Physiology

High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen

1. Wan-ping Yang
2. Mei-qi Li
3. Jie Ding
4. Jia-yan Li
5. Gang Wu
6. Bao Liu
7. Yu-qi Gao
8. Guo-hua Wang
9. Qian-qian Luo

• Curated by eLife

  eLife assessment

  This useful study reports that a week or more of hypoxia exposure in mice increases erythropoiesis and decreases the number of iron-recycling macrophages in the spleen, compromising their capacity for red blood cell phagocytosis – reflected by increased mature erythrocyte retention in the spleen. Compared to an earlier version, the study has been strengthened with mouse experiments under hypobaric hypoxia and complemented by extensive ex vivo analyses. Unfortunately, while some of the evidence is solid, the work as it currently stands only incompletely supports the authors' hypotheses. While the study would benefit from additional experiments that more directly buttress the central claims, it should be of interest to the fields of hemopoiesis and bone marrow biology and possibly also blood cancer.

Reviewed by eLife

Metformin protects the heart against chronic intermittent hypoxia through AMPK ‐dependent phosphorylation of HIF ‐1α

1. Sophie Moulin
2. Britanny Blachot‐Minassian
3. Anita Kneppers
4. Amandine Thomas
5. Stéphanie Paradis
6. Laurent Bultot
7. Claire Arnaud
8. Jean‐Louis Pépin
9. Luc Bertrand
10. Rémi Mounier
11. Elise Belaidi

Reviewed by Review Commons

Hammerhead-type FXR agonists induce an enhancer RNA Fincor that ameliorates nonalcoholic steatohepatitis in mice

1. Jinjing Chen
2. Ruoyu Wang
3. Feng Xiong
4. Hao Sun
5. Byron Kemper
6. Wenbo Li
7. Jongsook Kemper

• Curated by eLife

  eLife assessment

  Using unbiased transcriptional profiling, the study reports a fundamental discovery of a novel hepatic lncRNA, FincoR, which regulates FXR. The convincing findings have therapeutic implications in the treatment of MASH. The authors use state-of-the-art methodology and use unbiased transcriptomic profiling and epigenetic profiling, including validation in mouse models and human samples.

Reviewed by eLife

Deletion of FNDC5/irisin modifies murine osteocyte function in a sex-specific manner

1. Anika Shimonty
2. Fabrizio Pin
3. Matthew Prideaux
4. Gang Peng
5. Joshua Huot
6. Hyeonwoo Kim
7. Clifford J Rosen
8. Bruce M Spiegelman
9. Lynda F Bonewald

• Curated by eLife

  eLife assessment

  The study presents valuable findings on sexually dimorphic patterns of osteocytic transcriptomes and low calcium diet-induced osteocytic osteolysis in FNDC5-deficient mice. The authors present solid evidence for sex-specific changes in osteocyte morphology and gene expression under a calcium-demanding setting in this particular strain of mice, although the protective role of FNDC5-deficiency in lactation and low-calcium diet in female mice remains unclear due to lack of mechanistic studies. The study also lacks evidence that irisin, a proteolytically cleaved product of FNDC5, is responsible for the observed phenotypes, as irisin was not directly measured.

Reviewed by eLife

Changes in surface temperatures reveal the thermal challenge associated with catastrophic moult in captive Gentoo penguins

1. Agnès Lewden
2. Tristan Halna du Fretay
3. Antoine Stier

Reviewed by preLights

Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction

1. Martin Wohlwend
2. Pirkka-Pekka Laurila
3. Ludger JE Goeminne
4. Tanes Lima
5. Ioanna Daskalaki
6. Xiaoxu Li
7. Giacomo von Alvensleben
8. Barbara Crisol
9. Renata Mangione
10. Hector Gallart-Ayala
11. Amélia Lalou
12. Olivier Burri
13. Stephen Butler
14. Jonathan Morris
15. Nigel Turner
16. Julijana Ivanisevic
17. Johan Auwerx

• Curated by eLife

  eLife assessment

  This solid study presents valuable insights into the role of Cers1 on skeletal muscle function during aging, although further substantiation would help to fully establish the experimental assertions. It examines an unexplored aspect of muscle biology that is a relevant opening to future studies in this area of research.

Reviewed by eLife

Intermittent fasting promotes type 3 innate lymphoid cells secreting IL-22 contributing to the beigeing of white adipose tissue

1. Hong Chen
2. Lijun Sun
3. Lu Feng
4. Xue Han
5. Yunhua Zhang
6. Wenbo Zhai
7. Zehe Zhang
8. Michael Mulholland
9. Weizhen Zhang
10. Yue Yin

• Curated by eLife

  eLife assessment

  This study provides valuable findings showing the production of IL-22 from intestinal ILC3 during intermittent fasting promotes beigeing of white adipose tissue. The authors provided solid data and mechanistic insight by which IL-22-derived from ILC3 directly induces beigeing.

Reviewed by eLife

On-farm hatching and contact with adult hen post hatch induce sex-dependent effects on performance, health and robustness in broiler chickens

1. Laurence A Guilloteau
2. Aline Bertin
3. Sabine Crochet
4. Charlotte Bagnard
5. Alice Hondelatte
6. Laure Ravon
7. Catherine Schouler
8. Karine Germain
9. Anne Collin

Reviewed by Peer Community in Animal Science

Septin 7 interacts with Numb to preserve sarcomere structural organization and muscle contractile function

1. Rita De Gasperi
2. Laszlo Csernoch
3. Beatrix Dienes
4. Monika Gonczi
5. Jayanta K Chakrabarty
6. Shahar Goeta
7. Abdurrahman Aslan
8. Carlos A Toro
9. David Karasik
10. Lewis M Brown
11. Marco Brotto
12. Christopher P Cardozo

• Curated by eLife

  eLife assessment

  This convincing study demonstrates a potentially important role for the factor Numb in skeletal muscle excitation-contraction coupling, since a Numb knockout reduced contractile force. The authors thus demonstrate a novel role for Numb in calcium release in skeletal muscle.

Reviewed by eLife

Maresin 1 repletion improves muscle regeneration after volumetric muscle loss

1. Jesus A Castor-Macias
2. Jacqueline A Larouche
3. Emily C Wallace
4. Bonnie D Spence
5. Alec Eames
6. Pamela Duran
7. Benjamin A Yang
8. Paula M Fraczek
9. Carol A Davis
10. Susan V Brooks
11. Krishna Rao Maddipati
12. James F Markworth
13. Carlos A Aguilar

• Curated by eLife

  eLife assessment

  This is a compelling study on pro-inflammatory and anti-inflammatory lipids in relation to skeletal muscle injury. It convincingly identifies pro-inflammatory lipids during recovery predisposing to fibrosis, and maresin 1 as an anti-inflammatory lipid reducing fibrosis, improved muscle regeneration, partially restoring contractile function, of fundamental potential clinical application.

Reviewed by eLife