Immunology

CCR1 mediates Müller cell activation and photoreceptor cell death in macular and retinal degeneration

1. Sarah Elbaz-Hayoun
2. Batya Rinsky
3. Shira Hagbi-Levi
4. Michelle Grunin
5. Itay Chowers

• Curated by eLife

  eLife assessment

  Elbaz-Hayoun et al. investigate the role of macrophages in the gliotic response of retinal Müller glia and photoreceptor cell death. The authors find that macrophages play a role in inducing retinal damage. A role for the muller glia expressed, C-C chemokine receptor axis was identified as a causative factor in promoting retinal degeneration. These important data identify a new link between cells of the immune system and those within the retina which contribute to the progression of retinal degeneration.

Reviewed by eLife

Vaccination with mycobacterial lipid loaded nanoparticle leads to lipid antigen persistence and memory differentiation of antigen-specific T cells

1. Eva Morgun
2. Jennifer Zhu
3. Sultan Almunif
4. Sharan Bobbala
5. Melissa S Aguilar
6. Junzhong Wang
7. Kathleen Conner
8. Yongyong Cui
9. Liang Cao
10. Chetan Seshadri
11. Evan A Scott
12. Chyung-Ru Wang

• Curated by eLife

  eLife assessment

  The authors generate a new formulation built upon a previous nanoparticle platform to generate a new system termed bicontinuous nanospheres (BCN), allowing for the dual incorporation of lipid and protein antigens. The authors generate mycolic acid (MA)-loaded BCN and perform a series of characterization studies to demonstrate the superior performance of this new formulation relative to the original one in terms of antigen persistence, a quality needed to sustain responses after vaccination. This work provides important new insights relevant to the TB vaccine field and it suggests that alternative antigens to proteins could be used in TB vaccine formulations. The data are convincing and will be of interest to individuals working on tuberculosis, vaccines and basic immunology.

Reviewed by eLife

Lack of p38 activation in T cells increases IL-35 and protects against obesity by promoting thermogenesis

1. Ivana Nikolic
2. Irene Ruiz-Garrido
3. María Crespo
4. Rafael Romero-Becerra
5. Luis Leiva-Vega
6. Alfonso Mora
7. Marta León
8. Elena Rodríguez
9. Magdalena Leiva
10. Ana Belén Plata-Gómez
11. Maria Beatriz Alvarez Flores
12. Jorge L Torres
13. Lourdes Hernández-Cosido
14. Juan Antonio López
15. Jesús Vázquez
16. Alejo Efeyan
17. Pilar Martin
18. Miguel Marcos
19. Guadalupe Sabio

Reviewed by Review Commons

Selective loss of CD107a TIGIT+ memory HIV-1-specific CD8+ T cells in PLWH over a decade of ART

1. Oscar Blanch-Lombarte
2. Dan Ouchi
3. Esther Jimenez-Moyano
4. Julieta Carabelli
5. Miguel Angel Marin
6. Ruth Peña
7. Adam Pelletier
8. Aarthi Talla
9. Ashish Sharma
10. Judith Dalmau
11. José Ramón Santos
12. Rafick-Pierre Sékaly
13. Bonaventura Clotet
14. Julia G Prado

• Curated by eLife

  eLife assessment

  The present study shows that the expression of some inhibitory receptors (IRGs) on CD8 T cells is increased in people living with HIV (PLWH) and remain elevated even after years of viral suppression by antiretroviral therapy. The authors further report that inhibition of TGIT partially restores the ability of CD8 T cells to produce CD107a but not the other functions. Altogether, the results provide some valuable insights into our understanding of inhibitory receptor expression in the HIV infected individuals but some evidence seems incomplete.

Reviewed by eLife

Predicting developmental relationships of tumor resident and circulating T cells in ovarian cancer

1. Mayra S. Carneiro
2. Yacine Bareche
3. Cheng Zhao
4. Pamela Thébault
5. Kurosh Rahimi
6. Diane Provencher
7. Vanessa Samouélian
8. Béatrice Cormier
9. Jean-François Cailhier
10. Anne-Marie Mes-Masson
11. Sophie Petropoulos
12. John Stagg
13. Réjean Lapointe

Reviewed by Review Commons

Olfactory detection of viruses shapes brain immunity and behavior in zebrafish

1. Aurora Kraus
2. Benjamin Garcia
3. Jie Ma
4. Kristian J. Herrera
5. Hanna Zwaka
6. Roy Harpaz
7. Ryan Y. Wong
8. Florian Engert
9. Irene Salinas

• Curated by eLife

  eLife assessment

  This study presents a useful description of transcriptional responses in adult zebrafish olfactory bulb microglia and neurons following exposure to infectious hematopoietic necrosis virus. This solid work advances our understanding of central nervous system responses to viral infection and provides an inventory of gene expression changes in particular cell types that can be used as hypothesis generators for future studies. Experiments to assess behavioral and neural responses to the virus in adults and larvae are inadequate and would benefit from a clearer conceptual framework that connects these avenues of investigation both to published literature and to the authors' single cell RNA sequencing results.

Reviewed by eLife

Mast cell-derived BH4 is a critical mediator of postoperative pain

1. Philipp Starkl
2. Gustav Jonsson
3. Tyler Artner
4. Bruna Lenfers Turnes
5. Nadine Serhan
6. Tiago Oliveira
7. Laura-Marie Gail
8. Karel Stejskal
9. Keith M. Channon
10. Thomas Köcher
11. Georg Stary
12. Victoria Klang
13. Nicolas Gaudenzio
14. Sylvia Knapp
15. Clifford J. Woolf
16. Josef M. Penninger
17. Shane J.F. Cronin

Reviewed by Arcadia Science

C-terminal truncation of CXCL10 attenuates inflammatory activity but retains angiostatic properties

1. Luna Dillemans
2. Karen Yu
3. Alexandra De Zutter
4. Sam Noppen
5. Mieke Gouwy
6. Nele Berghmans
7. Mirre De Bondt
8. Lotte Vanbrabant
9. Stef Brusselmans
10. Erik Martens
11. Dominique Schols
12. Pedro Elias Marques
13. Sofie Struyf
14. Paul Proost

Reviewed by Review Commons

Quantitative analyses of T cell motion in tissue reveals factors driving T cell search in tissues

1. David J Torres
2. Paulus Mrass
3. Janie Byrum
4. Arrick Gonzales
5. Dominick N Martinez
6. Evelyn Juarez
7. Emily Thompson
8. Vaiva Vezys
9. Melanie E Moses
10. Judy L Cannon

• Curated by eLife

  eLife assessment

  This is a valuable study that quantifies CD8 T cell movement in different tissue environments and concludes that T cells display more confined movement in the inflamed lung than in lymph nodes or intestinal villi. The evidence supporting conclusions is solid with well-defined measurements and sufficient statistical analysis. The work will stimulate further efforts to understand the mechanisms behind the different behaviour of T cells that are important in host defence against intracellular pathogens and cancer.

Reviewed by eLife

Dynamic control of gene expression by ISGF3 and IRF1 during IFNβ and IFNγ signaling

1. Aarathy Ravi Sundar Jose Geetha
2. Katrin Fischer
3. Olga Babadei
4. Georg Smesnik
5. Alex Vogt
6. Ekaterini Platanitis
7. Mathias Müller
8. Matthias Farlik
9. Thomas Decker

Reviewed by Review Commons