Evaluated articles

Mixed alkyl/aryl phosphonates identify metabolic serine hydrolases as antimalarial targets

1. John M. Bennett
2. Sunil K. Narwal
3. Stephanie Kabeche
4. Daniel Abegg
5. Vandana Thathy
6. Fiona Hackett
7. Tomas Yeo
8. Veronica L. Li
9. Ryan Muir
10. Franco Faucher
11. Scott Lovell
12. Michael J. Blackman
13. Alexander Adibekian
14. Ellen Yeh
15. David A. Fidock
16. Matthew Bogyo

Reviewed by preLights

Integrin conformation-dependent neutrophil slowing obstructs the capillaries of the pre-metastatic lung in a model of breast cancer

1. Frédéric Fercoq
2. Gemma S. Cairns
3. Marco De Donatis
4. John B. G. Mackey
5. Alessia Floerchinger
6. Amanda McFarlane
7. Ximena L. Raffo-Iraolagoitia
8. Declan Whyte
9. Lindsey W. G. Arnott
10. Colin Nixon
11. Robert Wiesheu
12. Anna Kilbey
13. Leah Brown
14. Sarwah Al-Khalidi
15. Jim C. Norman
16. Edward W. Roberts
17. Karen Blyth
18. Seth B. Coffelt
19. Leo M. Carlin

Reviewed by preLights

An updated and expanded characterization of the biological sciences academic job market

1. Brooklynn Flynn
2. Ariangela J. Kozik
3. You Cheng
4. Ada K. Hagan
5. Jennifer Ng
6. Christopher T. Smith
7. Amanda Haage
8. Nafisa M. Jadavji

Reviewed by preLights

Modeling transcriptional profiles of gene perturbation with deep neural network

1. Wenke Liu
2. Xuya Wang
3. D R Mani
4. David Fenyö

Reviewed by preLights

The RNA binding protein HNRNPA2B1 regulates RNA abundance and motor protein activity in neurites

1. Joelle Lo
2. Katherine F. Vaeth
3. Gurprit Bhardwaj
4. Neelanjan Mukherjee
5. Holger A. Russ
6. Jeffrey K. Moore
7. J. Matthew Taliaferro

Reviewed by preLights

Engineered Nanotopographies Induce Transient Openings in the Nuclear Membrane

1. Einollah Sarikhani
2. Vrund Patel
3. Zhi Li
4. Dhivya Pushpa Meganathan
5. Keivan Rahmani
6. Leah Sadr
7. Ryan Hosseini
8. Diether Visda
9. Shivani Shukla
10. Hamed Naghsh‐Nilchi
11. Adarsh Balaji
12. Gillian McMahon
13. Shaoming Chen
14. Johannes Schöneberg
15. Colleen A. McHugh
16. Lingyan Shi
17. Zeinab Jahed

Reviewed by preLights

Pharyngeal neuronal mechanisms governing sour taste perception in Drosophila melanogaster

1. Bhanu Shrestha
2. Jiun Sang
3. Suman Rimal
4. Youngseok Lee

• Curated by eLife

  eLife Assessment

  This is a useful contribution to our understanding of taste perception. The idea that specific receptors function in the pharynx to mediate responses to carboxylic acids is interesting, although the expression analysis is incomplete. Reviewers also have a number of other suggestions for improvement, including the request that authors provide more details about the methodology used. In general, the claims are supported by solid evidence and add to a growing body of literature on this topic.

Reviewed by eLife, preLights

Feedback regulation by the RhoA-specific GEF ARHGEF17 regulates actomyosin network disassembly

1. Vasundhara Rao
2. Benjamin Grädel
3. Lucien Hinderling
4. Jakobus Van Unen
5. Olivier Pertz

Reviewed by preLights

Specialized signaling centers direct cell fate and spatial organization in a limb organoid model

1. Evangelia Skoufa
2. Jixing Zhong
3. Oliver Kahre
4. Kelly Hu
5. Georgios Tsissios
6. Louise Carrau
7. Antonio Herrera
8. Albert Dominguez Mantes
9. Alejandro Castilla-Ibeas
10. Hwanseok Jang
11. Martin Weigert
12. Gioele La Manno
13. Matthias Lutolf
14. Marian Ros
15. Can Aztekin

Reviewed by preLights

The role of ER exit sites in maintaining P-body organization and transmitting ER stress response during Drosophila melanogaster oogenesis

1. Samantha N. Milano
2. Livia V. Bayer
3. Julie J. Ko
4. Caroline E. Casella
5. Diana P. Bratu

Reviewed by preLights

Spiral-eyes: A soft active matter model of in vivo corneal epithelial cell migration

1. Kaja Kostanjevec
2. Rastko Sknepnek
3. Jon Martin Collinson
4. Silke Henkes

• Curated by eLife

  eLife Assessment

  This useful study describes a physical mechanism for the emergence of spiral patterns in the outer epithelial layer of the mammalian cornea independent of pre-patterning or guidance cues, using an agent-based model of self-propelled particles with alignment. The model is well constructed, however the central premise of the manuscript, that the spiral patterning of epithelial corneal cells occurs without guidance cues, is incomplete and not fully supported. Several significant questions remain unanswered, such as the role of the corneal curvature or the importance of topological defects. Furthermore, comparison between the model and data are qualitative at best for the moment.

Reviewed by eLife, preLights

Significantly reduced, but balanced, rates of mitochondrial fission and fusion are sufficient to maintain the integrity of yeast mitochondrial DNA

1. Brett T. Wisniewski
2. Jason C. Casler
3. Laura L. Lackner

Reviewed by preLights

Adult caudal fin shape is imprinted in the embryonic fin fold

1. Eric Surette
2. Joan Donahue
3. Stephanie Robinson
4. Deirdre McKenna
5. Crisvely Soto Martinez
6. Brendan Fitzgerald
7. Rolf O. Karlstrom
8. Nicolas Cumplido
9. Sarah K. McMenamin

Reviewed by preLights

Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted

1. Miguel Reina-Campos
2. Alexander Monell
3. Amir Ferry
4. Vida Luna
5. Kitty P. Cheung
6. Giovanni Galletti
7. Nicole E. Scharping
8. Kennidy K. Takehara
9. Sara Quon
10. Peter P. Challita
11. Brigid Boland
12. Yun Hsuan Lin
13. William H. Wong
14. Cynthia S. Indralingam
15. Hayley Neadeau
16. Suzie Alarcón
17. Gene W. Yeo
18. John T. Chang
19. Maximilian Heeg
20. Ananda W. Goldrath

Reviewed by preLights

Triglyceride metabolism controls inflammation and APOE4 -associated disease states in microglia

1. Roxan A. Stephenson
2. Kory R. Johnson
3. Linling Cheng
4. Linda G. Yang
5. Jessica T. Root
6. Jaanam Gopalakrishnan
7. Han-Yu Shih
8. Priyanka S. Narayan

Reviewed by preLights

Impaired 26S proteasome causes learning and memory deficiency and induces neuroinflammation mediated by NF-κB in mice

1. Christa C. Huber
2. Eduardo Callegari
3. Maria Paez
4. Xiaoping Li
5. Abena Dwamena
6. Hongmin Wang

Reviewed by preLights

The actin cortex acts as a mechanical memory of morphology in confined migrating cells

1. Yohalie Kalukula
2. Marine Luciano
3. Guillaume Charras
4. David B. Brückner
5. Sylvain Gabriele

Reviewed by preLights

High-fat and High-sucrose Diet-induced Hypothalamic Inflammation Shows Sex Specific Features in Mice

1. Gabriela C. De Paula
2. Rui F. Simões
3. Alba M. Garcia-Serrano
4. João M. N. Duarte

Reviewed by preLights

The bat influenza A virus subtype H18N11 induces nanoscale MHCII clustering upon host cell attachment

1. Maria Kaukab Osman
2. Jonathan Robert
3. Lukas Broich
4. Dennis Frank
5. Robert Grosse
6. Martin Schwemmle
7. Antoni G. Wrobel
8. Kevin Ciminski
9. Christian Sieben
10. Peter Reuther

Reviewed by preLights

TAK1 operates at the primary cilium in non-canonical TGFB/BMP signaling to control heart development

1. Canan Doganli
2. Daniel A. Baird
3. Yeasmeen Ali
4. Oskar Kaaber Thomsen
5. Enrique Audain
6. Line Jessen
7. Pauline Munck Truelsen
8. Johanne Bay Mogensen
9. Maria Schrøder Holm
10. Kateřina Apolínová
11. Lorenzo Buttò
12. Maria Diamanti
13. Jindřiška Leischner Fialová
14. Emma M. Wade
15. Stephen P. Robertson
16. Lotte Bang Pedersen
17. Laurent Argiro
18. Fabienne Lescroart
19. Marc-Phillip Hitz
20. Søren Tvorup Christensen
21. Lars Allan Larsen

Reviewed by preLights