Immunology

Multilevel human secondary lymphoid immune system compartmentalization revealed by complementary multiplexing and mass spectrometry imaging approaches

1. Benjamin L. Oyler
2. Jeferson A. Valencia-Dávila
3. Eirini Moysi
4. Adam Molyvdas
5. Kalliopi Ioannidou
6. Kylie March
7. David Ambrozak
8. Laurence de Leval
9. Giulia Fabozzi
10. Amina S. Woods
11. Richard A. Koup
12. Constantinos Petrovas

Reviewed by Arcadia Science

Kaempferol suppresses the activation of mast cells by modulating the expression of FcεRI and SHIP1

1. Kazuki Nagata
2. Sanae Araumi
3. Daisuke Ando
4. Miki Ando
5. Naoto Ito
6. Yuki Ikeda
7. Miki Takahashi
8. Sakura Noguchi
9. Takuya Yashiro
10. Masakazu Hachisu
11. Chiharu Nishiyama

Reviewed by Arcadia Science

Bacterial meningitis in the early postnatal mouse studied at single-cell resolution

1. Jie Wang
2. Amir Rattner
3. Jeremy Nathans

• Curated by eLife

  eLife assessment

  This study presents valuable findings on the changes of immune cell populations and stromal cells occurring at the CNS borders in a neonatal bacterial meningitis model, focusing on fibroblasts, macrophages and endothelial cells. The study provides solid snRNA-seq dataset and high quality immune fluorescence images of dissected brain border regions, that will be useful for the community. These observations and datasets will be of interest to the neuro-immunology community.

Reviewed by eLife

Differences in the inflammatory proteome of East African and Western European adults and associations with environmental and dietary factors

1. Godfrey S Temba
2. Nadira Vadaq
3. Vesla Kullaya
4. Tal Pecht
5. Paolo Lionetti
6. Duccio Cavalieri
7. Joachim L Schultze
8. Reginald Kavishe
9. Leo AB Joosten
10. Andre J van der Ven
11. Blandina T Mmbaga
12. Mihai G Netea
13. Quirijn de Mast

• Curated by eLife

  eLife assessment

  Non-communicable diseases (NCDs) are rising rapidly in urbanizing populations in many parts of the developing world, including in sub-Saharan Africa. Temba and colleagues show important evidence that healthy Tanzanians display a pro-inflammatory phenotype with enrichment of specific immune-metabolic pathways. Dood-derived metabolites were identified as an important driver of inflammation-related molecules. These findings provide solid evidence that the dietary transition that occurs in urbanizing areas in sub-Saharan Africa may contribute significantly to the increased incidence of non communicable diseases in this part of the world.

Reviewed by eLife

Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils

1. Jiang Li
2. Rebecca E Ruggiero-Ruff
3. Yuxin He
4. Xinru Qiu
5. Nancy Lainez
6. Pedro Villa
7. Adam Godzik
8. Djurdjica Coss
9. Meera G Nair

• Curated by eLife

  eLife assessment

  In this study, Li and al describe valuable insights into the mechanisms underlying sex-differences diet-induced obesity in mice, with a role of macrophage-derived RELMa secretion in female-specific protection. They provide solid evidence for the impact of RELMa signaling in eosinophil recruitment for diet-induced obesity protection in female mice. Single-cell RNA-seq analysis of the stromal vascular fraction of control and RELMa deficient animals methods were used to investigate molecular mechanisms underlying the protection as a powerful method, although the analysis of this data is difficult to evaluate with incomplete methodological information.

Reviewed by eLife

Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis

1. Yaeko Nakajima-Takagi
2. Motohiko Oshima
3. Junichiro Takano
4. Shuhei Koide
5. Naoki Itokawa
6. Shun Uemura
7. Masayuki Yamashita
8. Shohei Andoh
9. Kazumasa Aoyama
10. Yusuke Isshiki
11. Daisuke Shinoda
12. Atsunori Saraya
13. Fumio Arai
14. Kiyoshi Yamaguchi
15. Yoichi Furukawa
16. Haruhiko Koseki
17. Tomokatsu Ikawa
18. Atsushi Iwama

• Curated by eLife

  eLife assessment

  The authors present a manuscript aiming to understand the mechanism(s) underlying myeloid bias in HSCs, specifically focused on the role of Pcgf1, and therefore PRC1.1, in the regulation of hematopoiesis. This important work is of interest to the community of researchers interested in myeloid differentiation, lineage fate decisions in hematopoietic stem cells, and the molecular mechanisms that contribute to the initiation of myeloid malignancies. The methods are rigorous and the results convincingly support the authors' conclusions.

Reviewed by eLife

Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy

1. Pedro P Cunha
2. Eleanor Minogue
3. Lena CM Krause
4. Rita M Hess
5. David Bargiela
6. Brennan J Wadsworth
7. Laura Barbieri
8. Carolin Brombach
9. Iosifina P Foskolou
10. Ivan Bogeski
11. Pedro Velica
12. Randall S Johnson

• Curated by eLife

  eLife assessment

  In the current manuscript, the authors study the effects of hypoxia or genetic and pharmacologic modulation of the hypoxic pathways on T cells. The findings about T cells sense hypoxia and how hypoxia affects T cell (and CAR T cell) differentiation and function are significant and interesting for the field. The data supporting these findings are mostly robust, yet some questions remain open and some statements seem unsupported by evidence.

Reviewed by eLife

Integrated signaling and transcriptome analysis reveals Src family kinase individualities and novel pathways controlled by their constitutive activity

1. Nikolaos Koutras
2. Vasileios Morfos
3. Kyriakos Konnaris
4. Adamantia Kouvela
5. Athanasios-Nasir Shaukat
6. Constantinos Stathopoulos
7. Vassiliki Stamatopoulou
8. Konstantina Nika

• Curated by eLife

  **eLife assessment
  **
  This study presents valuable findings on how the ectopic expression of the Lck protein tyrosine kinase in Chronic Lymphocytic Leukemias (CLL) contributes to malignant transformation. The evidence supporting the claims of the authors is solid, although the use of gene editing to directly explore the functions unique to LCK in a CLL model would increase the appeal of the work.

Reviewed by eLife

Global profiling of human blood ILC subtypes reveals that NK cells produce homeostatic cytokine amphiregulin and sheds light on HIV-1 pathogenesis

1. Yetao Wang
2. Lawrence Lifshitz
3. Noah J. Silverstein
4. Esther Mintzer
5. Kevin Luk
6. Pam St. Louis
7. Michael A Brehm
8. Scot A. Wolfe
9. Steven G. Deeks
10. Jeremy Luban

Reviewed by Review Commons

Defining the Characteristics of Type I Interferon Stimulated Genes: Insight from Expression Data and Machine Learning

1. Haiting Chai
2. Quan Gu
3. Joseph Hughes
4. David L. Robertson

Reviewed by GigaScience