Microbiology

  1. Interplay between acetylation and ubiquitination of imitation switch chromatin remodeler Isw1 confers multidrug resistance in Cryptococcus neoformans

    1. Yang Meng
    2. Zhuoran Li
    3. Tianhang Jiang
    4. Tianshu Sun
    5. Yanjian Li
    6. Xindi Gao
    7. Hailong Li
    8. Chenhao Suo
    9. Chao Li
    10. Sheng Yang
    11. Tian Lan
    12. Guojian Liao
    13. Tong-Bao Liu
    14. Ping Wang
    15. Chen Ding

    • Curated by eLife

      eLife assessment

      This study links chromatin remodeling with antifungal drug resistance in Cryptococcus neoformans. The work is important because it reveals a new facet of how drug resistance can emerge and associates. The work presented is well done but the story is incomplete since there are questions about methods and association that need to be addressed. Establishing a link between chromatin remodeling and antifungal resistance is a finding that would be of interest to infectious disease researchers, cell biologists, and drug developers.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  2. Prolonged delays in human microbiota transmission after a controlled antibiotic perturbation

    1. Katherine S. Xue
    2. Sophie Jean Walton
    3. Doran A. Goldman
    4. Maike L. Morrison
    5. Adrian J. Verster
    6. Autumn B. Parrott
    7. Feiqiao Brian Yu
    8. Norma F. Neff
    9. Noah A. Rosenberg
    10. Benjamin D. Ross
    11. Dmitri A. Petrov
    12. Kerwyn Casey Huang
    13. Benjamin H. Good
    14. David A. Relman

    Reviewed by Arcadia Science

    12 evaluationsAppears in 1 listLatest version Latest activity

  3. Emergent Antibiotic Persistence in Cross-Feeding Bacteria in Structured Habitats

    1. Xianyi Xiong
    2. Hans G. Othmer
    3. William R. Harcombe

    Reviewed by Arcadia Science

    4 evaluationsAppears in 1 listLatest version Latest activity

  4. An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission

    1. Franziska Hentzschel
    2. David Jewanski
    3. Yvonne Sokolowski
    4. Pratika Agarwal
    5. Anna Kraeft
    6. Kolja Hildenbrand
    7. Lilian P. Dorner
    8. Mirko Singer
    9. Matthias Marti
    10. Friedrich Frischknecht

    Reviewed by Arcadia Science

    12 evaluationsAppears in 1 listLatest version Latest activity

  5. Transcriptional regulation of SARS-CoV-2 receptor ACE2 by SP1

    1. Hui Han
    2. Rong-Hua Luo
    3. Xin-Yan Long
    4. Li-Qiong Wang
    5. Qian Zhu
    6. Xin-Yue Tang
    7. Rui Zhu
    8. Yi-Cheng Ma
    9. Yong-Tang Zheng
    10. Cheng-Gang Zou

    • Curated by eLife

      eLife assessment

      This is a valuable report that describes that ACE2 expression is upregulated by SARS-CoV-2 infection via activation of transcription factor Sp1 and inhibition of HNF4α through the PI3K/AKT pathway. Inhibition of Sp1 reduces SARS-CoV-2 infection in vitro and in an animal model. This work is solid and will be of interest to those interested in ACE2 biology and its impact in COVID-19.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  6. Uncovering the Hidden Antibiotic Potential of Cannabis

    1. Maya A. Farha
    2. Omar M. El-Halfawy
    3. Robert T. Gale
    4. Craig R. MacNair
    5. Lindsey A. Carfrae
    6. Xiong Zhang
    7. Nicholas G. Jentsch
    8. Jakob Magolan
    9. Eric D. Brown

    Reviewed by PREreview

    2 evaluationsAppears in 1 listLatest version Latest activity

  7. A Chemical Reaction Similarity-Based Prediction Algorithm Identifies the Multiple Taxa Required to Catalyze an Entire Metabolic Pathway of Dietary Flavonoids

    1. Ebru Ece Gulsan
    2. Farrhin Nowshad
    3. Pomaikaimaikalani Yamaguchi
    4. Xiaokun Dong
    5. Arul Jayaraman
    6. Kyongbum Lee

    • Curated by eLife

      eLife assessment

      This paper reports useful findings regarding gut bacteria that metabolize dietary flavonoids, which can enhance, reduce, or otherwise alter the flavonoid bioactivities. With a newly developed bioinformatics tool, the authors predict bacterial species that can metabolize parts of the flavonoid tilianin. Formal proof of concept is missing, but if experimentally confirmed, the study will change the way we think about metabolism of flavonoids and would be of broad interest regarding gut bacterial metabolism. Most of the analyses are compelling, but others require further inquiry.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  8. Structure of a tripartite protein complex that targets toxins to the type VII secretion system

    1. Timothy A. Klein
    2. Prakhar Y. Shah
    3. Polyniki Gkragkopoulou
    4. Dirk W. Grebenc
    5. Youngchang Kim
    6. John C. Whitney

    Reviewed by Arcadia Science

    8 evaluationsAppears in 1 listLatest version Latest activity

  9. Divergent and diversified proteome content across a serially acquired plastid lineage

    1. Anna M. G. Novák Vanclová
    2. Charlotte Nef
    3. Adél Vancl
    4. Fuhai Liu
    5. Zoltán Füssy
    6. Chris Bowler
    7. Richard G. Dorrell

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  10. NAD(H) homeostasis is essential for host protection mediated by glycolytic myeloid cells in tuberculosis

    1. Hayden T. Pacl
    2. Krishna C. Chinta
    3. Vineel P. Reddy
    4. Sajid Nadeem
    5. Ritesh R. Sevalkar
    6. Kierveshan Nargan
    7. Kapongo Lumamba
    8. Threnesan Naidoo
    9. Joel N. Glasgow
    10. Anupam Agarwal
    11. Adrie J. C. Steyn

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity
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