Latest preprint reviews

  1. Targeting resident astrocytes attenuates neuropathic pain after spinal cord injury

    This article has 10 authors:
    1. Qing Zhao
    2. Yanjing Zhu
    3. Yilong Ren
    4. Lijuan Zhao
    5. Jingwei Zhao
    6. Shuai Yin
    7. Haofei Ni
    8. Rongrong Zhu
    9. Liming Cheng
    10. Ning Xie
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study demonstrated that ablation of astrocytes in the lumbar spinal cord not only reduced neuropathic pain but also caused microglia activation. The findings presented add considerable value to the current understanding of the role of astrocyte elimination in neuropathic pain, offering convincing evidence that supports existing hypotheses and insights into the interactions between astrocytes and microglial cells, likely through IFN-mediated mechanisms. This study may also offer a new therapeutic strategy for the treatment of debilitating neuropathic pain in patients with SCI.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  2. The value of livestock abortion surveillance in Tanzania: identifying disease priorities and informing interventions

    This article has 15 authors:
    1. F. Lankester
    2. T. Kibona
    3. K.J. Allan
    4. W.A. de Glanville
    5. J.J. Buza
    6. F. Katzer
    7. J.E.B. Halliday
    8. BT. Mmbaga
    9. N. Wheelhouse
    10. E.A. Innes
    11. K.M. Thomas
    12. O.M. Nyasebwa
    13. E.S. Swai
    14. J.R. Claxton
    15. S. Cleaveland
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study reports the use of a surveillance approach in identifying emerging diseases, monitoring disease trends, and informing evidence-based interventions in the control and prevention of livestock abortions, as it relates to their public health implications. The data support the convincing finding that abortion incidence is higher during the dry season, and occurs more in cross-bred and exotic livestock breeds. Aetiological and epidemiological data can be generated through established protocols for sample collection and laboratory diagnosis. These findings are of potential interest to the fields of veterinary medicine, public health, and epidemiology.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  3. Control of ciliary transcriptional programs during spermatogenesis by antagonistic transcription factors

    This article has 8 authors:
    1. Weihua Wang
    2. Junqiao Xing
    3. Xiqi Zhang
    4. Hongni Liu
    5. Haochen Jiang
    6. Cheng Xu
    7. Xue Zhao
    8. Zhangfeng Hu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study reports useful data suggesting the critical roles of two ancient proteins, XAP5 and XAP5L, in controlling the transcriptional program of ciliogenesis during mouse spermatogenesis. However, this study is considered incomplete because the data only partially support the conclusion. This work will be of interest to biomedical researchers who work on ciliogenesis and reproduction.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  4. N-Terminus of Drosophila Melanogaster MSL1 Is Critical for Dosage Compensation

    This article has 6 authors:
    1. Valentin Babosha
    2. Natalia Klimenko
    3. Anastasia Revel-Muroz
    4. Evgeniya Tikhonova
    5. Pavel Georgiev
    6. Oksana Maksimenko
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this paper, the male sex-lethal (MSL) complex of proteins and RNA is studied through a domain analysis of one of its components, MSL1, and its interaction with others. While these results could be useful to researchers in the field, several studies have shown that the view that the MSL complex mediates dosage compensation is no longer considered tenable. Since there are many ways to alter viability, claims based on sex-specific viability as a reflection of dosage compensation should be viewed with much caution, and the evidence is currently considered inadequate to support the claims.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  5. Age-Related Decline in BBB Function is More Pronounced in Males than Females

    This article has 16 authors:
    1. Xingfeng Shao
    2. Qinyang Shou
    3. Kimberly Felix
    4. Brandon Ojogho
    5. Xuejuan Jiang
    6. Brian T. Gold
    7. Megan M Herting
    8. Eric L Goldwaser
    9. Peter Kochunov
    10. L. Elliot Hong
    11. Ioannis Pappas
    12. Meredith Braskie
    13. Hosung Kim
    14. Steven Cen
    15. Kay Jann
    16. Danny JJ Wang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable finding that the blood-brain barrier functionality changes with age and differs between males and females. The analysis is solid, comprising a large and racially diverse dataset, and utilizes a contrast-agent-free MRI method. Since limited work has been done in the MRI field on the blood-brain barrier using this method, this study is of great interest to neuroimaging researchers and clinicians.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  6. Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers

    This article has 30 authors:
    1. Richard C. Centore
    2. Luis M. M. Soares
    3. Salih Topal
    4. Rishi G. Vaswani
    5. Kana Ichikawa
    6. Zhifang Li
    7. Hong Fan
    8. Jeremy W. Setser
    9. David L. Lahr
    10. Laura E. Zawadzke
    11. Xueying Chen
    12. Kimberly D. Barnash
    13. Jordana Muwanguzi
    14. Neville Anthony
    15. Gabriel J. Sandoval
    16. Katharine Feldman
    17. GiNell Elliott
    18. Ammar Adam
    19. David Huang
    20. Yunji Davenport
    21. Shawn Schiller
    22. Kevin J. Wilson
    23. Johannes Voigt
    24. Lan Xu
    25. Martin Hentemann
    26. David S. Millan
    27. Ho Man Chan
    28. Carl P. Decicco
    29. Ryan G. Kruger
    30. Steven F. Bellon
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This work substantially advances our understanding of pharmacological inhibition of SWI/SNF as a therapeutic approach for cancer. The study is well-written and provides compelling evidence, including comprehensive datasets, compound screens, gene expression analysis, epigenetics, as well as animal studies. This study provides a fundamental advance for the uveal melanoma research field that might be exploited to target this deadly cancer and more generally for targeting transcriptional dependency in cancers.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  7. RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation

    This article has 16 authors:
    1. Esther Castellano
    2. Alejandro Rosell
    3. Agata Krygowska
    4. Marta Alcón Pérez Alcón
    5. Mathieu-Benoit Voisin
    6. Juan de Paz
    7. Héctor Sanz-Fraile
    8. Vinothini Rajeeve
    9. Alberto Berral-González
    10. Cristina Cuesta
    11. Ottilie Swinyard
    12. Enrique Gabandé-Rodriguez
    13. Julian Downward
    14. Jordi Alcaraz
    15. Javier De Las Rivas
    16. Pedro Cutillas
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This useful study investigates the impact of disrupting the interaction of RAS with the PI3K subunit p110α in macrophage function in vitro and inflammatory responses in vivo. Solid data overall supports a role for RAS-p110α signalling in regulating macrophage activity and so inflammation, however for many of the readouts presented the magnitude of the phenotype is not particularly pronounced. Further analysis would be required to substantiate the claims that RAS-p110α signalling plays a key role in macrophage function. Of note, the molecular mechanisms of how exactly p110α regulating the functions in macrophage have not yet been established.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  8. Automated workflow for the cell cycle analysis of non-adherent and adherent cells using a machine learning approach

    This article has 12 authors:
    1. Kourosh Hayatigolkhatmi
    2. Chiara Soriani
    3. Emanuel Soda
    4. Elena Ceccacci
    5. Oualid El Menna
    6. Sebastiano Peri
    7. Ivan Negrelli
    8. Giacomo Bertolini
    9. Gian Martino Franchi
    10. Roberta Carbone
    11. Saverio Minucci
    12. Simona Rodighiero
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This paper presents a valuable automated method to track individual mammalian cells as they progress through the cell cycle using the FUCCI system. The authors have developed a technique for analyzing cells that grow in suspension and used their method to look at different tumor cell lines that grow in suspension and determine the effect of drugs that directly affect the cell cycle. They show solid evidence that the method can be applied to both adherent and non-adherent cell lines. This paper will be of interest to cell biologists investigating cell cycle effects.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  9. The T Cell Receptor β Chain Repertoire of Tumor Infiltrating Lymphocytes Improves Neoantigen Prediction and Prioritization

    This article has 18 authors:
    1. Thi Mong Quynh Pham
    2. Thanh Nhan Nguyen
    3. Bui Que Tran Nguyen
    4. Thi Phuong Diem Tran
    5. Nguyen My Diem Pham
    6. Hoang Thien Phuc Nguyen
    7. Thi Kim Cuong Ho
    8. Dinh Viet Linh Nguyen
    9. Huu Thinh Nguyen
    10. Duc Huy Tran
    11. Thanh Sang Tran
    12. Truong-Vinh Ngoc Pham
    13. Minh-Triet Le
    14. Thi Tuong Vy Nguyen
    15. Minh-Duy Phan
    16. Hoa Giang
    17. Hoai-Nghia Nguyen
    18. Le Son Tran
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The study is useful by attempting to present a new approach of combining two measurements (pHLA binding and pHLA-TCR binding) in order to refine predictions of which patient mutations are likely presented to and recognized by the immune system, but the evidence is incomplete. Whereas the novel methodology proposed is compelling, this article lacks a detailed explanation of the chosen model. The experimental validation confirming the computational predictions with actual immune responses is limited due to sample constraints.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  10. Embedding stochastic dynamics of the environment in spontaneous activity by prediction-based plasticity

    This article has 2 authors:
    1. Toshitake Asabuki
    2. Claudia Clopath
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is an important study that investigates how neural networks can learn to stochastically replay presented sequences of activity according to learned transition probabilities. The authors use error-based excitatory plasticity to minimize the difference between internally predicted activity and stimulus-driven activity, and inhibitory plasticity to maintain E-I balance. The approach is solid but the choice of learning rules and parameters is not always always justified, lacking a formal derivation and concrete experimental predictions.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
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