Evaluated articles

Condensation of Sidekick at tricellular junctions organizes mechanical forces for cell-cell adhesion remodeling

1. Hiroyuki Uechi
2. Daxiao Sun
3. Yuki Saeki
4. Tetsuya Hiraiwa
5. Alf Honigmann
6. Anthony A. Hyman
7. Erina Kuranaga

Reviewed by preLights

TAM receptors control actomyosin dynamics in osteoclasts via RHOA-COFILIN-MYOSIN II signaling

1. Janik Engelmann
2. Jennifer Zarrer
3. Max Schmerder
4. Christian Mess
5. Deniz Ragipoglu
6. Kristoffer Riecken
7. Tal Burstyn-Cohen
8. Emily J. Alberto
9. Sourav Ghosh
10. Carla Rothlin
11. Klaus Pantel
12. Carsten Bokemeyer
13. Eric Hesse
14. Hanna Taipaleenmäki
15. Sonja Loges
16. Isabel Ben-Batalla

Reviewed by preLights

Tandem duplication of serpin genes yields functional variation and snake venom inhibitors

1. Meilyn S. Ward
2. Matthew L. Holding
3. Laura M. Haynes
4. David Ginsburg

Reviewed by preLights

Hsp70 is phosphorylated in a conserved response to DNA damage and contributes to cell cycle control

1. Thomas Moss
2. Alexandra Wooldredge
3. Koustav Bhakta
4. Matthew Cronin
5. Jason E Gestwicki
6. Shaeri Mukherjee

• Curated by eLife

  eLife Assessment

  This potentially valuable manuscript focuses on the phosphorylation of residue T495 as a mechanism to inactivate HSP70 and disrupt cell cycle progression in response to DNA damage. The evidence supporting this model is solid, but would be significantly strengthened by additional studies defining the extent of T495 phosphorylation induced by DNA damage, identifying the kinase responsible for phosphorylating T495 of HSP70, and further elucidation of the functional implications of T495 phosphorylation in human cells. This work will be of interest to scientists focused on topics including chaperone biology, proteostasis, cell cycle progression, and DNA damage.

Reviewed by eLife, preLights

The cold tolerance of an adult winter-active stonefly: How Allocapnia pygmaea (Plecoptera: Capniidae) avoids freezing in Nova Scotian winters

1. Jona Lopez Pedersen
2. Luke S. Burton
3. Tamara M. Rodela
4. Jantina Toxopeus

Reviewed by preLights

In depth profiling of the cancer proteome from the flowthrough of standard RNA- preparation kits for precision oncology

1. Filip Mundt Madsen
2. Annelaura Bach Nielsen
3. Juanjuan Wang
4. Josephine Kerzel Duel
5. Christina Westmose Yde
6. Martina Amnitzbøll Eriksen
7. Ulrik Lassen
8. Finn Cilius Nielsen
9. Kristoffer Rohrberg
10. Matthias Mann

Reviewed by preLights

Lineage domains and cytoskeletal cables organize a cellular square grid in a crustacean

1. Beatrice L. Steinert
2. Leo Blondel
3. Chandrashekar Kuyyamudi
4. Evangelia Stamataki
5. Anastasios Pavlopoulos
6. Cassandra G. Extavour

Reviewed by preLights

Polyamine depletion inhibits norovirus infection by blocking virus-induced apoptosis

1. Maryna Chaika
2. Heike Laschin
3. Marina Pekelis
4. Carmen Mirabelli
5. Sandra Niendorf
6. Christiane E. Wobus
7. Stefan Taube

Reviewed by preLights

Single-Cell Network Analysis Identifies CLEC4E as a Key Mediator of Proinflammatory mDC Responses in Influenza Infection

1. Subin Cho
2. Gabriel Laghlali
3. Arturo Marin
4. Adolfo García-Sastre
5. Gagandeep Singh
6. Michael Schotsaert
7. Won-Min Song
8. Christian V. Forst

Reviewed by preLights

RNA Structure Directs RNA Partitioning and is Actively Disrupted inside Stress Granules to Enable Cellular Recovery

1. Bowen Zhu
2. Jovi Jian An Lim
3. Yu Zhang
4. Wen Ting Tan
5. Jiayi Zhang
6. Joy S Xiang
7. Roland Huber
8. Anthony Khong
9. Yue Wan

Reviewed by preLights

Targeting RhoA activity rejuvenates aged hematopoietic stem cells

1. Eva Mejía-Ramírez
2. Pablo Iañez Picazo
3. Barbara Walter
4. Sara Montserrat-Vazquez
5. Francesco Affuso
6. Stefan Wieser
7. Fabio Pezzano
8. Loïc Reymond
9. Jorge Castillo-Robles
10. Francesca Matteini
11. Loris Mularoni
12. Dídac Maciá
13. Ángel Raya
14. Verena Ruprecht
15. Yi Zheng
16. Paula Petrone
17. M. Carolina Florian

Reviewed by preLights

Paclitaxel compromises nuclear integrity in interphase through SUN2-mediated cytoskeletal coupling

1. Thomas Hale
2. Victoria L Hale
3. Piotr Kolata
4. Ália dos Santos
5. Matteo Allegretti

Reviewed by preLights, Review Commons

Epicardial Tcf21 facilitates cardiomyocyte dedifferentiation and heart regeneration in zebrafish

1. Miglė Kalvaitytė-Repečkė
2. Sofija Gabrilavičiūtė
3. Kotryna Kvederavičiūtė
4. Leonard Burg
5. Edita Bakūnaitė
6. Kenneth D. Poss
7. Darius Balciunas

Reviewed by preLights

MCL1 may not mediate chemoresistance

1. Kylin A. Emhoff
2. Kunho Chung
3. Dongmei Zhang
4. Belinda Willard
5. Timothy Chan
6. Babal Kant Jha
7. Shaun R. Stauffer
8. Jesse A. Coker
9. Jan Joseph Melenhorst

Reviewed by preLights

The nucleus follows an internal cellular scale during polarized root hair cell development

1. Jessica M. Orr
2. M. Arif Ashraf

Reviewed by preLights

Psychedelics Align Brain Activity with Context

1. Devon Stoliker
2. Leonardo Novelli
3. Moein Khajehnejad
4. Mana Biabani
5. Matthew D. Greaves
6. Tamrin Barta
7. Martin Williams
8. Sidhant Chopra
9. Olivier Bazin
10. Otto Simonsson
11. Richard Chambers
12. Frederick Barrett
13. Gustavo Deco
14. Katrin H. Preller
15. Robin Carhart-Harris
16. Anil Seth
17. Suresh Sundram
18. Gary F. Egan
19. Adeel Razi

Reviewed by preLights

Immune–Vascular intercellular signalling coordinates tissue plasticity during adult muscle repair in Drosophila

1. Nourhene Ammar
2. Olivier Josse
3. Aurélien Guillou
4. Jessica Perochon
5. Hadi Boukhatmi

Reviewed by preLights

Wide-ranging behavioral dysfunction in two mouse models of pathological human variants in the GRIK2 kainate receptor gene

1. Brynna T. Webb
2. Hieu Trinh
3. Emily A. Breach
4. Kendall M. Foote
5. Erica Binelli
6. Geoffrey T. Swanson

Reviewed by preLights

Malaria shaped human spatial organisation for the last 74 thousand years

1. Margherita Colucci
2. Michela Leonardi
3. James Blinkhorn
4. Seth R. Irish
5. Cecilia Padilla-Iglesias
6. Stefanie Kaboth-Bar
7. William D. Gosling
8. Robert W. Snow
9. Andrea Manica
10. Eleanor M.L. Scerri

Reviewed by preLights

Tumor-infiltrating CD27 ^- IgD ^- regulatory B cells suppress cytotoxic CD8 ⁺ T cell responses in renal cell carcinoma

1. Zara Baig
2. Isabella Withnell
3. Joseph C.F. Ng
4. Christopher J.M. Piper
5. Hannah F. Bradford
6. Antonio Rullan
7. Edward H. Arbe-Barnes
8. Camila G.X. de Brito
9. Alessandro Di Tullio
10. Thomas J. Mitchell
11. Hans J. Stauss
12. Maxine G.B. Tran
13. Franca Fraternali
14. Claudia Mauri

Reviewed by preLights