Immunology

Quantitative analyses of T cell motion in tissue reveals factors driving T cell search in tissues

1. David J Torres
2. Paulus Mrass
3. Janie Byrum
4. Arrick Gonzales
5. Dominick N Martinez
6. Evelyn Juarez
7. Emily Thompson
8. Vaiva Vezys
9. Melanie E Moses
10. Judy L Cannon

• Curated by eLife

  eLife assessment

  This is a valuable study that quantifies CD8 T cell movement in different tissue environments and concludes that T cells display more confined movement in the inflamed lung than in lymph nodes or intestinal villi. The evidence supporting conclusions is solid with well-defined measurements and sufficient statistical analysis. The work will stimulate further efforts to understand the mechanisms behind the different behaviour of T cells that are important in host defence against intracellular pathogens and cancer.

Reviewed by eLife

Dynamic control of gene expression by ISGF3 and IRF1 during IFNβ and IFNγ signaling

1. Aarathy Ravi Sundar Jose Geetha
2. Katrin Fischer
3. Olga Babadei
4. Georg Smesnik
5. Alex Vogt
6. Ekaterini Platanitis
7. Mathias Müller
8. Matthias Farlik
9. Thomas Decker

Reviewed by Review Commons

Decoupled neoantigen cross-presentation by dendritic cells limits anti-tumor immunity against tumors with heterogeneous neoantigen expression

1. Kim Bich Nguyen
2. Malte Roerden
3. Christopher J Copeland
4. Coralie M Backlund
5. Nory G Klop-Packel
6. Tanaka Remba
7. Byungji Kim
8. Nishant K Singh
9. Michael E Birnbaum
10. Darrell J Irvine
11. Stefani Spranger

• Curated by eLife

  eLife assessment

  This important work advances our understanding of the import of clonal heterogeneity in cancers in immune response to individual antigens. The evidence supporting the conclusions is convincing, and uses interesting tools, although the mechanistic basis of the observations is unclear. The work will be of broad interest to immunologists including cancer immunologists.

Reviewed by eLife

A simple protein-based surrogate neutralization assay for SARS-CoV-2

1. Kento T. Abe
2. Zhijie Li
3. Reuben Samson
4. Payman Samavarchi-Tehrani
5. Emelissa J. Valcourt
6. Heidi Wood
7. Patrick Budylowski
8. Alan P. Dupuis
9. Roxie C. Girardin
10. Bhavisha Rathod
11. Jenny H. Wang
12. Miriam Barrios-Rodiles
13. Karen Colwill
14. Allison J. McGeer
15. Samira Mubareka
16. Jennifer L. Gommerman
17. Yves Durocher
18. Mario Ostrowski
19. Kathleen A. McDonough
20. Michael A. Drebot
21. Steven J. Drews
22. James M. Rini
23. Anne-Claude Gingras

Reviewed by ScreenIT

Discriminating Mild from Critical COVID-19 by Innate and Adaptive Immune Single-cell Profiling of Bronchoalveolar Lavages

1. Els Wauters
2. Pierre Van Mol
3. Abhishek D. Garg
4. Sander Jansen
5. Yannick Van Herck
6. Lore Vanderbeke
7. Ayse Bassez
8. Bram Boeckx
9. Bert Malengier-Devlies
10. Anna Timmerman
11. Thomas Van Brussel
12. Tina Van Buyten
13. Rogier Schepers
14. Elisabeth Heylen
15. Dieter Dauwe
16. Christophe Dooms
17. Jan Gunst
18. Greet Hermans
19. Philippe Meersseman
20. Dries Testelmans
21. Jonas Yserbyt
22. Patrick Matthys
23. Sabine Tejpar
24. CONTAGIOUS collaborators
25. Johan Neyts
26. Joost Wauters
27. Junbin Qian
28. Diether Lambrechts

Reviewed by ScreenIT

Which animals are at risk? Predicting species susceptibility to Covid-19

1. MR Alexander
2. CT Schoeder
3. JA Brown
4. CD Smart
5. C Moth
6. JP Wikswo
7. JA Capra
8. J Meiler
9. W Chen
10. MS Madhur

Reviewed by ScreenIT

Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis

1. James Brett Case
2. Paul W. Rothlauf
3. Rita E. Chen
4. Natasha M. Kafai
5. Julie M. Fox
6. Swathi Shrihari
7. Broc T. McCune
8. Ian B. Harvey
9. Brittany Smith
10. Shamus P. Keeler
11. Louis-Marie Bloyet
12. Emma S. Winkler
13. Michael J. Holtzman
14. Daved H. Fremont
15. Sean P.J. Whelan
16. Michael S. Diamond

Reviewed by ScreenIT

SARS-CoV-2 infection in the lungs of human ACE2 transgenic mice causes severe inflammation, immune cell infiltration, and compromised respiratory function

1. Emma S. Winkler
2. Adam L. Bailey
3. Natasha M. Kafai
4. Sharmila Nair
5. Broc T. McCune
6. Jinsheng Yu
7. Julie M. Fox
8. Rita E. Chen
9. James T. Earnest
10. Shamus P. Keeler
11. Jon H. Ritter
12. Liang-I Kang
13. Sarah Dort
14. Annette Robichaud
15. Richard Head
16. Michael J. Holtzman
17. Michael S. Diamond

Reviewed by ScreenIT

Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8 ₊ T cells

1. Anthony Kusnadi
2. Ciro Ramírez-Suástegui
3. Vicente Fajardo
4. Serena J Chee
5. Benjamin J Meckiff
6. Hayley Simon
7. Emanuela Pelosi
8. Grégory Seumois
9. Ferhat Ay
10. Pandurangan Vijayanand
11. Christian H Ottensmeier

Reviewed by ScreenIT

Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy

1. Shuo Du
2. Yunlong Cao
3. Qinyu Zhu
4. Pin Yu
5. Feifei Qi
6. Guopeng Wang
7. Xiaoxia Du
8. Linlin Bao
9. Wei Deng
10. Hua Zhu
11. Jiangning Liu
12. Jianhui Nie
13. Yinghui Zheng
14. Haoyu Liang
15. Ruixue Liu
16. Shuran Gong
17. Hua Xu
18. Ayijiang Yisimayi
19. Qi Lv
20. Bo Wang
21. Runsheng He
22. Yunlin Han
23. Wenjie Zhao
24. Yali Bai
25. Yajin Qu
26. Xiang Gao
27. Chenggong Ji
28. Qisheng Wang
29. Ning Gao
30. Weijin Huang
31. Youchun Wang
32. X. Sunney Xie
33. Xiao-dong Su
34. Junyu Xiao
35. Chuan Qin

Reviewed by ScreenIT