1. Conserved and Unique Features of Terminal Telomeric Sequences in ALT-Positive Cancer Cells

    This article has 7 authors:
    1. Benura Azeroglu
    2. Wei Wu
    3. Raphael Pavani
    4. Ranjodh Sandhu
    5. Tadahiko Matsumoto
    6. André Nussenzweig
    7. Eros Lazzerini Denchi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study demonstrates the application of END-seq, originally developed to study genome-wide DNA double-strand breaks, to telomere biology; the work packs a punch, concisely demonstrating the utility of this approach and the new insights that can be gained. The authors confirm that telomeres in telomerase-positive cells terminate with 5'-ATC in a Pot1-dependent manner, and demonstrate that this principle holds true in telomerase-negative ALT cells as well; S1-END-seq is similarly developed for telomeres, showing that ALT cells harbor several regions of ssDNA. The study is well-executed, the new insights are fundamental and compelling, and the optimized END-seq approaches will be widely utilized. The interest of the paper could be heightened by deepening the discussion of potential biases in telomere representation, the origin of the ssDNA captured in ALT cells, and the occurrence of variant telomere repeats in the cell lines studied.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  2. Metabolic reprogramming by endothelial ANGPTL4 depletion protects against diabetic kidney disease

    This article has 16 authors:
    1. Swayam Prakash Srivastava
    2. Han Zhou
    3. Rachel Shenoi
    4. Myshal Morris
    5. Begoña Lainez-Mas
    6. Yuta Takagaki
    7. Barani Kumar Rajendran
    8. Ocean Setia
    9. Binod Aryal
    10. Keizo Kanasaki
    11. Daisuke Koya
    12. Ken Inoki
    13. Alan Dardik
    14. Carlos Fernández-Hernando
    15. Gerald I. Shulman
    16. Julie E. Goodwin

    Reviewed by Life Science Editors Foundation

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  3. Venomous Maggots? A first exploration of the toxin arsenal of larval stages of the horse fly Tabanus autumnalis

    This article has 4 authors:
    1. Jonas Krämer
    2. Ludwig Dersch
    3. Andreas Vilcinskas
    4. Tim Lüddecke

    Reviewed by Arcadia Science

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  4. PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

    This article has 5 authors:
    1. Roman O Fedoryshchak
    2. Karim El-Bouri
    3. Dhira Joshi
    4. Stephane Mouilleron
    5. Richard Treisman
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study reports on a basis for neurabin-mediated specification of substrate choice by protein phosphatase-1. The data from the comprehensive approach using structural, biochemical, and computational methods are compelling. This paper is broadly relevant to those investigating various cellular signaling cascades that entail phosphorylation as the main mechanism.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  5. Structural basis of lipopolysaccharide translocon assembly mediated by the small lipoprotein LptM

    This article has 4 authors:
    1. Ryoji Miyazaki
    2. Mai Kimoto
    3. Hidetaka Kohga
    4. Tomoya Tsukazaki

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  6. Ribosomal RNA synthesis by RNA polymerase I is regulated by premature termination of transcription

    This article has 12 authors:
    1. Chaïma Azouzi
    2. Katrin Schwank
    3. Sophie Queille
    4. Marta Kwapisz
    5. Marion Aguirrebengoa
    6. Anthony Henras
    7. Simon Lebaron
    8. Herbert Tschochner
    9. Annick Lesne
    10. Frédéric Beckouët
    11. Olivier Gadal
    12. Christophe Dez
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript characterizes a mutated clone of RNA polymerase I in yeast, referred to as SuperPol, to understand the mechanisms of RNA polymerase I elongation and termination. The authors present solid evidence that SuperPol has higher processivity during transcription elongation than wild-type RNA polymerase I. Notably, the study provides evidence that the transcriptional pause of RNA polymerase I may be a therapeutic vulnerability in cancers. Overall, the characterization of this RNA pol I is important as it provides insights into the regulation of ribosomal RNA transcription and its potential application in cancer pharmacology.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    This article has 9 evaluationsAppears in 2 listsLatest version Latest activity
  7. A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia

    This article has 3 authors:
    1. Sven M. Lange
    2. Robyn J. Eisert
    3. Alan Brown

    Reviewed by Arcadia Science

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  8. Rapid Raman spectroscopy-based test for antimicrobial resistance

    This article has 8 authors:
    1. Vladimir Mushenkov
    2. Ksenia Zhigalova
    3. Pavel Denisov
    4. Alexey Gordeev
    5. Dmitry Lukyanov
    6. Vladimir Kukushkin
    7. Tatiana Priputnevich
    8. Elena Zavyalova

    Reviewed by Arcadia Science

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  9. Autophagy Suppresses CCL2 to Preserve Appetite and Prevent Lethal Cachexia

    This article has 21 authors:
    1. Maria Ibrahim
    2. Maria Gomez-Jenkins
    3. Adina Scheinfeld
    4. Zhengqiao Zhao
    5. Eduardo Cararo Lopes
    6. Akshada Sawant
    7. Zhixian Hu
    8. Aditya Dharani
    9. Michael Sun
    10. Sarah Siddiqui
    11. Emily T. Mirek
    12. Johan Abram-Saliba
    13. Edmund C. Lattime
    14. Xiaoyang Su
    15. Tobias Janowitz
    16. Marcus D. Goncalves
    17. Steven M. Dunn
    18. Yuri Pritykin
    19. Tracy G. Anthony
    20. Joshua D. Rabinowitz
    21. Eileen White

    Reviewed by Life Science Editors Foundation

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  10. Rtf1 HMD domain facilitates global histone H2B monoubiquitination and regulates morphogenesis and virulence in the meningitis-causing pathogen Cryptococcus neoformans

    This article has 9 authors:
    1. Yixuan Jiang
    2. Ying Liang
    3. Fujie Zhao
    4. Zhenguo Lu
    5. Siyu Wang
    6. Yao Meng
    7. Zhanxiang Liu
    8. Jing Zhang
    9. Youbao Zhao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is an important study that connects the polymerase-associated factor 1 complex (Paf1C) with Histone 2B monoubiquitination and the expression of genes key to virulence in Cryptococcus neoformans. The provided information is convincing and has the potential to open several opportunities to further understand the basic biology of this significant human fungal pathogen.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
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