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   10.64898/2026.03.10.710929

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   10.64898/2026.06.26.734916

3. Lactylation of Influenza Virus Polymerase Acidic Protein Promotes Viral Replication and Pathogenicity

   This article has 14 authors:

   1. Shaoyu Tu
   2. Yue Du
   3. Wei Liang
   4. Xiaoyi Xu
   5. Jiahui Zou
   6. Yuchao Yang
   7. Chuhan Xiong
   8. Yanglin Li
   9. Meijun Jiang
   10. Aotian Ouyang
   11. Tong Chen
   12. Meilin Jin
   13. Huanchun Chen
   14. Hongbo Zhou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study reveals a role for lactylation in influenza polymerase function and virus replication. The evidence supporting the claims is solid, although the direct involvement of ATAT1 and SIRT1 in this modification and the functional relevance of the identified sites can be further substantiated. These findings will appeal broadly to influenza virologists studying polymerase regulation, as well as researchers investigating the functional roles of lactylation.

   Reviewed by eLife

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   10.64898/2026.07.01.735787

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   10.64898/2026.06.01.729383

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   10.1101/2025.09.19.677475

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   10.64898/2026.03.29.715140

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   10.64898/2026.07.01.735930

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   10.1101/2024.08.27.609980

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    10.64898/2026.06.03.729765