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  1. Sphingosine 1-phosphate receptor-1 signaling enhances neutrophil survival while suppressing inflammation and bacterial host defense functions

    This article has 15 authors:
    1. Yueh-chien Lin
    2. Takahiro Seno
    3. Alan Y Hsu
    4. Andreane Cartier
    5. Andrew Kuo
    6. Michel V Levesque
    7. Avishek Ghosh
    8. Ingo Fohmann
    9. Victoria A Blaho
    10. Sylvain Galvani
    11. Reed Crocker
    12. Samuel W Kazer
    13. Jose Ordovas-Montanes
    14. Hongbo R Luo
    15. Timothy Hla
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript examines how overexpression of sphingosine 1-phosphate receptor 1 in a mouse model affects neutrophil distribution, metabolism and function. Given the significance of S1PR1 in inflammatory mechanisms, this work is valuable for uncovering novel aspects of S1PR1 signaling in neutrophil dynamics and function. The evidence provided is solid as it integrates single-cell transcriptomics, flow cytometry, and multiple in vivo studies. This work also raises key questions about distinct physiological and pathophysiological roles of S1PR1 signaling in neutrophils that could become therapeutic targets.

    Reviewed by eLife

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