eLife

Latest preprint reviews

1. Genome-wide identification of stable RNA-chromatin interactions

   This article has 2 authors:

   1. Xingzhao Wen
   2. Sheng Zhong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a valuable look at genome-wide RNaseA-resistant RNA-DNA interactions in human embryonic stem cells. The research indicated that RNase treatment maintained long-range RNA-chromatin connections characterized by significant sequence conservation while abolishing permissive interactions. Interestingly, coding and non-coding RNA transcripts exhibited differing sensitivity to RNase treatment. Although the study findings reveal an intriguing RNase-inaccessible regulatory RNA-chromatin interactome, conclusions about the identity and regulatory significance of RNase-resistant RNA-chromatin interactions are incomplete and would benefit from more rigorous approaches that include additional computational and experimental controls.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2024.07.26.605302

3. We couldn't get details of this article at this time:
   10.1101/2024.11.04.621816

4. PDL-1+ Neutrophils mediate susceptibility during endotoxemia in Metabolically Dysfunctional-Associated Fatty Liver Disease

   This article has 9 authors:

   1. Cleyson da Cruz Oliveira Barros
   2. Alexandre Kanashiro
   3. Gabriel Victor Lucena da Silva
   4. Paulo Sérgio de Almeida Augusto
   5. Guilherme Cesar Martelossi Cebinelli
   6. Luiz Osório Leiria
   7. Thiago Mattar Cunha
   8. José Carlos Alves Filho
   9. Fernando Queiroz Cunha

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study highlights the key role of NK cells and PD-L1+ neutrophils in worsening sepsis responses in the context of MASH (metabolic dysfunction-associated steatohepatitis). It focused on the role of neutrophils in mediating this effect, which is based on a choline-deficient high-fat diet model of various knockouts or selective ablation of immune cell types. While the data presented are of great interest, there are concerns around the reliability of the strength of the evidence provided, which is currently considered incomplete. The study may be of interest to researchers in immunopathological disease mechanisms once confirmatory studies have been completed.

     [Editors' note: the authors no longer have access to the original flow cytometry data and plan to compile new datasets in the future.]

   Reviewed by eLife

5. Most Beefalo cattle have no detectable bison genetic ancestry

   This article has 7 authors:

   1. Beth Shapiro
   2. Jonas Oppenheimer
   3. Michael P Heaton
   4. Kristen L Kuhn
   5. Richard E Green
   6. Harvey D Blackburn
   7. Timothy PL Smith

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study used whole-genome data to investigate Beefalo ancestry for the first time, providing insight into the genetics of Beefalo cattle and challenging the long-held claim of 37.5% bison ancestry reported by the American Beefalo Association. Despite some limitations regarding sequencing depth and sampling, the expert use of a comprehensive set of population-genomic methods allowed the authors to demonstrate convincingly that Beefalo and bison hybrid ancestry profiles are consistent with repeated backcrossing to either parental species. The work will be of significant interest to evolutionary biologists, population geneticists, animal breeders, and those involved in the conservation genetics of bovine species.

   Reviewed by eLife

6. We couldn't get details of this article at this time:
   10.1101/2024.08.31.610621

7. We couldn't get details of this article at this time:
   10.1101/2024.07.02.600014

8. An H3-K9-me-independent binding of Swi6/HP1 to siRNA-DNA hybrids initiates heterochromatin assembly at cognate dg-dh repeats in Fission Yeast

   This article has 10 authors:

   1. Jyotsna Kumar
   2. Swati Haldar
   3. Neelima Gupta
   4. Viney Kumar
   5. Manisha Thakur
   6. Keerthivasan Raanin Chandradoss
   7. Debarghya Ghose
   8. Dipak Dutta
   9. Kuljeet Singh Sandhu
   10. Jagmohan Singh

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study aims to investigate the RNA binding activities of a conserved heterochromatin protein (Swi6) and proposes an entirely new model for how heterochromatin formation is initiated in fission yeast. While the concept is interesting, the data provided are inadequate, both for support of the claims regarding the new RNA binding activities and for support of the new model. The paper requires extensive editing as well as the inclusion of numerous experiments with appropriately controlled conditions.

   Reviewed by eLife

9. We couldn't get details of this article at this time:
   10.1101/2024.10.15.616556

10. We couldn't get details of this article at this time:
    10.1101/2024.10.02.616239