eLife

Latest preprint reviews

1. fmo-4 promotes longevity and stress resistance via ER to mitochondria calcium regulation in C. elegans

   This article has 9 authors:

   1. AM Tuckowski
   2. S Beydoun
   3. ES Kitto
   4. A Bhat
   5. MB Howington
   6. A Sridhar
   7. M Bhandari
   8. K Chambers
   9. SF Leiser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study offers convincing evidence that fmo-4 plays essential roles in established lifespan interventions and downstream of its paralog fmo-2, a beneficial advancement in our understanding of this enzyme family that underscores their importance in longevity and stress resistance. The study also suggests a connection between fmo-4 and dysregulation of calcium signalling. The authors' conclusions and interpretations were generally based on solid genetic methodology and evidence.

   Reviewed by eLife

2. Heparan sulphate binding controls in vivo half-life of the HpARI protein family

   This article has 9 authors:

   1. Florent Colomb
   2. Abhishek Jamwal
   3. Adefunke Ogunkanbi
   4. Tania Frangova
   5. Alice R Savage
   6. Sarah Kelly
   7. Gavin J Wright
   8. Matthew K Higgins
   9. Henry J McSorley

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study uses in vitro and in vivo methods to identify HpARI proteins from H. polygyrus as modulators of the host immune system. The data from comprehensive approaches for investigating differential roles of HpARI proteins are convincing. This paper is relevant to those who investigate host-pathogen interactions at the systems and molecular levels.

   Reviewed by eLife

3. Sensorimotor delays constrain robust locomotion in a 3D kinematic model of fly walking

   This article has 7 authors:

   1. Lili Karashchuk
   2. Jing Shuang (Lisa) Li
   3. Grant M Chou
   4. Sarah Walling-Bell
   5. Steven L Brunton
   6. John C Tuthill
   7. Bingni W Brunton

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study presents a computational model that simulates walking motions in Drosophila and suggests that, if sensorimotor delays in the neural circuitry were any longer, the system would be easily destabilized by external perturbations. The hierarchical control model is sensible and the evidence supporting the conclusions is solid. However, because the modular model has many interacting components with varying degrees of biological realism, it is difficult to judge the degree to which the observed differences between simulation and empirical data are meaningful, and the precise source of the discrepancies.

   Reviewed by eLife

4. Neural dynamics of visual working memory representation during sensory distraction

   This article has 4 authors:

   1. Jonas Karolis Degutis
   2. Simon Weber
   3. Joram Soch
   4. John-Dylan Haynes

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study reports a reanalysis of one experiment of a previously published report to characterize the dynamics of neural population codes during visual working memory in the presence of distracting information. The evidence supporting the claims of dynamic codes is incomplete, as only a subset of the original data is analyzed, there is only modest evidence for dynamic coding in the results, and the result might be affected by the signal-to-noise ratio. This research will be of interest to cognitive neuroscientists working on the neural bases of visual perception and memory.

   Reviewed by eLife

5. The inevitability and superfluousness of cell types in spatial cognition

   This article has 3 authors:

   1. Xiaoliang Luo
   2. Robert M Mok
   3. Bradley C Love

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study uses a deep neural network approach to challenge the role of spatially selective neurons like place, head or border cells for position decoding. The findings are important as they suggest that such functional cell types may emerge naturally from object recognition in complex visual environments, but are neither necessary, nor particularly critical for position decoding. However, direct evidence supporting this conclusion remains incomplete.

   Reviewed by eLife

6. Micro-Scale Control of Oligodendrocyte Morphology and Myelination by the Intellectual Disability-Linked Protein Acyltransferase ZDHHC9

   This article has 9 authors:

   1. Hey-Kyeong Jeong
   2. Estibaliz Gonzalez-Fernandez
   3. Ilan Crawley
   4. Jinha Hwang
   5. Dale DO Martin
   6. Shernaz X Bamji
   7. Jong-Il Kim
   8. Shin H Kang
   9. Gareth M Thomas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides an in-depth exploration of the impact of X-linked ZDHHC9 gene mutations on cognitive deficits and epilepsy, with a particular focus on the expression and function of ZDHHC9 in myelin-forming oligodendrocytes (OLs). These valuable findings offer insights into ZDHHC9-related X-linked intellectual disability (XLID) and shed light on the regulatory mechanisms of palmitoylation in myelination. The experimental design and analysis of results are solid, providing a reference for further research in this field.

   Reviewed by eLife

7. Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors

   This article has 8 authors:

   1. Abdulkadir Ozkan
   2. Hari K Padmanabhan
   3. Seth L Shipman
   4. Eiman Azim
   5. Priyanka Kumar
   6. Cameron Sadegh
   7. A Nazli Basak
   8. Jeffrey D Macklis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents fundamental new findings introducing a new approach for the reprogramming of brain glial cells to corticospinal neurons. The data is highly compelling, with multiple lines of evidence demonstrating the success of this new assay. These exciting findings set the stage for future studies of the potential of these reprogrammed cells to form functional connections in vivo and their utility in clinical conditions where corticospinal neurons are compromised.

   Reviewed by eLife

8. When Do Visual Category Representations Emerge in Infants’ Brains?

   This article has 6 authors:

   1. Xiaoqian Yan
   2. Sarah Tung
   3. Bella Fascendini
   4. Yulan Diana Chen
   5. Anthony M Norcia
   6. Kalanit Grill-Spector

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study investigates the development of high-level visual responses in infants, finding that neural responses specific to faces are present by 4-6 months but not earlier. The study is methodologically convincing, using state-of-the-art experimental design and analysis approaches. The findings would be of broad interest to the cognitive neuroscience and developmental psychology research communities.

   Reviewed by eLife

9. Single-cell RNA sequencing of the holothurian regenerating intestine reveals the pluripotency of the coelomic epithelium

   This article has 5 authors:

   1. Joshua G Medina-Feliciano
   2. Griselle Valentín-Tirado
   3. Kiara Luna-Martínez
   4. Yamil Miranda-Negrón
   5. José E García-Arrarás

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a dataset obtained through a single cell RNA-Sequencing of sea cucumber regenerating intestine 9 days post evisceration. The data were collected and analyzed using standard single cells analysis from n=2 adult sea cucumbers captured from the wild, which represents a useful resource for future studies. Although cell type validation is attempted, it is performed on samples from the same 2 animals (and not independent samples), rendering the validation incomplete. Further, the RNA localization images provided in the paper could benefit from improved spatial context, and many strong statements in the discussion should be better justified and supported by the presented data. With the validation part strengthened, this paper would be of interest to development and regeneration fields.

   Reviewed by eLife

10. Activity-dependent lateral inhibition enables the synchronization of olfactory bulb projection neurons

    This article has 2 authors:

    1. Tal Dalal
    2. Rafi Haddad

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This valuable study provides in vivo evidence for the synchronization of projection neurons in the olfactory bulb at gamma frequency in an activity-dependent manner. This study uses optogenetics in combination with single-cell recordings to selectively activate sensory input channels within the olfactory bulb. The data are thoughtfully analyzed and presented; the evidence is solid, although some of the conclusions are only partially supported.

    Reviewed by eLife