Neuroscience

High affinity cross-context cellular assays reveal novel protein-protein interactions of peripheral myelin protein of 22 kDa

1. D Stausberg
2. S Moshkovskii
3. FA Arlt
4. R Fledrich
5. RM Stassart
6. KA Nave
7. H Urlaub
8. D Ewers
9. MW Sereda

Reviewed by Review Commons

Hierarchical Neural Circuit Theory of Normalization and Inter-areal Communication

1. Asit Pal
2. Shivang Rawat
3. David J Heeger
4. Stefano Martiniani

• Curated by eLife

  eLife Assessment

  This important study extends a model of cortical normalization (ORGaNICs) to interacting cortical areas and shows that communication through coherence and communication subspaces can arise from a single set of dynamics. The evidence is convincing, showing analytically that contrast-dependent gamma dynamics and a low-dimensional inter-areal communication subspace arise from one parameter set. The work will interest neuroscientists and theorists concerned with inter-areal communication, cortical oscillations, and divisive normalization.

Reviewed by eLife

Pallium tracks valence-specific chemosensory amplification of eye-body coordination in larval zebrafish

1. Samuel KH Sy
2. Danny CW Chan
3. Jenny J Zhang
4. Jing Lyu
5. Crystal Feng
6. Kui Wang
7. Vincent CT Mok
8. Kenneth KY Wong
9. Yu Mu
10. Yu Hu
11. Ho Ko

• Curated by eLife

  eLife Assessment

  Using their unique Fish-On-Chips optofluidics platform, the authors make three important findings: the presence of precise coupling between saccades and tail flips can be used to discriminate between turning or gliding behaviours; aversive and appetitive chemosensory cues differentially modulate these behaviours; transformation from cue valence to behaviour is encoded by the pallium. The evidence supporting these findings is solid. The work advances our understanding of the ancient interplay between chemosensation and motor output through the modulation of eye-body coordination.

Reviewed by eLife

Enhancer-AAVs allow genetic access to oligodendrocytes and diverse populations of astrocytes across species

1. John K Mich
2. Smrithi Sunil
3. Nelson Johansen
4. Refugio A Martinez
5. Jiatai Liu
6. Bryan B Gore
7. Joseph T Mahoney
8. Mckaila Leytze
9. Yoav Ben-Simon
10. Darren Bertagnolli
11. Ravi Bhowmik
12. Yemeserach Bishaw
13. Krissy Brouner
14. Jazmin Campos
15. Ryan Canfield
16. Tamara Casper
17. Nicholas P Donadio
18. Nadezhda I Dotson
19. Tom Egdorf
20. Amanda Gary
21. Shane Gibson
22. Jeff Goldy
23. Erin L Groce
24. Kenta M Hagihara
25. Daniel Hirschstein
26. Han Hou
27. Will D Laird
28. Elizabeth Liang
29. Luke V Loftus
30. Nicholas Lusk
31. Jocelin Malone
32. Naomi X Martin
33. Deja Monet
34. Josh S Nagra
35. Dakota Newman
36. Nhan-Kiet Ngo
37. Paul A Olsen
38. Victoria Omstead
39. Ximena Opitz-Araya
40. Aaron Oster
41. Christina A Pom
42. Lydia Potekhina
43. Melissa Reding
44. Christine Rimorin
45. Augustin Ruiz
46. Adriana E Sedeño-Cortés
47. Nadiya V Shapovalova
48. Michael Taormina
49. Naz Taskin
50. Michael Tieu
51. Nasmil J Valera Cuevas
52. Sharon W Way
53. Natalie Weed
54. Vonn Wright
55. Zizhen Yao
56. Thomas Zhou
57. Delissa A McMillen
58. Michael Kunst
59. Medea McGraw
60. Bargavi Thyagarajan
61. Jack Waters
62. Trygve E Bakken
63. Nick Dee
64. Shenqin Yao
65. Kimberly A Smith
66. Karel Svoboda
67. Kaspar Podgorski
68. Yoshiko Kojima
69. Greg D Horwitz
70. Hongkui Zeng
71. Tanya L Daigle
72. Ed S Lein
73. Bosiljka Tasic
74. Jonathan T Ting
75. Boaz P Levi

• Curated by eLife

  eLife Assessment

  This important study presents convincing findings on creating an exhaustive library of new enhancer-AAVs targeting astrocytes and oligodendrocytes with high potential for both basic and translational work, which will be of value to a large and growing community. The revisions appropriately addressed some of the previous concerns by updating description of glial biology in the Introduction and modifying text on experimental results and approaches. Overall, these amendments have strengthened the claims. The work will be of interest to neuroscientists working on glial cell biology.

Reviewed by eLife

Neural Representation of Associative Threat Learning in Pulvinar Divisions, Lateral Geniculate Nucleus, and Mediodorsal Thalamus in Humans

1. Muhammad Badarnee
2. Zhenfu Wen
3. B Isabel Moallem
4. Stephen Maren
5. Mohammed R Milad

• Curated by eLife

  eLife Assessment

  This study provides valuable insights into the role of thalamic nuclei in associative threat and extinction learning, underpinned by a large dataset and rigorous, multipronged analyses. The evidence provided is solid, supporting the main conclusions. The manuscript will be of broad interest to researchers in learning and memory, fear, thalamic circuitry, and related mental health conditions.

Reviewed by eLife

Synaptic Organization of Surface AMPARs Changes by Brain Region and Tauopathy

1. Rohit M Vaidya
2. Jiahao Zhang
3. Duncan Nall
4. Rujuta Pendharkar
5. Yongjae Lee
6. Eung Chang Kim
7. Donghan Ma
8. Fang Huang
9. Hiroshi Nonaka
10. Shigeki Kiyonaka
11. Itaru Hamachi
12. Hee Jung Chung
13. Paul R Selvin

• Curated by eLife

  eLife Assessment

  This is an important study that establishes a novel and enabling 3D super-resolution imaging approach for visualizing the nanoscale organization of AMPA receptors in thick mouse brain tissue. The biological findings are of importance and interest to the neuroscience field, with potential implications for neurodegenerative disease research. However, the evidence remains incomplete and some of the biological conclusions would benefit from strengthened quantitative analysis and revisions to the manuscript to ensure that the interpretations are appropriately aligned with what is supported by the analysis.

Reviewed by eLife

Single neurons detect spatiotemporal activity transitions through STP and EI imbalance

1. Aditya Asopa
2. Upinder Singh Bhalla

• Curated by eLife

  eLife Assessment

  This valuable study examines excitation/inhibition (E/I) balance in the CA3-CA1 circuit of the hippocampus, yielding results that suggest a way in which CA1 neurons can perform mismatch detection. A combination of experimental and computational modeling results are presented and supported by solid evidence. The results are likely to be of interest to researchers who study computations in the hippocampal circuit.

Reviewed by eLife

Individual Taste Preferences Predict Cortical Taste Dynamics but Are Modified by Experience

1. Kathleen C Maigler
2. Jian-You Lin
3. Ethan Crouse
4. Bradly T Stone
5. Ainsley E Craddock
6. Donald B Katz

• Curated by eLife

  eLife Assessment

  This important study demonstrates how individual taste preferences change over time, how these changes are reflected in cortical activity, and how sensory experience contributes to reshaping both. The evidence is convincing and broadly supports the main conclusions. The findings should be of interest to neuroscientists studying sensory processing and cortical plasticity.

Reviewed by eLife

Striatal dopamine and serotonin release operate largely in parallel with limited, asymmetric crosstalk

1. Fabrice Chaudun
2. Yu Liu
3. Juan Enriquez Traba
4. Agnès Hiver
5. Christian Lüscher

• Curated by eLife

  eLife Assessment

  This valuable study tests to what extent dopamine neuron stimulation produces striatal serotonin release, and vice versa - a topic of interest to neuroscientists studying the basal ganglia, neuromodulation, and reward learning. Employing a combination of modern optical and genetic methods, it provides solid evidence that the mesolimbic dopamine and serotonin systems operate primarily in parallel, with little crosstalk observed when each of the pathways are activated individually. The results are generally convincing, although the reviewers were still concerned about the absence of control experiments examining light artifacts.

Reviewed by eLife

Neurotrophin-3 produced by motor neurons non-cell autonomously regulates the development of pre-motor interneurons in the developing spinal cord

1. Andrea Angla-Navarro
2. Ana Dominguez Bajo
3. Mathilde Toch
4. Cédric Francius
5. Maria Hidalgo-Figueroa
6. Jingwen Zhang
7. Mélina Finet
8. Olivier Schakman
9. Manon Martin
10. Xiuqian Mu
11. René Rezsohazy
12. Françoise Gofflot
13. Frédéric Clotman

• Curated by eLife

  eLife Assessment

  This is a useful study that seeks to elucidate the molecular mechanisms underlying spinal circuit assembly. The authors demonstrate that loss of Onecut transcription factors in spinal motor neurons affects the size and spatial distribution of pre-motor interneurons. The main conclusion that Onecut acts through Neurotrophin-3 to regulate interneuron development in a non-cell autonomous manner is partially supported by the data, rendering the study incomplete. The work will be of broad interest to cell and developmental biologists.

Reviewed by eLife