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  1. Membrane rupture and independent extension of sister membranes drive cytokinesis in C. elegans embryos

    1. Jingjing Liang
    2. Tingrui Huang
    3. Xun Huang
    4. Mei Ding

    • Curated by eLife

      eLife Assessment

      In this manuscript, based on electron microscopy observations of C. elegans embryos, the authors make the bold claim that the plasma membrane ruptures during cell division and that closure of this opening by membrane extension contributes to cytokinesis. Although the findings are potentially valuable, the evidence in support of the authors' claims is inadequate.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  4. Transposons contribute to splice-isoform diversity in the Drosophila brain

    1. Malak Choucri
    2. Christoph D Treiber

    • Curated by eLife

      eLife Assessment

      This valuable study addresses a timely question regarding the contribution of transposable elements to splice isoform diversity in the Drosophila brain, directly engaging with recent conflicting findings in the field. The work provides convincing evidence that TE-gene chimeric transcripts are detectable and that prior discrepancies largely arise from methodological differences in computational pipelines and experimental design. The combination of reanalysis, methodological clarification, and targeted validation represents a technical contribution that will be of interest to researchers studying transcriptome complexity and transposable elements. However, the strength of evidence would be further enhanced by increased methodological transparency, more rigorous experimental controls, and a more cautious interpretation of functional implications.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  6. Direction and orientation preferences in mouse superior colliculus and its retinal inputs exhibit a topography of cardinal biases atop locally mixed tuning

    1. Zhewen He
    2. María Florencia González Fleitas
    3. Raikhangul Gabdrashova
    4. Sylvia Schröder

    • Curated by eLife

      eLife Assessment

      This is a potentially important work on the organization of visual information in the rodent superior colliculus. It reports that the selectivity of neurons to line orientation and motion in the visual image is largely governed by the sensitivities of retinal neurons and their ordered projection to the superior colliculus. If confirmed, these conclusions could substantially revise prior thinking in this field. However, in the present state, the methods and analysis are incomplete and cannot justify all the claims.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  8. The CLAMP GA-binding transcription factor regulates heat stress-induced transcriptional repression

    1. Joseph Aguilera
    2. Jingyue Duan
    3. Kaitlyn Cortez
    4. Rachel S Lee
    5. Angelica Aragon
    6. Mukulika Ray
    7. Erica Larschan

    • Curated by eLife

      eLife Assessment

      This important study presents evidence that the Chromatin-linked adaptor for MSL complex proteins (CLAMP) GA-binding transcription factor (TF) regulates ~75% of HS-induced repression in Drosophila and suggests that CLAMP is the first known transcription factor to induce heat-stress-mediated repression of gene expression. While mechanistic details remain to be sorted out, this manuscript provides convincing evidence that novel pathways involving the CLAMP transcription factor repress gene expression during heat shock stress.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity
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