1. Co-release of opposing signaling molecules controls the escalation and release of aggression

    This article has 12 authors:
    1. Rachel E. Gatlin
    2. Jordyn Gagon
    3. Damhyeon Kwak
    4. Sewon Park
    5. Hailee Walker
    6. Lo Kronheim
    7. Thomas Everett
    8. Ashley Covington
    9. Michaela M. Fluck
    10. Tobias Zickmund
    11. Nicholas A. Frost
    12. Moriel Zelikowsky

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  2. Morphology and ultrastructure of pharyngeal sense organs of Drosophila larvae

    This article has 4 authors:
    1. Vincent Richter
    2. Tilman Triphan
    3. Albert Cardona
    4. Andreas S Thum
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this fundamental manuscript, Richter et al. present a thorough anatomical characterization of the Drosophila melanogaster larval pharyngeal sensory system, which is involved in taste-guided behaviors. This study fills a major gap in the larval sensory map, providing a compelling neuroanatomical foundation for future investigations into sensory circuits and behavior. The data presented here are of exceptional quality and will be of interest to the Drosophila neurobiology community.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. From cognition to compensation: Neurocomputational mechanisms of guilt-driven and shame-driven altruistic behavior

    This article has 6 authors:
    1. Ruida Zhu
    2. Huanqing Wang
    3. Chunliang Feng
    4. Linyuan Yin
    5. Ran Zhang
    6. Chao Liu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important work provides convincing evidence of the cognitive and neural mechanisms that give rise to feelings of shame and guilt, as well as their transformation into compensatory behavior. The authors combine well-designed manipulations of responsibility and harm with computational cognitive modeling and neuroimaging to provide a comprehensive account of how emotions are experienced and acted upon.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. Eye-specific active zone clustering underlies synaptic competition in the developing visual system

    This article has 3 authors:
    1. Chenghang Zhang
    2. Tarlan Vatan
    3. Colenso M Speer
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is a useful analysis of STORM data that characterizes the clustering of active zones in retinogeniculate terminals across ages and in the absence of retinal waves. The design makes it possible to relate fixed time point structural data to a known outcome of activity-dependent remodeling. However, the evidence is incomplete, weakening the claims the authors make regarding how activity influences the clustering of these synapses. This basic criticism has not improved with revisions.

    Reviewed by eLife

    This article has 14 evaluationsAppears in 2 listsLatest version Latest activity
  5. Remote automated delivery of mechanical stimuli coupled to brain recordings in behaving mice

    This article has 23 authors:
    1. Justin Burdge
    2. Anissa Jhumka
    3. Ashar Khan
    4. Simon Ogundare
    5. Nicholas Baer
    6. Sasha Fulton
    7. Alexander Kaplan
    8. Brittany Bistis
    9. William Foster
    10. Joshua Thackray
    11. Andre Toussaint
    12. Miao Li
    13. Yosuke M Morizawa
    14. Jacob Nazarian
    15. Leah Yadessa
    16. Arlene J George
    17. Abednego Delinois
    18. Wadzanayi Mayiseni
    19. Noah Loran
    20. Guang Yang
    21. David J Margolis
    22. Victoria E Abraira
    23. Ishmail Abdus-Saboor
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study describes the development and validation of an Automated Reproducible Mechano-stimulator (ARM), a tool for standardizing and automating tactile behavior experiments. The data supporting the use of the ARM system are compelling, and demonstrate that by removing experimenter effects on animals, it reduces variability in various parameters of stimulus application. Moreover, the authors demonstrate that any noise emitted from the ARM does not induce an increased stress state. Once commercially available, the ARM system has the potential to increase experimental reproducibility between laboratories in the somatosentation and pain fields.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  6. RubyACRs Enable Red-Shifted Optogenetic Inhibition in Freely Behaving Drosophila

    This article has 9 authors:
    1. Daniel Bushey
    2. Hiroshi Shiozaki
    3. Yichun Shuai
    4. Jihong Zheng
    5. Vivek Jayaraman
    6. Jeremy P Hasseman
    7. Ilya Kolb
    8. GENIE Project Team
    9. Glenn C Turner
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important work describes the adaptation and evaluation of two red-shifted anion channelrhodopsins (RubyACRs) for optogenetic inhibition in Drosophila. The study provides convincing evidence for the effectiveness of RubyACRs in fly neurons, including electrophysiology, calcium imaging, and behavioral analysis. With minor revisions to address potential toxicity and compatibility with 2-photon imaging, this paper and the publicly available fly lines it describes will be resources that are of value to the neuroscience community.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  7. Misclassification in memory modification in AppNL-G-F knock-in mouse model of Alzheimer’s disease

    This article has 6 authors:
    1. Mei-Lun Huang
    2. Yusuke Suzuki
    3. Hiroki Sasaguri
    4. Takashi Saito
    5. Takaomi C Saido
    6. Itaru Imayoshi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study employs a formalized computational model of learning to assess memory deficits in Alzheimer's Disease with the goal of developing an early diagnosis tool. Using an established mouse model of the disease, the authors studied multiple behavioral tasks and ages with the goal of showing similarities in behavioral deficits across tasks. Using the model, the authors indicate specific deficits in memory (overgeneralization and over differentiation) in mice with the transgene for the disease. The evidence presented is solid, yet certain concerns remain regarding the interpretation of the results of the modeling.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  8. Decision-making components and times revealed by the single-trial electro-encephalogram

    This article has 3 authors:
    1. Gabriel Weindel
    2. Jelmer P Borst
    3. Leendert van Maanen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study applies a novel signal decomposition method to disentangle distinct signals contributing to the decision-making process, and provides convincing evidence for the operation of separate sensory encoding, attentional orienting, and ramping evidence accumulation signals. These findings are consistent with previous work, except for the absence of a motor component, which may relate to limitations of the analysis approach.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. A conserved Arf-GEF modulates axonal integrity through RAB-35 by altering neuron-epidermal attachment

    This article has 3 authors:
    1. Igor Bonacossa-Pereira
    2. Sean Coakley
    3. Massimo A. Hilliard

    Reviewed by Review Commons

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  10. iGABASnFR2: Improved genetically encoded protein sensors of GABA

    This article has 19 authors:
    1. Ilya Kolb
    2. Jeremy P Hasseman
    3. Akihiro Matsumoto
    4. Thomas P Jensen
    5. Olga Kopach
    6. Benjamin J Arthur
    7. Yan Zhang
    8. Arthur Tsang
    9. Daniel Reep
    10. Getahun Tsegaye
    11. Jihong Zheng
    12. Ronak H Patel
    13. Loren L Looger
    14. Jonathan S Marvin
    15. Wyatt L Korff
    16. Dmitri A Rusakov
    17. Keisuke Yonehara
    18. GENIE Project Team
    19. Glenn C Turner
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript reports the development and characterization of iGABASnFR2, a genetically encoded GABA sensor that demonstrates substantially improved performance compared to its predecessor, iGABASnFR1. The work is comprehensive and methodologically rigorous, combining high-throughput mutagenesis, functional screening, structural analysis, biophysical characterization, and in vivo validation. The significance of the findings is fundamental, and the supporting evidence is compelling. iGABASnFR2 represents a notable advance in GABA sensor engineering, enabling enhanced imaging of GABA transmission both in brain slices and in vivo, and constitutes a timely, technically robust addition to the molecular toolkit for neuroscience research.

    Reviewed by eLife, PREreview

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
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