Pathology

Isoform-specific mutation in Dystonin-b gene causes late-onset protein aggregate myopathy and cardiomyopathy

1. Nozomu Yoshioka
2. Masayuki Kurose
3. Masato Yano
4. Dang Minh Tran
5. Shujiro Okuda
6. Yukiko Mori-Ochiai
7. Masao Horie
8. Toshihiro Nagai
9. Ichizo Nishino
10. Shinsuke Shibata
11. Hirohide Takebayashi

• Curated by eLife

  Evaluation Summary:

  The authors demonstrate that isoform-specific Dystonin-b (Dst-b) mutant mice show significant myopathy in skeletal and cardiac muscle at older ages without the peripheral neuropathy or post-natal lethality that are commonly observed by loss of function of the DST gene. The study provides novel information about the role of the Dst-b isoform in maintaining skeletal and cardiac muscle health. In addition, the study suggests that isoform-specific mutations in Dst-b gene may cause some hereditary skeletal and cardiac myopathies.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Evolution of nasal and olfactory infection characteristics of SARS-CoV-2 variants

1. Mengfei Chen
2. Andrew Pekosz
3. Jason S. Villano
4. Wenjuan Shen
5. Ruifeng Zhou
6. Heather Kulaga
7. Zhexuan Li
8. Amy Smith
9. Asiana Gurung
10. Sarah E. Beck
11. Kenneth W. Witwer
12. Joseph L. Mankowski
13. Murugappan Ramanathan
14. Nicholas R. Rowan
15. Andrew P. Lane

Reviewed by ScreenIT

Dietary αKG inhibits SARS CoV-2 infection and rescues inflamed lungs to restore normal O ₂ saturation in animals

1. Sakshi Agarwal
2. Simrandeep Kaur
3. Tejeswara Rao Asuru
4. Garima Joshi
5. Nishith M Shrimali
6. Anamika Singh
7. Oinam Ningthemmani Singh
8. Puneet Srivastva
9. Tripti Shrivastava
10. Sudhanshu Vrati
11. Milan Surjit
12. Prasenjit Guchhait

Reviewed by ScreenIT

Influenza infection in ferrets with SARS-CoV-2 infection history

1. Caroline Vilas Boas de Melo
2. Florence Peters
3. Harry van Dijken
4. Stefanie Lenz
5. Koen van de Ven
6. Lisa Wijsman
7. Angéla Gommersbach
8. Tanja Schouten
9. Puck B. van Kasteren
10. van den Brand Judith
11. Jørgen de Jonge

Reviewed by ScreenIT

Proteasome dysfunction disrupts adipogenesis and induces inflammation via ATF3

1. Nienke Willemsen
2. Isabel Arigoni
3. Maja Studencka-Turski
4. Elke Krüger
5. Alexander Bartelt

Reviewed by Review Commons

Pericyte-mediated constriction of renal capillaries evokes no-reflow and kidney injury following ischaemia

1. Felipe Freitas
2. David Attwell

• Curated by eLife

  Evaluation Summary:

  This paper extends our understanding of blood flow regulation in the ischemic kidney and adds to a growing body of literature on the role played by pericyte contraction in the aftermath of ischemia/reperfusion (much of it based on the CNS microvasculature), and the potential of capillary pericytes as therapeutic targets in mitigating ischemia/reperfusion injury. This is an important study which should be of interest to a wide variety of investigators in vascular and renal biology.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife

SAMD1 Distribution Patterns in Mouse Atherosclerosis Models Suggest Roles in LDL Retention, Antigen Presentation, and Cell Phenotype Modulation

1. Bruce Campbell
2. Patricia Bourassa
3. Robert Aiello

Reviewed by PeerRef

Host and microbiome features of secondary infections in lethal covid-19

1. Martin Zacharias
2. Karl Kashofer
3. Philipp Wurm
4. Peter Regitnig
5. Moritz Schütte
6. Margit Neger
7. Sandra Ehmann
8. Leigh M. Marsh
9. Grazyna Kwapiszewska
10. Martina Loibner
11. Anna Birnhuber
12. Eva Leitner
13. Andrea Thüringer
14. Elke Winter
15. Stefan Sauer
16. Marion J. Pollheimer
17. Fotini R. Vagena
18. Carolin Lackner
19. Barbara Jelusic
20. Lesley Ogilvie
21. Marija Durdevic
22. Bernd Timmermann
23. Hans Lehrach
24. Kurt Zatloukal
25. Gregor Gorkiewicz

Reviewed by ScreenIT

Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression

1. Georgia M Cook
2. Katherine Brown
3. Pengcheng Shang
4. Yanhua Li
5. Lior Soday
6. Adam M Dinan
7. Charlotte Tumescheit
8. AP Adrian Mockett
9. Ying Fang
10. Andrew E Firth
11. Ian Brierley

• Curated by eLife

  Evaluation Summary:

  The paper presents the first comprehensive gene expression analysis of two species of porcine reproductive and respiratory syndrome virus (PRRSV), an arterivirus that causes economically important diseases of pigs. By applying ribosome profiling to arterivirus-infected cells the authors discovered a substantial number of efficiently translated open reading frames in viral RNAs and obtained compelling evidence of changes in ribosome frameshifting efficiencies over the course of infection. The paper is of interest to virologists and researchers studying mRNA decoding, recoding, and translation.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Rapid, high-throughput, cost-effective whole-genome sequencing of SARS-CoV-2 using a condensed library preparation of the Illumina DNA Prep kit

1. Rebecca Hickman
2. Jason Nguyen
3. Tracy D. Lee
4. John R. Tyson
5. Robert Azana
6. Frankie Tsang
7. Linda Hoang
8. Natalie A. Prystajecky

Reviewed by ScreenIT