Microbiology

Prolonged delays in human microbiota transmission after a controlled antibiotic perturbation

1. Katherine S. Xue
2. Sophie Jean Walton
3. Doran A. Goldman
4. Maike L. Morrison
5. Adrian J. Verster
6. Autumn B. Parrott
7. Feiqiao Brian Yu
8. Norma F. Neff
9. Noah A. Rosenberg
10. Benjamin D. Ross
11. Dmitri A. Petrov
12. Kerwyn Casey Huang
13. Benjamin H. Good
14. David A. Relman

Reviewed by Arcadia Science

Emergent Antibiotic Persistence in Cross-Feeding Bacteria in Structured Habitats

1. Xianyi Xiong
2. Hans G. Othmer
3. William R. Harcombe

Reviewed by Arcadia Science

An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission

1. Franziska Hentzschel
2. David Jewanski
3. Yvonne Sokolowski
4. Pratika Agarwal
5. Anna Kraeft
6. Kolja Hildenbrand
7. Lilian P. Dorner
8. Mirko Singer
9. Matthias Marti
10. Friedrich Frischknecht

Reviewed by Arcadia Science

Transcriptional regulation of SARS-CoV-2 receptor ACE2 by SP1

1. Hui Han
2. Rong-Hua Luo
3. Xin-Yan Long
4. Li-Qiong Wang
5. Qian Zhu
6. Xin-Yue Tang
7. Rui Zhu
8. Yi-Cheng Ma
9. Yong-Tang Zheng
10. Cheng-Gang Zou

• Curated by eLife

  eLife assessment

  This is a valuable report that describes that ACE2 expression is upregulated by SARS-CoV-2 infection via activation of transcription factor Sp1 and inhibition of HNF4α through the PI3K/AKT pathway. Inhibition of Sp1 reduces SARS-CoV-2 infection in vitro and in an animal model. This work is solid and will be of interest to those interested in ACE2 biology and its impact in COVID-19.

Reviewed by eLife

Uncovering the Hidden Antibiotic Potential of Cannabis

1. Maya A. Farha
2. Omar M. El-Halfawy
3. Robert T. Gale
4. Craig R. MacNair
5. Lindsey A. Carfrae
6. Xiong Zhang
7. Nicholas G. Jentsch
8. Jakob Magolan
9. Eric D. Brown

Reviewed by PREreview

A Chemical Reaction Similarity-Based Prediction Algorithm Identifies the Multiple Taxa Required to Catalyze an Entire Metabolic Pathway of Dietary Flavonoids

1. Ebru Ece Gulsan
2. Farrhin Nowshad
3. Pomaikaimaikalani Yamaguchi
4. Xiaokun Dong
5. Arul Jayaraman
6. Kyongbum Lee

• Curated by eLife

  eLife assessment

  This paper reports useful findings regarding gut bacteria that metabolize dietary flavonoids, which can enhance, reduce, or otherwise alter the flavonoid bioactivities. With a newly developed bioinformatics tool, the authors predict bacterial species that can metabolize parts of the flavonoid tilianin. Formal proof of concept is missing, but if experimentally confirmed, the study will change the way we think about metabolism of flavonoids and would be of broad interest regarding gut bacterial metabolism. Most of the analyses are compelling, but others require further inquiry.

Reviewed by eLife

Structure of a tripartite protein complex that targets toxins to the type VII secretion system

1. Timothy A. Klein
2. Prakhar Y. Shah
3. Polyniki Gkragkopoulou
4. Dirk W. Grebenc
5. Youngchang Kim
6. John C. Whitney

Reviewed by Arcadia Science

Divergent and diversified proteome content across a serially acquired plastid lineage

1. Anna M. G. Novák Vanclová
2. Charlotte Nef
3. Adél Vancl
4. Fuhai Liu
5. Zoltán Füssy
6. Chris Bowler
7. Richard G. Dorrell

Reviewed by Review Commons

NAD(H) homeostasis is essential for host protection mediated by glycolytic myeloid cells in tuberculosis

1. Hayden T. Pacl
2. Krishna C. Chinta
3. Vineel P. Reddy
4. Sajid Nadeem
5. Ritesh R. Sevalkar
6. Kierveshan Nargan
7. Kapongo Lumamba
8. Threnesan Naidoo
9. Joel N. Glasgow
10. Anupam Agarwal
11. Adrie J. C. Steyn

Reviewed by preLights

The commensal protist Tritrichomonas musculus exhibits a dynamic life cycle that induces extensive remodeling of the gut microbiota

1. Ana Popovic
2. Eric Yixiao Cao
3. Joanna Han
4. Nirvana Nursimulu
5. Eliza V.C. Alves-Ferreira
6. Kyle Burrows
7. Andrea Kennard
8. Noor Alsmadi
9. Michael E. Grigg
10. Arthur Mortha
11. John Parkinson

Reviewed by Arcadia Science