Fatty acid synthesis promotes inflammasome activation through NLRP3 palmitoylation

  1. Stuart Leishman
  2. Najd M. Aljadeed
  3. Liyunhe Qian
  4. Shamshad Cockcroft
  5. Jacques Behmoaras
  6. Paras K. Anand

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Abstract

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  1. Version published to 10.1016/j.celrep.2024.114516
  3. Arcadia Science

    I may be missing this, but I don't see a description of how this assay is performed in the figure legend or a materials and methods section in the primary or supplemental text. Could it be that this change in mobility is due to another modification and, if so, could you confirm with mass spectrometry?

  4. Arcadia Science

    This is a really interesting study linking NLRP3 palmitoylation to inflammation. Here, could you use a more sensitive readout for cell cytotoxicity to confirm cell death is not obscuring your results?

  5. Version published to 10.1101/2023.10.30.564549v1 on bioRxiv