Neuroscience

Brain-derived estrogens facilitate male-typical behaviors by potentiating androgen receptor signaling in medaka

1. Yuji Nishiike
2. Shizuku Maki
3. Daichi Miyazoe
4. Kiyoshi Nakasone
5. Yasuhiro Kamei
6. Takeshi Todo
7. Tomoko Ishikawa-Fujiwara
8. Kaoru Ohno
9. Takeshi Usami
10. Yoshitaka Nagahama
11. Kataaki Okubo

• Curated by eLife

  eLife Assessment

  This is an overall compelling set of findings on the role of centrally produced estrogens in the control of behaviors in male medaka. The significance of the findings rests on the revealed potential mechanism between brain derived estrogens modulating social behaviors in males , supported by the analysis of multiple transgenic lines. The evidence for the broader claim is incomplete since it has not been extended to female medaka, and further experimentation would be necessary to fully validate the conclusions on the role of brain-derived estrogens. Nonetheless, the findings have led to important hypotheses on the hormonal control of behaviors in teleosts that can be tested further.

Reviewed by eLife

Odour representations supporting ethology-relevant categorisation and discrimination in the Drosophila mushroom body

1. Ivy Chi Wai Chan
2. Felipe Yaroslav Kalle Kossio
3. Gaia Tavosanis

Reviewed by PREreview

Imaging cellular activity simultaneously across all organs of a vertebrate reveals body-wide circuits

1. Virginia M. S. Ruetten
2. Wei Zheng
3. Igor Siwanowicz
4. Brett D. Mensh
5. Mark Eddison
6. Amy Hu
7. Yunfeng Chi
8. Andrew L. Lemire
9. Caiying Guo
10. Mykola Kadobianskyi
11. Marc Renz
12. Sara Lelek-Greskovic
13. Yisheng He
14. Kari Close
15. Gudrun Ihrke
16. Mariela D. Petkova
17. Michael Cook
18. Christopher J. Knecht
19. Aparna Dev
20. Alyson Petruncio
21. Yinan Wan
22. Jeff W. Lichtman
23. Florian Engert
24. Mark C. Fishman
25. Benjamin Judkewitz
26. Mikail Rubinov
27. Philipp J. Keller
28. Chie Satou
29. Guoqiang Yu
30. Paul W. Tillberg
31. Maneesh Sahani
32. Misha B. Ahrens

Reviewed by preLights

Context rescales a social action code in a hormone-sensitive network

1. Eartha Mae Guthman
2. Jorge M. Iravedra-Garcia
3. Lucy Sirrs
4. Alissa Le
5. Annegret L. Falkner

Reviewed by PREreview

Multiplexing behavioral signals in sensory representations

1. Julia M. Mayer
2. Wiktor F. Młynarski

Reviewed by PREreview

Single molecule counting detects low-copy glycine receptors in hippocampal and striatal synapses

1. Serena Camuso
2. Yana Vella
3. Souad Youjil Abadi
4. Clémence Mille
5. Bert Brône
6. Christian G Specht

• Curated by eLife

  eLife Assessment

  The study presents convincing quantitative evidence, supported by appropriate negative controls, for the presence of low-abundance glycine receptors (GlyRs) within inhibitory synapses in telencephalic regions of the mouse brain. Using sensitive single-molecule localization microscopy of endogenously tagged GlyRs, the authors reveal previously undetected populations of these receptors. Although the functional significance of these low-abundance GlyRs remains to be established, the findings offer valuable insights and methodologies that will be of interest to neuroscientists studying inhibitory synapse biology.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Two classes of amine/glutamate multi-transmitter neurons innervate Drosophila internal male reproductive organs

1. Martha Chaverra
2. John Paul Toney
3. Lizetta D Dardenne-Ankringa
4. Jace Tolleson Knee
5. Ann R Morris
6. Joseph B Wadhams
7. Sarah J Certel
8. R Steven Stowers

• Curated by eLife

  eLife Assessment

  This important study characterizes with rigorous methodology anatomical and functional aspects of the peripheral innervation of the Drosophila male reproductive tract. The convincing analysis reveals two distinct types of glutamatergic neurons that co-release either serotonin or octopamine. While serotonergic neurons are required for male fertility, octopaminergic neurons are dispensable. The work is providing invaluable insight into neurochemical control of insemination, peripheral motor control and neuromodulation in the male reproductive tract.

Reviewed by eLife

Affinity-guided labeling reveals P2X7 nanoscale membrane redistribution during BV2 microglial activation

1. Benoit Arnould
2. Adeline Martz
3. Pauline Belzanne
4. Francisco Andrés Peralta
5. Federico Cevoli
6. Volodya Hovhannisyan
7. Yannick Goumon
8. Eric Hosy
9. Alexandre Specht
10. Thomas Grutter

• Curated by eLife

  eLife Assessment

  The authors employ an unbiased, affinity-guided reagent to label P2X7 receptor and use super-resolution imaging to monitor P2X7 redistribution in response to inflammatory signaling. The evidence is convincing and the study will be valuable to those studying the dynamics of receptor distribution and clustering.

Reviewed by eLife

Local Inhibitory Dynamics Underpin Temporal Integration and Functional Segregation between Barrels and Septa in the Mouse Barrel Cortex

1. Ali Özgür Argunşah
2. Tevye Jason Stachniak
3. Jenq-Wei Yang
4. Linbi Cai
5. Alexander van der Bourg
6. Rahel Kastli
7. Theofanis Karayannis

• Curated by eLife

  eLife Assessment

  Argunşah et al. investigate the mechanisms underlying the differential response dynamics of barrel vs septa domains in shaping the responses to single vs multiple whiskers. Based on the observation of a higher density of SST+ interneurons in the septa, the authors investigate the hypothesis that Elfn1-dependent short-term plasticity shapes these responses. This important study is, however, supported by incomplete evidence; factors restricting the strength of evidence are the limited spatial resolution of the multi-unit activity, as well as the lack of a mechanistic explanation. This provocative and intellectually stimulating hypothesis provides a contribution to work on how different cell types shape cortical representation.

Reviewed by eLife

Neural basis of cognitive control signals in anterior cingulate cortex during delay discounting

1. Jeremy K Seamans
2. Shelby White
3. Mitchell Morningstar
4. Eldon Emberly
5. David Linsenbardt
6. Baofeng Ma
7. Cristine L Czachowski
8. Christopher C Lapish

• Curated by eLife

  eLife Assessment

  The authors studied cognitive control signals in the anterior cingulate cortex (ACC) while rats selected between small immediate and larger delayed rewards. The description of behavioral strategies related to value-tracking signals in ACC is potentially useful. The evidence in support of this finding is incomplete due to issues with the task design, analyses, and modeling.

Reviewed by eLife