Arcadia Science

Latest preprint reviews

1. From Mechanistic Interpretability to Mechanistic Biology: Training, Evaluating, and Interpreting Sparse Autoencoders on Protein Language Models

   This article has 5 authors:

   1. Etowah Adams
   2. Liam Bai
   3. Minji Lee
   4. Yiyang Yu
   5. Mohammed AlQuraishi

   Reviewed by Arcadia Science

2. IRF2 degradation tunes the innate immune response

   This article has 19 authors:

   1. Cristhian Cadena
   2. Rohit Reja
   3. Emma Bolech
   4. Joshua D. Webster
   5. Vasumathi Kameswaran
   6. Marco de Simone
   7. Cynthia Chen
   8. Jian Jiang
   9. Kathy Hotzel
   10. Kamela Alegre
   11. Zhenyu Tan
   12. Raymond Newland
   13. Ryan Kelly
   14. Spyros Darmanis
   15. Bence Daniel
   16. Ishan Deshpande
   17. Kim Newton
   18. Nobuhiko Kayagaki
   19. Vishva M. Dixit

   Reviewed by Arcadia Science

3. JIP4 deficiency causes a lysosomal storage disease arising from impaired cystine efflux

   This article has 5 authors:

   1. Layla M. Nassar
   2. Xiaojian Shi
   3. Agnes Roczniak-Ferguson
   4. Hongying Shen
   5. Shawn M. Ferguson

   Reviewed by Arcadia Science

4. Stress response of membrane-based cell organelles in budding yeast

   This article has 4 authors:

   1. Sheng Peng
   2. Bai Li-zhe
   3. Cao Hong
   4. Li Dan

   Reviewed by Arcadia Science

5. Stool Dynamics and the Developing Gut Microbiome During Infancy

   This article has 10 authors:

   1. Mohammed Al-Andoli
   2. Sarah Schoch
   3. Andjela Markovic
   4. Christophe Mühlematter
   5. Matthieu Beaugrand
   6. Oskar G. Jenni
   7. Rabia Liamlahi
   8. Jean-Claude Walser
   9. Dennis Nielsen
   10. Salome Kurth

   Reviewed by Arcadia Science

6. The Implications of Alternative Splicing Regulation for Maximum Lifespan

   This article has 3 authors:

   1. Wei Jiang
   2. Sika Zheng
   3. Liang Chen

   Reviewed by Arcadia Science

7. Targeting a novel chloroquine derivative to lysosomes induces massive and irreversible damage to lysosomes and suppresses autophagosomes and lysosomes assembly in cancer

   This article has 6 authors:

   1. Nitish Chauhan
   2. Ananda Guha Majumdar
   3. Sujit Kumar Bhutia
   4. Papiya Dey
   5. Mahesh Subramanian
   6. Birija Sankar Patro

   Reviewed by Arcadia Science

8. Quantifying a trait-mediated indirect effect of an environmental stressor on population dynamics

   This article has 2 authors:

   1. Shota Shibasaki
   2. Masato Yamamichi

   Reviewed by Arcadia Science

9. Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context

   This article has 27 authors:

   1. Sung Yun Park
   2. Arlo Sheridan
   3. Bobae An
   4. Erin Jarvis
   5. Julia Lyudchik
   6. William Patton
   7. Jun Y. Axup
   8. Stephanie W. Chan
   9. Hugo G.J. Damstra
   10. Daniel Leible
   11. Kylie S. Leung
   12. Clarence A. Magno
   13. Aashir Meeran
   14. Julia M. Michalska
   15. Franz Rieger
   16. Claire Wang
   17. Michelle Wu
   18. George M. Church
   19. Jan Funke
   20. Todd Huffman
   21. Kathleen G.C. Leeper
   22. Sven Truckenbrodt
   23. Johan Winnubst
   24. Joergen M.R. Kornfeld
   25. Edward S. Boyden
   26. Samuel G. Rodriques
   27. Andrew C. Payne

   Reviewed by Arcadia Science

10. Extracellular adenosine deamination primes tip organizer development in Dictyostelium

    This article has 2 authors:

    1. Pavani Hathi
    2. Baskar Ramamurthy

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      During the development of the unicellular eukaryote Dictyostelium discoideum, cells aggregate into mounds, which then form protrusions called tips, and the tips then become the front of migrating slugs and the top of fruiting bodies. This valuable study identifies a protein called adenosine deaminase-related growth factor (ADGF) as a key regulator of tip formation, and the authors convincingly show that ADGF catalyses the formation of ammonia from adenosine, allowing ammonia to initiate tip formation, and they then elucidate pathways upstream and downstream from ADGF. The authors discuss the intriguing possibility that mammalian ADGF may also regulate development in a similar manner.

    Reviewed by Arcadia Science, eLife