1. Erythrocyte invasion-neutralising antibodies prevent Plasmodium falciparum RH5 from binding to basigin-containing membrane protein complexes

    This article has 9 authors:
    1. Abhishek Jamwal
    2. Cristina F Constantin
    3. Stephan Hirschi
    4. Sebastian Henrich
    5. Wolfgang Bildl
    6. Bernd Fakler
    7. Simon J Draper
    8. Uwe Schulte
    9. Matthew K Higgins
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This elegantly performed and rigorous study generates new and conceptually important insights into the interaction between an essential malaria parasite invasion ligand (and vaccine candidate) called PfRH5, and its erythrocyte surface integral membrane receptor basigin. The authors provide compelling evidence based on rigorous biochemical assays that erythrocyte basigin is predominantly expressed in a complex with one of two distinct erythrocyte membrane proteins called PMCA and MCT1 and that PfRH5 binds to these complexes better than to isolated basigin. Certain invasion-inhibitory antibodies, that do not prevent binding of PfRH5 to isolated basigin, do in contrast prevent binding to the basigin complexes, explaining the mode of action of these previously enigmatic antibodies and providing valuable data towards the improved design of vaccines based on PfRH5.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Evolution of a functionally intact but antigenically distinct DENV fusion loop

    This article has 10 authors:
    1. Rita M Meganck
    2. Deanna Zhu
    3. Stephanie Dong
    4. Lisa J Snoderly-Foster
    5. Yago R Dalben
    6. Devina Thiono
    7. Laura J White
    8. Arivianda M DeSilva
    9. Ralph S Baric
    10. Longping V Tse
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study describes engineered dengue virus variants that can be used to dissect epitope specificities in polyclonal sera, and to design candidate vaccine antigens that dampen antibody responses against undesirable epitopes. While the major claims are supported by solid evidence, experiments to distinguish the impact on antibody binding from neutralizing activities would have strengthened the study. This work will be of interest to virologists and structural biologists working on antibody responses to flaviviruses.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  3. Oral Immunization with rVSV Bivalent Vaccine Elicits Protective Immune Responses, Including ADCC, against Both SARS-CoV-2 and Influenza A Viruses

    This article has 9 authors:
    1. Maggie Jing Ouyang
    2. Zhujun Ao
    3. Titus A. Olukitibi
    4. Peter Lawrynuik
    5. Christopher Shieh
    6. Sam K. P. Kung
    7. Keith R. Fowke
    8. Darwyn Kobasa
    9. Xiaojian Yao

    Reviewed by Rapid Reviews Infectious Diseases

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  4. Discovery of antimicrobial peptides in the global microbiome with machine learning

    This article has 17 authors:
    1. Célio Dias Santos-Júnior
    2. Marcelo D.T. Torres
    3. Yiqian Duan
    4. Álvaro Rodríguez del Río
    5. Thomas S.B. Schmidt
    6. Hui Chong
    7. Anthony Fullam
    8. Michael Kuhn
    9. Chengkai Zhu
    10. Amy Houseman
    11. Jelena Somborski
    12. Anna Vines
    13. Xing-Ming Zhao
    14. Peer Bork
    15. Jaime Huerta-Cepas
    16. Cesar de la Fuente-Nunez
    17. Luis Pedro Coelho

    Reviewed by Arcadia Science

    This article has 12 evaluationsAppears in 1 listLatest version Latest activity
  5. Metabolic diversity in commensal protists regulates intestinal immunity and trans-kingdom competition

    This article has 15 authors:
    1. Elias R. Gerrick
    2. Soumaya Zlitni
    3. Patrick T. West
    4. Matthew M. Carter
    5. Claire M. Mechler
    6. Matthew R. Olm
    7. Elisa B. Caffrey
    8. Jessica A. Li
    9. Steven K. Higginbottom
    10. Christopher J. Severyn
    11. Frauke Kracke
    12. Alfred M. Spormann
    13. Justin L. Sonnenburg
    14. Ami S. Bhatt
    15. Michael R. Howitt

    Reviewed by Arcadia Science

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  6. Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma

    This article has 10 authors:
    1. Alex W Chan
    2. Malgorzata Broncel
    3. Eden Yifrach
    4. Nicole R Haseley
    5. Sundeep Chakladar
    6. Elena Andree
    7. Alice L Herneisen
    8. Emily Shortt
    9. Moritz Treeck
    10. Sebastian Lourido
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study in the protozoan parasite Toxoplasma gondii significantly advances our understanding of calcium signaling mediated by the kinase CDPK1 in this species. The authors' conclusions are supported by convincing evidence, with rigorous biochemical experiments and microscopy analysis. The work will be of broad interest to researchers in the fields of signal transduction and protozoan biology.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  7. Non-invasive Analysis of Peptidoglycan from Living Animals

    This article has 8 authors:
    1. Karl L. Ocius
    2. Sree H. Kolli
    3. Saadman S. Ahmad
    4. Jules M. Dressler
    5. Mahendra D. Chordia
    6. Brandon L. Jutras
    7. Melanie R. Rutkowski
    8. Marcos M. Pires

    Reviewed by Arcadia Science

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  8. Characterization of a selective, iron-chelating antifungal compound that disrupts fungal metabolism and synergizes with fluconazole

    This article has 12 authors:
    1. Jeanne Corrales
    2. Lucia Ramos-Alonso
    3. Javier González-Sabín
    4. Nicolás Ríos-Lombardía
    5. Nuria Trevijano-Contador
    6. Henriette Engen Berg
    7. Frøydis Sved Skottvoll
    8. Francisco Moris
    9. Oscar Zaragoza
    10. Pierre Chymkowitch
    11. Ignacio Garcia
    12. Jorrit M. Enserink

    Reviewed by Arcadia Science

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  9. Secretory protein Rv1987, a ‘probable chitinase’ from Mycobacterium tuberculosis is a novel chitin and cellulose binding protein lacking enzymatic function

    This article has 2 authors:
    1. Chiranth M. Prakash
    2. Vani Janakiraman

    Reviewed by Arcadia Science

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  10. Glycan-specific IgM is critical for human immunity to Staphylococcus aureus

    This article has 17 authors:
    1. Astrid Hendriks
    2. Priscilla F. Kerkman
    3. Meri R.J. Varkila
    4. Jelle L.G. Haitsma-Mulier
    5. Sara Ali
    6. Thijs ten Doesschate
    7. Thomas W. van der Vaart
    8. Carla J.C. de Haas
    9. Piet C. Aerts
    10. Olaf L. Cremer
    11. Marc J.M. Bonten
    12. Victor Nizet
    13. George Y. Liu
    14. Jeroen D.C. Codée
    15. Suzan H.M. Rooijakkers
    16. Jos A.G. van Strijp
    17. Nina M. van Sorge

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
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