Latest preprint reviews

  1. Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

    This article has 16 authors:
    1. Youyou Zhang
    2. Mu Xu
    3. Jiao Yuan
    4. Zhongyi Hu
    5. Junjie Jiang
    6. Jie Huang
    7. Bingwei Wang
    8. Jianfeng Shen
    9. Meixiao Long
    10. Yi Fan
    11. Kathleen T Montone
    12. Janos L Tanyi
    13. Omid Tavana
    14. Ho Man Chan
    15. Xiaowen Hu
    16. Lin Zhang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable finding that PRMT inhibitors may exert synergistic effects with PARP inhibitors to eliminate ovarian and triple-negative cancer cells in vitro and in vivo using preclinical mouse models. The evidence supporting the claims of the authors is solid, although the inclusion of novelty justification would have strengthened the study. The work will be of interest to scientists working on breast cancer and ovarian cancer.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  2. Reproducible, data-driven characterization of sleep based on brain dynamics and transitions from whole-night fMRI

    This article has 6 authors:
    1. Fan Nils Yang
    2. Dante Picchioni
    3. Jacco A de Zwart
    4. Yicun Wang
    5. Peter van Gelderen
    6. Jeff H Duyn
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important work, leveraging state-of-the-art whole-night sleep EEG-fMRI methods, advances our understanding of the brain states underlying sleep and wakefulness. Despite a small sample size, the authors present convincing evidence for substates within N2 and REM sleep stages, with reliable transition structure, supporting the perspective that there are more than the five canonical sleep/wake states.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  3. Decoding the Cognitive map: Learning place cells and remapping

    This article has 4 authors:
    1. Markus Borud Pettersen
    2. Vemund Sigmundson Schøyen
    3. Anders Malthe-Sørenssen
    4. Mikkel Elle Lepperød
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This useful study shows the representations that emerge in a recurrent neural network trained on a navigation task by requiring path integration and decodability. The network modeling was solid, but interpretation of neural data and mechanisms was incomplete.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. Ligand-Coupled Conformational Changes in a Cyclic Nucleotide-Gated Ion Channel Revealed by Time-Resolved Transition Metal Ion FRET

    This article has 3 authors:
    1. Pierce Eggan
    2. Sharona E Gordon
    3. William N Zagotta
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This useful study uses fluorescence lifetime imaging (FLIM) and tmFRET to resolve resting vs. active conformational heterogeneity and free energy differences driven by cGMP and cAMP in a tetrameric arrangement of isolated CNBDs from a prokaryotic CNG channel. The data are compelling and the experimental approach features rigorous new methods and analyses. Limitations include (1) only the cytosolic fragments of the channel were studied; (2) the results are not adequately discussed in the context of the extensive prior literature about conformational dynamics and energetics of CNBD-containing ion channels; (3) ambiguity in the stoichiometry of labeled:unlabeled subunits; and (4) the lack of a discussion of alternative interpretations of the data. The study will be of interest to scientists working on the structural mechanisms of membrane proteins.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  5. Disparity in temporal and spatial relationships between resting-state electrophysiological and fMRI signals

    This article has 3 authors:
    1. Wenyu Tu
    2. Samuel R. Cramer
    3. Nanyin Zhang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study combines fMRI and electrophysiology in sedated and awake rats to show that LFPs strongly explain spatial correlations in resting-state fMRI but only weakly explain temporal variability. The authors propose that other, electrophysiology-invisible mechanisms contribute to the fMRI signal. The evidence supporting the separation of spatial and temporal correlations is convincing, and the authors consider alternative potential factors that could account for the differences in spatial and temporal correlation that were observed. This work will be of interest to researchers who study the mechanisms behind resting-state fMRI.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  6. Tradeoffs in Modeling Context Dependency in Complex Trait Genetics

    This article has 4 authors:
    1. Eric Weine
    2. Samuel Pattillo Smith
    3. Rebecca Kathryn Knowlton
    4. Arbel Harpak
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The study presents a framework viewing gene-by-environment (GxE) effect estimation as a bias-variance tradeoff problem. The authors convincingly show that greater statistical power can be achieved in detecting GxE if an underlying model of polygenic GxE is assumed. This polygenic amplification model is a truly novel view with fundamental promise for the detection of GxE in genomic datasets. That said, at present the polygenic architecture investigation presented in the manuscript is somewhat limited to specific models and may not adequately build over the bias-variance tradeoff part of the manuscript. If the authors can show in their simulations that they can in principle detect more complex scenarios of amplification, then the strength of the paper would be enhanced.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Thymic self-recognition-mediated TCR signal strength modulates antigen-specific CD8+ T cell pathogenicity in non-obese diabetic mice

    This article has 5 authors:
    1. Chia-Lo Ho
    2. Li-Tzu Yeh
    3. Yu-Wen Liu
    4. Jia-Ling Dong
    5. Huey-Kang Sytwu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study explores T cell receptor activation during autoreactive T cell development and how the strength of T cell receptor engagement in naïve cells can predispose T cells to develop into effector/memory T cells. Solid evidence confirms published data that naïve T cells with higher CD5 expression were poised for activation and more pathogenic in the mouse model of autoimmune diabetes. However, the evidence regarding the regulation of differentiation of these cells during development is still incomplete.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  8. Single-nucleus transcriptomics reveal the cytological mechanism of conjugated linoleic acids in regulating intramuscular fat deposition

    This article has 6 authors:
    1. Liyi Wang
    2. Shiqi Liu
    3. Shu Zhang
    4. Yizhen Wang
    5. Yanbing Zhou
    6. Tizhong Shan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The present study provides valuable information into the regulatory mechanisms through which conjugated linoleic acids influence intramuscular fat deposition and muscle fiber transformation in pigs. The data are analyzed comprehensively using solid and validated single nuclei methodology. Overall, the provided data are convincing and support the conclusion of the study.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  9. Atomistic Tuning of the GeoCas9 Recognition Lobe Modulates Allosteric Motions and Guide RNA Interactions

    This article has 7 authors:
    1. Helen B Belato
    2. Alexa L Knight
    3. Alexandra M D’Ordine
    4. Zhiqiang Fan
    5. Jinping Luo
    6. Gerwald Jogl
    7. George P Lisi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides useful insights into the conformational dynamics of the nucleic acid recognition lobe of GeoCas9, a thermophilic Cas9 from Geobacillus stearothermophilus. The influence of local dynamics and allosteric regulation on guide RNA binding affinity and DNA cleavage specificity is investigated via cutting-edge NMR approaches and mutagenesis. While backed by rigorous biophysical analyses, evidence supporting the proposed mechanistic model is found to be incomplete due to the limited impact of the studied mutations on GeoCas9 cleavage activity. This work will be of interest to biochemists and biophysicists interested in interdomain communication and allosteric mechanisms in Cas9 enzymes.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. Beyond A and B Compartments: how major nuclear locales define nuclear genome organization and function

    This article has 13 authors:
    1. Omid Gholamalamdari
    2. Tom van Schaik
    3. Yuchuan Wang
    4. Pradeep Kumar
    5. Liguo Zhang
    6. Yang Zhang
    7. Gabriela A. Hernandez Gonzalez
    8. Athanasios E. Vouzas
    9. Peiyao A. Zhao
    10. David M. Gilbert
    11. Jian Ma
    12. Bas van Steensel
    13. Andrew S. Belmont
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is a valuable manuscript that successfully integrates several datasets to determine genome interactions with several nuclear bodies. The integrative datasets are a major strength of the manuscript. The evidence supporting the central claims is varied in its strength ranging from solid to incomplete. Orthogonal evidence validating the novel methodologies with alternative approaches would better support the central claims. We encourage the authors to consider a revised manuscript which addresses these points.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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