Microbiology

A remarkable genetic shift in a transmitted/founder virus broadens antibody responses against HIV-1

1. Swati Jain
2. Gherman Uritskiy
3. Marthandan Mahalingam
4. Himanshu Batra
5. Subhash Chand
6. Hung V Trinh
7. Charles Beck
8. Woong-Hee Shin
9. Wadad Alsalmi
10. Gustavo Kijak
11. Leigh A Eller
12. Jerome Kim
13. Daisuke Kihara
14. Sodsai Tovanabutra
15. Guido Ferrari
16. Merlin L Robb
17. Mangala Rao
18. Venigalla B Rao

• Curated by eLife

  eLife assessment

  This study provides a detailed evaluation of how HIV evades nascent immune pressure from people living with HIV followed nearly immediately after infection. There is convincing evidence that H173 mutations in the V2 loop was a key determinant of selection pressure and escape. These data are congruent with protection in the RV144 clinical trial, the only trial that showed protection from infection. Overall, this study is an important contribution to the field.

Reviewed by eLife

Cas12f1 gene drives propagate efficiently in herpesviruses and induce minimal resistance

1. Zhuangjie Lin
2. Qiaorui Yao
3. Keyuan Lai
4. Kehua Jiao
5. Xianying Zeng
6. Guanxiong Lei
7. Tongwen Zhang
8. Hongsheng Dai

• Curated by eLife

  eLife assessment

  This valuable paper by Yao, Dai, and colleagues describes a viral gene drive against herpes simplex virus 1 in cell culture. The authors provided solid evidence that an engineered gene drive sequence, expressing either spCas9 or Un1Cas12f1 nuclease, could spread efficiently in the population of wild-type viruses and induce fewer drive-resistant mutations than spCas9. Limitations include a mechanistically inaccurate title, several methodologic flaws, and a paucity of descriptions of possible therapeutic applications.

Reviewed by eLife

Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants

1. Zunlong Ke
2. Thomas P Peacock
3. Jonathan C Brown
4. Carol M Sheppard
5. Tristan I Croll
6. Abhay Kotecha
7. Daniel H Goldhill
8. Wendy S Barclay
9. John A G Briggs

Reviewed by PREreview

A new archaeal virus that suppresses the transcription of host immunity genes

1. Israela Turgeman-Grott
2. Noam Golan
3. Uri Neri
4. Doron Naki
5. Neta Altman-Price
6. Kim Eizenshtein
7. Deepak K. Choudhary
8. Rachel Levy
9. Yarden Shalev
10. Himani Himani
11. Leah Reshef
12. Uri Gophna

Reviewed by Arcadia Science

Novel misos shape distinct microbial ecologies: opportunities for flavourful sustainable food innovation

1. Caroline Isabel Kothe
2. Christian Carøe
3. Florent Mazel
4. David Zilber
5. Pablo Cruz-Morales
6. Nacer Mohellibi
7. Joshua D. Evans

Reviewed by Arcadia Science

Lytic transglycosylase repertoire diversity enables daughter cell separation and antibiotic resistance in Escherichia coli under acidic stress

1. Chang-Ro Lee
2. Ji Eun Son
3. Si Hyoung Park
4. Umji Choi

Reviewed by Arcadia Science

Targeting host deoxycytidine kinase mitigates Staphylococcus aureus abscess formation

1. Volker Winstel
2. Evan R Abt
3. Thuc M Le
4. Caius G Radu

• Curated by eLife

  eLife assessment

  This valuable study combines in vitro and in vivo experiments designed to test if a deoxycytidine kinase inhibitor provides therapeutic benefit during infection with Staphylococcus aureus. The authors provide compelling evidence that this putative host-directed therapy has good potential to promote natural clearance of infection without targeting the bacterium. This paper would be of interest to bacteriologists, immunologists, and those studying host-microbe interactions.

Reviewed by eLife

Nitrogen signaling factor triggers a respiration-like gene expression program

1. Shin Ohsawa
2. Michaela Schwaiger
3. Vytautas Iesmantavicius
4. Rio Hashimoto
5. Hiromitsu Moriyama
6. Hiroaki Matoba
7. Go Hirai
8. Mikiko Sodeoka
9. Atsushi Hashimoto
10. Akihisa Matsuyama
11. Minoru Yoshida
12. Yoko Yashiroda
13. Marc Bühler

Reviewed by Review Commons

Cryptococcus neoformans Slu7 ensures nuclear positioning during mitotic progression through RNA splicing

1. Vishnu Priya Krishnan
2. Manendra Singh Negi
3. Raghavaram Peesapati
4. Usha Vijayraghavan

Reviewed by Review Commons

Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

1. Fangyan Wang
2. Xiujie Liu
3. Furong Huang
4. Yan Zhou
5. Xinyu Wang
6. Zhengyang Song
7. Sisi Wang
8. Xiaoting Wang
9. Dibang Shi
10. Gaoyi Ruan
11. Xiawei Ji
12. Eryao Zhang
13. Zenglin Tan
14. Yuqing Ye
15. Chuang Wang
16. Jesse Zhu
17. Wantie Wang

• Curated by eLife

  eLife assessment

  This study presents a valuable finding on the impact of metformin-induced shifts in gut microbial community structure and metabolite levels for drug efficacy in a mouse model of liver injury. The current evidence supporting the claims of the authors is solid. This paper will be of broad interest to researchers across multiple disciplines, including the microbiome, liver disease, and pharmacology.

Reviewed by eLife