1. The electrogenicity of the Na+/K+-ATPase poses challenges for computation in highly active spiking cells

    This article has 3 authors:
    1. Liz Weerdmeester
    2. Jan-Hendrik Schleimer
    3. Susanne Schreiber
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study provides new insights into the lesser-known effects of the sodium-potassium pump on how nerve cells process signals, particularly in highly active cells like those of weakly electric fish. The computational methods used to establish the claims in this work are compelling and can be used as a starting point for further studies.

    Reviewed by eLife

    This article has 12 evaluationsAppears in 1 listLatest version Latest activity
  2. Distinct evolutionary trajectories of two integration centres, the central complex and mushroom bodies, across Heliconiini butterflies

    This article has 6 authors:
    1. Max S Farnworth
    2. Yi Peng Toh
    3. Theodora Loupasaki
    4. Elizabeth A Hodge
    5. Basil el Jundi
    6. Stephen H Montgomery
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The analysis of neural morphology across Heliconiini butterfly species revealed brain area-specific changes associated with new foraging behaviours. While the volume of the centre for learning and memory, the mushroom bodies, was known to vary widely across species, new, valuable results show conservation of the volume of a center for navigation, the central complex. The presented evidence is convincing for both volumetric conservation in the central complex and fine neuroanatomical differences associated with pollen feeding, delivered by experimental approaches that are applicable to other insect species. This work will be of interest to evolutionary biologists, entomologists, and neuroscientists.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Regional heterogeneities of oligodendrocytes underlie biased Ranvier node spacing along single axons in sound localization circuit

    This article has 5 authors:
    1. Ryo Egawa
    2. Kota Hiraga
    3. Ryosuke Matsui
    4. Dai Watanabe
    5. Hiroshi Kuba
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study uses the delay line axon model in the chick brainstem auditory circuit to examine the interactions between oligodendrocytes and axons in the formation of internodal distances. This is a significant and actively studied topic, and the authors have used this preparation to support the hypothesis that regional heterogeneity in oligodendrocytes underlies the observed variation in internodal length. In a solid series of experiments, the authors have used enhanced tetanus neurotoxin light chains, a genetically encoded silencing tool, to inhibit vesicular release from axons and support the hypothesis that regional heterogeneity among oligodendrocytes may underlie the biased nodal spacing pattern in the sound localization circuit.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    This article has 13 evaluationsAppears in 2 listsLatest version Latest activity
  4. Astrocytes mobilize a broader repertoire of lysosomal repair mechanisms than neurons

    This article has 3 authors:
    1. Erin M. Smith
    2. Natali L. Chanaday
    3. Sandra Maday

    Reviewed by Arcadia Science

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  5. Dual-format attentional template during preparation in human visual cortex

    This article has 5 authors:
    1. Yilin Chen
    2. Taosheng Liu
    3. Ke Jia
    4. Jan Theeuwes
    5. Mengyuan Gong
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      By combining the 'pinging' technique with fMRI-based multivariate pattern analysis, this important study provides compelling evidence for a dual-format representation of attention during the preparatory period. The findings help reconcile the debate between sensory-like and non-sensory accounts of attentional templates and shed light on how the brain flexibly deploys different forms of templates to guide attention. This work will be of broad interest to researchers in psychology, vision science, and cognitive neuroscience.

    Reviewed by eLife

    This article has 13 evaluationsAppears in 1 listLatest version Latest activity
  6. Selective life-long suppression of an odor processing channel in response to critical period experience

    This article has 8 authors:
    1. Hans C Leier
    2. Julius Jonaitis
    3. Alexander J Foden
    4. Abigail J Wilkov
    5. Annika E Ross
    6. Paola Van der Linden Costello
    7. Heather T Broihier
    8. Andrew M Dacks
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study in the Drosophila antennal lobe, which contains multiple non-equivalent sensory channels, provides valuable new insight into how early-life sensory experience can produce lasting, cell-type-specific changes in neural circuit function. The work convincingly demonstrates that glial-mediated pruning during a defined developmental window leads to persistent suppression of odor responses in one olfactory neuron type, while sparing another. The evidence is solid and supported by multiple complementary approaches, although some mechanistic interpretations remain speculative and would benefit from additional functional testing.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  7. Spatially Periodic Computation in the Entorhinal-Hippocampal Circuit During Navigation

    This article has 4 authors:
    1. Bo Zhang
    2. Xin Guan
    3. Dean Mobbs
    4. Jia Liu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides valuable results on how entorhinal and hippocampal activity may support human thinking in perceptual spaces. It replicates the hexagonal symmetry of fMRI activity in the entorhinal cortex, reports novel findings on 3-fold symmetry in both behavioral performance and hippocampal fMRI activity, and links these results within a computational model. However, the methods while potentially creative and interesting are not fully justified or explained, and the conclusions remain incomplete. With further explanation, justification, and interpretation, this work could represent a significant step forward in understanding how cognitive maps are utilized.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  8. Dual transcranial electromagnetic stimulation of the precuneus boosts human long-term memory

    This article has 10 authors:
    1. Ilaria Borghi
    2. Lucia Mencarelli
    3. Michele Maiella
    4. Elias P Casula
    5. Matteo Ferraresi
    6. Francesca Candeo
    7. Elena Savastano
    8. Martina Assogna
    9. Sonia Bonnì
    10. Giacomo Koch
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This work presents important findings suggesting that a combination of transcranial stimulation approaches applied for a short period could improve memory performance. Solid methods and evidence, in line with current standards for non-invasive stimulation and recording, are included to broadly support the main findings. The results potentially have implications for non-invasive enhancement of cognitive functions.

    Reviewed by eLife

    This article has 23 evaluationsAppears in 1 listLatest version Latest activity
  9. Challenges in Replay Detection by TDLM in Post-Encoding Resting State

    This article has 6 authors:
    1. Simon Kern
    2. Juliane Nagel
    3. Lennart Wittkuhn
    4. Steffen Gais
    5. Ray Dolan
    6. Gordon Feld
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents valuable findings on the ability of a state-of-the-art method temporally delayed linear modelling (TDLM) to detect the replay of sequences in human memory. The investigation provides convincing evidence that TDLM has limitations in its sensitivity to detect replay when being applied to extended (minutes-long) rest periods, though a more thorough treatment of the relationship to prior positive findings would make the demonstration even stronger. The work will be of particular interest to researchers investigating memory reactivation in humans, especially using iEEG, MEG, and EEG.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. Diverse calcium dynamics underlie place field formation in hippocampal CA1 pyramidal cells

    This article has 6 authors:
    1. Mate Sumegi
    2. Gaspar Olah
    3. Istvan Paul Lukacs
    4. Martin Blazsek
    5. Judit K Makara
    6. Zoltan Nusser
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This fundamental study provides new insights into the plasticity mechanisms underlying the formation of spatial maps in the hippocampus. Supported by a large and comprehensive dataset, the evidence is convincing. This study will be of interest to neuroscientists focusing on spatial navigation, learning, and memory.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
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