pre-existing epigenetic modification in T cell plasticity. The evidence supporting the conclusions is compelling, supported by comprehensive transcriptional and epigenetic analyses. The work will be of interest to immunologists and colleagues studying transcriptional regulation.

   Reviewed by eLife

2. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2209.08066v5

3. Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis

   This article has 5 authors:

   1. Igor Kondrychyn
   2. Haymar Wint
   3. Liqun He
   4. Christer Betsholtz
   5. Li-Kun Phng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study convincingly shows that aquaporins play a key role in blood vessel formation during zebrafish development. In particular, the paper implicates hydrostatic pressure and water flow as mechanisms controlling endothelial cell migration during angiogenic sprouting. This important study significantly advances our understanding of cell migration during morphogenesis. As such, this work will be of great interest to developmental and cell biologists working on organogenesis, angiogenesis, and cell migration.

   Reviewed by eLife

4. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2311.00616

5. The transcriptional landscape underlying larval development and metamorphosis in the Malabar grouper (Epinephelus malabaricus)

   This article has 9 authors:

   1. Roger Huerlimann
   2. Natacha Roux
   3. Ken Maeda
   4. Polina Pilieva
   5. Saori Miura
   6. Hsiao-chian Chen
   7. Michael Izumiyama
   8. Vincent Laudet
   9. Timothy Ravasi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The work provides valuable genomic resources to address the endocrine control of a life cycle transition in the Malabar grouper fish. The revised manuscript is more solid and the resources and experimental data help to build up a meaningful biological understanding of thyroid signaling in grouper fish.

   Reviewed by eLife

6. Impact of Maximal Overexpression of a Non-toxic Protein on Yeast Cell Physiology

   This article has 3 authors:

   1. Yuri Fujita
   2. Shotaro Namba
   3. Hisao Moriya

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This convincing study advances our understanding of the physiological consequences of the strong overexpression of non-toxic proteins in baker's yeast. The findings suggest that a massive protein burden results in nitrogen starvation and a shift in metabolism likely regulated via the TORC1 pathway, as well as defects in ribosome biogenesis in the nucleolus. The study presents findings and tools that are important for the cell biology and protein homeostasis fields.

   Reviewed by eLife

7. Oxydifficidin, a potent Neisseria gonorrhoeae antibiotic due to DedA assisted uptake and ribosomal protein RplL sensitivity

   This article has 8 authors:

   1. Jingbo Kan
   2. Adrian Morales
   3. Yozen Hernandez
   4. Melinda A. Ternei
   5. Christophe Lemetre
   6. Logan W. Maclntyre
   7. Nicolas Biais
   8. Sean F. Brady

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study reports on the discovery of an antimicrobial agent that kills Neisseria gonorrhoeae. Sensitivity is attributed to a combination of DedA assisted uptake of oxydifficidin into the cytoplasm and the presence of a oxydifficidin-sensitive RpIl ribosomal protein. Due to the narrow scope, the broader antibacterial spectrum remains unclear and therefore the evidence supporting the conclusions is incomplete with key methods and data lacking. This work will be of interest to microbiologists and synthetic biologists.

   Reviewed by eLife

8. Tonotopy is not preserved in a descending stage of auditory cortex

   This article has 14 authors:

   1. Miaoqing Gu
   2. Shanshan Liang
   3. Jiahui Zhu
   4. Ruijie Li
   5. Ke Liu
   6. Xuanyue Wang
   7. Frank Ohl
   8. Yun Zhang
   9. Xiang Liao
   10. Chunqing Zhang
   11. Hongbo Jia
   12. Yi Zhou
   13. Jianxiong Zhang
   14. Xiaowei Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important characterization of mouse auditory cortex receptive field organization, using two-photon imaging of specific subpopulations. They demonstrate a degradation of tonotopic organization from the input to output neurons. The strength of the evidence is solid, but some controls are needed to further strengthen the conclusion.

   Reviewed by eLife

9. Cryo-EM structure of the bicarbonate receptor GPR30

   This article has 7 authors:

   1. Shota Kaneda
   2. Airi Jo-Watanabe
   3. Hiroaki Akasaka
   4. Hidetaka S. Oshima
   5. Takehiko Yokomizo
   6. Wataru Shihoya
   7. Osamu Nureki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study resolves a cryo-EM structure of the GPCR, human GPR30, which responds to bicarbonate and regulates cellular responses to pH and ion homeostasis. Understanding the ligand and the mechanism of activation is important to the field of receptor signaling and potentially facilitates drug development targeting this receptor. While the overall structures are solid, the identification of the bicarbonate binding site is only partly supported by the structural data and cell-based functional assays, leaving a major aim of the study incomplete.

   Reviewed by eLife

10. Epigenetic delineation of the earliest cardiac lineage segregation by single-cell multi-omics

    This article has 20 authors:

    1. Peng Xie
    2. Xu Jiang
    3. Jingjing He
    4. Qingyun Pan
    5. Zhongzhou Yang
    6. Yanying Zheng
    7. Wenli Fan
    8. Chen Wu
    9. Weiheng Zheng
    10. Ke Fang
    11. Shuhan Si
    12. Shiqi Zhu
    13. Yi Yang
    14. Tao P. Zhong
    15. Zhongzhou Yang
    16. Ke Wei
    17. Wei Xie
    18. Naihe Jing
    19. Zhuojuan Luo
    20. Chengqi Lin

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study combines extensive published and new datasets to provide a useful single-cell multi-omics analysis of early cardiac lineage segregation, highlighting the mutual regulation of key regulators for cardiac specification. While the data presentation is robust, the computational methods for delineating cardiac lineage trajectories and the functional analyses are incomplete and require further clarification and additional experiments. If validated, these findings will be of significant interest to researchers in the fields of cardiac development and congenital heart disease.

    Reviewed by eLife