eLife

Latest preprint reviews

1. Reversion to sensitivity explains limited transmission of resistance in a hospital pathogen

   This article has 7 authors:

   1. Kevin C Tracy
   2. Jordan McKaig
   3. Clare Kinnear
   4. Jess Millar
   5. Aaron A King
   6. Andrew F Read
   7. Robert J Woods

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study, which will be of interest to those studying the evolution and maintenance of antibiotic resistance, addresses the hypothesis that antibiotic resistance arising de novo during treatment will carry a higher fitness cost and will revert to susceptibility more readily than resistance that has been transmitted between hosts. There are, however, concerns that the 'putatively transmitted isolates' in this study do not necessarily represent resistant isolates that have been transmitted between hosts. The support for the central claim of different patterns of reversion between isolates with de novo resistance and putatively transmitted resistant isolates is currently incomplete.

   Reviewed by eLife

2. Valence and salience encoding in the central amygdala

   This article has 4 authors:

   1. Mi-Seon Kong
   2. Ethan Ancell
   3. Daniela M Witten
   4. Larry S Zweifel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful work reveals differential activity to food and shock outcomes in central amygdala GABAergic neurons. Evidence supports claims of unconditioned stimulus activity that changes with learning. Compelling evidence that the circular shift method rigorously identifies functional neuron types is also presented. However, the evidence regarding claims related to valence or salience signaling in these neurons is incomplete. This work will be of interest to neuroscientists studying sensory processing and learning in the amygdala.

   Reviewed by eLife

3. Characterization of postsynaptic glutamate transporter functionality in the zebrafish retinal first synapse across different wavelengths

   This article has 3 authors:

   1. Marco Garbelli
   2. Stephanie Niklaus
   3. Stephan CF Neuhauss

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study reveals that Excitatory Amino Acid Transporters play a role in chromatic information processing in the retina. The combination of (double) mutants, behavioral assays, immunohistochemistry, and electroretinograms provides solid evidence supporting the appropriately conservative conclusions. The work will be of interest to neurobiologists working on color vision or retinal processing.

   Reviewed by eLife

4. Becker muscular dystrophy mice showed site-specific decay of type IIa fibers with capillary change in skeletal muscle

   This article has 5 authors:

   1. Daigo Miyazaki
   2. Mitsuto Sato
   3. Naoko Shiba
   4. Takahiro Yoshizawa
   5. Akinori Nakamura

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors present three transgenic models carrying three representative exon deletions of the dystrophin gene. The findings presented are valuable to the field of muscle diseases, particularly muscular dystrophies. The evidence provided in the manuscript is convincing, with rigorous biochemical assays and state-of-the-art microscopy methods.

   Reviewed by eLife

5. Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single-cell RNA sequencing

   This article has 9 authors:

   1. Einav Somech
   2. Debdatta Halder
   3. Avishay Spitzer
   4. Chaya Barbolin
   5. Michael Tyler
   6. Reut Halperin
   7. Moshe Biton
   8. Amit Tirosh
   9. Itay Tirosh

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a valuable study that uses single-cell RNA sequencing to define tumor-intrinsic transcriptional programs that characterize distinct types of small intestine neuroendocrine tumors. The evidence supporting the claims of the authors is solid, but would benefit from a larger sample size. The work will be of interest to cancer biologists studying neuroendocrine tumors, as well as those studying tumor heterogeneity more broadly.

   Reviewed by eLife

6. Nociceptor neurons control pollution-mediated neutrophilic asthma

   This article has 9 authors:

   1. Jo-Chiao Wang
   2. Amelia Kulle
   3. Theo Crosson
   4. Amin Reza Nikpoor
   5. Surbhi Gupta
   6. Anais Roger
   7. Moutih Rafei
   8. Ajitha Thanabalasuriar
   9. Sebastien Talbot

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work shows that fine particulate matter exposure to the lungs led to nociceptor-dependent neutrophilic inflammation. Likely macrophage-neuronal crosstalk, via release of artemin from macrophages and activation of Gfra3 on the JNC neuron, potentiated the response. The data convincingly strengthens links between pollutants, immune and neural interactions.

   Reviewed by eLife

7. Nuclear Argonaute protein NRDE-3 switches small RNA partners during embryogenesis to mediate temporal-specific gene regulatory activity

   This article has 2 authors:

   1. Shihui Chen
   2. Carolyn Marie Phillips

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study by Chen and Phillips provides evidence for a dynamic switch in the small RNA repertoire of the Argonaute protein NRDE-3 during embryogenesis in C. elegans. The work is supported by convincing experimental data, shedding light on RNA regulation during development. While the functional relevance of this process warrants further investigation, this study provides valuable insights into small RNA pathways with broader implications for developmental biology and gene regulation in other systems.

   Reviewed by eLife

8. Identification of the trail-following pheromone receptor in termites

   This article has 13 authors:

   1. Souleymane Diallo
   2. Kateřina Kašparová
   3. Josef Šulc
   4. Jibin Johny
   5. Jan Křivánek
   6. Jana Nebesářová
   7. David Sillam-Dussès
   8. Pavlína Kyjaková
   9. Jiří Vondrášek
   10. Aleš Machara
   11. Ondřej Lukšan
   12. Ewald Grosse-Wilde
   13. Robert Hanus

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work by Diallo et al. substantially advances our understanding of the chemosensory system of a non-hymenopteran eusocial insect by identifying the first olfactory receptor for the trail pheromone in termites. The evidence supporting the conclusions that the receptor PsimOR14 is very narrowly tuned for the pheromone neocembrene is compelling. The work will be of broad interest to entomologists, chemical ecologists, neuroscientists, and molecular biologists.

   Reviewed by eLife

9. Aberration correction in long GRIN lens-based microendoscopes for extended field-of-view two-photon imaging in deep brain regions

   This article has 9 authors:

   1. Andrea Sattin
   2. Chiara Nardin
   3. Simon Daste
   4. Monica Moroni
   5. Innem Reddy
   6. Carlo Liberale
   7. Stefano Panzeri
   8. Alexander Fleischmann
   9. Tommaso Fellin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study builds on previous work by the authors by presenting a potentially key method for correcting optical aberrations in GRIN lens-based microendoscopes used for imaging deep brain regions. By combining simulations and experiments, the authors provide convincing evidence showing that the obtained field of view is significantly increased with corrected, versus uncorrected microendoscopes. Because the approach described in this paper does not require any microscope or software modifications, it can be readily adopted by neuroscientists who wish to image neuronal activity deep in the brain.

   Reviewed by eLife

10. Distinct gradients of cortical architecture capture visual representations and behavior across the lifespan

    This article has 7 authors:

    1. Xiayu Chen
    2. Xingyu Liu
    3. Patricia Maria Hoyos
    4. Edan Daniel Hertz
    5. Jewelia K Yao
    6. Zonglei Zhen
    7. Jesse Gomez

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable study draws on large-scale multimodal MRI measurements of human brain structure across the lifespan to offer a new perspective on visual cortex architecture. The data provide compelling evidence for two cortical architectural gradients that show distinct functional, cytoarchitectural, behavioural, and lifespan profiles. One gradient captures a broad early-to-higher-level visual cortical hierarchy in which cortical thickness tissue density covary; the other reflects more localised divergence from this relationship, notably predicting putative anterior temporal visual field representations that have not previously been described.

    Reviewed by eLife