Pathology

Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response

1. Edmée Eyraud
2. Elise Maurat
3. Jean-Marc Sac-Epée
4. Pauline Henrot
5. Maeva Zysman
6. Pauline Esteves
7. Thomas Trian
8. Jean-William Dupuy
9. Alexander Leipold
10. Antoine-Emmanuel Saliba
11. Hugues Begueret
12. Pierre-Olivier Girodet
13. Matthieu Thumerel
14. Romain Hustache-Castaing
15. Roger Marthan
16. Florian Levet
17. Pierre Vallois
18. Cécile Contin-Bordes
19. Patrick Berger
20. Isabelle Dupin

• Curated by eLife

  eLife assessment

  The manuscript by Eyraud and colleagues examines the role of interactions between fibrocytes and CD8 cells as drivers of disease progression in COPD (chronic obstructive pulmonary disease). The findings that there exist bidirectional interactions between CD8 cells and fibrocytes are supported by solid evidence that combines histology of clinical lung samples, in vitro studies obtained from circulating blood fibrocytes and CD8 cells, as well as a computational model that predicts how bidirectional interactions could promote disease progression over the course of 20 years. The study, which is based on patient samples, thus provides fundamental insights on COPD progression.

Reviewed by eLife

EPAC1 inhibition protects the heart from doxorubicin-induced toxicity

1. Marianne Mazevet
2. Anissa Belhadef
3. Maxance Ribeiro
4. Delphine Dayde
5. Anna Llach
6. Marion Laudette
7. Tiphaine Belleville
8. Philippe Mateo
9. Mélanie Gressette
10. Florence Lefebvre
11. Ju Chen
12. Christilla Bachelot-Loza
13. Catherine Rucker-Martin
14. Frank Lezoualch
15. Bertrand Crozatier
16. Jean-Pierre Benitah
17. Marie-Catherine Vozenin
18. Rodolphe Fischmeister
19. Ana-Maria Gomez
20. Christophe Lemaire
21. Eric Morel

• Curated by eLife

  eLife assessment

  This fundamental work substantially contributes to our understanding of the mechanisms underlying doxorubicin-induced cardiotoxicity. The evidence supporting the role of EPAC1 inhibition in this context is compelling, using rigorous molecular biology techniques. The work will be of broad interest to scientists and clinicians working in the field of oncology and cardiovascular medicine.

Reviewed by eLife

FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis

1. Cong Liu
2. Milena Schönke
3. Borah Spoorenberg
4. Joost M Lambooij
5. Hendrik JP van der Zande
6. Enchen Zhou
7. Maarten E Tushuizen
8. Anne-Christine Andreasson
9. Andrew Park
10. Stephanie Oldham
11. Martin Uhrbom
12. Ingela Ahlstedt
13. Yasuhiro Ikeda
14. Kristina Wallenius
15. Xiao-Rong Peng
16. Bruno Guigas
17. Mariëtte R Boon
18. Yanan Wang
19. Patrick CN Rensen

• Curated by eLife

  eLife assessment

  The authors present an important study of the effects of chronic hepatic FGF21 overexpression on the development of non-alcoholic steatohepatitis (NASH) in a model of obesity and dyslipidemia, i.e. ApoE3-Leiden CETP transgenic mice fed a western diet. NASH is a major global health problem and exogenous FGF21 treatment has been explored as a therapeutic strategy. The authors find that chronic overexpression of FGF21 blocks weight gain on the western diet, and even induces some weight loss compared to the control diet. The findings are convincing and methodologically sound.

Reviewed by eLife

Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts

1. Maxime RF Gosselin
2. Virginie Mournetas
3. Malgorzata Borczyk
4. Suraj Verma
5. Annalisa Occhipinti
6. Justyna Róg
7. Lukasz Bozycki
8. Michal Korostynski
9. Samuel C Robson
10. Claudio Angione
11. Christian Pinset
12. Dariusz C Gorecki

• Curated by eLife

  Evaluation Summary:

  This is an in-depth and rigorous analysis of transcriptomic changes in myogenic cells lacking dystrophin. Studies are made in both a mouse model and human subjects. the paper bears on possible roles of such alterations in pathogenesis of Duchenne muscular dystrophy. They draw attention to new therapeutic interventions for this condition.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Isoform-specific mutation in Dystonin-b gene causes late-onset protein aggregate myopathy and cardiomyopathy

1. Nozomu Yoshioka
2. Masayuki Kurose
3. Masato Yano
4. Dang Minh Tran
5. Shujiro Okuda
6. Yukiko Mori-Ochiai
7. Masao Horie
8. Toshihiro Nagai
9. Ichizo Nishino
10. Shinsuke Shibata
11. Hirohide Takebayashi

• Curated by eLife

  Evaluation Summary:

  The authors demonstrate that isoform-specific Dystonin-b (Dst-b) mutant mice show significant myopathy in skeletal and cardiac muscle at older ages without the peripheral neuropathy or post-natal lethality that are commonly observed by loss of function of the DST gene. The study provides novel information about the role of the Dst-b isoform in maintaining skeletal and cardiac muscle health. In addition, the study suggests that isoform-specific mutations in Dst-b gene may cause some hereditary skeletal and cardiac myopathies.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Evolution of nasal and olfactory infection characteristics of SARS-CoV-2 variants

1. Mengfei Chen
2. Andrew Pekosz
3. Jason S. Villano
4. Wenjuan Shen
5. Ruifeng Zhou
6. Heather Kulaga
7. Zhexuan Li
8. Amy Smith
9. Asiana Gurung
10. Sarah E. Beck
11. Kenneth W. Witwer
12. Joseph L. Mankowski
13. Murugappan Ramanathan
14. Nicholas R. Rowan
15. Andrew P. Lane

Reviewed by ScreenIT

Dietary αKG inhibits SARS CoV-2 infection and rescues inflamed lungs to restore normal O ₂ saturation in animals

1. Sakshi Agarwal
2. Simrandeep Kaur
3. Tejeswara Rao Asuru
4. Garima Joshi
5. Nishith M Shrimali
6. Anamika Singh
7. Oinam Ningthemmani Singh
8. Puneet Srivastva
9. Tripti Shrivastava
10. Sudhanshu Vrati
11. Milan Surjit
12. Prasenjit Guchhait

Reviewed by ScreenIT

Influenza infection in ferrets with SARS-CoV-2 infection history

1. Caroline Vilas Boas de Melo
2. Florence Peters
3. Harry van Dijken
4. Stefanie Lenz
5. Koen van de Ven
6. Lisa Wijsman
7. Angéla Gommersbach
8. Tanja Schouten
9. Puck B. van Kasteren
10. van den Brand Judith
11. Jørgen de Jonge

Reviewed by ScreenIT

Proteasome dysfunction disrupts adipogenesis and induces inflammation via ATF3

1. Nienke Willemsen
2. Isabel Arigoni
3. Maja Studencka-Turski
4. Elke Krüger
5. Alexander Bartelt

Reviewed by Review Commons

Pericyte-mediated constriction of renal capillaries evokes no-reflow and kidney injury following ischaemia

1. Felipe Freitas
2. David Attwell

• Curated by eLife

  Evaluation Summary:

  This paper extends our understanding of blood flow regulation in the ischemic kidney and adds to a growing body of literature on the role played by pericyte contraction in the aftermath of ischemia/reperfusion (much of it based on the CNS microvasculature), and the potential of capillary pericytes as therapeutic targets in mitigating ischemia/reperfusion injury. This is an important study which should be of interest to a wide variety of investigators in vascular and renal biology.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife