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  1. IRF2 degradation tunes the innate immune response

    This article has 19 authors:
    1. Cristhian Cadena
    2. Rohit Reja
    3. Emma Bolech
    4. Joshua D. Webster
    5. Vasumathi Kameswaran
    6. Marco de Simone
    7. Cynthia Chen
    8. Jian Jiang
    9. Kathy Hotzel
    10. Kamela Alegre
    11. Zhenyu Tan
    12. Raymond Newland
    13. Ryan Kelly
    14. Spyros Darmanis
    15. Bence Daniel
    16. Ishan Deshpande
    17. Kim Newton
    18. Nobuhiko Kayagaki
    19. Vishva M. Dixit

    Reviewed by Arcadia Science

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  2. Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context

    This article has 27 authors:
    1. Sung Yun Park
    2. Arlo Sheridan
    3. Bobae An
    4. Erin Jarvis
    5. Julia Lyudchik
    6. William Patton
    7. Jun Y. Axup
    8. Stephanie W. Chan
    9. Hugo G.J. Damstra
    10. Daniel Leible
    11. Kylie S. Leung
    12. Clarence A. Magno
    13. Aashir Meeran
    14. Julia M. Michalska
    15. Franz Rieger
    16. Claire Wang
    17. Michelle Wu
    18. George M. Church
    19. Jan Funke
    20. Todd Huffman
    21. Kathleen G.C. Leeper
    22. Sven Truckenbrodt
    23. Johan Winnubst
    24. Joergen M.R. Kornfeld
    25. Edward S. Boyden
    26. Samuel G. Rodriques
    27. Andrew C. Payne

    Reviewed by Arcadia Science

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  3. Extracellular adenosine deamination primes tip organizer development in Dictyostelium

    This article has 2 authors:
    1. Pavani Hathi
    2. Baskar Ramamurthy
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      During the development of the unicellular eukaryote Dictyostelium discoideum, cells aggregate into mounds, which then form protrusions called tips, and the tips then become the front of migrating slugs and the top of fruiting bodies. This valuable study identifies a protein called adenosine deaminase-related growth factor (ADGF) as a key regulator of tip formation, and the authors convincingly show that ADGF catalyses the formation of ammonia from adenosine, allowing ammonia to initiate tip formation, and they then elucidate pathways upstream and downstream from ADGF. The authors discuss the intriguing possibility that mammalian ADGF may also regulate development in a similar manner.

    Reviewed by Arcadia Science, eLife

    This article has 10 evaluationsAppears in 2 listsLatest version Latest activity
  4. Haploinsufficiency of lysosomal enzyme genes in Alzheimer’s disease

    This article has 19 authors:
    1. Bruno A. Benitez
    2. Clare E. Wallace
    3. Maulikkumar Patel
    4. Niko-Petteri Nykanen
    5. Carla M. Yuede
    6. Samantha L. Eaton
    7. Cyril Pottier
    8. Arda Cetin
    9. Matthew Johnson
    10. Mia T. Bevan
    11. Woodrow D. Gardiner
    12. Hannah M. Edwards
    13. Brookelyn M. Doherty
    14. Ryan T. Harrigan
    15. Dominic Kurian
    16. Thomas M. Wishart
    17. Colin Smith
    18. John R. Cirrito
    19. Mark S. Sands

    Reviewed by Arcadia Science

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  5. Unsupervised Representation Learning of C. elegans Poses and Behavior Sequences From Microscope Video Recordings

    This article has 2 authors:
    1. Maurice Deserno
    2. Katarzyna Bozek
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study introduces a self-supervised machine learning method to classify C. elegans postures and behaviors directly from video data, offering an alternative to the skeleton-based approaches that rely on often error-prone tracking. This novel approach holds promise for advancing ethology research. That said, the strength of evidence is currently incomplete, as key aspects - including measuring head-tail orientation, increased behavioral interpretability, and quantitative comparisons to established methods - are underdeveloped and would benefit from further validation.

    Reviewed by Arcadia Science, eLife

    This article has 7 evaluationsAppears in 2 listsLatest version Latest activity
  6. Breaking Through Biology's Data Wall: Expanding the Known Tree of Life by Over 10x using a Global Biodiscovery Pipeline

    This article has 21 authors:
    1. Oliver Vince
    2. Phoebe Oldach
    3. Valerio Pereno
    4. Marcus H Y Leung
    5. Carla Greco
    6. Gus Minto-Cowcher
    7. Saif Ur-Rehman
    8. Keith Y K Kam
    9. William Chow
    10. Emma Bolton
    11. Bupe R Mwambingu
    12. Nadine L Greenhalgh
    13. Ineke E Knot
    14. Leif Christoffersen
    15. Marlon Clark
    16. Robert Pecoraro
    17. Aaron W Kollasch
    18. Tanggis Bohnuud
    19. Matthew Bakalar
    20. Philipp Lorenz
    21. Glen Gowers

    Reviewed by Arcadia Science

    This article has 1 evaluationAppears in 1 listLatest version Latest activity