1. Proximity Interactome analyses unveil novel regulators of IRE1α canonical signaling

    This article has 16 authors:
    1. Simon Le Goupil
    2. Céline Philippe
    3. Hadrien Laprade
    4. Mathéo Lode
    5. Rachel Boniface
    6. Diana Pelizzari-Raymundo
    7. Kurt Dejgaard
    8. Gregor Jansen
    9. Celia Limia
    10. Claudio Hetz
    11. S. Jalil Mahdizadeh
    12. Luc Negroni
    13. Marc Aubry
    14. Jean-Ehrland Ricci
    15. Leif A. Eriksson
    16. Eric Chevet

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling

    This article has 14 authors:
    1. Nevin K Zacharia
    2. Stefanie Kuhns
    3. Niels Boegholm
    4. Anni Christensen
    5. Jiaolong Wang
    6. Narcis A Petriman
    7. Anna Lorentzen
    8. Jindriska L Fialova
    9. Lucie Menguy
    10. Sophie Saunier
    11. Soren T Christensen
    12. Jens S Andersen
    13. Sagar Bhogaraju
    14. Esben Lorentzen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important work advances our understanding of intraflagellar transport, ciliogenesis, and ciliary-based signaling, by identifying the interactions of IFT172 with IFT-A components, ubiquitin-binding, and ubiquitination, mediated by IFT172 C-terminus and its role in ciliogenesis and ciliary signaling. The results of the structural analysis of the IFT172 C-terminus and the evidence for the interaction between IFT172 and IFT-A components are convincing. However, the analysis of ubiquitin-binding and ubiquitination mediated by IFT172 is incomplete.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  3. Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter

    This article has 8 authors:
    1. Parveen Goyal
    2. KanagaVijayan Dhanabalan
    3. Mariafrancesca Scalise
    4. Rosmarie Friemann
    5. Cesare Indiveri
    6. Renwick CJ Dobson
    7. Kutti R Vinothkumar
    8. Subramanian Ramaswamy
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable work provides novel insights into the substrate binding mechanism of a tripartite ATP-independent periplasmic (TRAP) transporter, which may be helpful for the development of specific inhibitors. The structural analysis is convincing, but additional work will be required to establish the transport mechanism as well as well as binding sites for all ligands. This study will be of interest to the membrane transport and bacterial biochemistry communities.

    Reviewed by eLife

    This article has 12 evaluationsAppears in 2 listsLatest version Latest activity
  4. Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species

    This article has 13 authors:
    1. Man Zhu
    2. Meng Ma
    3. Lunan Luo
    4. Feiyang Li
    5. Jiashun Zheng
    6. Yan Pan
    7. Lu Yang
    8. Ying Xiao
    9. Ziyan Wang
    10. Bo Xian
    11. Yi Zheng
    12. Hao Li
    13. Jing Yang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Building on earlier evidence that Topoisomerase 2 depletion can extend yeast lifespan, the authors present convincing data demonstrating that reduced Top2 levels confer significant longevity benefits in C. elegans and mice. They show that these benefits encompass not only extended survival but also improved healthspan and mitigation of aging phenotypes, supported by robust transcriptomic, epigenetic, and histological analyses. While the exact mechanistic underpinnings-such as the potential connection to classical aging pathways and the selective down-regulation of genes with active promoters-remain to be fully elucidated, the breadth of these important findings strongly indicates a conserved role for Top2 in aging regulation.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  5. Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production

    This article has 5 authors:
    1. Parnian Arafi
    2. Sujan Devkota
    3. Emily Williams
    4. Masato Maesako
    5. Michael S Wolfe
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript provides fundamental studies to gain insight into the mutations in the presenilin-1 (PSEN1) gene on proteolytic processing of the amyloid precursor protein (APP). The authors provide compelling evidence using mutations in PSEN to understand what drives alternative substrate turnover with convincing data and rigorous analysis. This deep mechanistic study provides a framework towards the development of small molecule inhibitors to treat AD.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  6. Interaction hierarchy among Cdv proteins drives recruitment to membrane necks

    This article has 3 authors:
    1. Nicola De Franceschi
    2. Alberto Blanch-Jover
    3. Cees Dekker
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study investigates how the proteins of the Cdv division system in Metallosphaera sedula archaea sequentially interact with curved membranes in vitro, extending our understanding of this reduced ESCRT-like machinery. While the data support key aspects of protein recruitment and membrane remodeling, missing controls and statistical analysis information, unaddressed discrepancies, and limitations in recapitulating native geometry leave the data incomplete to fully support the proposed conclusions. The work will be of interest to evolutionary and synthetic biologists as membrane biophysicists but would benefit from additional experiments and a more cautious interpretation of results.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  7. Membrane mimetic thermal proteome profiling (MM-TPP) towards mapping membrane protein-ligand dynamics

    This article has 5 authors:
    1. Rupinder Singh Jandu
    2. Mohammed Al-Seragi
    3. Hiroyuki Aoki
    4. Mohan Babu
    5. Franck Duong van Hoa
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This useful study introduces the peptidisc-TPP approach as a promising solution to challenges in membrane proteomics, enabling thermal proteome profiling in a detergent-free system. While the concept is innovative and holds significant potential, the demonstration of its utility and validation remains incomplete. The method presents a strong foundation for broader applications in identifying physiologically and pharmacologically relevant membrane protein-ligand interactions.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  8. Enzymatic access to the rare ΔUA (1→4) Glc 3, 6, N-sulfated heparin disaccharide, implications for heparin quality control

    This article has 12 authors:
    1. T. K. Kandola
    2. C. J. Mycroft-West
    3. M. L. Andrade De Lima
    4. A. Turner
    5. C. Gardini
    6. E. Urso
    7. G.J. Miller
    8. A. Bisio
    9. E. A. Yates
    10. M. Guerrini
    11. L. Wu
    12. M. A. Skidmore

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  9. Curcuma longa Essential Oil Topically Mitigates Inflammatory Markers in Acetone-Induced Atopic Dermatitis in Wistar Albino Rats

    This article has 5 authors:
    1. Nathiim Namale
    2. Deusdedit Tusubira
    3. Kenneth Male
    4. Angela Mumbua Musyoka
    5. Patrick Maduabuchi Aja

    Reviewed by Arcadia Science

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  10. Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant

    This article has 7 authors:
    1. Patsy R Tomlinson
    2. Rachel G Knox
    3. Olga Perisic
    4. Helen Su
    5. Gemma V Brierley
    6. Roger L Williams
    7. Robert K Semple
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study reports on PI3KR mutations and a paradoxical mechanism of PI3KR signaling. The strength of evidence for the study is mostly convincing, as conclusions are supported by a variety of mutational strategies and cellular systems to look at interactions among signaling pathways.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
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