eLife

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1. We couldn't get details of this article at this time:
   10.64898/2026.06.15.732352

2. We couldn't get details of this article at this time:
   10.64898/2026.06.14.732185

3. Super compensatory substitutions restore protein function and flatten fitness landscapes

   This article has 5 authors:

   1. Wenhong Jiang
   2. Hengchuang Yin
   3. Saad S. Khan
   4. Yiparemu Abuduhaibaier
   5. Lucas B. Carey

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study identifies and characterizes a set of amino acid states that can rescue protein function in the presence of substantially deleterious mutations. Some of these super-compensatory substitutions also confer substantial mutational robustness, with broader implications for understanding epistasis, protein evolution, and protein engineering. The evidence is convincing, supported by a creative reanalysis of a large deep-mutational-scanning dataset, statistically rigorous treatment of anticipated error rates, experimental validation, and analyses of additional proteins, although clearer presentation and deeper investigation of the evolutionary implications and structural mechanisms would further strengthen the study.

   Reviewed by eLife

4. High basal autophagic activity in the brain revealed by systemic quantitative analysis using GFP-LC3-RFP mice

   This article has 7 authors:

   1. Yuki Kanda
   2. Tomoya Eguchi
   3. Hideaki Morishita
   4. Yutaro Hama
   5. Manabu Abe
   6. Kenji Sakimura
   7. Noboru Mizushima

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The ability to measure autophagic flux in vivo in response to physiological stresses remains a challenge for investigators in the field; the novel mouse model present in this work is significant and should prove valuable to investigators in addressing shortcomings of existing models. In addition, the development of the microplate reader approach to permit semi-high-throughput analysis of samples is convincing and a significant advance. The application of these approaches to measuring autophagy in multiple tissues is appreciated but raises some questions that need to be answered and highlighted, including what new biological insight has been generated for tissues under study, how overall autophagy versus rates of flux are determined, and how the sex of the animal affects outcomes. The neuronal populations under study should be reassessed.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.64898/2026.03.18.712569

6. Life-stage-specific specialities in the cell atlases of the Clytia hemisphaerica planula and medusa

   This article has 14 authors:

   1. Anna Ferraioli
   2. Julia Ramon Mateu
   3. Marc Meynadier
   4. Thomas Lamonerie
   5. Sophie Pagnotta
   6. Sandra Chevalier
   7. Marta Iglesias
   8. Sebastian R Najle
   9. Arnau Sebé-Pedrós
   10. Marie-Jeanne Arguel
   11. Julie Cazareth
   12. Virginie Magnone
   13. Evelyn Houliston
   14. Richard R. Copley

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a useful single-cell atlas of the Clytia hemisphaerica planula, complemented by an updated medusa dataset, ultrastructural analyses and in situ validation of expression patterns. The cross-stage comparison and cluster-similarity framework offer a promising basis for investigating cellular diversification across the life cycle. The evidence has the potential to be convincing, but is currently incomplete due to documentation deficits and insufficient cross-referencing with prior work. It should be relatively easy to address these issues, which should make this a valued resource for cnidarian researchers and for colleagues studying cell-type evolution.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.64898/2026.05.01.722137

8. We couldn't get details of this article at this time:
   10.1101/2025.09.09.675276

9. We couldn't get details of this article at this time:
   10.64898/2026.05.28.728318

10. Stimulating neurogenesis of distinct retinal lineages in human retinal pigmented epithelium (RPE) with proneural transcription factors

    This article has 6 authors:

    1. Lew Kaplan
    2. Abigail L Green
    3. Jaz Pang
    4. Marina Pavlou
    5. Juliette Wohlschlegel
    6. Thomas A Reh

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study provides an important contribution to retinal regeneration research by using overexpression of pro-neural factors to reprogram fetal human RPE cells into retinal neurons. The authors provide solid evidence of fetal RPE reprogramming into neural and photoreceptor-like states using scRNA-seq and imaging validation; however, there are concerns regarding comparisons between the effectiveness of different combinatorial transcription factor codes.

    Reviewed by eLife