Cell Biology

Basement membrane diversification relies on two competitive secretory routes defined by Rab10 and Rab8 and modulated by dystrophin and the exocyst complex

1. Cynthia Dennis
2. Pierre Pouchin
3. Graziella Richard
4. Vincent Mirouse

Reviewed by Review Commons

Arp2/3-dependent endocytosis ensures Cdc42 oscillations by removing Pak1-mediated negative feedback

1. Marcus A. Harrell
2. Ziyi Liu
3. Bethany F. Campbell
4. Olivia Chinsen
5. Tian Hong
6. Maitreyi Das

Reviewed by Arcadia Science

Characterizing Human KIF1Bß Motor Activity by Single-Molecule Motility Assays and Caenorhabtidis elegans Genetics

1. Rei Iguchi
2. Tomoki Kita
3. Taisei Watanabe
4. Kyoko Chiba
5. Shinsuke Niwa

Reviewed by Arcadia Science

TNF-alpha promotes cilia elongation via Mixed Lineage Kinases signaling

1. Amrita Kumari
2. Amada Caliz
3. Shashi Kant
4. Anastassiia Vertii

Reviewed by Arcadia Science

Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery

1. Jayne Aiken
2. Erika L. F. Holzbaur

Reviewed by preLights

Alternative end-joining results in smaller deletions in heterochromatin relative to euchromatin

1. Jacob M. Miller
2. Sydney Prange
3. Huanding Ji
4. Alesandra R. Rau
5. Varandt Y. Khodaverdian
6. Xiao Li
7. Avi Patel
8. Nadejda Butova
9. Avery Lutter
10. Helen Chung
11. Chiara Merigliano
12. Chetan C. Rawal
13. Terrence Hanscom
14. Mitch McVey
15. Irene Chiolo

• Curated by eLife

  eLife assessment

  This manuscript describes valuable new findings on the impact of chromatin context on the outcomes of microhomology-mediated end joining of DNA double-strand breaks (DSBs), specifically a preference for DSB-proximal microhomologies in repair within a heterochromatic compared to a euchromatic locus. The authors develop the Drosophila spermatogonia as a model for repair at induced DSBs in a mitotically-active tissue and leverage this system to provide convincing evidence that the local environment impacts the preference for repair mechanism and outcome. The work could be strengthened by the use of additional euchromatin insertion(s) to robustly validate the findings.

Reviewed by eLife