1. A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia

    This article has 3 authors:
    1. Sven M. Lange
    2. Robyn J. Eisert
    3. Alan Brown

    Reviewed by Arcadia Science

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  2. Rapid Raman spectroscopy-based test for antimicrobial resistance

    This article has 8 authors:
    1. Vladimir Mushenkov
    2. Ksenia Zhigalova
    3. Pavel Denisov
    4. Alexey Gordeev
    5. Dmitry Lukyanov
    6. Vladimir Kukushkin
    7. Tatiana Priputnevich
    8. Elena Zavyalova

    Reviewed by Arcadia Science

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  3. Autophagy Suppresses CCL2 to Preserve Appetite and Prevent Lethal Cachexia

    This article has 21 authors:
    1. Maria Ibrahim
    2. Maria Gomez-Jenkins
    3. Adina Scheinfeld
    4. Zhengqiao Zhao
    5. Eduardo Cararo Lopes
    6. Akshada Sawant
    7. Zhixian Hu
    8. Aditya Dharani
    9. Michael Sun
    10. Sarah Siddiqui
    11. Emily T. Mirek
    12. Johan Abram-Saliba
    13. Edmund C. Lattime
    14. Xiaoyang Su
    15. Tobias Janowitz
    16. Marcus D. Goncalves
    17. Steven M. Dunn
    18. Yuri Pritykin
    19. Tracy G. Anthony
    20. Joshua D. Rabinowitz
    21. Eileen White

    Reviewed by Life Science Editors Foundation

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  4. Rtf1 HMD domain facilitates global histone H2B monoubiquitination and regulates morphogenesis and virulence in the meningitis-causing pathogen Cryptococcus neoformans

    This article has 9 authors:
    1. Yixuan Jiang
    2. Ying Liang
    3. Fujie Zhao
    4. Zhenguo Lu
    5. Siyu Wang
    6. Yao Meng
    7. Zhanxiang Liu
    8. Jing Zhang
    9. Youbao Zhao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is an important study that connects the polymerase-associated factor 1 complex (Paf1C) with Histone 2B monoubiquitination and the expression of genes key to virulence in Cryptococcus neoformans. The provided information is convincing and has the potential to open several opportunities to further understand the basic biology of this significant human fungal pathogen.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  5. TDP-43 directly inhibits RNA accumulation in neurites through modulation of RNA stability

    This article has 10 authors:
    1. Charlie Moffatt
    2. Ankita Arora
    3. Katherine F. Vaeth
    4. Bryan B. Guzman
    5. Gurprit Bhardwaj
    6. Audrey Hoelscher
    7. Levi B. Gifford
    8. Holger A. Russ
    9. Daniel Dominguez
    10. J. Matthew Taliaferro

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  6. Sld3CBD–Cdc45 structural insights into Cdc45 recruitment for CMG complex formation on DNA replication

    This article has 9 authors:
    1. Hao Li
    2. Izumi Ishizaki
    3. Koji Kato
    4. XiaoMei Sun
    5. Sachiko Muramatsu
    6. Hiroshi Itou
    7. Toyoyuki Ose
    8. Hiroyuki Araki
    9. Min Yao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable paper describes the crystal structure of a complex of Sld3-Cdc45-binding domain (CBD) with Cdc45, which is essential for the assembly of an active Cdc45-MCM-GINS (CMG) double hexamers at the replication origin. Although the results shown in the paper are of interest to researchers in DNA replication and genome stability, the biochemical analysis of protein-protein interaction and DNA binding is incomplete, and the paper needs additional data.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  7. Context specific ubiquitin modification of ribosomes regulates translation under oxidative stress

    This article has 6 authors:
    1. Shannon E. Dougherty
    2. Géssica C. Barros
    3. Matthew W. Foster
    4. Guoshou Teo
    5. Hyungwon Choi
    6. Gustavo M. Silva

    Reviewed by Review Commons

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  8. SFSWAP is a negative regulator of OGT intron detention and global pre-mRNA splicing

    This article has 2 authors:
    1. Ashwin Govindan
    2. Nicholas K Conrad
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides fundamental insights into the regulation of a retained intron in the mRNA coding for OGT, a process known to be regulated by the O-GlcNAc cycling system, and highlights the functional role of the splicing regulator SFSWAP. The evidence supporting the claims of the authors is convincing; the authors performed an elegant state-of-the-art CRISPR knockout strategy and sophisticated bioinformatic analysis to identify SFSWAP as a negative regulator of alternative splicing. The work will be of interest to researchers in the fields of splicing and glycobiology.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  9. Inhibition of mitochondrial protein import and proteostasis by a pro-apoptotic lipid

    This article has 7 authors:
    1. Josep Fita-Torró
    2. José Luis Garrido-Huarte
    3. Lucía López-Gil
    4. Agnès H Michel
    5. Benoit Kornmann
    6. Amparo Pascual-Ahuir
    7. Markus Proft
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study is a valuable observation that deals with the toxic effects of an intermediary in lipid degradation [trans-2-hexadecenal (t-2-hex)] in yeast through modification of mitochondrial protein import via the TOM complex. We find that the claim that the TOM complex is a main target of t-2-hex are supported by solid evidence, however the molecular mechanism remains unclear allowing multiple interpretation. Despite the shortcomings, this study is inspiring for researchers from the organellar, protein trafficking and lipid field and serves as a starting point to further precise and mechanistic analyses of the phenomenon.

    Reviewed by eLife

    This article has 11 evaluationsAppears in 1 listLatest version Latest activity
  10. Nitrosation of CD36 Regulates Endothelial Function and Serum Lipids

    This article has 22 authors:
    1. Melissa A. Luse
    2. Wyatt J. Schug
    3. Luke S. Dunaway
    4. Shruthi Nyshadham
    5. Skylar A. Loeb
    6. Alicia Carvalho
    7. Rachel Tessema
    8. Caitlin Pavelec
    9. T.C. Stevenson Keller
    10. Xiaohong Shu
    11. Claire A. Ruddiman
    12. Anna Kosmach
    13. Timothy M. Sveeggen
    14. Ray Mitchell
    15. Pooneh Bagher
    16. Richard D. Minshall
    17. Norbert Leitnger
    18. Linda Columbus
    19. Kandice R. Levental
    20. Ilya Levental
    21. Miriam Cortese-Krott
    22. Brant E. Isakson

    Reviewed by Life Science Editors Foundation

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
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