Biochemistry

  1. A broad-spectrum antibiotic targets multiple-drug-resistant bacteria with dual binding targets and no detectable resistance

    1. Wenyan He
    2. Xueting Huan
    3. Yinchuan Li
    4. Qisen Deng
    5. Tao Chen
    6. Wen Xiao
    7. Yijun Chen
    8. Lingman Ma
    9. Nan Liu
    10. Zhuo Shang
    11. Zongqiang Wang

    Reviewed by Rapid Reviews Infectious Diseases

    2 evaluationsAppears in 1 listLatest version Latest activity

  3. Energetic and structural control of polyspecificity in a multidrug transporter

    1. Silas T. Miller
    2. Katherine A. Henzler-Wildman
    3. Srivatsan Raman

    Reviewed by PREreview

    1 evaluationAppears in 2 listsLatest version Latest activity

  5. The alternative oxidase reconfigures the larval mitochondrial electron transport system to accelerate growth and development in Drosophila melanogaster

    1. Geovana S Garcia
    2. Murilo F Othonicar
    3. Antonio Thiago P Campos
    4. Eric A Kilbourn
    5. Kênia C Bícego
    6. Johannes Lerchner
    7. Jason M Tennessen
    8. Marcos T Oliveira

    • Curated by eLife

      eLife Assessment

      The findings in this manuscript are important because they demonstrate the key role of metabolism in insect development. The data were collected and analyzed using solid and validated methodologies, but the evidence is incomplete, as the extent of the involvement of AOX activity in vivo and in physiological conditions is not addressed. This manuscript will be of interest for the fields of mitochondrial bioenergetics, metabolism and development.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  7. One-carbon metabolism enzyme Ahcy is a redox sensor that modulates gene expression to protect against light stress-induced retinal degeneration

    1. Sarah C. Stanhope
    2. Kratika Singhal
    3. Nicolás M. Morato
    4. Yunfei Feng
    5. Gaoya Meng
    6. Makayla N. Marlin
    7. Claudia C. Kotanko
    8. Madolyn M. Jarrett
    9. Andrew D. Mesecar
    10. Graham R. Cooks
    11. Vikki M. Weake

    Reviewed by PREreview

    1 evaluationAppears in 1 listLatest version Latest activity

  8. In silico discovery of nanobody binders to a G-protein coupled receptor using AlphaFold-Multimer

    1. Edward P. Harvey
    2. Jeffrey S. Smith
    3. Joseph D. Hurley
    4. Alyana J. Granados
    5. Ernst W. Schmid
    6. Jason G. Liang-Lin
    7. Huyang Zhang
    8. Emily M. Meara
    9. Elizabeth K. Wren
    10. Steffanie Paul
    11. Matthew P. Ferguson
    12. Victor G. Calvillo-Miranda
    13. Miguel A. Alcantar
    14. Debora S. Marks
    15. Johannes C. Walter
    16. Andrew C. Kruse
    17. Katherine J. Susa

    Reviewed by Arcadia Science

    2 evaluationsAppears in 2 listsLatest version Latest activity

  9. Fibroblast growth factor 21 regulates neuromuscular junction innervation through HDAC4 in denervation-induced skeletal muscle atrophy

    1. Lirong Zheng
    2. Takashi Sasaki
    3. Liyang Ni
    4. Yu Takahashi
    5. Yoshio Yamauchi
    6. Makoto Shimizu
    7. Sato Ryuichiro

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity
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