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  1. Break-induced replication drives large-scale genomic amplifications in cancer cells

    This article has 4 authors:
    1. Mouadh Benamar
    2. Rebeka Eki
    3. Kang-Ping Du
    4. Tarek Abbas
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents important findings that genome-wide DNA double-strand breaks trigger large-scale genomic amplification (DIGA), which does not require origin re-licensing, but is dependent on some proteins that are involved in break-induced replication (BIR). While the findings and model are compelling, the evidence supporting the claims is largely incomplete, as it depends primarily on a single assay to examine amplification. This work will be of interest to scientists in the DNA repair, replication, and cell cycle fields, as well as cancer biologists.

    Reviewed by eLife

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