Latest preprint reviews

  1. Late maturation of semantic control promotes conceptual development

    This article has 3 authors:
    1. Rebecca L. Jackson
    2. Matthew A. Lambon Ralph
    3. Timothy T. Rogers
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents valuable findings suggesting that the late maturation of prefrontal cortex-based control processes enhances conceptual learning by allowing a period of less-constrained knowledge acquisition. The authors provide convincing computational evidence that delayed semantic control promotes learning without compromising representation integrity, with the strongest benefits emerging when control connections target intermediate layers of the model. However, the model's narrow scope raises concerns about scalability to more complex, real-world learning environments, and the meta-analysis, while supporting the developmental trajectory, does not directly test the model's specific predictions regarding task outcomes or error patterns.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. A Titin Missense Variant Causes Atrial Fibrillation

    This article has 14 authors:
    1. Mahmud Arif Pavel
    2. Hanna Chen
    3. Michael Hill
    4. Arvind Sridhar
    5. Miles Barney
    6. Jaime DeSantiago
    7. Asia Owais
    8. Shashank Sandu
    9. Faisal A. Darbar
    10. Aylin Ornelas-Loredo
    11. Bahaa Al-Azzam
    12. Brandon Chalazan
    13. Jalees Rehman
    14. Dawood Darbar
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The study presents valuable findings regarding the incidence and clinical impact of a mutation in a cardiac muscle protein and its association with the development of atrial fibrillation. The authors provide some convincing evidence of electrophysiological disturbances in cells with this mutation which would be of interest to cellular electrophysiologists. However, evidence supporting the conclusion that this mutation causes atrial fibrillation would benefit from more rigorous electrophysiologic approaches.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  3. Heat Stress Induced Bacterial Tolerance against Phage Facilitates the Evolution of Resistance

    This article has 7 authors:
    1. Liu Jiafeng
    2. Fan Zhang
    3. Hao-Ze Chen
    4. Bo Zheng
    5. liang huang
    6. Ye Xiang
    7. Jing-Ren Zhang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study analyzes the effect of heat treatment on phage-bacterial interactions and convincingly shows that prior heat exposure alters the bacterial cell envelope, enhancing persistence and bacterial survival when exposed to lytic phages. The study will interest researchers working on antibiotic resistance, tolerance, and phage therapy.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. The capsule and genetic background, rather than specific loci, strongly influence pneumococcal growth kinetics

    This article has 11 authors:
    1. Chrispin Chaguza
    2. Daan W. Arends
    3. Stephanie W. Lo
    4. Indri Hapsari Putri
    5. Anna York
    6. John A. Lees
    7. Anne L. Wyllie
    8. Daniel M. Weinberger
    9. Stephen D. Bentley
    10. Marien I. de Jonge
    11. Amelieke J.H. Cremers
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is an important study that examines the impact of Streptococcus pneumoniae genetics on its in vitro growth kinetics, aiming to identify potential targets for vaccines and therapeutics. The study identified significant variations in growth characteristics among capsular serotypes and lineages, linked to phylogeny and high heritability, but genome-wide association studies did not reveal specific genomic loci associated with growth features independent of the genetic background. The evidence supporting these findings is solid.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. Dynamic modulation of social gaze by sex and familiarity in marmoset dyads

    This article has 5 authors:
    1. Feng Xing
    2. Alec G. Sheffield
    3. Monika P. Jadi
    4. Steve W. C. Chang
    5. Anirvan S. Nandy
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study establishes the methodology (machine vision and gaze pose estimation) and behavioral apparatus for examining social interactions between pairs of marmoset monkeys. Their results enable unrestrained social interactions under more rigorous conditions with detailed quantification of position and gaze. It has been difficult to study social interactions using artificial stimuli, as opposed to genuine interactions between unrestrained animals. This study makes an important contribution to studying social neuroscience within a laboratory setting; the approach is novel and well-executed, backed by convincing evidence.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  6. The relationship between cognitive abilities and mental health as represented by cognitive abilities at the neural and genetic levels of analysis

    This article has 3 authors:
    1. Yue Wang
    2. Richard Anney
    3. Narun Pat
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study examines the relationship between cognition and mental health and investigates how brain, genetics, and environmental measures mediate that relationship. The methods and results are compelling and well-executed. Overall, this study will be of interest in the field of population neuroscience and in studies of mental health.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  7. A gradual transition toward categorical representations along the visual hierarchy during working memory, but not perception

    This article has 4 authors:
    1. Chaipat Chunharas
    2. Michael J Wolff
    3. Meike D Hettwer
    4. Rosanne L Rademaker
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study examined orientation representations along the visual hierarchy during perception and working memory. The authors provide results suggesting that during working memory there is a gradient where representations are more categorical in nature later in the visual hierarchy. The evidence presented is solid, most notably a match between behavioral data, though minor weakness can be attributed to the tasks and behaviors not being designed to address this question. The findings should be of interest to a relatively broad audience, namely those interested in the relationship between sensory coding and memory.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  8. Synaptic Connectivity of Sensorimotor Circuits for Vocal Imitation in the Songbird

    This article has 6 authors:
    1. Massimo Trusel
    2. Ziran Zhao
    3. Danyal H. Alam
    4. Ethan S. Marks
    5. Maaya Z. Ikeda
    6. Todd F. Roberts
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The songbird vocal motor nucleus HVC contains cells that project to the basal ganglia, the auditory system, or downstream vocal motor structures. In this fundamental study, the authors conduct optogenetic circuit mapping to clarify how four distinct inputs to HVC act on these distinct HVC cell types. They provide compelling evidence that all long-range projections engage inhibitory circuits in HVC and can also exhibit cell-type specific preferences in monosynaptic input strength. Understanding the HVC microcircuit at this microcircuit level is critical for informing models of song learning and production.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. Distancing alters the controllability of emotional states by affecting both intrinsic stability and extrinsic sensitivity

    This article has 2 authors:
    1. Jolanda Malamud
    2. Quentin JM Huys
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important manuscript proposes a dual behavioral/computational approach to assess emotional regulation in humans. The authors present solid evidence for the idea that emotional distancing (as routinely used in clinical interventions for e.g. mood and anxiety disorders) enhances emotional control.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
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