1. Neuropeptidergic circuit modulation of developmental sleep in Drosophila

    This article has 5 authors:
    1. Chikayo Hemmi
    2. Kenichi Ishii
    3. Mana Motoyoshi
    4. Masato Tsuji
    5. Kazuo Emoto
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The study investigates an emerging research field: the interaction between sleep and development. The authors use Drosophila larvae sleep as a study model and provide valuable insight into how neuropeptide circuitry controls larvae sleep. By using a broad range of behaviour and imaging methods and analysis, the authors conclude a sleep regulatory neural pathway of Hugin-PK2-Dilps in the Drosophila neurosecretory centre IPC. However, the evidence that supports this pathway is incomplete - in particular, the methodology in sleep measurement and the specificity at each step of the Hugin-PK2-Dilps pathway require further clarifying experiments or explanation.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Neural signatures of model-based and model-free reinforcement learning across prefrontal cortex and striatum

    This article has 6 authors:
    1. Bruno Miranda
    2. James L Butler
    3. W M Nishantha Malalasekera
    4. Timothy EJ Behrens
    5. Peter Dayan
    6. Steven W Kennerley
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study presents single-unit activity collected during model-based (MB) and model-free (MF) reinforcement learning in non-human primates. The dataset was carefully collected, and the statistical analyses, including the modeling, are rigorous. The evidence convincingly supports different roles for particular cortical and subcortical areas in representing key variables during reinforcement learning.

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    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  3. Criterion placement threatens the construct validity of neural measures of consciousness

    This article has 5 authors:
    1. Johannes J Fahrenfort
    2. Philippa A Johnson
    3. Niels A Kloosterman
    4. Timo Stein
    5. Simon van Gaal
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This fundamental study provides a critical challenge to a great many studies of the neural correlates of consciousness that were based on post hoc sorting of reported awareness experience. The evidence supporting this criticism is compelling, based on simulations and decoding analysis of EEG data. The results will be of interest not only to psychologists and neuroscientists but also to philosophers who work on addressing mind-body relationships.

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    This article has 12 evaluationsAppears in 1 listLatest version Latest activity
  4. Microglia aging in the hippocampus advances through intermediate states that drive activation and cognitive decline

    This article has 2 authors:
    1. Jeremy M Shea
    2. Saul A Villeda
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important work advances our understanding of the aging trajectory and heterogeneity of hippocampal microglia. The authors provide an in-depth characterization of microglia in young and old mice as well as at intermediate time points, which reveals the existence of intermediate states characterized by a distinct transcriptional signature. The experimental approach is solid, especially with the validation of scRNA-seq findings with other methods. The study should be of interest to neuroimmunologists and biologists interested in aging

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  5. Automatic learning mechanisms for flexible human locomotion

    This article has 4 authors:
    1. Cristina Rossi
    2. Kristan A Leech
    3. Ryan T Roemmich
    4. Amy J Bastian
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study introduces a novel split-belt treadmill learning task to reveal distinct and parallel learning sub-components of gait adaptation: slow and gradual error-based perceptual realignment, and a more deliberate and flexible "stimulus-response" style learning process. The behavioural results convincingly support the presence of a non-error-based learning process during continuous movements, and the computational modelling provides comprehensive further evidence for establishing this learning process. These results will be of interest for the broader motor learning community.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  6. A unified rodent atlas reveals the cellular complexity and evolutionary divergence of the dorsal vagal complex

    This article has 7 authors:
    1. Cecilia Hes
    2. Abigail J Tomlinson
    3. Lieke Michielsen
    4. Hunter J Murdoch
    5. Fatemeh Soltani
    6. Maia Kokoeva
    7. Paul V Sabatini
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript applies state-of-the-art techniques to define the cellular composition of the dorsal vagal complex in two rodent species (mice and rats). The result is an important resource that substantially advances our understanding of the dorsal vagal complex's role in the regulation of feeding and metabolism while also highlighting key differences between species. While most of the analyses in the manuscript provide convincing insight into the cellular architecture of the dorsal vagal complex, other aspects are incomplete and could be bolstered by additional evidence.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Unexpected mechanisms of sex-specific memory vulnerabilities to acute traumatic stress

    This article has 12 authors:
    1. Rachael E. Hokenson
    2. Kiara L. Rodríguez-Acevedo
    3. Yuncai Chen
    4. Annabel K. Short
    5. Sara A. Samrari
    6. Brinda Devireddy
    7. Brittany J. Jensen
    8. Julia J. Winter
    9. Christine M. Gall
    10. Kiran K. Soma
    11. Elizabeth A. Heller
    12. Tallie Z. Baram

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  8. Age-related changes in “cortical” 1/f dynamics are linked to cardiac activity

    This article has 6 authors:
    1. Fabian Schmidt
    2. Sarah K Danböck
    3. Eugen Trinka
    4. Dominic P Klein
    5. Gianpaolo Demarchi
    6. Nathan Weisz
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Examination of (a)periodic brain activity has gained particular interest in the last few years in the neuroscience fields relating to cognition, disorders, and brain states. Using large EEG/MEG datasets from younger and older adults, the current study provides compelling evidence that age-related differences in aperiodic EEG/MEG signals can be driven by cardiac rather than brain activity. Their findings have important implications for all future research that aims to assess aperiodic neural activity, suggesting control for the influence of cardiac signals is essential.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  9. Neural Geometry from Mixed Sensorimotor Selectivity for Predictive Sensorimotor Control

    This article has 4 authors:
    1. Yiheng Zhang
    2. Yun Chen
    3. Tianwei Wang
    4. He Cui
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This useful study examines the neural activity in the motor cortex as a monkey reaches to intercept moving targets, focusing on how tuned single neurons contribute to an interesting overall population geometry. The presented results and analyses are solid, though the investigation of this novel task could be strengthened by clarifying the assumptions behind the single neuron analyses, and further analyses of the neural population activity and its relation to different features of behaviour.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 2 listsLatest version Latest activity
  10. Precise Spatial Tuning of Visually Driven Alpha Oscillations in Human Visual Cortex

    This article has 13 authors:
    1. Kenichi Yuasa
    2. Iris IA Groen
    3. Giovanni Piantoni
    4. Stephanie Montenegro
    5. Adeen Flinker
    6. Sasha Devore
    7. Orrin Devinsky
    8. Werner Doyle
    9. Patricia Dugan
    10. Daniel Friedman
    11. Nick Ramsey
    12. Natalia Petridou
    13. Jonathan Winawer
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This intracranial EEG study presents important and convincing neural evidence supporting the high spatial specificity (receptive field) of visually driven alpha-band oscillation in human brains and its potential role in exogenous cuing attention. The work challenges the predominant view about the role of alpha-band oscillation in visual attention and advocates that stimulus-driven alpha suppression is precisely tuned and might contribute to exogenous spatial attention.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
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