eLife

Latest preprint reviews

1. Hypermetabolism in mice carrying a near-complete human chromosome 21

   This article has 12 authors:

   1. Dylan C Sarver
   2. Cheng Xu
   3. Susana Rodriguez
   4. Susan Aja
   5. Andrew E Jaffe
   6. Feng J Gao
   7. Michael Delannoy
   8. Muthu Periasamy
   9. Yasuhiro Kazuki
   10. Mitsuo Oshimura
   11. Roger H Reeves
   12. G William Wong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important paper provides new insight into the effect of extra-copies of a chromosome, thus aneuploidy, on body metabolisms in mammals. The authors used various solid analyses on the metabolisms and physiology of the transgenic mouse with most of human chromosome 21 and presented convincing results to support the authors' claims. The work would be of interest to researchers who work on the physiology and biochemistry of body metabolisms in mammals.

   Reviewed by eLife

2. Spike-phase coupling patterns reveal laminar identity in primate cortex

   This article has 5 authors:

   1. Zachary W Davis
   2. Nicholas M Dotson
   3. Tom P Franken
   4. Lyle Muller
   5. John H Reynolds

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors present a novel and precise method for determining boundaries of cortical layers from multi-electrode recordings in marmosets and macaques. Their method requires less data than current approaches to finding a systematic relationship between slow local field potentials and spiking across cortical columns. This approach may be broadly useful to those doing electrophysiological recordings in the primate brain.

   Reviewed by eLife

3. Endosomal trafficking of two-pore K+ efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury

   This article has 8 authors:

   1. Long Shuang Huang
   2. Mohammad Anas
   3. Jingsong Xu
   4. Bisheng Zhou
   5. Peter T Toth
   6. Yamuna Krishnan
   7. Anke Di
   8. Asrar B Malik

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this important study, Di et al., examine the mechanism by which potassium channels are activated prior to NLRP3 inflammasome activation. The main strength of the study is that it uses a combination of cell culture work and a mouse model to address the cell biology of inflammasome activation. However, certain aspects of the study including the characterization of inflammasome activation and the evidence to support the role of Rab11a in the translocation of TWIK2 are incomplete.

   Reviewed by eLife

4. Contribution of linear and nonlinear mechanisms to predictive motion estimation

   This article has 4 authors:

   1. Belle Liu
   2. Arthur Hong
   3. Fred Rieke
   4. Michael B. Manookin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper will be of interest to sensory and computational neuroscientists. In it, the authors find maximally informative dimensions for primate retinal ganglion cells and use models based on these analyses to examine features of early visual processing that impact predictive coding of visual motion.

   Reviewed by eLife

5. The impact of local genomic properties on the evolutionary fate of genes

   This article has 2 authors:

   1. Yuichiro Hara
   2. Shigehiro Kuraku

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment:

     This study is fundamental to understanding the intrinsic driving forces of gene losses during mammalian genome evolution, linking the propensity for gene losses to the local genomic features such as mutation rate and spatially restricted expression. In general, the study is methodologically convincing because independent gene losses in at least two mammalian lineages were identified as "elusive human genes". However, additional (comparative genomics and statistical) analyses would make the current study more rigorous. This manuscript will appeal to readers interested in the evolutionary fates of genes across the phylogenetic tree.

   Reviewed by eLife

6. Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling

   This article has 13 authors:

   1. Kieran A Boyle
   2. Erika Polgar
   3. Maria Gutierrez-Mecinas
   4. Allen C Dickie
   5. Andrew H Cooper
   6. Andrew M Bell
   7. Evelline Jumolea
   8. Adrian Casas-Benito
   9. Masahiko Watanabe
   10. David I Hughes
   11. Gregory A Weir
   12. John S Riddell
   13. Andrew J Todd

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Boyle et al identify Npy-expressing dorsal horn neurons as powerfully inhibiting pain and itch under normal and pathological conditions. The valuable data are convincing, and the effect sizes are robust and directly challenge previous work.

   Reviewed by eLife

7. Surface curvature and basal hydraulic stress induce spatial bias in cell extrusion

   This article has 4 authors:

   1. Cheng-Kuang Huang
   2. Xianbin Yong
   3. David T. She
   4. Chwee Teck Lim

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper presents important findings into the response of epithelial monolayers to the combined effects of surface curvature and hydraulic stress, offering insights into how these cues contribute to epithelial cell extrusion. Most of the evidence is convincing, relying mainly on a combination of imaging-based techniques. This paper is of interest to a broad and growing community of biologists, biophysicists, and engineers interested in cell-geometry interactions.

   Reviewed by eLife

8. Dally is not essential for Dpp spreading or internalization but for Dpp stability by antagonizing Tkv-mediated Dpp internalization

   This article has 4 authors:

   1. Niklas Simon
   2. Abu Safyan
   3. George Pyrowolakis
   4. Shinya Matsuda

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study uses genomically-engineered glypican alleles (Dally and Dally-like) to determine the role of these proteins on the Dpp/BMP morphogen gradient in the wing disc of Drosophila melanogaster. The new glypican null and tagged add-back alleles, as well as a Dpp mutant that cannot bind heparin sulfate moieties in glypicans, provide solid results that support the model in which Dally but not Dally-like stabilizes Dpp on the cell surface by counteracting receptor-mediated Dpp internalization. This paper would be of interest to developmental biologists working on morphogens.

   Reviewed by eLife

9. An unexpected role of neutrophils in clearing apoptotic hepatocytes in vivo

   This article has 24 authors:

   1. Luyang Cao
   2. Lixiang Ma
   3. Juan Zhao
   4. Xiangyu Wang
   5. Xinzou Fang
   6. Wei Li
   7. Yawen Qi
   8. Yingkui Tang
   9. Jieya Liu
   10. Shengxian Peng
   11. Li Yang
   12. Liangxue Zhou
   13. Li Li
   14. Xiaobo Hu
   15. Yuan Ji
   16. Yingyong Hou
   17. Yi Zhao
   18. Xianming Zhang
   19. You-yang Zhao
   20. Yong Zhao
   21. Yuquan Wei
   22. Asrar B Malik
   23. Hexige Saiyin
   24. Jingsong Xu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper reports the fundamental discovery of a new function of neutrophil in specifically clearing apoptotic hepatocytes by penetrating the cells rather than engulfing them without causing inflammation as a part of tissue homeostasis. This solid study transforms the way we think about role of neutrophil in pathogenesis of autoimmune liver disease.

   Reviewed by eLife

10. Quantitative analyses of T cell motion in tissue reveals factors driving T cell search in tissues

    This article has 10 authors:

    1. David J Torres
    2. Paulus Mrass
    3. Janie Byrum
    4. Arrick Gonzales
    5. Dominick N Martinez
    6. Evelyn Juarez
    7. Emily Thompson
    8. Vaiva Vezys
    9. Melanie E Moses
    10. Judy L Cannon

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This is a valuable study that quantifies CD8 T cell movement in different tissue environments and concludes that T cells display more confined movement in the inflamed lung than in lymph nodes or intestinal villi. The evidence supporting conclusions is solid with well-defined measurements and sufficient statistical analysis. The work will stimulate further efforts to understand the mechanisms behind the different behaviour of T cells that are important in host defence against intracellular pathogens and cancer.

    Reviewed by eLife