Microbiology

The inter-continental population dynamics of Neisseria gonorrhoeae

1. Magnus N Osnes
2. Ola B Brynildsrud
3. Kristian Alfsnes
4. Lucy van Dorp
5. Samantha A McKeand
6. Jonathan Ross
7. Katy Town
8. Jolinda de Korne-Elenbaas
9. Alje van Dam
10. Sylvia Bruisten
11. Birgitte F de Blasio
12. Dominique A Caugant
13. Yonatan H. Grad
14. Deborah A Williamson
15. Francois Balloux
16. Xavier Didelot
17. Vegard Eldholm

• Curated by eLife

  eLife assessment

  This important work provides a detailed analysis of the population dynamics of an important human bacterial pathogen, Neisseria gonorrhoeae, using a large global collection of genomes with geographic, temporal, and demographic metadata. A unique facet of this work is the focus on both importation and exportation of N. gonorrhoeae; whilst quantifying importation is important to national public health efforts, quantifying exportation is relevant on an international level. However, the evidence supporting the conclusions is incomplete, due to potential inaccuracies in the method used for phylogenetic analysis, which forms the basis of this work. With the phylogenetic analysis strengthened, this paper would be of interest to epidemiologists and public health officials working on N. gonorrhoeae epidemiology and interventions.

Reviewed by eLife

Recruitment of apolipoprotein E facilitates Herpes simplex virus 1 attachment and release

1. Lifeng Liu
2. Fouzia Bano
3. Dario Valter Conca
4. Konrad Thorsteinsson
5. Sanduni Wasana Jayaweera
6. Damien Avinens
7. Hudson Pace
8. Hugo Lövheim
9. Anders Olofsson
10. Marta Bally

Reviewed by Review Commons

Phenotypic heterogeneity drives phage-bacteria coevolution in the intestinal tract

1. Nicolas Wenner
2. Anouk Bertola
3. Louise Larsson
4. Andrea Rocker
5. Nahimi Amare Bekele
6. Chris Sauerbeck
7. Leonardo F. Lemos Rocha
8. Valentin Druelle
9. Alexander Harms
10. Médéric Diard

Reviewed by Arcadia Science

The Parkinson’s drug entacapone disrupts gut microbiome homeostasis via iron sequestration

1. Fátima C. Pereira
2. Xiaowei Ge
3. Jannie Munk Kristensen
4. Rasmus H. Kirkegaard
5. Klara Maritsch
6. Yifan Zhu
7. Marie Decorte
8. Bela Hausmann
9. David Berry
10. Kenneth Wasmund
11. Arno Schintlmeister
12. Thomas Boettcher
13. Ji-Xin Cheng
14. Michael Wagner

Reviewed by Arcadia Science

The infection-tolerant white-footed deermouse tempers interferon responses to endotoxin in comparison to the mouse and rat

1. Ana Milovic
2. Jonathan V Duong
3. Alan G Barbour

• Curated by eLife

  eLife assessment

  This study provides a comprehensive whole genome transcriptomic analysis of three small mammals, including Peromyscus leucopus, after exposure to endotoxin lipopolysaccharide. The authors find that the inflammatory response of the three species is complex and that P. leucopus responds differently compared to mice and rats. The data are convincing and constitute an important advance in our understanding of inflammatory responses in animals that serve as reservoirs for relevant pathogens.

Reviewed by eLife

A Vibrio cholerae viral satellite maximizes its spread and inhibits phage by remodeling hijacked phage coat proteins into small capsids

1. Caroline M Boyd
2. Sundharraman Subramanian
3. Drew T Dunham
4. Kristin N Parent
5. Kimberley D Seed

• Curated by eLife

  eLife assessment

  This valuable study reports on the structure and function of capsid size-determining external scaffolding protein encoded by a Vibrio phage satellite. The structural work is of high quality and the presented reconstructions are compelling. The paper offers a substantial advance in the field of phage and virus structure and assembly, with implications for understanding the evolution of phage satellites.

Reviewed by eLife, PREreview

Protein kinase PfPK2 mediated signalling is critical for host erythrocyte invasion by malaria parasite

1. Rahul Singh Rawat
2. Ankit Gupta
3. Neelam Antil
4. Sonika Bhatnagar
5. Monika Singh
6. Akanksha Rawat
7. T. S. Keshava Prasad
8. Pushkar Sharma

Reviewed by Review Commons

Agrobacteria deploy two classes of His-Me finger superfamily nuclease effectors exerting different antibacterial capacities against specific bacterial competitors

1. Mary Nia M. Santos
2. Katherine L. Pintor
3. Pei-Yu Hsieh
4. Yee-Wai Cheung
5. Li-Kang Sung
6. Yu-Ling Shih
7. Erh-Min Lai

Reviewed by Review Commons

A novel glideosome-associated protein S14 coordinates sporozoite gliding motility and infectivity in mosquito and mammalian hosts

1. Ankit Ghosh
2. Aastha Varshney
3. Sunil Kumar Narwal
4. Nirdosh
5. Sachin Gaurav
6. Roshni Gupta
7. Shakil Ahmed
8. Satish Mishra

Reviewed by Review Commons

Single-cell transcriptome analysis illuminating the characteristics of species-specific innate immune responses against viral infections

1. Hirofumi Aso
2. Jumpei Ito
3. Haruka Ozaki
4. Yukie Kashima
5. Yutaka Suzuki
6. Yoshio Koyanagi
7. Kei Sato

Reviewed by GigaScience