Molecular Biology

Role of ADMA-histones in dual-strand piRNA source loci recognition by Rhino

1. Raku Saito
2. Hirotsugu Ishizu
3. Ritsuko Harigai
4. Kensaku Murano
5. Yurika Namba
6. Mikiko C Siomi

• Curated by eLife

  eLife Assessment

  This valuable study identifies asymmetric dimethylarginine (ADMA) modification of histones as a potential key determinant of the initial genomic binding of Rhino, a Drosophila-specific chromatin protein essential for piRNA cluster specification. The authors provide correlative genomic and imaging data to support their model, although functional validation of the proposed mechanism remains incomplete. Testing the redundancy between dART4 and dART1, which together could affect the prominent piRNA loci, in addition to the minor ones investigated in the manuscript, may change our assessment.

Reviewed by eLife

Opposing CTCF and GATA4 activities set the pace of chromatin topology remodeling during cardiomyogenesis

1. Silvia Becca
2. Sara Bianchi
3. Elisa M. Hahn
4. Kirsten E. Snijders
5. Lukasz Truszkowski
6. Anna Krepelova
7. Francesco Neri
8. Davide Cacchiarelli
9. Sasha Mendjan
10. Elisa Balmas
11. Alessandro Bertero

Reviewed by Review Commons

Lipid-Mediated Control of ER Function During Apoptosis

1. José Luis Garrido-Huarte
2. Josep Fita-Torró
3. Amparo Pascual-Ahuir
4. Markus Proft

Reviewed by Arcadia Science

Dietary sulfur amino acid restriction elicits a cold-like transcriptional response in inguinal but not epididymal white adipose tissue of male mice

1. Philip MM Ruppert
2. Aylin S Güller
3. Marcus Rosendal
4. Natasa Stanic
5. Jan-Wilhelm Kornfeld

• Curated by eLife

  eLife Assessment

  The present study employed transcriptomics to investigate the impact of methionine restriction (MR) and cold exposure (CE) on liver and adipose tissues in mice. The authors demonstrate that responses to MR and CE are tissue-specific, while both MR and CE have a similar effect on beige adipose tissue. While these findings are somewhat descriptive, this work is considered important, as it provides a comprehensive resource for enhancing our understanding of these lifestyle interventions. The study is of high scientific quality, and the analyses are convincing.

Reviewed by eLife

Proximity labeling reveals ZFP36L1 as a central hub for post-transcriptional regulation networks in T cells

1. Anouk P. Jurgens
2. Branka Popović
3. Floris P.J. van Alphen
4. Leyma Wardak
5. Antonia Bradarić
6. Sander Engels
7. Carmen van der Zwaan
8. Maartje van den Biggelaar
9. Arie J. Hoogendijk
10. Julien Béthune
11. Monika C. Wolkers

Reviewed by Review Commons

NASP functions in the cytoplasm to prevent histone H3 aggregation during early embryogenesis

1. Mohit Das
2. Eli Coronado-Chavez
3. Anusha D Bhatt
4. Reyhaneh Tirgar
5. Amanda A Amodeo
6. Jared Nordman

Reviewed by Review Commons

Inhibiting Glutamine Metabolism Blocks Coronavirus Replication in Mammalian Cells

1. Kai Su Greene
2. Annette Choi
3. Matthew Chen
4. Nianhui Yang
5. Ruizhi Li
6. Yijian Qiu
7. Michael J Lukey
8. Katherine S Rojas
9. Jonathan Shen
10. Kristin F Wilson
11. William P Katt
12. Gary R Whittaker
13. Richard A Cerione

Reviewed by Rapid Reviews Infectious Diseases

Malaria parasite resistance to azithromycin is not readily transmitted by mosquitoes

1. Hayley D. Buchanan
2. Robyn McConville
3. Lee M. Yeoh
4. Michael F. Duffy
5. Justin A. Boddey
6. Geoffrey I. McFadden
7. Christopher D. Goodman

• Curated by eLife

  eLife assessment

  This important work addressed the identifcation of antimalarial drug resistance mutations that do not readily transmit to new human hosts, focusing on azithromycin resistance. The technically challenging analyses of azithromycin-resistant parasites as they traverse the mosquito host and human liver are conducted using state-of-the-art tools, including humanized mice. While the claim regarding the lack of transmission by atovaquone-resistant P. berghei is convincing, the evidence for the lack of transmission by atovaquone-resistant P. falciparum is insufficient. This work will appeal to biologists and biomedical scientists in parasitology and drug discovery, offering insights into combating antimalarial drug resistance and understanding the fitness costs associated with drug-resistant parasites.

Reviewed by eLife, Rapid Reviews Infectious Diseases

Interplay between cohesin and TORC1 links chromosome segregation and gene expression to environmental changes

1. Dorian Besson
2. Sabine Vaur
3. Stéphanie Vazquez
4. Sylvie Tournier
5. Yannick Gachet
6. Adrien Birot
7. Stéphane Claverol
8. Adèle Marston
9. Anastasios Damdimopoulos
10. Karl Ekwall
11. Jean-Paul Javerzat

• Curated by eLife

  eLife Assessment

  This important study describes a new link between nutrient signaling and chromosome regulation, providing compelling evidence that reduced activity in the central nutrient-sensing pathway governed by TORC1 improves chromosome stability and alters gene expression in S. pombe through effects on cohesin. While the biological importance of this newly described circuit is not yet fully known, and some data would benefit from further clarification, the overall body of evidence supports the main conclusions.

Reviewed by eLife

Single cell transcriptomics and development of gametocyte-specific molecular markers for avian malaria parasites

1. A Berthomieu
2. S Gandon
3. AM Talman
4. A Rivero

Reviewed by PREreview