Pathology

Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans

1. Sharon E Fox
2. Aibek Akmatbekov
3. Jack L Harbert
4. Guang Li
5. J Quincy Brown
6. Richard S Vander Heide

Reviewed by ScreenIT

Optimize Clinical Laboratory Diagnosis of COVID-19 from Suspect Cases by Likelihood Ratio of SARS-CoV-2 IgM and IgG antibody

1. Feng Yangchun

Reviewed by ScreenIT

Plasma metabolomic and lipidomic alterations associated with COVID-19

1. Di Wu
2. Ting Shu
3. Xiaobo Yang
4. Jian-Xin Song
5. Mingliang Zhang
6. Chengye Yao
7. Wen Liu
8. Muhan Huang
9. Yuan Yu
10. Qingyu Yang
11. Tingju Zhu
12. Jiqian Xu
13. Jingfang Mu
14. Yaxin Wang
15. Hong Wang
16. Tang Tang
17. Yujie Ren
18. Yongran Wu
19. Shu-Hai Lin
20. Yang Qiu
21. Ding-Yu Zhang
22. You Shang
23. Xi Zhou

Reviewed by ScreenIT

Are pangolins the intermediate host of the 2019 novel coronavirus (SARS-CoV-2)?

1. Ping Liu
2. Jing-Zhe Jiang
3. Xiu-Feng Wan
4. Yan Hua
5. Linmiao Li
6. Jiabin Zhou
7. Xiaohu Wang
8. Fanghui Hou
9. Jing Chen
10. Jiejian Zou
11. Jinping Chen

Reviewed by ScreenIT

Pangolin homology associated with 2019-nCoV

1. Tao Zhang
2. Qunfu Wu
3. Zhigang Zhang

Reviewed by ScreenIT

Causes of death in newborn C57BL/6J mice

1. Sara Capas-Peneda
2. Gabriela Munhoz Morello
3. Sofia Lamas
4. I Anna S Olsson
5. Colin Gilbert

Reviewed by ScreenIT

Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response

1. Edmée Eyraud
2. Elise Maurat
3. Jean-Marc Sac-Epée
4. Pauline Henrot
5. Maeva Zysman
6. Pauline Esteves
7. Thomas Trian
8. Jean-William Dupuy
9. Alexander Leipold
10. Antoine-Emmanuel Saliba
11. Hugues Begueret
12. Pierre-Olivier Girodet
13. Matthieu Thumerel
14. Romain Hustache-Castaing
15. Roger Marthan
16. Florian Levet
17. Pierre Vallois
18. Cécile Contin-Bordes
19. Patrick Berger
20. Isabelle Dupin

• Curated by eLife

  eLife assessment

  The manuscript by Eyraud and colleagues examines the role of interactions between fibrocytes and CD8 cells as drivers of disease progression in COPD (chronic obstructive pulmonary disease). The findings that there exist bidirectional interactions between CD8 cells and fibrocytes are supported by solid evidence that combines histology of clinical lung samples, in vitro studies obtained from circulating blood fibrocytes and CD8 cells, as well as a computational model that predicts how bidirectional interactions could promote disease progression over the course of 20 years. The study, which is based on patient samples, thus provides fundamental insights on COPD progression.

Reviewed by eLife

EPAC1 inhibition protects the heart from doxorubicin-induced toxicity

1. Marianne Mazevet
2. Anissa Belhadef
3. Maxance Ribeiro
4. Delphine Dayde
5. Anna Llach
6. Marion Laudette
7. Tiphaine Belleville
8. Philippe Mateo
9. Mélanie Gressette
10. Florence Lefebvre
11. Ju Chen
12. Christilla Bachelot-Loza
13. Catherine Rucker-Martin
14. Frank Lezoualch
15. Bertrand Crozatier
16. Jean-Pierre Benitah
17. Marie-Catherine Vozenin
18. Rodolphe Fischmeister
19. Ana-Maria Gomez
20. Christophe Lemaire
21. Eric Morel

• Curated by eLife

  eLife assessment

  This fundamental work substantially contributes to our understanding of the mechanisms underlying doxorubicin-induced cardiotoxicity. The evidence supporting the role of EPAC1 inhibition in this context is compelling, using rigorous molecular biology techniques. The work will be of broad interest to scientists and clinicians working in the field of oncology and cardiovascular medicine.

Reviewed by eLife

FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis

1. Cong Liu
2. Milena Schönke
3. Borah Spoorenberg
4. Joost M Lambooij
5. Hendrik JP van der Zande
6. Enchen Zhou
7. Maarten E Tushuizen
8. Anne-Christine Andreasson
9. Andrew Park
10. Stephanie Oldham
11. Martin Uhrbom
12. Ingela Ahlstedt
13. Yasuhiro Ikeda
14. Kristina Wallenius
15. Xiao-Rong Peng
16. Bruno Guigas
17. Mariëtte R Boon
18. Yanan Wang
19. Patrick CN Rensen

• Curated by eLife

  eLife assessment

  The authors present an important study of the effects of chronic hepatic FGF21 overexpression on the development of non-alcoholic steatohepatitis (NASH) in a model of obesity and dyslipidemia, i.e. ApoE3-Leiden CETP transgenic mice fed a western diet. NASH is a major global health problem and exogenous FGF21 treatment has been explored as a therapeutic strategy. The authors find that chronic overexpression of FGF21 blocks weight gain on the western diet, and even induces some weight loss compared to the control diet. The findings are convincing and methodologically sound.

Reviewed by eLife

Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts

1. Maxime RF Gosselin
2. Virginie Mournetas
3. Malgorzata Borczyk
4. Suraj Verma
5. Annalisa Occhipinti
6. Justyna Róg
7. Lukasz Bozycki
8. Michal Korostynski
9. Samuel C Robson
10. Claudio Angione
11. Christian Pinset
12. Dariusz C Gorecki

• Curated by eLife

  Evaluation Summary:

  This is an in-depth and rigorous analysis of transcriptomic changes in myogenic cells lacking dystrophin. Studies are made in both a mouse model and human subjects. the paper bears on possible roles of such alterations in pathogenesis of Duchenne muscular dystrophy. They draw attention to new therapeutic interventions for this condition.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife