Cell Biology

Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes

1. Xiang Wang
2. Vitaliy V Bondar
3. Oliver B Davis
4. Michael T Maloney
5. Maayan Agam
6. Marcus Y Chin
7. Audrey Cheuk-Nga Ho
8. Rajarshi Ghosh
9. Dara E Leto
10. David Joy
11. Meredith EK Calvert
12. Joseph W Lewcock
13. Gilbert Di Paolo
14. Robert G Thorne
15. Zachary K Sweeney
16. Anastasia G Henry

• Curated by eLife

  eLife assessment

  This valuable study shows that Rab12 is required for LRRK2 activation. However, while some of the data are compelling, some claims, especially the ones related to LRRK2's membrane association are not supported. Addressing discrepancies between figures (pointed out by reviewers) and re-writing certain sections will greatly improve this manuscript.

Reviewed by eLife

Synchronization of oscillatory growth prepares fungal hyphae for fusion

1. Valentin Wernet
2. Marius Kriegler
3. Vojtech Kumpost
4. Ralf Mikut
5. Lennart Hilbert
6. Reinhard Fischer

• Curated by eLife

  eLife assessment

  This valuable study combines live cell imaging and mathematical modeling to show how an emerging model fungus engages in an oscillatory chemical dialogue to prepare for cell-cell fusion. Cell data and modeling are in compelling agreement but leave many open questions as to the nature of coordination between cells and the significance of oscillations, rendering the strength of evidence in support of the authors' inferences incomplete.

Reviewed by eLife

Transcription inhibition suppresses nuclear blebbing and rupture independently of nuclear rigidity

1. Isabel K. Berg
2. Marilena L. Currey
3. Sarthak Gupta
4. Yasmin Berrada
5. Bao V. Nguyen
6. Mai Pho
7. Alison E. Patteson
8. J. M. Schwarz
9. Edward J. Banigan
10. Andrew D. Stephens

Reviewed by Review Commons

Centriolar defects underlie a primary ciliary dyskinesia phenotype in an adenylate kinase 7 deficient ciliated epithelium

1. Jennifer Sheridan
2. Aline Grata
3. Julia Dorr
4. Eve E. Suva
5. Enzo Bresteau
6. Linus R. Mitchell
7. Osama Hassan
8. Brian Mitchell

Reviewed by Arcadia Science

Caspase-mediated nuclear pore complex trimming in cell differentiation and endoplasmic reticulum stress

1. Ukrae H Cho
2. Martin W Hetzer

• Curated by eLife

  eLife assessment

  This important study outlines a new role for caspases during cellular differentiation. The methodology used is convincing and state-of-the-art. The newly discovered cellular cascade described here uncovers that caspases can achieve high substrate specificity during differentiation. As such, the work will be of broad interest to cell biologists.

Reviewed by eLife

The maintenance of centriole appendages and motile cilia basal body anchoring relies on TBCCD1

1. Bruno Carmona
2. Carolina Camelo
3. Manon Mehraz
4. Michel Lemullois
5. Mariana Lince Faria
6. Étienne Coyaud
7. H. Susana Marinho
8. João Gonçalves
9. Sofia Nolasco
10. Francisco Pinto
11. Brian Raught
12. Anne-Marie Tassin
13. France Koll
14. Helena Soares

Reviewed by Arcadia Science

CryoET shows cofilactin filaments inside the microtubule lumen

1. Camilla Ventura Santos
2. Stephen L. Rogers
3. Andrew P. Carter

Reviewed by Arcadia Science

Cooperative Motility, Force Generation and Mechanosensing in a Foraging Non-Photosynthetic Diatom

1. Peng Zheng
2. Kayo Kumadaki
3. Christopher Quek
4. Zeng Hao Lim
5. Yonatan Ashenafi
6. Zhi Ting Yip
7. Jay Newby
8. Andrew J. Alverson
9. Yan Jie
10. Gregory Jedd

Reviewed by Arcadia Science

Single-cell intracellular pH dynamics regulate the cell cycle by timing the G1 exit and G2 transition

1. Julia S. Spear
2. Katharine A. White

Reviewed by Arcadia Science, ASAPbio crowd review

Tunnelling nanotube formation is driven by Eps8/IRSp53‐dependent linear actin polymerization

1. J Michael Henderson
2. Nina Ljubojevic
3. Sevan Belian
4. Thibault Chaze
5. Daryl Castaneda
6. Aude Battistella
7. Quentin Giai Gianetto
8. Mariette Matondo
9. Stéphanie Descroix
10. Patricia Bassereau
11. Chiara Zurzolo

Reviewed by Arcadia Science, Review Commons