eLife

Latest preprint reviews

1. Spatiotemporal ecological chaos enables gradual evolutionary diversification without niches or tradeoffs

   This article has 3 authors:

   1. Aditya Mahadevan
   2. Michael T Pearce
   3. Daniel S Fisher

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study explores the question of "what gives rise to micro-diversity in ecological settings", and proposes a scenario of spatiotemporal chaos, in which interactions between strains drive large changes in the relative abundances of strains. The presented theoretical approach is compelling and goes beyond the current state of the art. This innovative theoretical work is of broad interest to the field of ecology and evolution.

   Reviewed by eLife

2. Femora from an exceptionally large population of coeval ornithomimosaurs yield evidence of sexual dimorphism in extinct theropod dinosaurs

   This article has 4 authors:

   1. Romain Pintore
   2. Raphaël Cornette
   3. Alexandra Houssaye
   4. Ronan Allain

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important contribution to the field of dinosaur palaeontology. The authors provide convincing evidence for sexual dimorphism in dinosaurs, based on limb bones of ornithomimosaurs from the Cretaceous of France. The article makes several valuable and important contributions -- including the use of a large dataset and robust statistical approaches -- and will serve as a benchmark for future studies on dinosaurs and other fossil reptiles.

   Reviewed by eLife

3. The differential regulation of placenta trophoblast bisphosphoglycerate mutase in fetal growth restriction: preclinical study in mice and observational histological study of human placenta

   This article has 14 authors:

   1. Sima Stroganov
   2. Talia Harris
   3. Liat Fellus-Alyagor
   4. Lital Ben Moyal
   5. Romina Plitman Mayo
   6. Ofra Golani
   7. Dana Hirsch
   8. Shifra Ben-Dor
   9. Alexander Brandis
   10. Tevie Mehlman
   11. Michal Kovo
   12. Tal Biron-Shental
   13. Nava Dekel
   14. Michal Neeman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable finding of the role of under investigated pathway associated with development of placental oxygenation during pregnancy. The evidence supporting the claims of the authors is incomplete, although inclusion of a larger number of patient samples and an animal model have strengthened the study. The work will be of interest to developmental biologists working on placental function.

   Reviewed by eLife

4. A hardware system for real-time decoding of in vivo calcium imaging data

   This article has 10 authors:

   1. Zhe Chen
   2. Garrett J Blair
   3. Changliang Guo
   4. Jim Zhou
   5. Juan-Luis Romero-Sosa
   6. Alicia Izquierdo
   7. Peyman Golshani
   8. Jason Cong
   9. Daniel Aharoni
   10. Hugh T Blair

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study demonstrates ultrafast real-time decoding of place fields in the hippocampus thanks to a head-mounted microscope for calcium imaging and to a novel data processing pipeline. This is a useful tool that aims at obtaining real-time capabilities that will enable closed-loop experiments that include decoding of a wide neuronal population, which could be applied in a variety of neuroscience fields. This will be of interest to anyone studying behaviors or functions that involve the hippocampus.

   Reviewed by eLife

5. Creating an atlas of the bone microenvironment during oral inflammatory-related bone disease using single-cell profiling

   This article has 8 authors:

   1. Yi Fan
   2. Ping Lyu
   3. Ruiye Bi
   4. Chen Cui
   5. Ruoshi Xu
   6. Clifford J Rosen
   7. Quan Yuan
   8. Chenchen Zhou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this important project, the authors used single-cell RNA-sequencing (scRNA-Seq) technology to profile the transcriptome of alveolar bone marrow single cells and demonstrated the protective role of mesenchymal stem cells (MSCs) during apical periodontitis. With comprehensive data, the authors identified new inflammatory biomarkers associated with the pathogenesis of oral inflammatory diseases. Their study suggests that certain MSC subsets may have a potential role in healing bone lesions.

   Reviewed by eLife

6. MCT1-dependent energetic failure and neuroinflammation underlie optic nerve degeneration in Wolfram syndrome mice

   This article has 14 authors:

   1. Greta Rossi
   2. Gabriele Ordazzo
   3. Niccolò N Vanni
   4. Valerio Castoldi
   5. Angelo Iannielli
   6. Dario Di Silvestre
   7. Edoardo Bellini
   8. Letizia Bernardo
   9. Serena G Giannelli
   10. Mirko Luoni
   11. Sharon Muggeo
   12. Letizia Leocani
   13. PierLuigi Mauri
   14. Vania Broccoli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The primary goal of this paper is to characterize retinal dysfunction and retinal ganglion cell degeneration in the Wfs1exon8del murine model of Wolfram Syndrome 1. The study provides fundamental insight into the timelines of degeneration as well as valuable transcriptomic and proteomic datasets. The methodologies performed are generally rigorous and the conclusions reached are mostly well supported by the data, however, the interrogation of the mechanism is largely circumstantial and the relevance to disease is primarily speculative. The results of this study are highly relevant for molecular mechanisms in Wolfram Syndrome 1 and are of potential interest to scientists interested in oligodendrocyte and neuron communication.

   Reviewed by eLife

7. Network-based multi-omics integration reveals metabolic at-risk profile within treated HIV-infection

   This article has 14 authors:

   1. Flora Mikaeloff
   2. Marco Gelpi
   3. Rui Benfeitas
   4. Andreas D Knudsen
   5. Beate Vestad
   6. Julie Høgh
   7. Johannes R Hov
   8. Thomas Benfield
   9. Daniel Murray
   10. Christian G Giske
   11. Adil Mardinoglu
   12. Marius Trøseid
   13. Susanne D Nielsen
   14. Ujjwal Neogi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study systematically integrates multi-omics data to identify the metabolic at-risk profiles within people living with HIV on antiretroviral therapy and presents findings that have focused importance and scope. The methods, data, and analyses as described now only partially support the primary claims.

   Reviewed by eLife

8. Iron status influences mitochondrial disease progression in Complex I-deficient mice

   This article has 13 authors:

   1. CJ Kelly
   2. Reid K Couch
   3. Vivian T Ha
   4. Camille M Bodart
   5. Judy Wu
   6. Sydney Huff
   7. Nicole T Herrel
   8. Hyunsung D Kim
   9. Azaad O Zimmermann
   10. Jessica Shattuck
   11. Yu-Chen Pan
   12. Matt Kaeberlein
   13. Anthony S Grillo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript starts from the hypothesis that a model of mitochondrial disease, the NDUFS4 knockout mouse, causes iron dysregulation, and that iron status may modify the neurological phenotypes that result in the mouse. This study has the potential to inform how body iron homeostasis can modify neurological phenotypes caused by mitochondrial disease. This study will be of interest to a broad audience of neuroscientists, particularly those with an interest in mitochondrial diseases.

   Reviewed by eLife

9. Belly roll, a GPI-anchored Ly6 protein, regulates Drosophila melanogaster escape behaviors by modulating the excitability of nociceptive peptidergic interneurons

   This article has 12 authors:

   1. Kai Li
   2. Yuma Tsukasa
   3. Misato Kurio
   4. Kaho Maeta
   5. Akimitsu Tsumadori
   6. Shumpei Baba
   7. Risa Nishimura
   8. Akira Murakami
   9. Koun Onodera
   10. Takako Morimoto
   11. Tadashi Uemura
   12. Tadao Usui

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study presents valuable findings on a gene called bero that affects the way larval Drosophila respond to nociceptive stimuli. This discovery is followed-up by the identification of neurons in which bero function is relevant for the modulation of nociceptive behavior, and by the additional identification of likely signaling molecules for conferring such modulation. The work will be of interest to neurobiologists working on genes, neural circuits, and behavior. While both interesting and methodologically elegant and diverse, important genetic controls for leaky expression of transgenes seem to be missing, as are alternative scenarios for results that, as the authors acknowledge, are unexpected or seemingly contradictory.

   Reviewed by eLife

10. A comprehensive survey of C. elegans argonaute proteins reveals organism-wide gene regulatory networks and functions

    This article has 10 authors:

    1. Uri Seroussi
    2. Andrew Lugowski
    3. Lina Wadi
    4. Robert X Lao
    5. Alexandra R Willis
    6. Winnie Zhao
    7. Adam E Sundby
    8. Amanda G Charlesworth
    9. Aaron W Reinke
    10. Julie M Claycomb

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This impressive study presents the most comprehensive analysis of the Argonautes, their small RNA partners, their targets, and their biological functions in any species to date. The work provides new insights into Argonaute-based pathways, it includes extensive validation of existing models, and describes overall a treasure-trove of reagents and datasets for future exploration of the vast Argonaute world in C. elegans.

    Reviewed by eLife