Physiology

  1. Lac-Phe mediates the anti-obesity effect of metformin

    1. Shuke Xiao
    2. Veronica L. Li
    3. Xuchao Lyu
    4. Xudong Chen
    5. Wei Wei
    6. Fahim Abbasi
    7. Joshua W. Knowles
    8. Shuliang Deng
    9. Gaurav Tiwari
    10. Xu Shi
    11. Shuning Zheng
    12. Laurie Farrell
    13. Zsu-Zsu Chen
    14. Kent D. Taylor
    15. Xiuqing Guo
    16. Mark O. Goodarzi
    17. Alexis C. Wood
    18. Yii-Der Ida Chen
    19. Leslie A. Lange
    20. Stephen S. Rich
    21. Jerome I. Rotter
    22. Clary B. Clish
    23. Usman A. Tahir
    24. Robert E. Gerszten
    25. Mark D. Benson
    26. Jonathan Z. Long

    Reviewed by PREreview

    1 evaluationAppears in 2 listsLatest version Latest activity

  2. Binding and sequestration of poison frog alkaloids by a plasma globulin

    1. Aurora Alvarez-Buylla
    2. Marie-Therese Fischer
    3. Maria Dolores Moya Garzon
    4. Alexandra E Rangel
    5. Elicio E Tapia
    6. Julia T Tanzo
    7. H Tom Soh
    8. Luis A Coloma
    9. Jonathan Z Long
    10. Lauren A O'Connell

    • Curated by eLife

      eLife assessment

      Poison frogs sequester alkaloids to make themselves toxic or unpalatable to predators, but how this sequestration occurs is not well understood. This valuable study identifies an alkaloid-binding protein in the plasma of poison frogs, which may help explain how these animals are able to sequester a diversity of alkaloids with different target sites. The supporting evidence is solid and the study adds to our understanding of how toxic animals resist the effects of their own defenses.

    Reviewed by eLife, Arcadia Science

    10 evaluationsAppears in 2 listsLatest version Latest activity

  3. Inhibition of mammalian mtDNA transcription paradoxically activates liver fatty acid oxidation to reverse diet-induced hepatosteatosis and obesity

    1. Shan Jiang
    2. Taolin Yuan
    3. Laura S Kremer
    4. Florian A Rosenberger
    5. Fynn M Hansen
    6. Melissa Borg
    7. Diana Rubalcava-Gracia
    8. Mara Mennuni
    9. Roberta Filograna
    10. David Alsina
    11. Jelena Misic
    12. Camilla Koolmeister
    13. Lipeng Ren
    14. Olov Andersson
    15. Anke Unger
    16. Tim Bergbrede
    17. Raffaella Di Lucrezia
    18. Rolf Wibom
    19. Juleen R Zierath
    20. Anna Krook
    21. Patrick Giavalisco
    22. Matthias Mann
    23. Nils-Göran Larsson

    Reviewed by PREreview

    1 evaluationAppears in 2 listsLatest version Latest activity

  4. Resistance exercise protects mice from protein-induced fat accretion

    1. Michaela E Trautman
    2. Leah N Braucher
    3. Christian Elliehausen
    4. Wenyuan G Zhu
    5. Esther Zelenovskiy
    6. Madelyn Green
    7. Michelle M Sonsalla
    8. Chung-Yang Yeh
    9. Troy A Hornberger
    10. Adam R Konopka
    11. Dudley W Lamming

    • Curated by eLife

      eLife assessment

      This study presents a valuable finding on relationship between high protein diet and resistance exercise on fat accumulation and glucose homeostasis. The evidence supporting the claims of the authors is solid, although inclusion of mechanistic insight would have strengthened the study. The work will be of interest to dietician and exercise biologists working to understand the synergy between diet and physical activity.

    Reviewed by eLife

    8 evaluationsAppears in 1 listLatest version Latest activity

  5. Effects of Aerobic Exercise in Hepatic Lipid Droplet-Mitochondria interaction in Non-alcoholic Fatty Liver Disease

    1. Juan Carlos Bórquez
    2. Francisco Díaz-Castro
    3. Francisco Pino-de La Fuente
    4. Karla Espinoza
    5. Ana María Figueroa
    6. Inma Martínez-Ruíz
    7. Vanessa Hernández
    8. Iliana López-Soldado
    9. Raúl Ventura
    10. Alejandra Espinosa
    11. Víctor Cortés
    12. María Isabel Hernández-Alvarez
    13. Rodrigo Troncoso

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Ryanodine receptor 2 inhibition reduces dispersion of cardiac repolarization, improves contractile function, and prevents sudden arrhythmic death in failing hearts

    1. Pooja Joshi
    2. Shanea Estes
    3. Deeptankar DeMazumder
    4. Bjorn C Knollmann
    5. Swati Dey

    • Curated by eLife

      eLife assessment

      This important study examined the use of dantrolene, a Ryanodine Receptor stabilizer, in slowing pathological progression of pressure-overload heart failure in a guinea pig model and reducing arrhythmias. Convincing data were collected and analyzed using validated methodology and can be used as a starting point for future studies of dantrolene in Ca2+ handling in ROS production and further deterioration of cardiac function in chronic heart failure.

    Reviewed by eLife

    7 evaluationsAppears in 1 listLatest version Latest activity

  7. Molecular tuning of sea anemone stinging

    1. Lily S He
    2. Yujia Qi
    3. Corey AH Allard
    4. Wendy A Valencia-Montoya
    5. Stephanie P Krueger
    6. Keiko Weir
    7. Agnese Seminara
    8. Nicholas W Bellono

    • Curated by eLife

      eLife assessment

      This is an important paper that links distinctive stinging behavior of two related anemones occupying different ecological niches to varying inactivation properties of voltage-gated calcium channels conferred by auxiliary Cavβ subunits. Further convincing evidence is provided that these differences are mediated by alternative splicing of Cavβ subunit of the calcium channel. The study will be of interest to scientists studying Ca2+ signaling, ion channel biophysicists, and marine biologists.

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity

  8. Hypoxia blunts angiogenic signaling and upregulates the antioxidant system in elephant seal endothelial cells

    1. Kaitlin N Allen
    2. Julia María Torres-Velarde
    3. Juan Manuel Vazquez
    4. Diana D Moreno-Santillan
    5. Peter H Sudmant
    6. José Pablo Vázquez-Medina

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity

  9. Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity

    1. Chandramohan Chitraju
    2. Alexander W Fischer
    3. Yohannes A Ambaw
    4. Kun Wang
    5. Bo Yuan
    6. Sheng Hui
    7. Tobias C Walther
    8. Robert V Farese

    • Curated by eLife

      eLife assessment:

      This study introduces a valuable paradigm in the field of adipose tissue biology: blocking triglyceride storage in adipose tissue does not lead to lipodystrophy and impaired glucose homeostasis but instead improves metabolic health. The evidence supporting these claims is convincing, based on a comprehensive metabolic analysis, although mechanistic studies would strengthen the study and its impact. This study will be of high interest to those in the adipose tissue biology and metabolism fields.

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity

  10. Melanocortin 1 receptor regulates cholesterol and bile acid metabolism in the liver

    1. Keshav Thapa
    2. James J Kadiri
    3. Karla Saukkonen
    4. Iida Pennanen
    5. Bishwa Ghimire
    6. Minying Cai
    7. Eriika Savontaus
    8. Petteri Rinne

    • Curated by eLife

      eLife assessment

      The significance of this manuscript is that is provides useful information for the field of hepatology and endocrinology on the regulatory mechanisms of cholesterol homeostasis by melanocortin. The authors provide solid evidence utilizing both in vivo and in vitro molecular, cellular, and biochemical approaches to support their claims.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity
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