eLife

Latest preprint reviews

1. Optimized path planning surpasses human efficiency in cryo-EM imaging

   This article has 10 authors:

   1. Yilai Li
   2. Quanfu Fan
   3. Ziping Xu
   4. Emma Rose Lee
   5. John Cohn
   6. Veronique Demers
   7. Ja Young Lee
   8. Lucy Yip
   9. Michael A. Cianfrocco
   10. Seychelle M. Vos

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Cryo-EM has become the dominant method in structural biochemistry, and making more efficient use of expensive microscope time is therefore of broad interest to academic and industrial users. The authors identify a bottleneck in cryoEM data collection, namely path optimization, and provide a valuable machine-learning model to overcome this bottleneck. The solid data presented suggests their model can replace a human operator to automate efficient data collection.

   Reviewed by eLife

2. Ulk4 promotes Shh signaling by regulating Stk36 ciliary localization and Gli2 phosphorylation

   This article has 3 authors:

   1. Mengmeng Zhou
   2. Yuhong Han
   3. Jin Jiang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study substantially advances our understanding of how the pseudokinase ULK4 interacts with an active member of the same kinase subfamily (STK36) to promote GLI phosphorylation and Hedgehog pathway activation. The evidence supporting the proposed mechanism is compelling, with rigorous biochemical assays and state-of-the-art cell based imaging techniques. The work will be of broad interest to cell biologists and biochemists.

   Reviewed by eLife

3. We couldn't get details of this article at this time:
   10.1101/2022.04.08.487398

4. How hibernation in frogs drives brain and reproductive evolution in opposite directions

   This article has 4 authors:

   1. Wenbo Liao
   2. Ying Jiang
   3. Long Jin
   4. Stefan Lüpold

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this important paper, the authors report a link between brumation (or "hibernation") and tissue size in frogs, summarizing convincing evidence that extended brumation is associated with smaller brain size and increased investment in reproduction-related tissues. The research is of broad interest to ecologists, evolutionary biologists, and those interested in global change biology, as the dataset involves significant field work and advanced statistical analyses for insights into how expensive tissues in these ectothermic animals respond to environmental seasonality.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.1101/2023.03.02.530691

6. We couldn't get details of this article at this time:
   10.1101/2023.03.02.530449

7. We couldn't get details of this article at this time:
   10.1101/2022.04.29.488779

8. We couldn't get details of this article at this time:
   10.1101/2023.06.20.545708

9. We couldn't get details of this article at this time:
   10.1101/2023.06.11.544486

10. We couldn't get details of this article at this time:
    10.1101/2022.06.27.497802