1. Afadin-deficient retinas exhibit severe neuronal lamination defects but preserve visual functions

    This article has 15 authors:
    1. Akiko Ueno
    2. Konan Sakuta
    3. Hiroki Ono
    4. Aki Hashio
    5. Haruki Tokumoto
    6. Mikiya Watanabe
    7. Taketo Nishimoto
    8. Toru Konishi
    9. Yuki Emori
    10. Shunsuke Mizuno
    11. Mao Hiratsuka
    12. Jun Miyoshi
    13. Yoshimi Takai
    14. Masao Tachibana
    15. Chieko Koike
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study demonstrates that conditional knockout of afadin disrupts retinal laminar organization and reduces the number of photoreceptors, while preserving certain aspects of retinal ganglion cell structure and light responsiveness. The work is valuable and well-supported by revised figures and comprehensive data on retinal cell types, lamination patterns, and visual functio. The findings are solid and intriguing, and the study provides insights into the relationship between retinal lamination and neural circuit function.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  2. Progressive overfilling of readily releasable pool underlies short-term facilitation at recurrent excitatory synapses in layer 2/3 of the rat prefrontal cortex

    This article has 4 authors:
    1. Jiwoo Shin
    2. Seung Yeon Lee
    3. Yujin Kim
    4. Suk-Ho Lee
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable work explores how synaptic activity encodes information during memory tasks. All reviewers agree that the work is of very high quality and that the methodological approach is praiseworthy. Although the experimental data support the possibility that phospholipase diacylglycerol signaling and synaptotagmin 7 (Syt7) dynamically regulate the vesicle pool required for presynaptic release, a concern remains that the central finding of paired-pulse depression at very short intervals could be due to a mechanism that does not depend on exocytosis, such as Ca²⁺ channel inactivation, rather than vesicle pool depletion. Overall, this is a solid study although the results still warrant consideration of alternative interpretations.

    Reviewed by eLife

    This article has 16 evaluationsAppears in 1 listLatest version Latest activity
  3. Auditory perception and neural representation of temporal features are altered by age but not by cochlear synaptopathy

    This article has 5 authors:
    1. Friederike Steenken
    2. Rainer Beutelmann
    3. Henning Oetjen
    4. Christine Köppl
    5. Georg M Klump
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study tested the specific hypothesis that age-related changes to hearing involve a partial loss of synapse connections between sensory cells in the ear and the nerve fibers that carry information about sounds to the brain, and that this interferes with the ability to discriminate rapid temporal fluctuations in sounds. Physiological, behavioral, and histological analyses provide a powerful combination to test this hypothesis in gerbils. Contrary to previous suggestions, it was found that chemically-induced isolated synaptopathy (at similar levels as observed in aged gerbils) did not result in worse performance on a behavioral task measuring sensitivity to temporal fine-structure, nor did it produce degradations in auditory-nerve fiber encoding of fine structure. Aged gerbils showed degraded behavior and stronger than normal envelope responses, but temporal fine-structure coding was not affected; interpreted by the authors as suggesting central processing contributions to aging effects on discrimination. These findings are important for advancing our knowledge of the mechanistic bases for age-related changes to hearing, and the evidence provided is solid with the results largely supporting the claims made and minor limitations related to possible confounds discussed in reasonable depth.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  4. Local synthesis of Reticulon-1C lessens the outgrowth of injured axons and Spastin activity

    This article has 22 authors:
    1. Alejandro Luarte
    2. Javiera Gallardo
    3. Daniela Corvalan
    4. Ankush Chakraborty
    5. Claudio Gouveia-Roque
    6. Francisca Bertin
    7. Carlos Contreras
    8. Juan Pablo Ramirez
    9. Andre Weber
    10. Waldo Acevedo
    11. Werner Zuschratter
    12. Rodrigo Herrera
    13. Ursula Wyneken
    14. Andrea Paula Lima
    15. Tatiana Adasme
    16. Antonia Figueroa
    17. Carolina Gonzalez
    18. Rodrigo Vergara
    19. Christian Gonzalez-Billault
    20. Jorge Toledo
    21. Ulrich Hengst
    22. Andres Couve

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. The gut-brain vagal axis governs mesolimbic dopamine dynamics and reward events

    This article has 16 authors:
    1. Oriane Onimus
    2. Faustine Arrivet
    3. Tinaïg Le Borgne
    4. Sylvie Perez
    5. Julien Castel
    6. Anthony Ansoult
    7. Benoit Bertrand
    8. Nejmeh Mashhour
    9. Camille de Almeida
    10. Linh-Chi Bui
    11. Marie Vandecasteele
    12. Serge Luquet
    13. Laurent Venance
    14. Nicolas Heck
    15. Fabio Marti
    16. Giuseppe Gangarossa

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  6. Rhythmic Sampling and Competition of Target and Distractor in a Motion Detection Task

    This article has 6 authors:
    1. Changhao Xiong
    2. Nathan M Petro
    3. Ke Bo
    4. Lihan Cui
    5. Andreas Keil
    6. Mingzhou Ding
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This work presents important information on rhythmicity of overlapping target and distractor processing and how this affects behaviour. The methods are, in general, clearly laid out and defensible, with several supplementary analyses leading to a solid base of evidence for their claims.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  7. Realistic coupling enables flexible macroscopic traveling waves in the mouse cortex

    This article has 4 authors:
    1. Guanhua Sun
    2. James Hazelden
    3. Ruby Kim
    4. Daniel B Forger
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable work presents a novel computational framework for modeling macroscopic traveling waves in the mouse cortex by integrating open-source connectomic and transcriptomic data into a spiking network model. This approach allows the computational model to assign excitatory/inhibitory connections based on neurotransmitter profiles and extends simulations to the 3D domain. The authors present results that demonstrate how spatiotemporal dynamics such as slow oscillations (0.5-4 Hz) emerge and self-organize at the whole-brain scale. This study provides convincing initial insights into the structural basis of traveling waves at the whole-brain scale in the mouse.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  8. Adrenomedullin restores human cortical interneurons migration defects induced by hypoxia

    This article has 14 authors:
    1. Alyssa Puno
    2. Wojciech M Michno
    3. Li Li
    4. Amanda Everitt
    5. Kate McCluskey
    6. Saw Htun
    7. Dhriti Nagar
    8. Jong Bin Choi
    9. Yuqin Dai
    10. Seyeon Park
    11. Emily Gurwitz
    12. Jeremy Willsey
    13. Fikri Birey
    14. Anca M Pasca
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this manuscript, the authors investigate the migration of human cortical interneurons under hypoxic conditions using forebrain assembloids and developing human brain tissue, and probe the underlying mechanisms. The study provides the first direct evidence that hypoxia delays interneuron migration and identifies adrenomedullin (ADM) as a potential therapeutic intervention. The findings are important, and the conclusions are convincingly supported by experimental evidence.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. Cortical projection neurons with distinct axonal connectivity employ ribosomal complexes with distinct protein compositions

    This article has 4 authors:
    1. Tien Phuoc Tran
    2. Bogdan Budnik
    3. John E. Froberg
    4. Jeffrey D. Macklis
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents a valuable and rigorous molecular resource, offering subtype-specific insight into the composition of ribosome-associated protein complexes in the developing cerebral cortex. The evidence is compelling in terms of data quality and is strongly supported by the results, given the rigorous technical execution. However, the findings remain primarily descriptive, as the study lacks functional validation to support mechanistic conclusions.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  10. Identification of low copy synaptic glycine receptors in the mouse brain using single molecule localisation microscopy

    This article has 6 authors:
    1. Serena Camuso
    2. Yana Vella
    3. Souad Youjil Abadi
    4. Clémence Mille
    5. Bert Brône
    6. Christian G Specht

    Reviewed by Review Commons

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
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