eLife

Latest preprint reviews

1. Massively Parallel Polyribosome Profiling Reveals Translation Defects of Human Disease-Relevant UTR Mutations

   This article has 12 authors:

   1. Wei-Ping Li
   2. Jia-Ying Su
   3. Yu-Chi Chang
   4. Yun-Lin Wang
   5. Hung-Lun Chiang
   6. Yu-Tung Hsieh
   7. Yi-Hsuan Chiang
   8. Yen-Ling Ko
   9. Bing-Jen Chiang
   10. Cheng-Han Yang
   11. Yen-Tsung Huang
   12. Chien-Ling Lin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     To elucidate the precise function of variants in the UTRs, the authors established and conducted a massively parallel poly(ribo)some profiling method to compare ribosome associations and effects of genetic variants. The approach and results are valuable, as this is a new approach to studying UTRs. However, the experimental and analytic validation seems to be incomplete, as the results are less robust than expected.

   Reviewed by eLife

2. Arabidopsis SDG proteins mediate Polycomb removal and transcription-coupled H3K36 methylation for gene activation

   This article has 12 authors:

   1. Nobutoshi Yamaguchi
   2. Wang Yicong
   3. Masato Abe
   4. Yuka Kadoya
   5. Takeru Saiki
   6. Kanae Imai
   7. Xuejing Wang
   8. Taiko To
   9. Soichi Inagaki
   10. Takamasa Suzuki
   11. Tetsuji Kakutani
   12. Toshiro Ito

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study advances our understanding of the mechanisms underlying chromatin-mediated gene regulation by SET DOMAIN-CONTAINING PROTEIN 7 (SDG7). The evidence supporting the author's claims – centered on a combination of imaging approaches with molecular and genetic experiments – is convincing, although certain aspects can be improved. The work will be of broad interest to molecular biologists studying epigenetic regulation of gene expression.

   Reviewed by eLife

3. Deficiency in a special dynein DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice

   This article has 21 authors:

   1. Menglei Yang
   2. Hafiz Muhammad Jafar Hussain
   3. Manan Khan
   4. Zubair Muhammad
   5. Jianteng Zhou
   6. Ao Ma
   7. Xiongheng Huang
   8. Jingwei Ye
   9. Min Chen
   10. Aoran Zhi
   11. Tao Liu
   12. Ranjha Khan
   13. Asim Ali
   14. Wasim Shah
   15. Aurang Zeb
   16. Nisar Ahmad
   17. Huan Zhang
   18. Bo Xu
   19. Hui Ma
   20. Qinghua Shi
   21. Baolu Shi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study further validates DNAH12 as a causative gene for asthenoteratozoospermia and male infertility in humans and mice. The data supporting the notion that DNAH12 is required for proper axonemal development are generally convincing, although more experiments would solidify the conclusions. This work will interest reproductive biologists working on spermatogenesis and sperm biology, as well as andrologists working on male fertility.

   Reviewed by eLife

4. Structure transfer and consolidation in visual implicit learning

   This article has 2 authors:

   1. Dominik Garber
   2. József Fiser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study investigates the conditions under which abstract knowledge transfers to new learning. It presents evidence across a number of behavioral experiments that when explicit awareness of learned statistical structure is present, knowledge can transfer immediately, but that otherwise similar transfer requires sleep-dependent consolidation. The valuable results provide new constraints on theories of transfer learning and consolidation, though limitations in the statistical approach and interpretation make the current evidence incomplete.

   Reviewed by eLife

5. Single dopaminergic neuron DAN-c1 in Drosophila larval brain mediates aversive olfactory learning through D2-like receptors

   This article has 5 authors:

   1. Cheng Qi
   2. Cheng Qian
   3. Emma Steijvers
   4. Robert A Colvin
   5. Daewoo Lee

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable finding on the role of dopamine receptor D2R in dopaminergic neurons DAN-c1 and mushroom body neurons (Y201-GAL4 pattern) on aversive and appetitive conditioning. The evidence supporting the claims of the authors is solid and promotes the investigation using fly larvae, which have interesting advantages in the time required for obtaining experimental animals and the use of optogenetics. The work will be of interest to researchers studying neuronal control of behaviour and learning and memory in general.

   Reviewed by eLife

6. Spatiotemporal brain complexity quantifies consciousness outside of perturbation paradigms

   This article has 8 authors:

   1. Martin Breyton
   2. Jan Fousek
   3. Giovanni Rabuffo
   4. Pierpaolo Sorrentino
   5. Lionel Kusch
   6. Marcello Massimini
   7. Spase Petkoski
   8. Viktor Jirsa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study examined the complexity of emergent dynamics of large-scale neural network models after perturbation (perturbational complexity index, PCI) and used it as a measurement of consciousness to account for previous recordings of humans at various anesthetized levels. The evidence supporting the conclusion is solid and constitutes a unified framework for different observations related to consciousness. There are many fields that would be interested in this study, including cognitive neuroscience, psychology, complex systems, neural networks, and neural dynamics.

   Reviewed by eLife

7. A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective and anti-inflammatory properties following status epilepticus in mice

   This article has 20 authors:

   1. Lotfi Ferhat
   2. Rabia Soussi
   3. Maxime Masse
   4. Grigorios Kyriatzis
   5. Stéphane D Girard
   6. Fanny Gassiot
   7. Nicolas Gaudin
   8. Mathieu Laurencin
   9. Anne Bernard
   10. Angélique Bôle
   11. Géraldine Ferracci
   12. Maria Smirnova
   13. François Roman
   14. Vincent Dive
   15. Salvatore Cisternino
   16. Jamal Temsamani
   17. Marion David
   18. Pascaline Lécorché
   19. Guillaume Jacquot
   20. Michel Khrestchatisky

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors developed a method to allow a hypothermic agent, neurotensin, to cross the blood-brain barrier so it could potentially protect the brain from seizures and the adverse effects of seizures. The work is important because it is known that cooling the brain can protect it but developing a therapeutic approach based on that knowledge has not been done. The paper is well presented and the data are convincing.

   Reviewed by eLife

8. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2310.02257v3

9. Different treatment durations of loperamide in preventing pyrotinib-induced diarrhea: A randomized, parallel-group sub-study of the phase II PHAEDRA trial

   This article has 22 authors:

   1. Changjun Wang
   2. Yan Lin
   3. Ying Xu
   4. Feng Mao
   5. Jinghong Guan
   6. Xuejing Wang
   7. Yanna Zhang
   8. Xiaohui Zhang
   9. Songjie Shen
   10. Ying Zhong
   11. Bo Pan
   12. Li Peng
   13. Xin Huang
   14. Xi Cao
   15. Ru Yao
   16. Xintong Zhou
   17. Zecheng He
   18. Yuhan Liu
   19. Jie Lang
   20. Chenggang Li
   21. Yidong Zhou
   22. Qiang Sun

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a useful finding for the prevention of diarrhea with loperamide in patients with early HER2-positive breast cancer treated with nab-paclitaxel in combination with pyrotinib. The evidence supporting the claims of the authors is somewhat incomplete. The enrollment of patients as a control group who have not received prophylactic treatment for diarrhea would have strengthened the study, and the addition of double-blinding for the assessment of treatment may be necessary. The work will be of interest to scientists working in the field of clinical breast cancer treatment.

   Reviewed by eLife

10. Spatial localization of hippocampal replay requires dopamine signaling

    This article has 2 authors:

    1. Matthew R. Kleinman
    2. David J. Foster

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The study by Kleinman and Foster identifies a role for VTA dopamine signaling in modulating hippocampal replay and sharp-wave ripples, specifically highlighting how VTA inactivation leads to aberrant replay activities in scenarios without reward changes and during exposure to novel environments. This valuable work contributes to our understanding of the neurobiological mechanisms underlying spatial memory and learning, suggesting that dopamine plays a pivotal role in linking reward context and novelty to memory consolidation processes. However, the evidence as currently presented is incomplete. More rigorous statistical reporting and histological verification of the experimental approach, and a more consistent approach to experimental dosing and timing, which are crucial for confirming the reproducibility and reliability of the observed effects, are needed.

    Reviewed by eLife