1. Humans adapt rationally to approximate estimates of uncertainty

    This article has 2 authors:
    1. Erdem Pulcu
    2. Michael Browning
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study makes an important contribution by showing that humans adapt learning rates rationally to environmental volatility yet systematically misattribute noise as volatility, demonstrating approximate rationality with simplified internal models. The evidence is compelling, encompassing a cleverly designed volatility-versus-noise paradigm, innovative lesion-based comparisons between reinforcement-learning and degraded Bayesian Observer Models, and convergent behavioural and pupillometric data. Expanding formal model comparisons (e.g., BIC/AIC) and directly contrasting RL and Bayesian fits to physiological markers would further enhance the work, but these are minor limitations that do not detract from the core findings.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  2. The NIH BRAIN Initiative’s Impacts in Systems and Computational Neuroscience and Team-Scale Research, 2014-2023

    This article has 8 authors:
    1. Farah Bader
    2. Clayton Bingham
    3. Karen K. David
    4. Hermon Gebrehiwet
    5. Crystal Lantz
    6. Grace C.Y. Peng
    7. Mauricio Rangel-Gomez
    8. James Gnadt
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors provide a convincing summary of ten years of Brain Initiative funding including the historical development, the specific funding mechanisms, and examples of grants funded and work produced. It is particularly valuable at this moment in history, given the cataclysmic changes in the US government structure and function occurring in early 2025.

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    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  3. FMRP Regulates Neuronal RNA Granules Containing Stalled Ribosomes, Not Where Ribosomes Stall

    This article has 7 authors:
    1. Jewel T-Y Li
    2. Mehdi Amiri
    3. Senthilkumar Kailasam
    4. Jingyu Sun
    5. Nahum Sonenberg
    6. Joaquin Ortega
    7. Wayne S Sossin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Based on several lines of interesting data, the authors conclude that FMRP, though associated with stalled ribosomes, does not determine the position on the mRNAs at which ribosomes stall. Although this conclusion would be valuable if clearly established, the current set of data are incomplete and it is unclear if the methodologies applied in this paper are fully adequate to address this gap.

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    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  4. Stimulus-specificity of surround-induced responses in primary visual cortex

    This article has 8 authors:
    1. Nisa Cuevas
    2. Boris Sotomayor-Gómez
    3. Athanasia Tzanou
    4. Irene Onorato
    5. Brian Rummell
    6. Cem Uran
    7. Ana Broggini
    8. Martin Vinck
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study investigates the selectivity of neuronal responses in the neocortex and thalamus to visual stimuli presented far outside their receptive fields. The study shows convincing evidence for a long-latency surround-induced response in primary visual cortex that is absent in the dorsal lateral geniculate nucleus and does not depend strongly on the visual characteristics of the surround stimulus. The paper should be of interest to neurophysiologists interested in vision and contextual modulations.

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    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  5. Brain-derived estrogens facilitate male-typical behaviors by potentiating androgen receptor signaling in medaka

    This article has 11 authors:
    1. Yuji Nishiike
    2. Shizuku Maki
    3. Daichi Miyazoe
    4. Kiyoshi Nakasone
    5. Yasuhiro Kamei
    6. Takeshi Todo
    7. Tomoko Ishikawa-Fujiwara
    8. Kaoru Ohno
    9. Takeshi Usami
    10. Yoshitaka Nagahama
    11. Kataaki Okubo
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is an overall valuable set of findings on the role of centrally produced estrogens in the control of behaviors in male and female medaka. The significance of the findings rests on the revealed potential mechanism between brain derived estrogens modulating social behaviors in males as well as females. The results are supported by the analysis of multiple transgenic lines although the evidence is incomplete, and further validation would be necessary to fully validate the conclusions on the role of brain-derived estrogens. Nonetheless, the findings have led to helpful hypotheses on the hormonal control of behaviors in teleosts that can be tested further.

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    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  6. Dual-format attentional template during preparation in human visual cortex

    This article has 5 authors:
    1. Yilin Chen
    2. Taosheng Liu
    3. Ke Jia
    4. Jan Theeuwes
    5. Mengyuan Gong
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      By combining the 'pinging' technique with fMRI-based multivariate pattern analysis, this important study provides convincing evidence for a dual-format of attentional representation during preparatory period. The result reconciles the competing views between the sensory-like versus non-sensory accounts of attentional template and advances our understanding of how the brain flexibly utilizes different versions of template to guide attention. This work will be of interest to researchers in psychology, vision science, and cognitive science.

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    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  7. Increased listening effort and cochlear neural degeneration underlie behavioral deficits in speech perception in noise in normal hearing middle-aged adults

    This article has 11 authors:
    1. Maggie E Zink
    2. Leslie Zhen
    3. Jacie R McHaney
    4. Jennifer Klara
    5. Kimberly Yurasits
    6. Victoria Cancel
    7. Olivia Flemm
    8. Claire Mitchell
    9. Jyotishka Datta
    10. Bharath Chandrasekaran
    11. Aravindakshan Parthasarathy
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study aims to clarify the effects of cochlear neural degeneration on auditory processing in listeners with normal audiograms (sometimes referred to as 'hidden hearing loss'). The authors provide important new data demonstrating associations between cochlear neural degeneration, non-invasive assays of auditory processing, and speech perception. Based on a cross-species comparison, the findings pose compelling evidence that cochlear synaptopathy is associated with a significant part of hearing difficulties in complex environments.

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    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  8. Sexual Failure Decreases Sweet Taste Perception in Male Drosophila via Dopaminergic Signaling

    This article has 4 authors:
    1. Gaohang Wang
    2. Wei Qi
    3. Rui Huang
    4. Liming Wang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides valuable findings on the effects of mating experience on sweet taste perception. The data as presented provide convincing evidence that the dopaminergic signaling-mediated reward system underlies this mating state-dependent behavioral modulation. The work will interest neuroscientists and particularly biologists working on neuromodulation and the effects of internal states on sensory perception.

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    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  9. Inhibitory basal ganglia nuclei differentially innervate pedunculopontine nucleus subpopulations and evoke differential motor and valence behaviors

    This article has 5 authors:
    1. Michel Fallah
    2. Kenea C Udobi
    3. Aleksandra E Swiatek
    4. Chelsea B Scott
    5. Rebekah C Evans
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Fallah et al carefully dissect projections from substantia nigra pars reticulata (SNr) and the globus pallidus externa (GPe) - two key basal ganglia nuclei - to the pedunculopontine nucleus (PPN), a brainstem nucleus that has a central role in motor control. They consider inputs from these two areas onto three types of downstream PPN neurons - GABAergic, glutamatergic, and cholinergic neurons - and carefully map connectivity along the rostrocaudal axis of the PPN. Overall, this important study provides convincing data on PPN connectivity with two key input structures that will provide a basis for further understanding PPN function.

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    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  10. Learning Place Cells and Remapping by Decoding the Cognitive Map

    This article has 4 authors:
    1. Markus Borud Pettersen
    2. Vemund Sigmundson Schøyen
    3. Anders Malthe-Sørenssen
    4. Mikkel Elle Lepperød
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This useful modeling study shows how spatial representations similar to experiment emerge in a recurrent neural network trained on a navigation task by requiring path integration and decodability, but without relying on grid cells. The network modeling results are solid, although the link to experimental data may benefit from further development.

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    This article has 14 evaluationsAppears in 1 listLatest version Latest activity
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