Neuroscience

Prolonged oscillating kisspeptin neuron activity underlies the preovulatory luteinizing hormone surge in mice

1. Ziyue Zhou
2. Cheng-Yu Huang
3. Allan E Herbison

• Curated by eLife

  eLife Assessment

  This important work advances our understanding of the role of kisspeptin neurons in regulating the luteinizing hormone (LH) surge in females. The evidence demonstrating increased neuronal activity in anterior hypothalamic kisspeptin neurons just before the LH surge is compelling, though additional neuroanatomical evidence showing the specificity of the methods would strengthen the study. It also confirms that high circulating levels of estradiol, but also other unidentified factors, are required for the full daily activation. This research will be of interest to reproductive biologists and neuroscientists studying the female ovarian cycle.

Reviewed by eLife

Spatial learning in multi-scale environments: Roles of hippocampus, orbitofrontal cortex, and retrosplenial cortex

1. Yidan Qiu
2. Senning Zheng
3. Huakang Li
4. Shuting Lin
5. Ruiwang Huang

• Curated by eLife

  eLife Assessment

  The goal of this useful study is to examine learning-related changes in neural representations of global and local spatial reference frames in a spatial navigation task. Although the study addresses an interesting question, the evidence for neural representations in the hippocampus and retrosplenial cortex remains incomplete because of confounds in the experimental design and partial data analysis. There are further concerns about the framing of the study in the context of the relevant literature as well as the discussion.

Reviewed by eLife

Functional Connectivity-based Attractor Dynamics in Rest, Task, and Disease

1. Robert Englert
2. Balint Kincses
3. Raviteja Kotikalapudi
4. Giuseppe Gallitto
5. Jialin Li
6. Kevin Hoffschlag
7. Choong-Wan Woo
8. Tor D Wager
9. Dagmar Timmann
10. Ulrike Bingel
11. Tamas Spisak

• Curated by eLife

  eLife Assessment

  This study presents a valuable approach for revealing large-scale brain attractor dynamics during resting states, task processing, and disease conditions using insights from Hopfield neural networks. The evidence supporting the findings is convincing across the many datasets analysed. The work will be of broad interest to neuroscientists using neuroimaging data with interest in computational modelling of brain activity.

Reviewed by eLife

A unifying account of replay as context-driven memory reactivation

1. Zhenglong Zhou
2. Michael J Kahana
3. Anna C Schapiro

• Curated by eLife

  eLife Assessment

  This is an important account of replay as recency-weighted context-guided memory reactivation that explains a number of empirical findings across human and rodent memory literatures. The evidence is compelling and the work is likely to inspire further adaptions to incorporate additional biological and cognitive features.

Reviewed by eLife

Developmental oligodendrocytes regulate brain function through the mediation of synchronized spontaneous activity

1. Ryo Masumura
2. Kyosuke Goda
3. Mariko Sekiguchi
4. Naofumi Uesaka

• Curated by eLife

  eLife Assessment

  This study investigates the role of developmental oligodendrocytes in synchronising spontaneous activity in neuronal circuits and influencing cerebellar-dependent behaviour. The authors use advanced viral targeting techniques to deplete oligodendrocytes in a cell-specific manner, paired with in vivo calcium imaging of Purkinje cells, to establish a relationship between oligodendrocyte-mediated neuronal synchrony and complex brain function. The authors present compelling evidence of oligodendrocyte-regulated neuronal synchrony. Overall, this manuscript holds promise as an important contribution to neurodevelopment research.

Reviewed by eLife

Synergistic MAPT mutations as a platform to uncover modifiers of tau pathogenesis

1. Miles R Bryan
2. Michael F Almeida
3. Kyle Pellegrino
4. Carli K Opland
5. J Ethan Paulakonis
6. Jake McGillion-Moore
7. Hanna Trzeciakiewicz
8. Diamond King
9. Xu Tian
10. Jui-Heng Tseng
11. Jonathan C Schisler
12. Nicholas G Brown
13. Ben A Bahr
14. Todd J Cohen

• Curated by eLife

  eLife Assessment

  This study presents compelling new data that combine two FTD-tau mutations, P301L/S320F (PL-SF), that reliably induce spontaneous full-length tau aggregation across multiple cellular systems. The findings are important for the field of neurodegenerative disease. The strength of evidence is solid; however, several conclusions would benefit from more validation.

Reviewed by eLife

Decoding Spine Nanostructure in Mental Disorders Reveals a Schizophrenia-Linked Role for Ecrg4

1. Yutaro Kashiwagi
2. Qingrui Liu
3. Yasuhiro Go
4. Ryo Saito
5. Atsu Aiba
6. Takanobu Nakazawa
7. Shigeo Okabe

• Curated by eLife

  eLife Assessment

  By investigating spine nanostructure and dynamics across multiple genetic mouse models for neurodevelopmental disorders, this important study has the potential to uncover convergent or divergent synaptic phenotypes that may be specifically associated with autism versus schizophrenia risk. While the imaging and breadth are impressive, there are potential methodological concerns, especially around statistical analyses, which render the evidence incomplete and should be addressed. The purely in vitro nature of the study also slightly limits the generalisability of the findings.

Reviewed by eLife

A neuropeptide-specific signaling pathway for state-dependent regulation of the mesolimbic dopamine system

1. Mollie X. Bernstein
2. Omar Koita
3. Marta Trzeciak
4. Andrew Fan
5. Daniel T. McAuley
6. Seung-Woo Jin
7. Larry S. Zweifel

Reviewed by PREreview

ATF4 activates a transcriptional program that chronically suppresses mTOR activity promoting neurodegeneration in Parkinson’s disease models

1. Matthew D. Demmings
2. Erica A. Kane
3. Elizabeth C. Tennyson
4. Kate Hurley
5. Joy Zhao
6. Nicholas A. Cruickshanks
7. Victoria Ciz
8. Jordan M. Krupa
9. Stephen H. Pasternak
10. Sean P. Cregan

Reviewed by PREreview

Grid cells encode reward distance during path integration in cue-rich environments

1. Satoshi Kuroki
2. Sébastien Royer

Reviewed by PREreview