eLife

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1. Persistent Microglial HIV Infection Drives Neuroinflammation Despite Viral Suppression: Insights from Rapid Postmortem Brain Biopsies

   This article has 19 authors:

   1. M. Nühn Marieke
   2. Nadia Sabet
   3. Nanouk Zuidmeer
   4. C.J. van Abeelen Kirsten
   5. E. Hermans Lucas
   6. J. Schipper Pauline
   7. Raphael Kübler
   8. E. Basson Adriaan
   9. Tanvier Omar
   10. Ebrahim Variava
   11. A. Martinson Neil
   12. Stefanie Giacopazzi
   13. D. F. Venter Willem
   14. J. Muraro Mauro
   15. M. J. Wensing Annemarie
   16. D. de Witte Lot
   17. A. Papathanasopoulos Maria
   18. Monique Nijhuis
   19. Jori Symons

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a valuable study that contributes to our understanding of transcriptomic responses in microglia to HIV infection in the human brain. The evidence provided remains incomplete, and further analyses are required (i.e., a bigger sample size) to eliminate confounding factors so that the study can unequivocally ascertain the persistent inflammatory state of microglia in HIV-suppressed brains.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.64898/2026.05.11.723797

3. We couldn't get details of this article at this time:
   10.1101/2025.09.29.679272

4. We couldn't get details of this article at this time:
   10.1101/2025.07.18.665565

5. We couldn't get details of this article at this time:
   10.64898/2026.03.25.714244

6. We couldn't get details of this article at this time:
   10.1101/2025.07.02.662782

7. We couldn't get details of this article at this time:
   10.1101/2025.02.13.638167

8. We couldn't get details of this article at this time:
   10.64898/2025.12.03.692065

9. We couldn't get details of this article at this time:
   10.64898/2026.05.28.728389

10. Dual regulation of chemical stress-induced DDI2/3 expression by a transcription factor Fzf1 and nucleosome in Saccharomyces cerevisiae

    This article has 5 authors:

    1. Ying Du
    2. Aiyang Lin
    3. Joshua A.R. Brown
    4. LeAnn J. Howe
    5. Wei Xiao

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable study identifies an upstream repressive region in the Saccharomyces cerevisiae DDI2/3 promoter and shows that chemical stress induced by cyanamide or MMS is accompanied by reduced histone abundance and decreased nucleosome occupancy across the DDI2/3 locus. Genetic histone depletion is sufficient to enhance DDI2/3 expression, while MNase-seq and genetic analyses support a model in which the transcription factor Fzf1 both activates transcription through its established promoter-binding function and promotes chromatin changes that relieve nucleosome-mediated repression, helping to explain the unusually strong induction of DDI2/3 relative to other Fzf1 targets. The study is significant, as it provides a conceptually interesting extension of Fzf1-mediated stress regulation. The strength of the evidence is solid, although additional controls and a more cautious treatment of whether Fzf1 directly drives nucleosome eviction versus acting indirectly through transcriptional recruitment or chromatin-remodeling factors would further strengthen the mechanistic conclusions.

    Reviewed by eLife