eLife

Latest preprint reviews

1. We couldn't get details of this article at this time:
   10.1101/2023.02.21.529383

2. We couldn't get details of this article at this time:
   10.1101/2023.03.21.533599

3. We couldn't get details of this article at this time:
   10.1101/2023.04.13.536715

4. Loss of Ptpmt1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure in tissue-specific knockout mice

   This article has 14 authors:

   1. Hong Zheng
   2. Qianjin Li
   3. Shanhu Li
   4. Zhiguo Li
   5. Marco Brotto
   6. Daiana Weiss
   7. Domenick Prosdocimo
   8. Chunhui Xu
   9. Ashruth Reddy
   10. Michelle Puchowicz
   11. Xinyang Zhao
   12. M Neale Weitzmann
   13. Mukesh K Jain
   14. Cheng-Kui Qu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper provides a useful set of data examining the role of PTPMT1, a mitochondria-based phosphatase, in mitochondrial fuel selection. The data were collected and analyzed using solid methodology and can be used as a starting point for further studies that build on the findings here.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.1101/2023.03.26.534303

6. The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2

   This article has 12 authors:

   1. Hsiao-Fan Chen
   2. Wei-Jan Wang
   3. Chung-Yu Chen
   4. Wei-Chao Chang
   5. Po-Ren Hsueh
   6. Shin-Lei Peng
   7. Chen-Shiou Wu
   8. Yeh Chen
   9. Hsin-Yu Huang
   10. Wan-Jou Shen
   11. Shao-Chun Wang
   12. Mien-Chie Hung

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental work provides preclinical evidence to support that natural tannins derived from grapeseed can inhibit or prevent infection by the SARS-CoV-2 viruses. The evidence provided is mostly solid to convincing and supports the conclusions. This work will be of broad interest to cell biologists and physicians.

   Reviewed by eLife

7. SNORD90 induces glutamatergic signaling following treatment with monoaminergic antidepressants

   This article has 28 authors:

   1. Rixing Lin
   2. Aron Kos
   3. Juan Pablo Lopez
   4. Julien Dine
   5. Laura M Fiori
   6. Jennie Yang
   7. Yair Ben-Efraim
   8. Zahia Aouabed
   9. Pascal Ibrahim
   10. Haruka Mitsuhashi
   11. Tak Pan Wong
   12. El Cherif Ibrahim
   13. Catherine Belzung
   14. Pierre Blier
   15. Faranak Farzan
   16. Benicio N Frey
   17. Raymond W Lam
   18. Roumen Milev
   19. Daniel J Muller
   20. Sagar V Parikh
   21. Claudio Soares
   22. Rudolf Uher
   23. Corina Nagy
   24. Naguib Mechawar
   25. Jane A Foster
   26. Sidney H Kennedy
   27. Alon Chen
   28. Gustavo Turecki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study that uncovers a new molecular pathway that links traditional monoaminergic antidepressants with regulation of glutamate neurotransmission. The data provided for the model are convincing and demonstrate the pathway in human plasma and brain, mouse brain, and cultured cells, using the relative strengths of each system. The work will be of interest to psychiatrists studying depression as well as basic neurobiologists interested in monoamine signaling in the brain.

   Reviewed by eLife

8. Coronary artery established through amniote evolution

   This article has 12 authors:

   1. Kaoru Mizukami
   2. Hiroki Higashiyama
   3. Yuichiro Arima
   4. Koji Ando
   5. Norihiro Okada
   6. Katsumi Kose
   7. Shigehito Yamada
   8. Jun K Takeuchi
   9. Kazuko Koshiba-Takeuchi
   10. Shigetomo Fukuhara
   11. Sachiko Miyagawa-Tomita
   12. Hiroki Kurihara

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Mizukami et al. propose a scenario for the evolutionary origin of the coronary artery in amniotes by comparing the morphologies of the vasculatures across several species and developmental timepoints. They show that the coronary arteries of non-amniotes most closely resemble embryonic amniote aortic subepicardial vessels (ASVs), which are replaced by the true coronary arteries during amniote development. While the identification of common vascular structures in diverse taxa is a valuable contribution, additional developmental evidence is needed to confirm that such vessels are truly homologous.

   Reviewed by eLife

9. Spatial structure favors microbial coexistence except when slower mediator diffusion weakens interactions

   This article has 4 authors:

   1. Alexander Lobanov
   2. Samantha Dyckman
   3. Helen Kurkjian
   4. Babak Momeni

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study uses computational simulations to explore how spatial structure can affect the coexistence between different microbial species, ultimately helping to explain diversity in microbial communities. The evidence supporting the conclusions is solid, although the parameter values used in the simulations were deemed to be unrealistic. Further investigation on whether the conclusions would hold under more realistic assumptions would be very interesting to microbial ecologists quite broadly.

   Reviewed by eLife

10. Complex subsets but redundant clonality after B cells egress from spontaneous germinal centers

    This article has 7 authors:

    1. Carlos Castrillon
    2. Lea Simoni
    3. Theo van den Broek
    4. Cees van der Poel
    5. Elliot H Akama-Garren
    6. Minghe Ma
    7. Michael C Carroll

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      Understanding the heterogeneity of the B cell response induced in autoimmune individuals is important for the development of therapies designed to target the cells underlying disease progression. Here the authors use a new mouse model of autoimmunity to assess the heterogeneity of the B cell response using single-cell RNA-sequencing and BCR-sequencing and found that these B cell responses are similar to those by exogenous protein immunization.

    Reviewed by eLife