Physiology

Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues

1. Mingqi Zhou
2. Ian Tamburini
3. Cassandra Van
4. Jeffrey Molendijk
5. Christy M Nguyen
6. Ivan Yao-Yi Chang
7. Casey Johnson
8. Leandro M Velez
9. Youngseo Cheon
10. Reichelle Yeo
11. Hosung Bae
12. Johnny Le
13. Natalie Larson
14. Ron Pulido
15. Carlos HV Nascimento-Filho
16. Cholsoon Jang
17. Ivan Marazzi
18. Jamie Justice
19. Nicholas Pannunzio
20. Andrea L Hevener
21. Lauren Sparks
22. Erin E Kershaw
23. Dequina Nicholas
24. Benjamin L Parker
25. Selma Masri
26. Marcus M Seldin

• Curated by eLife

  eLife assessment

  This important paper provides web based interface for cross-tissue analysis of omics datasets from – so far – two different human populations, with compelling evidence that the tool can be used to make meaningful scientific discoveries. Conceptually, these analyses are relevant for any systems biologist or bioinformatician who is interested in integrating large population datasets. Currently, the resource is already of use for scientists studying the HMDP or using GTEx data, and we hope to see updates in the coming years that incorporate more populations and more datatypes, which could make it a general tool for a wide community.

Reviewed by eLife

CRISPR-Cas9 knockdown of ESR1 in preoptic GABA-kisspeptin neurons suppresses the preovulatory surge and estrous cycles in female mice

1. Jenny Clarkson
2. Siew Hoong Yip
3. Robert Porteous
4. Alexia Kauff
5. Alison K Heather
6. Allan E Herbison

• Curated by eLife

  eLife assessment

  This important study provides convincing evidence of the criticality of estradiol – estrogen receptor-mediated upregulation of kisspeptin within neurons of the preoptic area to generate an ovulation-inducing luteinizing hormone surge. The use of in vivo CRIPSR-Cas9 is novel in this system and provides a road map for future studies in reproductive neuroendocrinology. This paper will be of interest to reproductive neuroscientists and endocrinologists.

Reviewed by eLife

Exercise training and cold exposure trigger distinct molecular adaptations to inguinal white adipose tissue

1. Maria Vamvini
2. Pasquale Nigro
3. Tiziana Caputo
4. Kristin I. Stanford
5. Michael F. Hirshman
6. Roeland J.W. Middelbeek
7. Laurie J. Goodyear

Reviewed by PREreview

Lac-Phe mediates the anti-obesity effect of metformin

1. Shuke Xiao
2. Veronica L. Li
3. Xuchao Lyu
4. Xudong Chen
5. Wei Wei
6. Fahim Abbasi
7. Joshua W. Knowles
8. Shuliang Deng
9. Gaurav Tiwari
10. Xu Shi
11. Shuning Zheng
12. Laurie Farrell
13. Zsu-Zsu Chen
14. Kent D. Taylor
15. Xiuqing Guo
16. Mark O. Goodarzi
17. Alexis C. Wood
18. Yii-Der Ida Chen
19. Leslie A. Lange
20. Stephen S. Rich
21. Jerome I. Rotter
22. Clary B. Clish
23. Usman A. Tahir
24. Robert E. Gerszten
25. Mark D. Benson
26. Jonathan Z. Long

Reviewed by PREreview

Binding and sequestration of poison frog alkaloids by a plasma globulin

1. Aurora Alvarez-Buylla
2. Marie-Therese Fischer
3. Maria Dolores Moya Garzon
4. Alexandra E Rangel
5. Elicio E Tapia
6. Julia T Tanzo
7. H Tom Soh
8. Luis A Coloma
9. Jonathan Z Long
10. Lauren A O'Connell

• Curated by eLife

  eLife assessment

  Poison frogs sequester alkaloids to make themselves toxic or unpalatable to predators, but how this sequestration occurs is not well understood. This valuable study identifies an alkaloid-binding protein in the plasma of poison frogs, which may help explain how these animals are able to sequester a diversity of alkaloids with different target sites. The supporting evidence is solid and the study adds to our understanding of how toxic animals resist the effects of their own defenses.

Reviewed by eLife, Arcadia Science

Inhibition of mammalian mtDNA transcription paradoxically activates liver fatty acid oxidation to reverse diet-induced hepatosteatosis and obesity

1. Shan Jiang
2. Taolin Yuan
3. Laura S Kremer
4. Florian A Rosenberger
5. Fynn M Hansen
6. Melissa Borg
7. Diana Rubalcava-Gracia
8. Mara Mennuni
9. Roberta Filograna
10. David Alsina
11. Jelena Misic
12. Camilla Koolmeister
13. Lipeng Ren
14. Olov Andersson
15. Anke Unger
16. Tim Bergbrede
17. Raffaella Di Lucrezia
18. Rolf Wibom
19. Juleen R Zierath
20. Anna Krook
21. Patrick Giavalisco
22. Matthias Mann
23. Nils-Göran Larsson

Reviewed by PREreview

Resistance exercise protects mice from protein-induced fat accretion

1. Michaela E Trautman
2. Leah N Braucher
3. Christian Elliehausen
4. Wenyuan G Zhu
5. Esther Zelenovskiy
6. Madelyn Green
7. Michelle M Sonsalla
8. Chung-Yang Yeh
9. Troy A Hornberger
10. Adam R Konopka
11. Dudley W Lamming

• Curated by eLife

  eLife assessment

  This study presents a valuable finding on relationship between high protein diet and resistance exercise on fat accumulation and glucose homeostasis. The evidence supporting the claims of the authors is solid, although inclusion of mechanistic insight would have strengthened the study. The work will be of interest to dietician and exercise biologists working to understand the synergy between diet and physical activity.

Reviewed by eLife

Effects of Aerobic Exercise in Hepatic Lipid Droplet-Mitochondria interaction in Non-alcoholic Fatty Liver Disease

1. Juan Carlos Bórquez
2. Francisco Díaz-Castro
3. Francisco Pino-de La Fuente
4. Karla Espinoza
5. Ana María Figueroa
6. Inma Martínez-Ruíz
7. Vanessa Hernández
8. Iliana López-Soldado
9. Raúl Ventura
10. Alejandra Espinosa
11. Víctor Cortés
12. María Isabel Hernández-Alvarez
13. Rodrigo Troncoso

Reviewed by preLights

Ryanodine receptor 2 inhibition reduces dispersion of cardiac repolarization, improves contractile function, and prevents sudden arrhythmic death in failing hearts

1. Pooja Joshi
2. Shanea Estes
3. Deeptankar DeMazumder
4. Bjorn C Knollmann
5. Swati Dey

• Curated by eLife

  eLife assessment

  This important study examined the use of dantrolene, a Ryanodine Receptor stabilizer, in slowing pathological progression of pressure-overload heart failure in a guinea pig model and reducing arrhythmias. Convincing data were collected and analyzed using validated methodology and can be used as a starting point for future studies of dantrolene in Ca2+ handling in ROS production and further deterioration of cardiac function in chronic heart failure.

Reviewed by eLife

Molecular tuning of sea anemone stinging

1. Lily S He
2. Yujia Qi
3. Corey AH Allard
4. Wendy A Valencia-Montoya
5. Stephanie P Krueger
6. Keiko Weir
7. Agnese Seminara
8. Nicholas W Bellono

• Curated by eLife

  eLife assessment

  This is an important paper that links distinctive stinging behavior of two related anemones occupying different ecological niches to varying inactivation properties of voltage-gated calcium channels conferred by auxiliary Cavβ subunits. Further convincing evidence is provided that these differences are mediated by alternative splicing of Cavβ subunit of the calcium channel. The study will be of interest to scientists studying Ca2+ signaling, ion channel biophysicists, and marine biologists.

Reviewed by eLife