eLife

Latest preprint reviews

1. Removal of extracellular human amyloid beta aggregates by extracellular proteases in C. elegans

   This article has 4 authors:

   1. Elisabeth Jongsma
   2. Anita Goyala
   3. José Maria Mateos
   4. Collin Yvès Ewald

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Using a newly developed C. elegans model of Alzheimer's disease that expresses Abeta aggregates extracellularly, the authors provide convincing evidence of a disintegrin and an ortholog of human ADAM9 that participate in removing these extracellular aggregates. The worm model presented in this important paper may be very useful to the Alzheimer Disease field.

   Reviewed by eLife

2. The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1

   This article has 11 authors:

   1. Maikel Castellano-Pozo
   2. Georgios Sioutas
   3. Consuelo Barroso
   4. Josh P Prince
   5. Pablo Lopez-Jimenez
   6. Joseph Davy
   7. Angel-Luis Jaso-Tamame
   8. Oliver Crawley
   9. Nan Shao
   10. Jesus Page
   11. Enrique Martinez-Perez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important paper reveals distinct dynamics of two meiosis-specific cohesin complexes containing either REC-8 or CHO-3/4 in C. elegans: REC-8-cohesin is essential for sister chromatid cohesion in meiosis I and DNA double-strand break repair, while COH-3/4-cohesin, whose binding to meiotic chromosomes is stabilized by the cohesin accessory protein SCC-2, is necessary for loop-axis formation. The experimental evidence in the paper is solid based on cytological analysis using a conditional depletion of the gene. The work will be of interest to researchers working on meiosis and chromosome dynamics.

   Reviewed by eLife

3. We couldn't get details of this article at this time:
   10.1101/2022.08.26.22279009

4. Atypical cognitive training-induced learning and brain plasticity and their relation to insistence on sameness in children with autism

   This article has 7 authors:

   1. Jin Liu
   2. Hyesang Chang
   3. Daniel A Abrams
   4. Julia Boram Kang
   5. Lang Chen
   6. Miriam Rosenberg-Lee
   7. Vinod Menon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study on learning strategy differences in autism vs typically developing controls. The study identifies similar learning rates but different learning strategies. The evidence provided by the authors is convincing, relying on well-done tasks and fMRI analyses.

   Reviewed by eLife

5. Examining the association of clinician characteristics with perceived changes in cervical cancer screening and colposcopy practice during the COVID-19 pandemic: a mixed methods assessment

   This article has 10 authors:

   1. Lindsay Fuzzell
   2. Naomi C Brownstein
   3. Holly B Fontenot
   4. Paige W Lake
   5. Alexandra Michel
   6. Ashley Whitmer
   7. Sarah L Rossi
   8. McKenzie McIntyre
   9. Susan T Vadaparampil
   10. Rebecca B Perkins

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important work provides evidence regarding the impact of the COVID-19 pandemic on cervical cancer screening and precancer treatments in the USA. As there are few screening registries, the study provides solid evidence using a survey of health providers' impressions to assess whether cervical cancer screening services declined during the pandemic. The work will be of interest to public health professionals working in cancer prevention.

   Reviewed by eLife

6. A pH-sensitive switch activates virulence in Salmonella

   This article has 2 authors:

   1. Dasvit Shetty
   2. Linda J Kenney

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Salmonella invades and survives in host cells via SPI-1 and SPI-2 type III secretion system mechanisms, with the SPI-2 system allowing for intracellular survival in Salmonella-containing vacuoles, which have a low-pH environment. Transcription of SPI-2 genes at low pH is activated by the DNA-binding SsrB protein, which sits at the top of the SPI-2 regulatory hierarchy. This study provides important insights as to how SsrB is allosterically affected by pH resulting in acid-dependent DNA binding. However, there are concerns about some experiments, and the evidence presented is not fully conclusive.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2023.06.23.546323

8. We couldn't get details of this article at this time:
   10.1101/2023.06.22.546097

9. Single-cell RNAseq analysis of spinal locomotor circuitry in larval zebrafish

   This article has 3 authors:

   1. Jimmy J Kelly
   2. Hua Wen
   3. Paul Brehm

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In zebrafish, primary motor neurons (PMNs) control escape movements, and a more heterogeneous population of secondary motor neurons (SMNs) regulate the speed of rhythmic swimming. Using single cell RNA sequencing (scRNAseq), the authors have obtained compelling evidence that PMNs, and two types of interneurons innervating them, express a set of three genes encoding voltage-gated ion channels enabling rapid firing. The PMNs also express high transcript levels of proteins involved in exocytosis, which would be expected to support rapid neurotransmitter release. These results will be important for those working on spinal cord function and zebrafish genomics/transcriptomics.

   Reviewed by eLife

10. We couldn't get details of this article at this time:
    10.1101/2020.11.25.398081