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   10.1101/2023.11.23.568420

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   10.1101/2023.05.26.542373

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   10.1101/2024.09.19.613969

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   10.1101/2024.09.24.610715

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   10.1101/2024.09.27.615463

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   10.1101/2024.10.24.620021

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   10.1101/2024.09.26.615110

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   10.1101/2024.09.05.611301

9. Naa10 regulates hippocampal neurite outgrowth via Btbd3 N-α-acetylation-mediated actin dynamics

   This article has 5 authors:

   1. Chien-Te Chou
   2. Ming-Lun Kang
   3. Chen-Cheng Lee
   4. Pang-Hung Hsu
   5. Li-Jung Juan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study suggests that Naa10, an N-α-acetyltransferase with known mutations that disrupt neurodevelopment, acetylates Btbd3, which has been implicated in neurite outgrowth and obsessive-compulsive disorder, in a manner that regulates F-actin dynamics to facilitate neurite outgrowth. While the study provides promising insights and biochemical, co-immunoprecipitation, and proteomic data that enhance our understanding of protein N-acetylation in neuronal development, the evidence supporting larger claims is incomplete. Nonetheless, the implications of these findings are noteworthy, particularly regarding neurodevelopmental and psychiatric conditions tied to altered expression of Naa10 or Btbd3.

   Reviewed by eLife

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    10.1101/2024.09.12.602176