eLife

Latest preprint reviews

1. Lipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation

   This article has 8 authors:

   1. Dana MS Cheung
   2. Momchil Razsolkov
   3. Fabrizia Bonacina
   4. Stephen Andrews
   5. Megan Sumoreeah
   6. Linda V Sinclair
   7. Andrew JM Howden
   8. J Simon C Arthur

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Findings from this study are considered fundamental because they identify amino acid uptake, cholesterol synthesis, and protein prenylation as key metabolic regulators of B cell activation, proliferation, and survival, advancing understanding of T-independent immune responses. The study links metabolic reprogramming directly to B cell function, highlighting how cellular metabolism supports immune fitness. The evidence is compelling, combining unbiased proteomic profiling with genetic and pharmacological validation to demonstrate causal roles for these pathways.

   Reviewed by eLife

2. Evolution of a fuzzy ribonucleoprotein complex in viral assembly

   This article has 15 authors:

   1. Huaying Zhao
   2. Tiansheng Li
   3. Sergio A Hassan
   4. Ai Nguyen
   5. Siddhartha AK Datta
   6. Guofeng Zhang
   7. Camden Trent
   8. Agata M Czaja
   9. Di Wu
   10. Maria A Aronova
   11. Kin Kui Lai
   12. Grzegorz Piszczek
   13. Richard Leapman
   14. Jonathan W Yewdell
   15. Peter Schuck

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a valuable study that combines biophysical and evolutionary approaches to understand why particular mutations in the SARS-CoV-2 protein N arose during the COVID-19 pandemic. The evidence is solid and supports the conclusions.

   Reviewed by eLife

3. A recursive pathway for isoleucine biosynthesis arises from enzyme promiscuity

   This article has 4 authors:

   1. Vittorio Rainaldi
   2. Stefano Donati
   3. Sarah D’Adamo
   4. Nico J Claassens

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study reports a potential pathway for isoleucine biosynthesis mediated by the underground activity of AHASII, which converts glyoxylate and pyruvate to 2-ketobutyrate. While the findings are valuable in revealing a possible alternative route for isoleucine production, the evidence presented remains incomplete. More comprehensive biochemical experiments are required to substantiate the physiological feasibility of this pathway.

   Reviewed by eLife

4. Acetylation of H3K115 is associated with fragile nucleosomes at CpG island promoters and active regulatory sites

   This article has 10 authors:

   1. Yatendra Kumar
   2. Dipta Sengupta
   3. Elias T Friman
   4. Robert S Illingworth
   5. Manon Soleil
   6. Zheng Fan
   7. Hua Wang
   8. Kristian Helin
   9. Matthieu Gérard
   10. Wendy A Bickmore

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental study provides the first genome-wide characterization of H3K115 acetylation and identifies a striking and previously unappreciated association of this globular-domain histone modification with fragile nucleosomes at CpG island promoters, active enhancers, and CTCF binding sites. While the work is largely descriptive and correlative in nature the evidence is compelling. The authors present multiple, orthogonal genomic and biochemical analyses that consistently support their central conclusions.

   Reviewed by eLife

5. The influence of sample size and covariate distributions on neuroanatomical normative modeling

   This article has 4 authors:

   1. Camille Elleaume
   2. Bruno Hebling Vieira
   3. Dorothea L Floris
   4. Nicolas Langer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important manuscript evaluates how sample size and demographic balance of reference cohorts affect the reliability of normative models. The evidence supporting the conclusions is convincing. This work will be of interest to clinicians and scientists working with normative models.

   Reviewed by eLife

6. Distinct cortical encoding of acoustic and electrical cochlear stimulation

   This article has 8 authors:

   1. Ariel Edward Hight
   2. Michele N Insanally
   3. Julia K Scarpa
   4. Yew-Song Cheng
   5. Michael Trumpis
   6. Jonathan Viventi
   7. Mario A Svirsky
   8. Robert C Froemke

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study compares auditory cortex responses to sounds and cochlear implant stimulation measured with surface electrode grids in rats. Beyond the reduced frequency resolution of cochlear implants observed previously, this study suggests key discrepancies between neuronal representations of cochlear stimulations and natural sounds. However, the evidence for this potentially interesting result is incomplete because there is a lack of evidence for the effectiveness of the comparison method. This study is of interest to researchers in the auditory neuroscience field and clinicians implementing treatments with cochlear implants.

   Reviewed by eLife

7. Allocentric and egocentric cues constitute an internal reference frame for real-world visual search

   This article has 2 authors:

   1. Yan Chen
   2. Zhe-Xin Xu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study shows that visual search for upright and rotated objects is affected by rotating participants in a VR and gravitational reference frame. However, the evidence supporting this conclusion is incomplete, given the authors' use of normalized response time and the assumption that object recognition across rotations requires mental rotation.

   Reviewed by eLife

8. Frequency and Laminar Profile of Feature Specific Visual Activity Revealed by Interleaved EEG-fMRI

   This article has 4 authors:

   1. Tommy Clausner
   2. José P Marques
   3. René Scheeringa
   4. Mathilde Bonnefond

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study uses simultaneous EEG and fMRI recordings to shed light on the relationship between alpha and gamma oscillations and specific cortical layers. The sophisticated methodology provides solid evidence for correlations between oscillatory power and the strength and contents of fMRI signals in different cortical layers, though some caveats remain. This paper will be of interest to neuroscientists studying the role and mechanisms of alpha and gamma oscillations.

   Reviewed by eLife

9. Adult-neurogenesis allows for representational stability and flexibility in early olfactory system

   This article has 2 authors:

   1. Zhen Chen
   2. Krishnan Padmanabhan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper presents a valuable theory and analysis of the role of neurogenesis and inhibitory plasticity in the drift of neural representations in the olfactory system. For one of the findings, regarding the impact of neurogenesis on the drift, the evidence remains incomplete. The reason lies in the differences in variability/drift of the mitral/tufted cell responses observed in the model compared to experimental observations, where these responses remain stable over extended time scales.

   Reviewed by eLife

10. Absence of Systematic Effects of Internalizing Psychopathology on Learning Under Uncertainty

    This article has 7 authors:

    1. Muhammad H Satti
    2. Katharina Wille
    3. Matthew R Nassar
    4. Radoslaw M Cichy
    5. Nicolas W Schuck
    6. Peter Dayan
    7. Rasmus Bruckner

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study provides important results with regard to the ongoing debate of the relationship between internalizing psychopathology and learning under uncertainty. The methods and analyses are solid, and the results are backed by a large sample size, yet the study could still benefit from a more detailed discussion about the difference in experimental design and analysis compared to previous studies. If these concerns are addressed, this study would be of interest to researchers in clinical and computational psychiatry for the behavioral markers of psychopathological symptoms.

    Reviewed by eLife