Physiology

Calcium and bicarbonate signaling pathways have pivotal, resonating roles in matching ATP production to demand

1. Maura Greiser
2. Mariusz Karbowski
3. Aaron David Kaplan
4. Andrew Kyle Coleman
5. Nicolas Verhoeven
6. Carmen A Mannella
7. W Jonathan Lederer
8. Liron Boyman

• Curated by eLife

  eLife assessment

  The important work presented here provides findings that substantially advance our understanding of a major research question into how bicarbonate/CO2 signaling regulates cardiac mitochondrial energy supply. The methods, data, and analyses broadly support the claims with only minor weaknesses concerning the exact spatial location of the enzymes involved. The work will be of broad interest to cell biologists and biochemists interested in metabolic control.

Reviewed by eLife

A cell-and-plasma numerical model reveals hemodynamic stress and flow adaptation in zebrafish microvessels after morphological alteration

1. Swe Soe Maung Ye
2. Li-Kun Phng

Reviewed by Review Commons

VO2max prediction based on submaximal cardiorespiratory relationships and body composition in male runners and cyclists: a population study

1. Szczepan Wiecha
2. Przemysław Seweryn Kasiak
3. Piotr Szwed
4. Tomasz Kowalski
5. Igor Cieśliński
6. Marek Postuła
7. Andrzej Klusiewicz

• Curated by eLife

  eLife assessment

  The authors have established new formulas to predict maximum oxygen uptake for cyclists and runners based on submaximal exercise testing and anthropometric characteristics. This is an important study with a large and comprehensive dataset, which may be helpful for many exercise labs. The work is convincing, using appropriate and validated methodology in line with the current state-of-the-art, as shown by references to common exercise books.

Reviewed by eLife

Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor

1. Erin J Ciampa
2. Padraich Flahardy
3. Harini Srinivasan
4. Christopher Jacobs
5. Linus Tsai
6. S Ananth Karumanchi
7. Samir M Parikh

• Curated by eLife

  eLife assessment

  This valuable study provides insights into mechanisms of placental aging and its relationship to labor initiation. The authors provide solid evidence and have thoroughly investigated the molecular characteristics of normal placental aging using in vivo and in vitro model systems and human placental tissue analysis to corroborate their findings. This work contributes to existing work in placental aging and preterm birth and will be of interest to reproductive scientists.

Reviewed by eLife

Tmem117 in AVP neurons regulates the counterregulatory response to hypoglycemia

1. Sevasti Gaspari
2. Gwenaël Labouèbe
3. Alexandre Picard
4. Xavier Berney
5. Ana Rodriguez Sanchez‐Archidona
6. Bernard Thorens

Reviewed by Review Commons

Hypermetabolism in mice carrying a near-complete human chromosome 21

1. Dylan C Sarver
2. Cheng Xu
3. Susana Rodriguez
4. Susan Aja
5. Andrew E Jaffe
6. Feng J Gao
7. Michael Delannoy
8. Muthu Periasamy
9. Yasuhiro Kazuki
10. Mitsuo Oshimura
11. Roger H Reeves
12. G William Wong

• Curated by eLife

  eLife assessment

  This important paper provides new insight into the effect of extra-copies of a chromosome, thus aneuploidy, on body metabolisms in mammals. The authors used various solid analyses on the metabolisms and physiology of the transgenic mouse with most of human chromosome 21 and presented convincing results to support the authors' claims. The work would be of interest to researchers who work on the physiology and biochemistry of body metabolisms in mammals.

Reviewed by eLife

An unexpected role of neutrophils in clearing apoptotic hepatocytes in vivo

1. Luyang Cao
2. Lixiang Ma
3. Juan Zhao
4. Xiangyu Wang
5. Xinzou Fang
6. Wei Li
7. Yawen Qi
8. Yingkui Tang
9. Jieya Liu
10. Shengxian Peng
11. Li Yang
12. Liangxue Zhou
13. Li Li
14. Xiaobo Hu
15. Yuan Ji
16. Yingyong Hou
17. Yi Zhao
18. Xianming Zhang
19. You-yang Zhao
20. Yong Zhao
21. Yuquan Wei
22. Asrar B Malik
23. Hexige Saiyin
24. Jingsong Xu

• Curated by eLife

  eLife assessment

  This paper reports the fundamental discovery of a new function of neutrophil in specifically clearing apoptotic hepatocytes by penetrating the cells rather than engulfing them without causing inflammation as a part of tissue homeostasis. This solid study transforms the way we think about role of neutrophil in pathogenesis of autoimmune liver disease.

Reviewed by eLife

Osteoblast-intrinsic defect in glucose metabolism impairs bone formation in type II diabetic male mice

1. Fangfang Song
2. Won Dong Lee
3. Tyler Marmo
4. Xing Ji
5. Chao Song
6. Xueyang Liao
7. Rebecca Seeley
8. Lutian Yao
9. Haoran Liu
10. Fanxin Long

• Curated by eLife

  eLife assessment

  In this study, the authors made important progress in understanding bone metabolic defects of T2D. They have established a valuable model that could mimic some aspects of T2D in mice. Particularly, the study provided important evidence showing bone turnover and metabolism were in defects, and changes in glycolysis would rescue bone defects in T2D. Overall, the authors provide compelling evidence from dynamic histomorphometry, C13 isotype labeling in vivo, scRNA-seq, and metabolic assays to demonstrate that the defective glucose metabolism causes osteopenia associated with T2D.

Reviewed by eLife

Lipid hydroperoxides promote sarcopenia through carbonyl stress

1. Hiroaki Eshima
2. Justin L Shahtout
3. Piyarat Siripoksup
4. MacKenzie J Pearson
5. Ziad S Mahmassani
6. Patrick J Ferrara
7. Alexis W Lyons
8. John Alan Maschek
9. Alek D Peterlin
10. Anthony RP Verkerke
11. Jordan M Johnson
12. Anahy Salcedo
13. Jonathan J Petrocelli
14. Edwin R Miranda
15. Ethan J Anderson
16. Sihem Boudina
17. Qitao Ran
18. James E Cox
19. Micah J Drummond
20. Katsuhiko Funai

• Curated by eLife

  eLife assessment

  This important paper advances our understanding of the role of lipid peroxidation in loss of muscle mass and force-generating capacity during aging and hind-limb suspension. The evidence is in general solid, drawing from experiments in vivo and cell culture using multiple types of manipulations of the formation of lipid peroxides although some weaknesses were identified. The results should be of interest to those who study the molecular basis for sarcopenia and disuse atrophy of skeletal muscle.

Reviewed by eLife

Quantitative proteomic analysis of skeletal muscles from wild-type and transgenic mice carrying recessive Ryr1 mutations linked to congenital myopathies

1. Jan Eckhardt
2. Alexis Ruiz
3. Stéphane Koenig
4. Maud Frieden
5. Hervé Meier
6. Alexander Schmidt
7. Susan Treves
8. Francesco Zorzato

• Curated by eLife

  eLife assessment

  This paper provides a valuable systematic analysis of proteomic profiles associated with a particular murine Ryanodine receptor abnormality. Its analysis technique provides a solid and systematic set of data summarising the differences in different muscle types. The work emerges with insights into pathological mechanism of congenital muscle diseases linked to mutations in a range of other genes related to excitation contraction coupling in workers within the skeletal muscle field.

Reviewed by eLife