eLife

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1. We couldn't get details of this article at this time:
   10.64898/2026.01.13.699318

2. We couldn't get details of this article at this time:
   10.64898/2026.02.09.704846

3. NAD boosting mediated by CD38 inhibition drives reversal of a pathological vicious cycle of intracrine activity and inflammation in eyelid meibomian gland dysfunction

   This article has 8 authors:

   1. Yuki Hamada
   2. Takehide Sakamoto
   3. Daisuke Yarimizu
   4. Hikari Uehara
   5. Xinyan Shao
   6. Tom Macpherson
   7. Emi Hasegawa
   8. Masao Doi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors provide valuable data linking NAD+ dependent HSD3b6 gene expression in the eyelid to a vicious cycle involving decreased steroidogenesis and AR signaling, pro-inflammatory cytokine release, inflammation, CD38 activation, and further NAD+ decline, which induces meibomian gland atrophy leading to dry eye disease. Overall, the presented work provides evidence for the pathologic relationship between a pro-inflammatory environment, intracrine activity, and the NAD+ cofactor. However, the current study does not clearly establish the proposed intracrine mechanism and may largely reflect systemic hormonal effects resulting from the global Had3b6 knockout, leading to an incomplete narrative.

   Reviewed by eLife

4. We couldn't get details of this article at this time:
   10.64898/2025.12.25.696548

5. During an inflammatory response, zebrafish tnfa and tnfb are expressed by different cell types and have distinct expression kinetics

   This article has 7 authors:

   1. Kaylee SE van Dijk
   2. Christina Begon-Pescia
   3. Boudewijn A de Bruin
   4. Resul Özbilgiç
   5. Philip M Elks
   6. Mai E Nguyen-Chi
   7. Maria Forlenza

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a valuable contribution to the field of zebrafish immunology by demonstrating that the two TNF paralogs tnfa and tnfb show distinct cellular sources and temporal expression patterns during inflammation. These findings are potentially significant because they suggest regulatory divergence and functional specialization within the TNF signaling system in teleosts. While the evidence supporting differential expression is convincing, the work remains largely observational and would benefit from functional experiments and deeper mechanistic insight to determine whether these differences translate into distinct roles in inflammatory signaling. This work will be of interest to immunologists interested in inflammatory cytokine evolution and immune regulation in vertebrates.

   Reviewed by eLife

6. Chromatin priming and Hunchback recruitment integrate spatial and temporal cues in Drosophila neuroblasts

   This article has 3 authors:

   1. Ayanthi Bhattacharya
   2. Hemalatha Rao
   3. Sonia Q Sen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study provides an important advance towards understanding how spatial and temporal transcriptional programs are integrated to regulate lineage-specific chromatin and enhancer activation. The functional evidence is currently incomplete, but the current data provide a solid correlative and conceptual foundation. Functional experiments directly linking Gsb occupancy to chromatin state and regulation of some lineage-specific targets would further strengthen the causal interpretation of the model. Clarifying the scope of conclusions and explicitly acknowledging the technical limitations of current chromatin assays would provide a more balanced interpretation of the manuscript.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2025.09.03.674034

8. The spike tip protein of bacteriophage T4

   This article has 8 authors:

   1. Yves Mattenberger
   2. Ekaterina S Knyazhanskaya
   3. Mikhail M Shneider
   4. Sergey A Buth
   5. Sergey Nazarov
   6. William P Robins
   7. Petr G Leiman
   8. Dominique Belin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study by Mattenburger et al. employs structural biology, biochemistry, and genetics to advance understanding of how bacteriophage contractile injection systems mediate host recognition and DNA delivery, yielding a remarkable 1.15 A crystal structure of the T4 spike tip complex (gp5-gp5.4). The compelling evidence presented demonstrates that the spike tip protein gp5.4 is essential for phage fitness and successful infection of Escherichia coli strains bearing truncated lipopolysaccharide; however, direct proof regarding interaction with the cell wall or its components is lacking. The study further provides biochemical evidence that the analogous spike tip protein from phage P2 (GpV) is translocated into the host periplasm during infection, together establishing the spike tip as a critical and active component of the phage infection machinery.

   Reviewed by eLife

9. We couldn't get details of this article at this time:
   10.1101/2025.10.16.682983

10. Leveraging AI to explore structural contexts of post-translational modifications in drug binding

    This article has 3 authors:

    1. Kirill E. Medvedev
    2. R. Dustin Schaeffer
    3. Nick V. Grishin

    Reviewed by eLife