Evaluated articles

Haploinsufficiency of lysosomal enzyme genes in Alzheimer’s disease

1. Bruno A. Benitez
2. Clare E. Wallace
3. Maulikkumar Patel
4. Niko-Petteri Nykanen
5. Carla M. Yuede
6. Samantha L. Eaton
7. Cyril Pottier
8. Arda Cetin
9. Matthew Johnson
10. Mia T. Bevan
11. Woodrow D. Gardiner
12. Hannah M. Edwards
13. Brookelyn M. Doherty
14. Ryan T. Harrigan
15. Dominic Kurian
16. Thomas M. Wishart
17. Colin Smith
18. John R. Cirrito
19. Mark S. Sands

Reviewed by Arcadia Science

Unsupervised Representation Learning of C. elegans Poses and Behavior Sequences From Microscope Video Recordings

1. Maurice Deserno
2. Katarzyna Bozek

• Curated by eLife

  eLife Assessment

  This valuable study introduces a self-supervised machine learning method to classify C. elegans postures and behaviors directly from video data, offering an alternative to the skeleton-based approaches that rely on often error-prone tracking. This novel approach holds promise for advancing ethology research. That said, the strength of evidence is currently incomplete, as key aspects - including measuring head-tail orientation, increased behavioral interpretability, and quantitative comparisons to established methods - are underdeveloped and would benefit from further validation.

Reviewed by Arcadia Science, eLife

The reproductive microbiome inhibits pollen germination in milkweed

1. Harmony J. Dalgleish
2. Joshua R. Puzey
3. Katie Barlow
4. Olivia Cunningham
5. Elizabeth M. Davies
6. Hannah Machiorlete
7. Geneva Waynick
8. Kurt E. Williamson

Reviewed by Arcadia Science

Isolation of functional lysosomes from skeletal muscle

1. Thulasi Mahendran
2. Anastasiya Kuznyetsova
3. Neushaw Moradi
4. David A. Hood

Reviewed by Arcadia Science

Leaffooted bugs enrich local soil with their horizontally acquired symbiont

1. Bibek Singh Parajuli
2. John Teodosio
3. Alison Ravenscraft

Reviewed by Arcadia Science

Predicting functional constraints across evolutionary timescales with phylogeny-informed genomic language models

1. Chengzhong Ye
2. Gonzalo Benegas
3. Carlos Albors
4. Jianan Canal Li
5. Sebastian Prillo
6. Peter D. Fields
7. Brian Clarke
8. Yun S. Song

Reviewed by Arcadia Science

Scaling down protein language modeling with MSA Pairformer

1. Yo Akiyama
2. Zhidian Zhang
3. Milot Mirdita
4. Martin Steinegger
5. Sergey Ovchinnikov

Reviewed by Arcadia Science

A High-Throughput Multiwell-Plate based Approach for the combined Expression, Export and Assay of Recombinant Proteins

1. Karen Baker
2. Daniel P. Mulvihill

Reviewed by Arcadia Science

Breaking Through Biology's Data Wall: Expanding the Known Tree of Life by Over 10x using a Global Biodiscovery Pipeline

1. Oliver Vince
2. Phoebe Oldach
3. Valerio Pereno
4. Marcus H Y Leung
5. Carla Greco
6. Gus Minto-Cowcher
7. Saif Ur-Rehman
8. Keith Y K Kam
9. William Chow
10. Emma Bolton
11. Bupe R Mwambingu
12. Nadine L Greenhalgh
13. Ineke E Knot
14. Leif Christoffersen
15. Marlon Clark
16. Robert Pecoraro
17. Aaron W Kollasch
18. Tanggis Bohnuud
19. Matthew Bakalar
20. Philipp Lorenz
21. Glen Gowers

Reviewed by Arcadia Science

Non-destructive label-free automated identification of bacterial colonies at the species level directly on agar media using digital holography and convolutional neural network algorithms

1. Prisca Perlemoine
2. Jordan Belissard
3. Bruno Burtschell
4. Nassim Halli
5. Luc Martin
6. Camille Brunet
7. Maxime Gougis
8. Patrick Schiavone
9. Yvan Caspar

Reviewed by Arcadia Science

WAChRs are excitatory opsins sensitive to indoor lighting

1. Amanda J. Tose
2. Alberto A. Nava
3. Sara N. McGrath
4. Alan R. Mardinly
5. Alexander Naka

Reviewed by Arcadia Science

Astrocytes mobilize a broader repertoire of lysosomal repair mechanisms than neurons

1. Erin M. Smith
2. Natali L. Chanaday
3. Sandra Maday

Reviewed by Arcadia Science

Sustainable production of plastic-degrading enzymes in Chlamydomonas pacifica

1. Crisandra Jade Diaz
2. João Vitor Dutra Molino
3. Barbara Saucedo
4. Kalisa Kang
5. Évellin do Espirito Santo
6. Marissa Tessman
7. Abhishek Gupta
8. Michael D. Burkart
9. Ryan Simkovsky
10. Stephen Mayfield

Reviewed by Arcadia Science

CF2H: a Cell-Free Two-Hybrid platform for rapid protein binder screening

1. Julien Capin
2. Pauline Mayonove
3. Angelique DeVisch
4. Amon Becher
5. Giang Ngo
6. Alexis P Courbet
7. Robert J Ragotte
8. Martin Cohen-Gonsaud
9. Julien Espeut
10. Jerome Bonnet

Reviewed by Arcadia Science

Determinants of mutation load in birds

1. Fidel Botero-Castro
2. Jochen B. W. Wolf

Reviewed by Arcadia Science

Raman spectra identify vancomycin-resistant phenotypes and their transcriptomic features in Staphylococcus aureus

1. Ken-ichiro F. Kamei
2. Reiko Okura
3. Koseki J. Kobayashi-Kirschvink
4. Yuki Katayama
5. Yuichi Wakamoto

Reviewed by Arcadia Science

Unbiased whole genome comparison of Pan paniscus (bonobo) and Homo sapiens (human) through a novel sequence match-based approach

1. Christof Rosler
2. Derick DuFriend
3. Evonn Annor
4. Rita Njoroge
5. Elena Davis
6. Ywahae Law Anthem
7. Celestino Velásquez
8. William P. Ranahan
9. Matthew H. Goelzer
10. Stephen Wheat
11. Julianna A. Goelzer

Reviewed by Arcadia Science

On the utility of Deep Learning for model classification and parameter estimation on complex diversification scenarios

1. P.G. Peña
2. G. Iglesias
3. E. Talavera
4. AS. Meseguer
5. I. Sanmartín

Reviewed by Arcadia Science

Label-Free In-Line Characterization of Immune Cell Culture using Quantitative Phase Imaging

1. Caroline E. Serafini
2. Viswanath Gorti
3. Paloma Casteleiro Costa
4. Aaron D. Silva Trenkle
5. Bharat Kanwar
6. Bryan Wang
7. Brian Wicker
8. Linda E. Kippner
9. Isaac LeCompte
10. Rui Qi Chen
11. Benjamin Joffe
12. Ye Li
13. Annie C. Bowles-Welch
14. Jing Li
15. Christine E. Brown
16. Gabriel A. Kwong
17. Stephen Balakirsky
18. Krishnendu Roy
19. Francisco E. Robles

Reviewed by Arcadia Science