eLife

Latest preprint reviews

1. Glycosylated IgG antibodies accelerated the recovery of haemorrhagic fever with renal syndrome patients

   This article has 15 authors:

   1. Chuansong Quan
   2. Lu Wang
   3. Jiming Gao
   4. Yaoni Li
   5. Xiaoyu Xu
   6. Houqiang Li
   7. Zixuan Gao
   8. Wenxu Ruan
   9. Hongzhi Liu
   10. Qian Li
   11. Weijia Xing
   12. Liqiong Zhao
   13. Michael J Carr
   14. Weifeng Shi
   15. Haifeng Hou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors investigated the potential role of IgG N-glycosylation in Haemorrhagic Fever with Renal Syndrome (HFRS), which may offer significant insights for understanding molecular mechanisms and for the development of therapeutic strategies for this infectious disease. The findings are useful to the field, although the strength of evidence to support the findings is incomplete. Several issues need to be addressed, including more detail on the background, methods, and results. Additional statistical tests should be performed, and the conclusions should reflect the correlational findings of the paper.

   Reviewed by eLife

2. C. elegans food choice exhibits effort discounting-like behavior

   This article has 6 authors:

   1. Jonathan R. M. Millet
   2. Serge Faumont
   3. Aaron B. Schatz
   4. Amanda M. White
   5. Kathy D. Chicas-Cruz
   6. Shawn R. Lockery

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work develops C. elegans as a model organism for studying effort-based discounting by asking the worms to choose between easy and hard to digest bacteria. The authors provide convincing evidence that the nematodes are effort-discounting. However, evidence regarding the role of dopamine is incomplete and this weakens the authors connection of the behavior in C. elegans with mammals.

   Reviewed by eLife

3. The Self-Interest of Adolescents Overrules Cooperation in Social Dilemmas

   This article has 6 authors:

   1. Xiaoyan Wu
   2. Hongyu Fu
   3. Gökhan Aydogan
   4. Chunliang Feng
   5. Shaozheng Qin
   6. Chao Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable work investigates cooperative behaviors in adolescents using a repeated Prisoner's Dilemma game. The computational modeling approach used in the study is solid and well established, yet evidence supporting certain claims remains incomplete. The work could be strengthened with the consideration of additional experimental contexts, non-linear relationships between age and observed behavior, and modeling details. If these concerns are addressed, the results will be of interest to developmental psychologists, economists, and social psychologists.

   Reviewed by eLife

4. Inducible, virus-free direct lineage reprogramming enhances scalable generation of human inner ear hair cell-like cells

   This article has 11 authors:

   1. Robert N. Rainey
   2. Sam D. Houman
   3. Louise Menendez
   4. Ryan Chang
   5. Litao Tao
   6. Helena Bugacov
   7. Andrew P. McMahon
   8. Radha Kalluri
   9. John S. Oghalai
   10. Andrew K. Groves
   11. Neil Segil

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The findings of this important study substantially advance our understanding of the transcription factors that can induce hair cell-like cells from human pluripotent stem cells. The presented evidence supporting these findings is compelling, including rigorous characterization of the effects of hair cell induction using both single-cell RNA sequencing and electrophysiological assessments.

   Reviewed by eLife

5. Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment

   This article has 12 authors:

   1. Nicholas Tolman
   2. Taibo Li
   3. Revathi Balasubramanian
   4. Guorong Li
   5. Violet Bupp-Chickering
   6. Ruth A. Kelly
   7. Marina Simón
   8. John Peregrin
   9. Christa Montgomery
   10. W. Daniel Stamer
   11. Jiang Qian
   12. Simon W.M. John

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a fundamental study that provides a detailed single-cell transcriptomic and epigenomic map of the mouse trabecular meshwor, identifying three distinct trabecular meshwor subtypes with specific functional roles. It links the glaucoma-associated transcription factor LMX1B to mitochondrial regulation in TM3 cells and demonstrates that nicotinamide treatment prevents IOP elevation in Lmx1bV265D/+ mutant mice, highlighting a potential metabolic therapeutic strategy for glaucoma. This convincing work would be further supported by data that link the transcriptional data with mitochondrial functional assays.

   Reviewed by eLife

6. Passive muscle forces in Drosophila are large but insufficient to support a fly’s weight

   This article has 7 authors:

   1. Ninghan Wang
   2. Helene Babski
   3. Jonathan Elliot Perdomo
   4. Sarah Beth McMahan
   5. Arun Ramakrishnan
   6. Tirthabir Biswas
   7. Vikas Bhandawat

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study introduces a novel experimental and modeling framework to quantify passive joint torques in Drosophila, revealing that passive forces are insufficient to support body weight, contrary to prior assumptions based on larger insects. The approach is technically impressive, combining genetic silencing, kinematic tracking, and biomechanical modeling. However, the strength of evidence is incomplete, limited by concerns about the specificity of the genetic tools, simplifications in the mechanical model, and limited functional interpretation.

   Reviewed by eLife

7. Longitudinal tracking of neuronal activity from the same cells in the developing brain using Track2p

   This article has 7 authors:

   1. Jure Majnik
   2. Manon Mantez
   3. Sofia Zangila
   4. Stéphane Bugeon
   5. Leo Guignard
   6. Jean-Claude Platel
   7. Rosa Cossart

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study presents a new method for longitudinally tracking cells in two-photon imaging data that addresses the specific challenges of imaging neurons in the developing cortex. It provides compelling evidence demonstrating reliable longitudinal identification of neurons across the second postnatal week in mice. The study should be of interest to development neuroscientists engaged in population-level recordings using two-photon imaging.

   Reviewed by eLife

8. A quantitative pipeline for whole-mount deep imaging and analysis of multi-layered organoids across scales

   This article has 8 authors:

   1. Alice Gros
   2. Jules Vanaret
   3. Valentin Dunsing-Eichenauer
   4. Agathe Rostan
   5. Philippe Roudot
   6. Pierre-François Lenne
   7. Léo Guignard
   8. Sham Tlili

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study introduces a powerful imaging approach that enables deep-tissue visualization in gastruloids using two-photon microscopy, combined with spectral imaging and unmixing to achieve four-color 3D image acquisition. The evidence is compelling that many of the established methods are very helpful (e.g., registration, corrections, signal normalisation, lazy loading bioimage visualisation, spectral decomposition analysis), facilitate the development of quantitative research, and would be of interest to the wider scientific community.

   Reviewed by eLife

9. SETD2 suppresses tumorigenesis in a KRAS ^G12C -driven lung cancer model and its catalytic activity is regulated by histone acetylation

   This article has 11 authors:

   1. Ricardo J. Mack
   2. Natasha M. Flores
   3. Geoffrey C. Fox
   4. Hanyang Dong
   5. Metehan Cebeci
   6. Simone Hausmann
   7. Tourkian Chasan
   8. Jill M. Dowen
   9. Brian D. Strahl
   10. Pawel K. Mazur
   11. Or Gozani

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important study providing molecular insight into how cross-talk between histone modifications regulates the histone H3K36 methyltransferase SETD2. The manuscript contains excellent quality data, and the conclusions are convincing and justified. This work will be of interest to many biochemists working in the field of chromatin biology and epigenetics.

   Reviewed by eLife

10. Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules

    This article has 10 authors:

    1. Samantha J Cassell
    2. Weiyan Li
    3. Simon Krautwald
    4. Maryam Khoshouei
    5. Yan Tony Lee
    6. Joyce Hou
    7. Wendy Guan
    8. Stefan Peukert
    9. Wilhelm A Weihofen
    10. Jonathan R Whicher

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      In this important manuscript, Cassell and colleagues set out on a mechanistic and pharmacological exploration of an engineered chimeric small conductance calcium-activated potassium channel 2 (SK2). They show convincing evidence that the SK2 channel possesses a unique extracellular structure that modulates the conductivity of the selectivity filter, and that this structure is the target for the SK2 inhibitor apamin. While the interpretations are sound and the writing is clear, the manuscript would be strengthened by providing more detailed information for the electrophysiological experiments and the structural analyses attempted, in addition to relating dilation of the filter to mechanisms of inactivation in other potassium channels. This high-quality study will be of interest to membrane protein structural biologists, ion channel biophysicists, and chemical biologists, and will inform future drug development targeting SK channels.

    Reviewed by eLife