eLife

Latest preprint reviews

1. Monocyte-derived macrophage recruitment mediated by TRPV1 is required for eardrum wound healing

   This article has 6 authors:

   1. Yunpei Zhang
   2. Pingting Wang
   3. Lingling Neng
   4. Kushal Sharma
   5. Allan Kachelmeier
   6. Xiaorui Shi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study exploring the role of TRPV1 signaling in recruiting macrophages and promoting angiogenesis during tympanic membrane wound healing presents useful findings. However, the strength of evidence supporting the central claims is incomplete, as the mechanistic links between TRPV1 activation and immune cell recruitment remain largely correlative and rely heavily on previously published datasets without sufficient functional validation. The work will be of interest to researchers studying wound healing and sensory-immune interactions, though substantial revisions are needed to support its broader significance.

   Reviewed by eLife

2. Evidence for systematic - yet task- and motor-contingent - rhythmicity of auditory perceptual judgements

   This article has 2 authors:

   1. Cécile Fabio
   2. Christoph Kayser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This high-N, multi-task study offers a comprehensive examination of rhythmicity in behavioral performance during listening. It presents a valuable set of findings that reveal task- and ear-specific effects, challenging the notion of a universal rhythmicity in auditory perception. While the evidence is solid, the study would benefit from a stronger conceptual framework to contextualize and explain the observed patterns. Nonetheless, the work is likely to be of significant interest to behavioral and cognitive scientists focused on perception and neural oscillations.

   Reviewed by eLife

3. Sparse innervation and local heterogeneity in the vibrissal corticostriatal projection

   This article has 5 authors:

   1. Kenza Amroune
   2. Lorenzo Fontolan
   3. Agnès Baude
   4. David Robbe
   5. Ingrid Bureau

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work provides fundamental findings on how the mouse barrel cortex connects to the dorsolateral striatum, uncovering that inputs from discrete whisker cortical columns are convergent and SPN-specific, but topographically organized at the population level. The evidence supporting this claim is compelling, demonstrating that SPNs uniquely integrate sparse input from variable stretches across the barrel cortex. The study would be of interest to basal ganglia and sensory-motor integration researchers.

   Reviewed by eLife

4. Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response

   This article has 11 authors:

   1. CJ San Felipe
   2. Jyoti Batra
   3. Monita Muralidharan
   4. Shivali Malpotra
   5. Durga Anand
   6. Rachel Bauer
   7. Kliment A Verba
   8. Danielle L. Swaney
   9. Nevan J. Krogan
   10. Michael Grabe
   11. James S. Fraser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study demonstrates that lipid binding can regulate the dimerization state of the SARS-CoV2 Orf9b protein. The data from biophysical and cellular experiments, along with mathematical modeling, are convincing. However, this study can further benefit from more rigorous quantitative analyses and from resolving the role of dimerization in viral infection and host innate responses. This paper is broadly relevant to those studying coupled equilibria across all aspects of biology.

   Reviewed by eLife

5. Recurrent Mutations Drive the Rapid Evolution of Pesticide Resistance in the Two-spotted Spider Mite Tetranychus urticae

   This article has 16 authors:

   1. Li-Jun Cao
   2. Jin-Cui Chen
   3. Joshua A. Thia
   4. Thomas L. Schmidt
   5. Richard Ffrench-Constant
   6. Lin-Xi Zhang
   7. Yu Yang
   8. Meng-Chu Yuan
   9. Jia-Yue Zhang
   10. Xiao-Yang Zhang
   11. Qiong Yang
   12. Ya-Jun Gong
   13. Hu Li
   14. Xue-Xin Chen
   15. Ary A. Hoffmann
   16. Shu-Jun Wei

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable insights into the evolution of pesticide resistance, demonstrating that resistance can arise rapidly and repeatedly, which complements prior work on parallel evolution across species. The combination of extensive temporal sampling in the field, experimental evolution, and genomics makes for convincing findings. The authors are to be commended for acknowledging the main limitations of their study in the Discussion. Framing the work in a broader context of resistance beyond arthropod pests would further increase the appeal of the study, which is of relevance for both agronomic practitioners and evolutionary biologists.

   Reviewed by eLife

6. Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds

   This article has 21 authors:

   1. Dominique Meunier
   2. Ricardo Corona-Torres
   3. Kay Boulton
   4. Zhiguang Wu
   5. Maeve Ballantyne
   6. Laura Glendinning
   7. Anum Ali Ahmad
   8. Dominika Borowska
   9. Lorna Taylor
   10. Lonneke Vervelde
   11. Jorge del Pozo
   12. Marili Vasilogianni
   13. José Jaramillo-Ortiz
   14. Gonzalo Sanchez-Arsuaga
   15. Androniki Psifidi
   16. Fiona Tomley
   17. Kellie A. Watson
   18. Michael J. McGrew
   19. Mark P. Stevens
   20. Damer P. Blake
   21. David A. Hume

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Despite the conserved anti-inflammatory activity in birds, whether IL-10 also controls avian intestinal homeostasis remains unclear. Generating genetic knockouts, Meunier et al. firmly established that a complete lack of IL-10 strengthened immunity against enteric bacteria in chickens, while also aggravating infection-inflicted tissue damage upon parasite infection. The findings presented in this manuscript are valuable, and the strength of evidence is convincing; however, it is advised that the deficiencies and weaknesses pointed out by all the reviewers are meticulously addressed.

   Reviewed by eLife

7. Heritability of movie-evoked brain activity and connectivity

   This article has 4 authors:

   1. David C. Gruskin
   2. Daniel J. Vieira
   3. Jessica K. Lee
   4. Gaurav H. Patel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper addresses a valuable research question on the heritability of the brain's response to movie watching, given various parameters such as regional spatial hyperalignment and BOLD frequency bands. The topic of this paper would be of interest to fMRI methodological experts, and potentially to a broader cognitive neuroscience audience, and those with an interest in understanding the heritable sources of individual differences in brain function. However, the current findings provide incomplete support for the conclusions, since several key methodological concerns need to be addressed to ensure the validity of the analyses and results.

   Reviewed by eLife

8. Ribosomal RNA synthesis by RNA polymerase I is regulated by premature termination of transcription

   This article has 12 authors:

   1. Chaïma Azouzi
   2. Katrin Schwank
   3. Sophie Queille
   4. Marta Kwapisz
   5. Marion Aguirrebengoa
   6. Anthony Henras
   7. Simon Lebaron
   8. Herbert Tschochner
   9. Annick Lesne
   10. Frédéric Beckouët
   11. Olivier Gadal
   12. Christophe Dez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript characterizes a mutated clone of RNA polymerase I in yeast, referred to as SuperPol, to understand the mechanisms of RNA polymerase I elongation and termination. The authors present solid evidence that SuperPol has higher processivity during transcription elongation than wild-type RNA polymerase I. Notably, the study provides evidence that the transcriptional pause of RNA polymerase I may be a therapeutic vulnerability in cancers. Overall, the characterization of this RNA pol I is important as it provides insights into the regulation of ribosomal RNA transcription and its potential application in cancer pharmacology.

     [Editors' note: this paper was reviewed by Review Commons.]

   Reviewed by eLife, Review Commons

9. microRNA-19b regulates proliferation & patterning in the avian forebrain

   This article has 4 authors:

   1. Archita Mishra
   2. Suvimal Kumar Sindhu
   3. Niveda Udaykumar
   4. Jonaki Sen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study provides insights into a key question in comparative neuroanatomy and development. The authors provide evidence of the role for a particular micro-RNA in regulating the development of key transcription factors that control forebrain development. The study rests on clear but incomplete results.

   Reviewed by eLife

10. CHROMAS: A Computational Pipeline to Track Chromatophores and Analyze their Dynamics

    This article has 4 authors:

    1. Johann Ukrow
    2. Mathieu DM Renard
    3. Mahyar Moghimi
    4. Gilles Laurent

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      The open-source software Chromas tracks and analyses cephalopod chromatophore dynamics. The software features a user-friendly interface alongside detailed instructions for its application, with compelling exemplary applications to two widely divergent cephalopod species, a squid and a cuttlefish, over time periods large enough to encompass new chromatophore development among existing ones. It demonstrates accurate tracking of the position and identity of each chromatophore. The software and methods outlined therein will become an important tool for scientists tracking dynamic signaling in animals.

    Reviewed by eLife