eLife

Latest preprint reviews

1. Humans underestimate their body mass in microgravity: evidence from reaching movements during spaceflight

   This article has 8 authors:

   1. Zhaoran Zhang
   2. Yu Tian
   3. Chunhui Wang
   4. Changhua Jiang
   5. Bo Wang
   6. Hongqiang Yu
   7. Rui Zhao
   8. Kunlin Wei

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper undertakes an important investigation to determine whether movement slowing in microgravity is due to a strategic conservative approach or rather due to an underestimation of the mass of the arm. While the experimental dataset is unique and the coupled experimental and computational analyses comprehensive, the authors present incomplete results to support the claim that movement slowing is due to mass underestimation. Further analysis is needed to rule out alternative explanations.

   Reviewed by eLife

2. Development of Auditory and Spontaneous Movement Responses to Music over the First Year of Life

   This article has 8 authors:

   1. Trinh Nguyen
   2. Félix Bigand
   3. Susanne Reisner
   4. Atesh Koul
   5. Roberta Bianco
   6. Gabriela Markova
   7. Stefanie Hoehl
   8. Giacomo Novembre

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study offers important insights into the development of infants' responses to music based on the exploration of EEG neural auditory responses and video-based movement analysis. The convincing results revealed that evoked responses emerge between 3 and 12 months of age, but data analysis requires further refinement to fully complement the findings related to movement in response to music. This study will be of significant interest to developmental psychologists and neuroscientists, as well as researchers interested in music processing and in the translation of perception into action.

   Reviewed by eLife

3. Hippocampal single-cell RNA Atlas of chronic methamphetamine abuse-induced cognitive decline in mice

   This article has 6 authors:

   1. Hai Qiu
   2. Xia Yue
   3. Yuebing Huang
   4. Ziling Meng
   5. Jiahong Wang
   6. Dongfang Qiao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors proposed two hypotheses: first, that methamphetamine induces neuroinflammation, and second, that it alters neuronal stem cell differentiation. These are valuable hypotheses, and the authors provided in vivo observations of the methamphetamine response in mice. However, concerns remain regarding the interpretation of the data, and the current evidence is incomplete, requiring substantial experimental validation.

   Reviewed by eLife

4. A cortical–hippocampal communication undergoes rebalancing after new learning

   This article has 2 authors:

   1. Arron F Hall
   2. Dong V Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study investigates the neural basis of bidirectional communication between the cortex and hippocampus during learning. The evidence supporting the identification of specific circuits and functional cell types involved is convincing. However, certain aspects of the behavioral analysis and statistical interpretation remain incomplete. Overall, the work will be of interest to neuroscientists studying learning and memory.

   Reviewed by eLife

5. Unreliable homeostatic action potential broadening in cultured dissociated neurons

   This article has 16 authors:

   1. Andreas Ritzau-Jost
   2. Salil Rajayer
   3. Jana Nerlich
   4. Filip Maciag
   5. Alexandra John
   6. Michael Russier
   7. Victoria Gonzalez Sabater
   8. Luke J Steiger
   9. Jacques-Olivier Coq
   10. Jens Eilers
   11. Maren Engelhardt
   12. Juan Burrone
   13. Dominique Debanne
   14. Martin Heine
   15. Stephen M Smith
   16. Stefan Hallermann

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides compelling evidence that action potential (AP) broadening is not a universal feature of homeostatic plasticity in response to chronic activity deprivation. By leveraging state-of-the-art methods across multiple brain regions and laboratories, the authors demonstrate that AP half-width remains largely stable, challenging previous assumptions in the field. These important findings help resolve longstanding inconsistencies in the literature and significantly advance our understanding of neuronal network homeostasis.

   Reviewed by eLife

6. Glycosylated IgG antibodies accelerated the recovery of haemorrhagic fever with renal syndrome patients

   This article has 15 authors:

   1. Chuansong Quan
   2. Lu Wang
   3. Jiming Gao
   4. Yaoni Li
   5. Xiaoyu Xu
   6. Houqiang Li
   7. Zixuan Gao
   8. Wenxu Ruan
   9. Hongzhi Liu
   10. Qian Li
   11. Weijia Xing
   12. Liqiong Zhao
   13. Michael J Carr
   14. Weifeng Shi
   15. Haifeng Hou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors investigated the potential role of IgG N-glycosylation in Haemorrhagic Fever with Renal Syndrome (HFRS), which may offer significant insights for understanding molecular mechanisms and for the development of therapeutic strategies for this infectious disease. The findings are useful to the field, although the strength of evidence to support the findings is incomplete. Several issues need to be addressed, including more detail on the background, methods, and results. Additional statistical tests should be performed, and the conclusions should reflect the correlational findings of the paper.

   Reviewed by eLife

7. C. elegans food choice exhibits effort discounting-like behavior

   This article has 6 authors:

   1. Jonathan R. M. Millet
   2. Serge Faumont
   3. Aaron B. Schatz
   4. Amanda M. White
   5. Kathy D. Chicas-Cruz
   6. Shawn R. Lockery

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work develops C. elegans as a model organism for studying effort-based discounting by asking the worms to choose between easy and hard to digest bacteria. The authors provide convincing evidence that the nematodes are effort-discounting. However, evidence regarding the role of dopamine is incomplete and this weakens the authors connection of the behavior in C. elegans with mammals.

   Reviewed by eLife

8. The Self-Interest of Adolescents Overrules Cooperation in Social Dilemmas

   This article has 6 authors:

   1. Xiaoyan Wu
   2. Hongyu Fu
   3. Gökhan Aydogan
   4. Chunliang Feng
   5. Shaozheng Qin
   6. Chao Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable work investigates cooperative behaviors in adolescents using a repeated Prisoner's Dilemma game. The computational modeling approach used in the study is solid and well established, yet evidence supporting certain claims remains incomplete. The work could be strengthened with the consideration of additional experimental contexts, non-linear relationships between age and observed behavior, and modeling details. If these concerns are addressed, the results will be of interest to developmental psychologists, economists, and social psychologists.

   Reviewed by eLife

9. Inducible, virus-free direct lineage reprogramming enhances scalable generation of human inner ear hair cell-like cells

   This article has 11 authors:

   1. Robert N. Rainey
   2. Sam D. Houman
   3. Louise Menendez
   4. Ryan Chang
   5. Litao Tao
   6. Helena Bugacov
   7. Andrew P. McMahon
   8. Radha Kalluri
   9. John S. Oghalai
   10. Andrew K. Groves
   11. Neil Segil

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The findings of this important study substantially advance our understanding of the transcription factors that can induce hair cell-like cells from human pluripotent stem cells. The presented evidence supporting these findings is compelling, including rigorous characterization of the effects of hair cell induction using both single-cell RNA sequencing and electrophysiological assessments.

   Reviewed by eLife

10. Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment

    This article has 12 authors:

    1. Nicholas Tolman
    2. Taibo Li
    3. Revathi Balasubramanian
    4. Guorong Li
    5. Violet Bupp-Chickering
    6. Ruth A. Kelly
    7. Marina Simón
    8. John Peregrin
    9. Christa Montgomery
    10. W. Daniel Stamer
    11. Jiang Qian
    12. Simon W.M. John

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This is a fundamental study that provides a detailed single-cell transcriptomic and epigenomic map of the mouse trabecular meshwor, identifying three distinct trabecular meshwor subtypes with specific functional roles. It links the glaucoma-associated transcription factor LMX1B to mitochondrial regulation in TM3 cells and demonstrates that nicotinamide treatment prevents IOP elevation in Lmx1bV265D/+ mutant mice, highlighting a potential metabolic therapeutic strategy for glaucoma. This convincing work would be further supported by data that link the transcriptional data with mitochondrial functional assays.

    Reviewed by eLife