Molecular Biology

Patterns of aDNA damage through time and environments—lessons from herbarium specimens

1. Stefano Porrelli
2. Alice Fornasiero
3. Hong Phuong Le
4. Wenzhe Yin
5. María E Navarrete Rodríguez
6. Nahed Mohammed
7. Axel Himmelbach
8. Andrew C Clarke
9. Nils Stein
10. Paul J Kersey
11. Rod A Wing
12. Rafal M Gutaker

Reviewed by GigaScience

CUTS RNA Biosensor for the Real-Time Detection of TDP-43 Loss-of-Function

1. Longxin Xie
2. Jessica Merjane
3. Cristian A Bergmann
4. Jiazhen Xu
5. Shruthi Balasubramaniyan
6. Bryan Hurtle
7. Charleen T Chu
8. Christopher J Donnelly

• Curated by eLife

  eLife Assessment

  This important study developed a new sensor for TDP-43 activity that is sensitive and robust that should strongly impact the field's ability to monitor whether TDP-43 is functional or not. The evidence, though limited to cell culture, is compelling and is the first demonstration that a GFP on/off system can be used to assess genetic TDP-43 mutants as well as loss of soluble TDP-43.

Reviewed by eLife

Liquid-Liquid Phase Separation-mediated formation of amyloid fibrils from DcpS scavenger enzymes

1. Aleksandra Ferenc-Mrozek
2. Maria Winiewska-Szajewska
3. Hanna Nieznańska
4. Wojciech Dzwolak
5. Maciej Łukaszewicz

Reviewed by preLights

Oxidative stress triggers RNAPII arrest through PARylation and DNA damage

1. Quentin A. Thomas
2. Liyang Wu
3. Emma Lesage
4. Henriette K. M. Iversen
5. David López Martínez
6. Smaragda Kompocholi
7. Haiyue Liu
8. Nicolás Nieto Moreno
9. Lea H. Gregersen

Reviewed by preLights

Frataxin depletion leads to decreased soma size and activation of AMPK metabolic pathway in dorsal root ganglia sensory neurons

1. Olivier Griso
2. Deepika Chellapandi
3. Amélie Weiss
4. Ioannis Manolaras
5. Hélène Puccio

Reviewed by Review Commons

Protein secretion routes in fungi are mostly determined by the length of the hydrophobic helix in the signal peptide

1. Tristan Sones-Dykes
2. Edward Wallace

Reviewed by Review Commons

The spike tip protein of bacteriophage T4

1. Yves Mattenberger
2. Ekaterina S Knyazhanskaya
3. Mikhail M Shneider
4. Sergey A Buth
5. Sergey Nazarov
6. William P Robins
7. Petr G Leiman
8. Dominique Belin

• Curated by eLife

  eLife Assessment

  This important study by Mattenburger et al. employs structural biology, biochemistry, and genetics to advance understanding of how bacteriophage contractile injection systems mediate host recognition and DNA delivery, yielding a remarkable 1.15 A crystal structure of the T4 spike tip complex (gp5-gp5.4). The compelling evidence presented demonstrates that the spike tip protein gp5.4 is essential for phage fitness and successful infection of Escherichia coli strains bearing truncated lipopolysaccharide; however, direct proof regarding interaction with the cell wall or its components is lacking. The study further provides biochemical evidence that the analogous spike tip protein from phage P2 (GpV) is translocated into the host periplasm during infection, together establishing the spike tip as a critical and active component of the phage infection machinery.

Reviewed by eLife