Latest preprint reviews

1. Membrane potential modulates ERK activity and cell proliferation

   This article has 4 authors:

   1. Mari Sasaki
   2. Masanobu Nakahara
   3. Takuya Hashiguchi
   4. Fumihito Ono

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important paper employs multiple experimental approaches and presents evidence that changes in membrane voltage directly affect ERK signaling to regulate cell division. This result is relevant because it supports an ion channel-independent pathway by which changes in membrane voltage can affect cell growth. The reviewers point out that some experimental results and interpretations are compelling, but the strength of evidence is incomplete and additional experiments are needed to rule out other possible interpretations of the data.

   Reviewed by eLife

2. 3D Reconstruction of Neuronal Allometry and Neuromuscular Projections in Asexual Planarians Using Expansion Tiling Light Sheet Microscopy

   This article has 7 authors:

   1. Jing Lu
   2. Hao Xu
   3. Dongyue Wang
   4. Yanlu Chen
   5. Takeshi Inuoe
   6. Liang Gao
   7. Kai Lei

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study presents a novel microscopy technique called "Expansion Tiling Light Sheet Microscopy" and an accompanying computational pipeline for the faster collection and analysis of 3D volumetric images in animals like planarians. This approach produces beautiful 3D microscropy images and is solid on a technical level. However, due to the use of antibody reagents that visualize many – but not all – neurons and muscle subtypes, the evidence for the biological conclusions in this study remains incomplete. With the claims appropriately contextualized, this paper will be of interest to cell biologists working on imaging and analyzing whole animals.

   Reviewed by eLife

3. AIVE: accurate predictions of SARS-CoV-2 infectivity from comprehensive analysis

   This article has 17 authors:

   1. Jongkeun Park
   2. Won Jong Choi
   3. Do Young Seong
   4. Seung Pil Jeong
   5. Ju Young Lee
   6. Hyo Jeong Park
   7. Dae Sun Chung
   8. Ki Jong Yi
   9. Uijin Kim
   10. Ga-Yeon Yoon
   11. Hyeran Kim
   12. Taehoon Kim
   13. Sooyeon Go
   14. Eun Jeong Min
   15. Hyun-Soo Cho
   16. Nam-Hyeok Cho
   17. Dongwan Hong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study provides valuable insight into the biological significance of SARS-CoV-2 by using a series of computational analyses of viral proteins. While evidence is solid, it is obscured by a lack of clarity about the objectives of the analyses and in the overall writing of the article. The study will be impactful to the researchers in the field but will benefit from improved presentation.

   Reviewed by eLife

4. Modulation of aperiodic EEG activity provides sensitive index of cognitive state changes during working memory task

   This article has 5 authors:

   1. Tisa Frelih
   2. Andraž Matkovič
   3. Tjaša Mlinarič
   4. Jurij Bon
   5. Grega Repovš

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable work explores the timely idea that aperiodic activity in human electrophysiology recordings shows changes in response to task events, which may be relevant for performance, and that these changes could be misinterpreted as oscillatory changes. While it is a timely and interesting topic in principle, in the present form, the analytic approach is incomplete. Further, the data offer inadequate support for the conclusions related to theta without demonstrations that the task evokes theta power. Impressions were split, but there was consensus that the Discussion should be tempered and that further revisions could improve the manuscript.

   Reviewed by eLife

5. Parabrachial CGRP neurons modulates conditioned active defensive behavior under a naturalistic threat

   This article has 5 authors:

   1. Gyeong Hee Pyeon
   2. Hyewon Cho
   3. Byung Min Chung
   4. June-Seek Choi
   5. Yong Sang Jo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work advances our understanding of parabrachial CGRP threat function. The evidence supporting CGRP aversive outcome signaling is solid, while the evidence for cue signaling and fear behavior generation is incomplete. The work will be of interest to neuroscientists studying defensive behaviors.

   Reviewed by eLife

6. An integrin centered complex coordinates ion transport and pH to regulate f-actin organization and cell migration in breast cancer

   This article has 12 authors:

   1. Chiara Capitani
   2. Jessica Iorio
   3. Elena Lastraioli
   4. Claudia Duranti
   5. Giacomo Bagni
   6. Ginevra Chioccioli Altadonna
   7. Rossella Colasurdo
   8. Giorgia Scarpellino
   9. Scott P. Fraser
   10. Andrea Becchetti
   11. Mustafa B. A. Djamgoz
   12. Annarosa Arcangeli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding on the identification of a complex consisting of NHE1, hERG1, β1/integrin and NaV1.5 on the membrane of breast cancer cells. The evidence supporting the claims of the authors is somewhat incomplete. The inclusion of clarification of some experimental design and the amendment of cropping Western blot data would have strengthened the study. The work will be of interest to scientists working on breast cancer.

   Reviewed by eLife

7. Dapagliflozin improves endothelial integrity and hemodynamics in endotoxin treated mice through an apolipoprotein M dependent pathway

   This article has 18 authors:

   1. Carla Valenzuela Ripoll
   2. Zhen Guo
   3. Tripti Kumari
   4. Kana N. Miyata
   5. Mualla Ozcan
   6. Ahmed Diab
   7. Amanda Girardi
   8. Li He
   9. Attila Kovacs
   10. Carla Weinheimer
   11. Jess Nigro
   12. Jan Oscarsson
   13. Russell Esterline
   14. Joel Schilling
   15. Mikhail Kosiborod
   16. Christina Christoffersen
   17. Jaehyung Cho
   18. Ali Javaheri

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     SGLT2 inhibitors (SGLT2i) have assumed important roles in reducing cardiovascular risk, particularly in those with diabetes. It has become appreciated that its protective effects are likely beyond their ability to lower blood sugar levels. This research presents a novel approach to studying the SGLT2i mechanism of action which is yet to be fully elucidated.

   Reviewed by eLife

8. Marcks and Marcks-like 1 proteins promote spinal cord development and regeneration in Xenopus

   This article has 3 authors:

   1. Mohamed El Amri
   2. Abhay Pandit
   3. Gerhard Schlosser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work addresses the role of Marcks/Markcksl during spinal cord development and regeneration. The study is exceptional in combining molecular approaches to understand the mechanisms of tissue regeneration with behavioural assays, which is not commonly employed in the field. The data presented is convincing and comprehensive, using many complementary methodologies.

   Reviewed by eLife

9. Serum metabolome indicators of early childhood development in the Brazilian National Survey on Child Nutrition (ENANI-2019)

   This article has 14 authors:

   1. Marina Padilha
   2. Victor N. Keller
   3. Paula Normando
   4. Raquel M. Schincaglia
   5. Nathalia C. Freitas-Costa
   6. Samary S. R. Freire
   7. Felipe M. Delpino
   8. Inês R. R. de Castro
   9. Elisa M. A. Lacerda
   10. Dayana R. Farias
   11. Zachary Kroezen
   12. Meera Shanmuganathan
   13. Philip Britz-Mckibbin
   14. Gilberto Kac

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work advances our understanding of factors influencing early childhood development. The large sample size and methodology applied make the findings of this study convincing; however, support for some of the claims made by the authors is incomplete. The work will be of interest to researchers in developmental science and early childhood pediatrics.

   Reviewed by eLife

10. Error Prediction Determines the Coordinate System Used for Novel Dynamics Representation

    This article has 2 authors:

    1. Raz Leib
    2. David W. Franklin

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study provides a valuable new perspective on how motor learning occurring in one state generalizes to new states (for example, a different limb posture). The proposed model improves upon previous theories in its ability to predict patterns of generalization, but evidence supporting this specific proposed model over possible alternatives is incomplete. The newly proposed theory appears promising but would be more convincing if its conceptual and theoretical basis were clearer and more rigorously derived.

    Reviewed by eLife