Microbiology

Agrobacteria deploy two classes of His-Me finger superfamily nuclease effectors exerting different antibacterial capacities against specific bacterial competitors

1. Mary Nia M. Santos
2. Katherine L. Pintor
3. Pei-Yu Hsieh
4. Yee-Wai Cheung
5. Li-Kang Sung
6. Yu-Ling Shih
7. Erh-Min Lai

Reviewed by Review Commons

A novel glideosome-associated protein S14 coordinates sporozoite gliding motility and infectivity in mosquito and mammalian hosts

1. Ankit Ghosh
2. Aastha Varshney
3. Sunil Kumar Narwal
4. Nirdosh
5. Sachin Gaurav
6. Roshni Gupta
7. Shakil Ahmed
8. Satish Mishra

Reviewed by Review Commons

Single-cell transcriptome analysis illuminating the characteristics of species-specific innate immune responses against viral infections

1. Hirofumi Aso
2. Jumpei Ito
3. Haruka Ozaki
4. Yukie Kashima
5. Yutaka Suzuki
6. Yoshio Koyanagi
7. Kei Sato

Reviewed by GigaScience

Interplay between acetylation and ubiquitination of imitation switch chromatin remodeler Isw1 confers multidrug resistance in Cryptococcus neoformans

1. Yang Meng
2. Zhuoran Li
3. Tianhang Jiang
4. Tianshu Sun
5. Yanjian Li
6. Xindi Gao
7. Hailong Li
8. Chenhao Suo
9. Chao Li
10. Sheng Yang
11. Tian Lan
12. Guojian Liao
13. Tong-Bao Liu
14. Ping Wang
15. Chen Ding

• Curated by eLife

  eLife assessment

  This study links chromatin remodeling with antifungal drug resistance in Cryptococcus neoformans. The work is important because it reveals a new facet of how drug resistance can emerge and associates. The work presented is well done but the story is incomplete since there are questions about methods and association that need to be addressed. Establishing a link between chromatin remodeling and antifungal resistance is a finding that would be of interest to infectious disease researchers, cell biologists, and drug developers.

Reviewed by eLife

Prolonged delays in human microbiota transmission after a controlled antibiotic perturbation

1. Katherine S. Xue
2. Sophie Jean Walton
3. Doran A. Goldman
4. Maike L. Morrison
5. Adrian J. Verster
6. Autumn B. Parrott
7. Feiqiao Brian Yu
8. Norma F. Neff
9. Noah A. Rosenberg
10. Benjamin D. Ross
11. Dmitri A. Petrov
12. Kerwyn Casey Huang
13. Benjamin H. Good
14. David A. Relman

Reviewed by Arcadia Science

Emergent Antibiotic Persistence in Cross-Feeding Bacteria in Structured Habitats

1. Xianyi Xiong
2. Hans G. Othmer
3. William R. Harcombe

Reviewed by Arcadia Science

An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission

1. Franziska Hentzschel
2. David Jewanski
3. Yvonne Sokolowski
4. Pratika Agarwal
5. Anna Kraeft
6. Kolja Hildenbrand
7. Lilian P. Dorner
8. Mirko Singer
9. Matthias Marti
10. Friedrich Frischknecht

Reviewed by Arcadia Science

Transcriptional regulation of SARS-CoV-2 receptor ACE2 by SP1

1. Hui Han
2. Rong-Hua Luo
3. Xin-Yan Long
4. Li-Qiong Wang
5. Qian Zhu
6. Xin-Yue Tang
7. Rui Zhu
8. Yi-Cheng Ma
9. Yong-Tang Zheng
10. Cheng-Gang Zou

• Curated by eLife

  eLife assessment

  This is a valuable report that describes that ACE2 expression is upregulated by SARS-CoV-2 infection via activation of transcription factor Sp1 and inhibition of HNF4α through the PI3K/AKT pathway. Inhibition of Sp1 reduces SARS-CoV-2 infection in vitro and in an animal model. This work is solid and will be of interest to those interested in ACE2 biology and its impact in COVID-19.

Reviewed by eLife

Uncovering the Hidden Antibiotic Potential of Cannabis

1. Maya A. Farha
2. Omar M. El-Halfawy
3. Robert T. Gale
4. Craig R. MacNair
5. Lindsey A. Carfrae
6. Xiong Zhang
7. Nicholas G. Jentsch
8. Jakob Magolan
9. Eric D. Brown

Reviewed by PREreview

A Chemical Reaction Similarity-Based Prediction Algorithm Identifies the Multiple Taxa Required to Catalyze an Entire Metabolic Pathway of Dietary Flavonoids

1. Ebru Ece Gulsan
2. Farrhin Nowshad
3. Pomaikaimaikalani Yamaguchi
4. Xiaokun Dong
5. Arul Jayaraman
6. Kyongbum Lee

• Curated by eLife

  eLife assessment

  This paper reports useful findings regarding gut bacteria that metabolize dietary flavonoids, which can enhance, reduce, or otherwise alter the flavonoid bioactivities. With a newly developed bioinformatics tool, the authors predict bacterial species that can metabolize parts of the flavonoid tilianin. Formal proof of concept is missing, but if experimentally confirmed, the study will change the way we think about metabolism of flavonoids and would be of broad interest regarding gut bacterial metabolism. Most of the analyses are compelling, but others require further inquiry.

Reviewed by eLife