eLife

Latest preprint reviews

1. Auditory perception and neural representation of temporal fine structure are impaired by age but not by cochlear synaptopathy

   This article has 5 authors:

   1. Friederike Steenken
   2. Rainer Beutelmann
   3. Henning Oetjen
   4. Christine Köppl
   5. Georg M. Klump

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study tested the specific hypothesis that age-related changes to hearing involve a partial loss of synapse connections between sensory cells in the ear and the nerve fibers that carry information about sounds to the brain, and that this interferes with the ability to discriminate rapid temporal fluctuations in sounds. Physiological, behavioral, and histological analyses provide a powerful combination to test this hypothesis in gerbils. Contrary to previous suggestions, it was found that chemically-induced isolated synaptopathy (at similar levels as observed in aged gerbils) did not result in worse performance on a behavioral task measuring sensitivity to fine-structure. Further, altered neural coding of rapid fluctuations produced no perceptual deficits in either these gerbils or in aged gerbils. These findings are important understanding age-related changes to hearing; however, the evidence provided is incomplete due to problems in interpretation and the discussion of possible confounds and/or limitations of these data that currently limits mechanistic insight.

   Reviewed by eLife

2. TRPV4 overactivation enhances cellular contractility and drives ocular hypertension in TGFβ2 overexpressing eyes

   This article has 10 authors:

   1. Christopher N. Rudzitis
   2. Monika Lakk
   3. Ayushi Singh
   4. Sarah N. Redmon
   5. Denisa Kirdajova
   6. Yun-Ting Tseng
   7. Michael L. De Ieso
   8. W. Daniel Stamer
   9. Samuel Herberg
   10. David Križaj

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental work extends our understanding of the role of TGFβ2 as a modulator of mechanosensing in the eye and identifies the TRPV4 ion channel as a common regulator of Trabecular Meshwork (TM) contractility and pathological OHT. The data and evidence are convincing, with some minor limitations. This work will clearly be of interest to researchers investigating the role of mechanosensors in the TM and may underpin future research into treatments that aim to lower intra ocular pressure. This work will additionally be of interest to the growing field of researchers investigating the regulation of force sensing via ion channels and their roles in health and disease, in particular the ion channel TRPV4.

   Reviewed by eLife

3. The title and authors for this article are not available from our external data provider yet:
   10.31219/osf.io/kcwm8

4. Machine learning of honey bee olfactory behavior identifies repellent odorants in free flying bees in the field

   This article has 7 authors:

   1. Joel Kowalewski
   2. Barbara Baer-Imhoof
   3. Tom Guda
   4. Matthew Luy
   5. Payton DePalma
   6. Boris Baer
   7. Anandasankar Ray

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study tests a methodology for the discovery of new honey bee-repellent odorants via machine learning. The conclusions of the study are supported by solid evidence, with predicted compounds validated in the lab and the field. This work will be of interest to researchers in ecology, pest control and olfactory neuroscience.

   Reviewed by eLife

5. Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa

   This article has 9 authors:

   1. Hyun Beom Song
   2. Laura Campello
   3. Anupam Mondal
   4. Holly Y Chen
   5. Milton A English
   6. Michael Glen
   7. Phillip Vanlandingham
   8. Rafal Farjo
   9. Anand Swaroop

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important Research Advance presents convincing evidence on the neuroprotective effects of reserpine in a well-established model of retinitis pigmentosa (P23H-1). This study builds on previous work establishing reserpine as a neuroprotectant in models of Leber congenital amaurosis. Here authors show reserpine's disease gene-independent influence on photoreceptor survival and emphasizes the importance of considering biological sex in understanding inherited retinal degeneration and the impact of drug treatments on mutant retinas. The work will be of interest to vision researchers as well as a broad audience in translational research.

   Reviewed by eLife

6. Cell type-specific driver lines targeting the Drosophila central complex and their use to investigate neuropeptide expression and sleep regulation

   This article has 7 authors:

   1. Tanya Wolff
   2. Mark Eddison
   3. Nan Chen
   4. Aljoscha Nern
   5. Preeti Sundaramurthi
   6. Divya Sitaraman
   7. Gerald M Rubin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a fundamental body of work reporting anatomical, molecular, and functional mapping of the central complex in Drosophila. The tools generated and the findings, which include characterization of neuromodulators used by different cells, will undoubtedly serve as a foundation for future studies of this brain region. Overall, the data are compelling and likely to have a major impact.

   Reviewed by eLife

7. Gamma Knife Stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: A Phase II Trial Analysis

   This article has 16 authors:

   1. Yiran Zhang
   2. Hanyang Guan
   3. Shijin Liu
   4. Haoquan Li
   5. Zili Bian
   6. Jiashuai He
   7. Zhan Zhao
   8. Shenghui Qiu
   9. Tianmu Mo
   10. Xiangwei Zhang
   11. Zuyang Chen
   12. Hui Ding
   13. Xiaoxu Zhao
   14. Liang Wang
   15. Yunlong Pan
   16. Jinghua Pan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study highlights the potential of combining immunotherapy for pMMR CRC by selecting suitable cases and demonstrating that Gamma Knife SBRT with tislelizumab provides a safe and effective later-line treatment option for patients with pMMR/MSS/MSI-L mCRC unresponsive to standard chemotherapy. The authors employed a robust experimental design and rigorous statistical analyses to ensure the reliability of their findings. Their results offer compelling evidence to support the clinical value of this combined therapeutic approach.

   Reviewed by eLife

8. Integration of parallel pathways for flight control in a hawkmoth reflects prevalence and relevance of natural visual cues

   This article has 3 authors:

   1. Ronja Bigge
   2. Rebecca Grittner
   3. Anna Stöckl

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study investigates how hummingbird hawkmoths integrate stimuli from across their visual field to guide flight behavior. Cue conflict experiments provide solid evidence for an integration hierarchy within the visual field: hawkmoths prioritize the avoidance of dorsal visual stimuli, potentially to avoid crashing into foliage, while they use ventrolateral optic flow to guide flight control. With a more systematic quantification of specific parameter combinations, this paper would be of broad interest to enthusiasts of visual neuroscience and ethology.

   Reviewed by eLife

9. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2407.21115v1

10. Preparatory attentional templates in prefrontal and sensory cortex encode target-associated information

    This article has 2 authors:

    1. Zhiheng Zhou
    2. Joy J Geng

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable study decoded target-associated information in prefrontal and sensory cortex during the preparatory period of a visual search task, suggesting a memory-driven attentional template. The evidence supporting this claim is convincing, based on multivariate pattern analyses of fMRI data. The results will be of interest to psychologists and cognitive neuroscientists.

    Reviewed by eLife