Biochemistry

Tentative evidence that aging is caused by a small number of interacting processes

1. Axel Kowald
2. Thomas B L Kirkwood

Reviewed by PREreview

Chronobot: Deep learning guided time-resolved cryo-EM captures molecular choreography of RecA in homology search

1. Märt-Erik Mäeots
2. Simon Tupin
3. Mohammad M. N. Esfahani
4. Juan B. Rodriguez Molina
5. Julie A. Clapperton
6. Aran Amin
7. Albane Imbert
8. Radoslav I. Enchev

Reviewed by PREreview

A Miniaturized, High-Throughput Aqueous Solvent-Centric Method for Protein Solubility Screening

1. Adrian Svoboda
2. Marina Molineris
3. Theodora Tureckiova
4. Klára Hlouchová
5. Tomáš Pluskal
6. Teo Hebra

Reviewed by Arcadia Science

Allosteric modulation of dimeric GPR3 by ligands in the dimerization interface

1. Zeming Qiu
2. Wei Wang
3. Yingying Nie
4. Junxiang Lin
5. Beimeng Zhang
6. Haonan Xing
7. Sanduo Zheng

• Curated by eLife

  eLife Assessment

  Qiu et al. present multiple dimeric structures of GPR3, which reveal the binding mode of the inverse agonist AF64394. The findings provide important insights into the regulation of GPCR3 and potentially other related orphan GPCRs. The authors present convincing evidence of their claims through thoughtful analysis of their cryo-EM structures, mutagenesis, and cell-based assays. This work will be of interest to GPCR investigators, especially those studying the signaling of orphan receptors.

Reviewed by eLife

Inherited CDA-I disease: anemia-associated mutations disrupt CDIN1-Codanin1 complex

1. Martin Stojaspal
2. Tomáš Brom
3. Ivona Nečasová
4. Tomáš Janovič
5. Pavel Veverka
6. Naina Verma
7. Lukáš Uhrík
8. Lenka Hernychova
9. Ctirad Hofr

Reviewed by Review Commons