1. Enhancing Statistical Power While Maintaining Small Sample Sizes in Behavioral Neuroscience Experiments Evaluating Success Rates

    This article has 7 authors:
    1. Theo Desachy
    2. Marc Thevenet
    3. Samuel Garcia
    4. Anistasha Lightning
    5. Anne Didier
    6. Nathalie Mandairon
    7. Nicola Kuczewski

    Reviewed by Peer Community in Neuroscience

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  2. Local, calcium- and reward-based synaptic learning rule that enhances dendritic nonlinearities can solve the nonlinear feature binding problem

    This article has 4 authors:
    1. Zahra Khodadadi
    2. Daniel Trpevski
    3. Robert Lindroos
    4. Jeanette Hellgren Kotaleski
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This computational modeling study builds on multiple previous lines of experimental and theoretical research to investigate how a single neuron can solve a nonlinear pattern classification task. The revised manuscript presents convincing evidence that the location of synapses on dendritic branches, as well as synaptic plasticity of excitatory and inhibitory synapses, influences the ability of a neuron to discriminate combinations of sensory stimuli. The ideas in this work are very interesting, presenting an important direction in the computational neuroscience field about how to harness the computational power of "active dendrites" for solving learning tasks.

    Reviewed by eLife

    This article has 12 evaluationsAppears in 2 listsLatest version Latest activity
  3. Diffusion MRS tracks distinct trajectories of neuronal development in the cerebellum and thalamus of rat neonates

    This article has 6 authors:
    1. Clémence Ligneul
    2. Lily Qiu
    3. William T Clarke
    4. Saad Jbabdi
    5. Marco Palombo
    6. Jason P Lerch
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents a valuable investigation into cell-specific microstructural development in the neonatal rat brain using diffusion-weighted magnetic resonance spectroscopy. The evidence supporting the core claims is solid, with innovative in vivo data acquisition and modeling, noting residual caveats with regard to the limitations of diffusion-weighted magnetic resonance spectroscopy for strict validation of cell-type-specific metabolite compartmentation. In addition, the study provides community resources that will benefit researchers in this field. The work will be of interest to researchers studying brain development and biophysical imaging methods.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  4. Relative Timescale of Channel Voltage-Dependence and Channel Density Regulation Impacts Assembly and Recovery of Activity

    This article has 3 authors:
    1. Yugarshi Mondal
    2. Ronald L Calabrese
    3. Eve Marder
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important computational study investigates homeostatic plasticity mechanisms that neurons may employ to achieve and maintain stable target activity patterns. The work extends previous analyses of calcium-dependent homeostatic mechanisms based on ion channel density by considering activity-dependent shifts in channel activation and inactivation properties that operate on faster and potentially variable timescales. The model simulations convincingly demonstrate the potential functional importance of these mechanisms.

    Reviewed by eLife

    This article has 15 evaluationsAppears in 1 listLatest version Latest activity
  5. Afadin-deficient retinas exhibit severe neuronal lamination defects but preserve visual functions

    This article has 15 authors:
    1. Akiko Ueno
    2. Konan Sakuta
    3. Hiroki Ono
    4. Aki Hashio
    5. Haruki Tokumoto
    6. Mikiya Watanabe
    7. Taketo Nishimoto
    8. Toru Konishi
    9. Yuki Emori
    10. Shunsuke Mizuno
    11. Mao Hiratsuka
    12. Jun Miyoshi
    13. Yoshimi Takai
    14. Masao Tachibana
    15. Chieko Koike
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study demonstrates that conditional knockout of afadin disrupts retinal laminar organization and reduces the number of photoreceptors, while preserving certain aspects of retinal ganglion cell structure and light responsiveness. The work is valuable and well-supported by revised figures and comprehensive data on retinal cell types, lamination patterns, and visual functio. The findings are solid and intriguing, and the study provides insights into the relationship between retinal lamination and neural circuit function.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  6. Progressive overfilling of readily releasable pool underlies short-term facilitation at recurrent excitatory synapses in layer 2/3 of the rat prefrontal cortex

    This article has 4 authors:
    1. Jiwoo Shin
    2. Seung Yeon Lee
    3. Yujin Kim
    4. Suk-Ho Lee
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable work explores how synaptic activity encodes information during memory tasks. All reviewers agree that the work is of very high quality and that the methodological approach is praiseworthy. Although the experimental data support the possibility that phospholipase diacylglycerol signaling and synaptotagmin 7 (Syt7) dynamically regulate the vesicle pool required for presynaptic release, a concern remains that the central finding of paired-pulse depression at very short intervals could be due to a mechanism that does not depend on exocytosis, such as Ca²⁺ channel inactivation, rather than vesicle pool depletion. Overall, this is a solid study although the results still warrant consideration of alternative interpretations.

    Reviewed by eLife

    This article has 16 evaluationsAppears in 1 listLatest version Latest activity
  7. Auditory perception and neural representation of temporal features are altered by age but not by cochlear synaptopathy

    This article has 5 authors:
    1. Friederike Steenken
    2. Rainer Beutelmann
    3. Henning Oetjen
    4. Christine Köppl
    5. Georg M Klump
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study tested the specific hypothesis that age-related changes to hearing involve a partial loss of synapse connections between sensory cells in the ear and the nerve fibers that carry information about sounds to the brain, and that this interferes with the ability to discriminate rapid temporal fluctuations in sounds. Physiological, behavioral, and histological analyses provide a powerful combination to test this hypothesis in gerbils. Contrary to previous suggestions, it was found that chemically-induced isolated synaptopathy (at similar levels as observed in aged gerbils) did not result in worse performance on a behavioral task measuring sensitivity to temporal fine-structure, nor did it produce degradations in auditory-nerve fiber encoding of fine structure. Aged gerbils showed degraded behavior and stronger than normal envelope responses, but temporal fine-structure coding was not affected; interpreted by the authors as suggesting central processing contributions to aging effects on discrimination. These findings are important for advancing our knowledge of the mechanistic bases for age-related changes to hearing, and the evidence provided is solid with the results largely supporting the claims made and minor limitations related to possible confounds discussed in reasonable depth.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  8. Local synthesis of Reticulon-1C lessens the outgrowth of injured axons and Spastin activity

    This article has 22 authors:
    1. Alejandro Luarte
    2. Javiera Gallardo
    3. Daniela Corvalán
    4. Ankush Chakraborty
    5. Cláudio Gouveia-Roque
    6. Francisca Bertin
    7. Carlos Contreras
    8. Juan Pablo Ramírez
    9. André Weber
    10. Waldo Acevedo
    11. Werner Zuschratter
    12. Rodrigo Herrera-Molina
    13. Úrsula Wyneken
    14. Andrea Paula-Lima
    15. Tatiana Adasme-Rocha
    16. Jorge Toledo
    17. Rodrigo Vergara
    18. Antonia Figueroa
    19. Carolina González
    20. Christian González-Billault
    21. Ulrich Hengst
    22. Andrés Couve

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. The gut-brain vagal axis governs mesolimbic dopamine dynamics and reward events

    This article has 16 authors:
    1. Oriane Onimus
    2. Faustine Arrivet
    3. Tinaïg Le Borgne
    4. Sylvie Perez
    5. Julien Castel
    6. Anthony Ansoult
    7. Benoit Bertrand
    8. Nejmeh Mashhour
    9. Camille de Almeida
    10. Linh-Chi Bui
    11. Marie Vandecasteele
    12. Serge Luquet
    13. Laurent Venance
    14. Nicolas Heck
    15. Fabio Marti
    16. Giuseppe Gangarossa

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  10. Rhythmic Sampling and Competition of Target and Distractor in a Motion Detection Task

    This article has 6 authors:
    1. Changhao Xiong
    2. Nathan M Petro
    3. Ke Bo
    4. Lihan Cui
    5. Andreas Keil
    6. Mingzhou Ding
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This work presents important information on rhythmicity of overlapping target and distractor processing and how this affects behaviour. The methods are, in general, clearly laid out and defensible, with several supplementary analyses leading to a solid base of evidence for their claims.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
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