Latest preprint reviews

  1. WNK-SPAK/OSR1 signaling pathway facilitates ictal activity via reduced neuronal chloride extrusion rate

    This article has 7 authors:
    1. Volodymyr I. Dzhala
    2. Fu Hung Shiu
    3. Negah Rahmati
    4. Aloe Carroll
    5. Reagan Bae
    6. Kristopher T. Kahle
    7. Kevin J Staley
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents a valuable investigation of how inhibition of the WNK-SPAK/OSR1 pathway influences neuronal chloride homeostasis and seizure-like activity in organotypic hippocampal slice cultures. The evidence supporting the principal mechanistic conclusions is incomplete because several proposed mechanisms are inferred from changes in chloride dynamics rather than directly demonstrated. The work will be of interest to researchers studying chloride homeostasis, inhibitory neurotransmission, and epilepsy.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Persistent Microglial HIV Infection Drives Neuroinflammation Despite Viral Suppression: Insights from Rapid Postmortem Brain Biopsies

    This article has 19 authors:
    1. M. Nühn Marieke
    2. Nadia Sabet
    3. Nanouk Zuidmeer
    4. C.J. van Abeelen Kirsten
    5. E. Hermans Lucas
    6. J. Schipper Pauline
    7. Raphael Kübler
    8. E. Basson Adriaan
    9. Tanvier Omar
    10. Ebrahim Variava
    11. A. Martinson Neil
    12. Stefanie Giacopazzi
    13. D. F. Venter Willem
    14. J. Muraro Mauro
    15. M. J. Wensing Annemarie
    16. D. de Witte Lot
    17. A. Papathanasopoulos Maria
    18. Monique Nijhuis
    19. Jori Symons
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is a valuable study that contributes to our understanding of transcriptomic responses in microglia to HIV infection in the human brain. The evidence provided remains incomplete, and further analyses are required (i.e., a bigger sample size) to eliminate confounding factors so that the study can unequivocally ascertain the persistent inflammatory state of microglia in HIV-suppressed brains.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
Newer Page 2 of 862 Older