Physiology

Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction

1. Martin Wohlwend
2. Pirkka-Pekka Laurila
3. Ludger JE Goeminne
4. Tanes Lima
5. Ioanna Daskalaki
6. Xiaoxu Li
7. Giacomo von Alvensleben
8. Barbara Crisol
9. Renata Mangione
10. Hector Gallart-Ayala
11. Amélia Lalou
12. Olivier Burri
13. Stephen Butler
14. Jonathan Morris
15. Nigel Turner
16. Julijana Ivanisevic
17. Johan Auwerx

• Curated by eLife

  eLife assessment

  This solid study presents valuable insights into the role of Cers1 on skeletal muscle function during aging, although further substantiation would help to fully establish the experimental assertions. It examines an unexplored aspect of muscle biology that is a relevant opening to future studies in this area of research.

Reviewed by eLife

Intermittent fasting promotes type 3 innate lymphoid cells secreting IL-22 contributing to the beigeing of white adipose tissue

1. Hong Chen
2. Lijun Sun
3. Lu Feng
4. Xue Han
5. Yunhua Zhang
6. Wenbo Zhai
7. Zehe Zhang
8. Michael Mulholland
9. Weizhen Zhang
10. Yue Yin

• Curated by eLife

  eLife assessment

  This study provides valuable findings showing the production of IL-22 from intestinal ILC3 during intermittent fasting promotes beigeing of white adipose tissue. The authors provided solid data and mechanistic insight by which IL-22-derived from ILC3 directly induces beigeing.

Reviewed by eLife

On-farm hatching and contact with adult hen post hatch induce sex-dependent effects on performance, health and robustness in broiler chickens

1. Laurence A Guilloteau
2. Aline Bertin
3. Sabine Crochet
4. Charlotte Bagnard
5. Alice Hondelatte
6. Laure Ravon
7. Catherine Schouler
8. Karine Germain
9. Anne Collin

Reviewed by Peer Community in Animal Science

Septin 7 interacts with Numb to preserve sarcomere structural organization and muscle contractile function

1. Rita De Gasperi
2. Laszlo Csernoch
3. Beatrix Dienes
4. Monika Gonczi
5. Jayanta K Chakrabarty
6. Shahar Goeta
7. Abdurrahman Aslan
8. Carlos A Toro
9. David Karasik
10. Lewis M Brown
11. Marco Brotto
12. Christopher P Cardozo

• Curated by eLife

  eLife assessment

  This convincing study demonstrates a potentially important role for the factor Numb in skeletal muscle excitation-contraction coupling, since a Numb knockout reduced contractile force. The authors thus demonstrate a novel role for Numb in calcium release in skeletal muscle.

Reviewed by eLife

Maresin 1 repletion improves muscle regeneration after volumetric muscle loss

1. Jesus A Castor-Macias
2. Jacqueline A Larouche
3. Emily C Wallace
4. Bonnie D Spence
5. Alec Eames
6. Pamela Duran
7. Benjamin A Yang
8. Paula M Fraczek
9. Carol A Davis
10. Susan V Brooks
11. Krishna Rao Maddipati
12. James F Markworth
13. Carlos A Aguilar

• Curated by eLife

  eLife assessment

  This is a compelling study on pro-inflammatory and anti-inflammatory lipids in relation to skeletal muscle injury. It convincingly identifies pro-inflammatory lipids during recovery predisposing to fibrosis, and maresin 1 as an anti-inflammatory lipid reducing fibrosis, improved muscle regeneration, partially restoring contractile function, of fundamental potential clinical application.

Reviewed by eLife

Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition

1. Dylan C Sarver
2. Jean Garcia-Diaz
3. Muzna Saqib
4. Ryan C Riddle
5. G William Wong

• Curated by eLife

  eLife assessment

  This study discloses important physiological function for TMEM63 in regulating postnatal growth in mice. The data supporting the impaired body growth and skeletal phenotype as well as disrupted growth hormone/insulin-like growth factor-I (GH/IGF-I) signaling in TMEM63 knockout mice are compelling. However, to establish that alteration of hepatic GH/IGF-I signaling is the cause for observed growth and skeletal phenotype in TMEM63 knockout mice would need additional work.

Reviewed by eLife

Auxin exposure disrupts feeding behavior and fatty acid metabolism in adult Drosophila

1. Sophie A Fleck
2. Puja Biswas
3. Emily D DeWitt
4. Rebecca L Knuteson
5. Robert C Eisman
6. Travis Nemkov
7. Angelo D'Alessandro
8. Jason M Tennessen
9. Elizabeth Rideout
10. Lesley N Weaver

• Curated by eLife

  eLife assessment

  This valuable study shows that auxin exposure perturbs feeding behavior, survival rates, lipid metabolism, and gene expression patterns in adult Drosophila flies. The results are solid with proper methods and data analyses, and the evidence broadly supports the conclusions with only minor weaknesses. This work is relevant for fly geneticists who are interested in using the auxin-inducible gene expression system for inducing target protein degradation acutely.

Reviewed by eLife

Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation

1. Rabina Mainali
2. Nancy Buechler
3. Cristian Otero
4. Laken Edwards
5. Chia-Chi Key
6. Cristina Furdui
7. Matthew A Quinn

• Curated by eLife

  eLife assessment

  This work describes a connection between inflammation and metabolism, in which itaconate stabilizes the mitochondrial fatty acid uptake enzyme Cpt1a to enhance fatty acid oxidation. The mechanism for itaconate action may be generalizable to other protein targets. This is an important advance, which is supported by solid experimental data.

Reviewed by eLife

A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle

1. Gonzalo Hernandez-Hernandez
2. Samantha C O'Dwyer
3. Pei-Chi Yang
4. Collin Matsumoto
5. Mindy Tieu
6. Zhihui Fong
7. Timothy J Lewis
8. L Fernando Santana
9. Colleen E Clancy

• Curated by eLife

  eLife assessment

  The study is of importance for the cardiac modeling field by developing a novel mathematical model with sex difference. The data are compelling, and the model is helpful for mechanistic understanding, and thus is also important for experimental physiology. The model is based on experimental data and validated against some experimental data.

Reviewed by eLife

Oxytocin alleviated colitis and colitis-associated colorectal tumorigenesis by targeting fucosylated MUC2

1. Xia Wang
2. Dawei chen
3. MengNan guo
4. Yao Ning
5. Jing Guo
6. Jiahui Gao
7. Xiaoran Xie
8. Dong Zhao
9. Lixiang Li
10. Shiyang Li
11. Yanqing Li
12. Xiuli Zuo
13. Jingxin Li

Reviewed by Review Commons