1. The conserved biochemical activity and function of an early metazoan phosphatidylinositol 5 phosphate 4-kinase regulates growth and development

    This article has 7 authors:
    1. Harini Krishnan
    2. Suhail Muzaffar
    3. Sanjeev Sharma
    4. Visvanathan Ramya
    5. Avishek Ghosh
    6. Ramanathan Sowdhamini
    7. Padinjat Raghu

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Medium-sized protein language models perform well at transfer learning on realistic datasets

    This article has 3 authors:
    1. Luiz C. Vieira
    2. Morgan L. Handojo
    3. Claus O. Wilke

    Reviewed by Arcadia Science

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  3. Acetylation of RORβ by histone acetyltransferase p300 and deacetylation by SIRT1 modulates receptor stability, turnover and transcriptional activity

    This article has 5 authors:
    1. Timothy O’Leary
    2. Denis Shutin
    3. Dean P. Edwards
    4. Patrick R. Griffin
    5. Mi Ra Chang

    Reviewed by Arcadia Science

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. Computational enzyme design by catalytic motif scaffolding

    This article has 16 authors:
    1. Markus Braun
    2. Adrian Tripp
    3. Morakot Chakatok
    4. Sigrid Kaltenbrunner
    5. Celina Fischer
    6. David Stoll
    7. Aleksandar Bijelic
    8. Wael Elaily
    9. Massimo G. Totaro
    10. Melanie Moser
    11. Shlomo Y. Hoch
    12. Horst Lechner
    13. Federico Rossi
    14. Matteo Aleotti
    15. Mélanie Hall
    16. Gustav Oberdorfer

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  5. Allosteric modulation of the Lon protease by effector binding and local charges

    This article has 2 authors:
    1. Justyne L Ogdahl
    2. Peter Chien

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  6. Mechanistic Studies of Small Molecule Ligands Selective to RNA Single G Bulges

    This article has 18 authors:
    1. Shalakha Hegde
    2. Sana Akhter
    3. Zhichao Tang
    4. Chang Qi
    5. Chenguang Yu
    6. Anna Lewicka
    7. Yu Liu
    8. Kushal Koirala
    9. Mikhail Reibarkh
    10. Kevin P. Battaile
    11. Anne Cooper
    12. Scott Lovell
    13. Erik D. Holmstrom
    14. Xiao Wang
    15. Joseph A. Piccirilli
    16. Qi Gao
    17. Yinglong Miao
    18. Jingxin Wang

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  7. The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

    This article has 3 authors:
    1. Elise S Bruguera
    2. Jacob P Mahoney
    3. William I Weis
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is a fundamental study that addresses the key question of how the tetraspanin Tspan12 functions biochemically as a co-receptor for Norrin to initiate β-catenin signaling. The strength of the work lies in the rigorous and compelling binding analyses involving various purified receptors, co-receptors, and ligands, as well as molecular modeling by AlphaFold that was subsequently validated by an extensive series of mutagenesis experiments. The study advances the field by providing a novel mechanism of co-receptor function and shedding new light on how signaling specificity is achieved in the complex Wnt/Norrin signaling system.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  8. Structure of the human CTF18 clamp loader bound to PCNA

    This article has 7 authors:
    1. Giuseppina R Briola
    2. Muhammad Tehseen
    3. Amani Al-Amodi
    4. Phong Quoc Nguyen
    5. Christos G Savva
    6. Samir M Hamdan
    7. Alfredo De Biasio
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Briola and co-authors determined the structure of the human CTF18 clamp loader bound to PCNA to high resolution, analyzed the structure, and tested a new mechanism involving a human-specific Ctf18 beta-hairpin docking onto Rfc5, which represents a valuable contribution. The data are solid and complement data recently published by others.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. Protonation/deprotonation-driven switch for the redox stability of low-potential [4Fe-4S] ferredoxin

    This article has 18 authors:
    1. Kei Wada
    2. Kenji Kobayashi
    3. Iori Era
    4. Yusuke Isobe
    5. Taigo Kamimura
    6. Masaki Marukawa
    7. Takayuki Nagae
    8. Kazuki Honjo
    9. Noriko Kaseda
    10. Yumiko Motoyama
    11. Kengo Inoue
    12. Masakazu Sugishima
    13. Katsuhiro Kusaka
    14. Naomine Yano
    15. Keiichi Fukuyama
    16. Masaki Mishima
    17. Yasutaka Kitagawa
    18. Masaki Unno
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Ferredoxins are ubiquitous electron transfer proteins that drive essential metabolic processes across all domains of life. This fundamental contribution to the field provides the first description of how specific amino acids, though a series of hydrogen bonds, control the ability of iron-sulfur clusters in ferrodoxins to accept and donate electrons. The evidence supporting the conclusions is compelling as is the combined use of neutron crystallography with X-ray crystallography and classical spectral/redox studies.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  10. Interactions with multiple inner kinetochore proteins determine mitotic localization of FACT

    This article has 6 authors:
    1. Julia Schweighofer
    2. Bhagyashree Mulay
    3. Ingrid Hoffmann
    4. Doro Vogt
    5. Marion E. Pesenti
    6. Andrea Musacchio

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
Previous Page 9 of 90 Next