Immunology

Lack of p38 activation in T cells increases IL-35 and protects against obesity by promoting thermogenesis

1. Ivana Nikolic
2. Irene Ruiz-Garrido
3. María Crespo
4. Rafael Romero-Becerra
5. Luis Leiva-Vega
6. Alfonso Mora
7. Marta León
8. Elena Rodríguez
9. Magdalena Leiva
10. Ana Belén Plata-Gómez
11. Maria Beatriz Alvarez Flores
12. Jorge L Torres
13. Lourdes Hernández-Cosido
14. Juan Antonio López
15. Jesús Vázquez
16. Alejo Efeyan
17. Pilar Martin
18. Miguel Marcos
19. Guadalupe Sabio

Reviewed by Review Commons

Selective loss of CD107a TIGIT+ memory HIV-1-specific CD8+ T cells in PLWH over a decade of ART

1. Oscar Blanch-Lombarte
2. Dan Ouchi
3. Esther Jimenez-Moyano
4. Julieta Carabelli
5. Miguel Angel Marin
6. Ruth Peña
7. Adam Pelletier
8. Aarthi Talla
9. Ashish Sharma
10. Judith Dalmau
11. José Ramón Santos
12. Rafick-Pierre Sékaly
13. Bonaventura Clotet
14. Julia G Prado

• Curated by eLife

  eLife assessment

  The present study shows that the expression of some inhibitory receptors (IRGs) on CD8 T cells is increased in people living with HIV (PLWH) and remain elevated even after years of viral suppression by antiretroviral therapy. The authors further report that inhibition of TGIT partially restores the ability of CD8 T cells to produce CD107a but not the other functions. Altogether, the results provide some valuable insights into our understanding of inhibitory receptor expression in the HIV infected individuals but some evidence seems incomplete.

Reviewed by eLife

Predicting developmental relationships of tumor resident and circulating T cells in ovarian cancer

1. Mayra S. Carneiro
2. Yacine Bareche
3. Cheng Zhao
4. Pamela Thébault
5. Kurosh Rahimi
6. Diane Provencher
7. Vanessa Samouélian
8. Béatrice Cormier
9. Jean-François Cailhier
10. Anne-Marie Mes-Masson
11. Sophie Petropoulos
12. John Stagg
13. Réjean Lapointe

Reviewed by Review Commons

Olfactory detection of viruses shapes brain immunity and behavior in zebrafish

1. Aurora Kraus
2. Benjamin Garcia
3. Jie Ma
4. Kristian J. Herrera
5. Hanna Zwaka
6. Roy Harpaz
7. Ryan Y. Wong
8. Florian Engert
9. Irene Salinas

• Curated by eLife

  eLife assessment

  This study presents a useful description of transcriptional responses in adult zebrafish olfactory bulb microglia and neurons following exposure to infectious hematopoietic necrosis virus. This solid work advances our understanding of central nervous system responses to viral infection and provides an inventory of gene expression changes in particular cell types that can be used as hypothesis generators for future studies. Experiments to assess behavioral and neural responses to the virus in adults and larvae are inadequate and would benefit from a clearer conceptual framework that connects these avenues of investigation both to published literature and to the authors' single cell RNA sequencing results.

Reviewed by eLife

Mast cell-derived BH4 is a critical mediator of postoperative pain

1. Philipp Starkl
2. Gustav Jonsson
3. Tyler Artner
4. Bruna Lenfers Turnes
5. Nadine Serhan
6. Tiago Oliveira
7. Laura-Marie Gail
8. Karel Stejskal
9. Keith M. Channon
10. Thomas Köcher
11. Georg Stary
12. Victoria Klang
13. Nicolas Gaudenzio
14. Sylvia Knapp
15. Clifford J. Woolf
16. Josef M. Penninger
17. Shane J.F. Cronin

Reviewed by Arcadia Science

C-terminal truncation of CXCL10 attenuates inflammatory activity but retains angiostatic properties

1. Luna Dillemans
2. Karen Yu
3. Alexandra De Zutter
4. Sam Noppen
5. Mieke Gouwy
6. Nele Berghmans
7. Mirre De Bondt
8. Lotte Vanbrabant
9. Stef Brusselmans
10. Erik Martens
11. Dominique Schols
12. Pedro Elias Marques
13. Sofie Struyf
14. Paul Proost

Reviewed by Review Commons

Quantitative analyses of T cell motion in tissue reveals factors driving T cell search in tissues

1. David J Torres
2. Paulus Mrass
3. Janie Byrum
4. Arrick Gonzales
5. Dominick N Martinez
6. Evelyn Juarez
7. Emily Thompson
8. Vaiva Vezys
9. Melanie E Moses
10. Judy L Cannon

• Curated by eLife

  eLife assessment

  This is a valuable study that quantifies CD8 T cell movement in different tissue environments and concludes that T cells display more confined movement in the inflamed lung than in lymph nodes or intestinal villi. The evidence supporting conclusions is solid with well-defined measurements and sufficient statistical analysis. The work will stimulate further efforts to understand the mechanisms behind the different behaviour of T cells that are important in host defence against intracellular pathogens and cancer.

Reviewed by eLife

Dynamic control of gene expression by ISGF3 and IRF1 during IFNβ and IFNγ signaling

1. Aarathy Ravi Sundar Jose Geetha
2. Katrin Fischer
3. Olga Babadei
4. Georg Smesnik
5. Alex Vogt
6. Ekaterini Platanitis
7. Mathias Müller
8. Matthias Farlik
9. Thomas Decker

Reviewed by Review Commons

Decoupled neoantigen cross-presentation by dendritic cells limits anti-tumor immunity against tumors with heterogeneous neoantigen expression

1. Kim Bich Nguyen
2. Malte Roerden
3. Christopher J Copeland
4. Coralie M Backlund
5. Nory G Klop-Packel
6. Tanaka Remba
7. Byungji Kim
8. Nishant K Singh
9. Michael E Birnbaum
10. Darrell J Irvine
11. Stefani Spranger

• Curated by eLife

  eLife assessment

  This important work advances our understanding of the import of clonal heterogeneity in cancers in immune response to individual antigens. The evidence supporting the conclusions is convincing, and uses interesting tools, although the mechanistic basis of the observations is unclear. The work will be of broad interest to immunologists including cancer immunologists.

Reviewed by eLife

A simple protein-based surrogate neutralization assay for SARS-CoV-2

1. Kento T. Abe
2. Zhijie Li
3. Reuben Samson
4. Payman Samavarchi-Tehrani
5. Emelissa J. Valcourt
6. Heidi Wood
7. Patrick Budylowski
8. Alan P. Dupuis
9. Roxie C. Girardin
10. Bhavisha Rathod
11. Jenny H. Wang
12. Miriam Barrios-Rodiles
13. Karen Colwill
14. Allison J. McGeer
15. Samira Mubareka
16. Jennifer L. Gommerman
17. Yves Durocher
18. Mario Ostrowski
19. Kathleen A. McDonough
20. Michael A. Drebot
21. Steven J. Drews
22. James M. Rini
23. Anne-Claude Gingras

Reviewed by ScreenIT