eLife

Latest preprint reviews

1. Prolonged Pain Reliably Slows Peak Alpha Frequency by Reducing Fast Alpha Power

   This article has 7 authors:

   1. Andrew J Furman
   2. Mariya Prokhorenko
   3. Michael L Keaser
   4. Jing Zhang
   5. Shuo Chen
   6. Ali Mazaheri
   7. David A Seminowicz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable findings on changes in neuronal alpha activity elicited by prolonged pain in healthy human participants. The evidence supporting the claims of the authors, however, is incomplete and would benefit from clarifications of analytical strategies, additional statistical analyses, and shaping of the interpretations. With the methodological and interpretative parts strengthened, the work will be of interest to neuroscientists investigating the brain mechanisms of pain to identify new approaches to pain treatment

   Reviewed by eLife

2. Membrane potential modulates ERK activity and cell proliferation in human cells

   This article has 4 authors:

   1. Mari Sasaki
   2. Masanobu Nakahara
   3. Takuya Hashiguchi
   4. Fumihito Ono

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important paper employs multiple experimental approaches and presents evidence that changes in membrane voltage directly affect ERK signaling to regulate cell division. This result is relevant because it supports an ion channel-independent pathway by which changes in membrane voltage can affect cell growth. The evidence now presented is solid and the data support the conclusions. This paper should be of interest to a broad readershp in the areas of cell and developemental biology and electrophysiology.

   Reviewed by eLife

3. We couldn't get details of this article at this time:
   10.1101/2024.08.01.606161

4. Accurate predictions of SARS-CoV-2 infectivity from comprehensive analysis

   This article has 17 authors:

   1. Jongkeun Park
   2. WonJong Choi
   3. Do Young Seong
   4. Seungpil Jeong
   5. Ju Young Lee
   6. Hyo Jeong Park
   7. Dae Sun Chung
   8. Kijong Yi
   9. Uijin Kim
   10. Ga-Yeon Yoon
   11. Hyeran Kim
   12. Taehoon Kim
   13. Sooyeon Ko
   14. Eun Jeong Min
   15. Hyun-Soo Cho
   16. Nam-Hyuk Cho
   17. Dongwan Hong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study provides valuable insight into the biological significance of SARS-CoV-2 by using a series of computational analyses of viral proteins. While the evidence is solid, the reviewers noted a lack of clarity about the objectives of the analyses. While impactful for the field, the manuscript would benefit from improved presentation.

   Reviewed by eLife

5. Modulation of aperiodic EEG activity provides sensitive index of cognitive state changes during working memory task

   This article has 5 authors:

   1. Tisa Frelih
   2. Andraž Matkovič
   3. Tjaša Mlinarič
   4. Jurij Bon
   5. Grega Repovš

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable work explores the timely idea that aperiodic activity in human electrophysiology recordings is dynamically modulated in response to task events in a manner that may be relevant for behavioral performance. Moreover, the authors present solid evidence that, in some circumstances, these aperiodic changes might be misinterpreted as oscillatory changes.

   Reviewed by eLife

6. Parabrachial CGRP neurons modulate active defensive behavior under a naturalistic threat

   This article has 5 authors:

   1. Gyeong Hee Pyeon
   2. Hyewon Cho
   3. Byung Min Chung
   4. June-Seek Choi
   5. Yong Sang Jo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work advances our understanding of parabrachial CGRP threat function. The evidence supporting CGRP aversive outcome signaling is solid, while the evidence for cue signaling and fear behavior generation is incomplete. The work will be of interest to neuroscientists studying defensive behaviors.

   Reviewed by eLife

7. An integrin centered complex coordinates ion transport and pH to regulate f-actin organization and cell migration in breast cancer

   This article has 12 authors:

   1. Chiara Capitani
   2. Jessica Iorio
   3. Elena Lastraioli
   4. Claudia Duranti
   5. Giacomo Bagni
   6. Ginevra Chioccioli Altadonna
   7. Rossella Colasurdo
   8. Giorgia Scarpellino
   9. Scott P. Fraser
   10. Andrea Becchetti
   11. Mustafa B. A. Djamgoz
   12. Annarosa Arcangeli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding on the identification of a complex consisting of NHE1, hERG1, β1/integrin and NaV1.5 on the membrane of breast cancer cells. The evidence supporting the claims of the authors is somewhat incomplete. The inclusion of clarification of some experimental design and the amendment of cropping Western blot data would have strengthened the study. The work will be of interest to scientists working on breast cancer.

   Reviewed by eLife

8. We couldn't get details of this article at this time:
   10.1101/2022.04.27.489709

9. Marcks and Marcks-like 1 proteins promote spinal cord development and regeneration in Xenopus

   This article has 3 authors:

   1. Mohamed El Amri
   2. Abhay Pandit
   3. Gerhard Schlosser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work addresses the role of Marcks/Markcksl during spinal cord development and regeneration. The study is exceptional in combining molecular approaches to understand the mechanisms of tissue regeneration with behavioural assays, which is not commonly employed in the field. The data presented is convincing and comprehensive, using many complementary methodologies.

   Reviewed by eLife

10. Serum metabolome indicators of early childhood development in the Brazilian National Survey on Child Nutrition (ENANI-2019)

    This article has 14 authors:

    1. Marina Padilha
    2. Victor Nahuel Keller
    3. Paula Normando
    4. Raquel M Schincaglia
    5. Nathalia C Freitas-Costa
    6. Samary SR Freire
    7. Felipe M Delpino
    8. Inês RR de Castro
    9. Elisa MA Lacerda
    10. Dayana R Farias
    11. Zachary Kroezen
    12. Meera Shanmuganathan
    13. Philip Britz-Mckibbin
    14. Gilberto Kac

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important work advances our understanding of factors influencing early childhood development. The large sample size and methodology applied make the findings of this study convincing; however, support for some of the claims made by the authors is incomplete. The work will be of interest to researchers in developmental science and early childhood pediatrics.

    Reviewed by eLife