Microbiology

Phenotypic heterogeneity drives phage-bacteria coevolution in the intestinal tract

1. Nicolas Wenner
2. Anouk Bertola
3. Louise Larsson
4. Andrea Rocker
5. Nahimi Amare Bekele
6. Chris Sauerbeck
7. Leonardo F. Lemos Rocha
8. Valentin Druelle
9. Alexander Harms
10. Médéric Diard

Reviewed by Arcadia Science

The Parkinson’s drug entacapone disrupts gut microbiome homeostasis via iron sequestration

1. Fátima C. Pereira
2. Xiaowei Ge
3. Jannie Munk Kristensen
4. Rasmus H. Kirkegaard
5. Klara Maritsch
6. Yifan Zhu
7. Marie Decorte
8. Bela Hausmann
9. David Berry
10. Kenneth Wasmund
11. Arno Schintlmeister
12. Thomas Boettcher
13. Ji-Xin Cheng
14. Michael Wagner

Reviewed by Arcadia Science

The infection-tolerant white-footed deermouse tempers interferon responses to endotoxin in comparison to the mouse and rat

1. Ana Milovic
2. Jonathan V Duong
3. Alan G Barbour

• Curated by eLife

  eLife assessment

  This study provides a comprehensive whole genome transcriptomic analysis of three small mammals, including Peromyscus leucopus, after exposure to endotoxin lipopolysaccharide. The authors find that the inflammatory response of the three species is complex and that P. leucopus responds differently compared to mice and rats. The data are convincing and constitute an important advance in our understanding of inflammatory responses in animals that serve as reservoirs for relevant pathogens.

Reviewed by eLife

A Vibrio cholerae viral satellite maximizes its spread and inhibits phage by remodeling hijacked phage coat proteins into small capsids

1. Caroline M Boyd
2. Sundharraman Subramanian
3. Drew T Dunham
4. Kristin N Parent
5. Kimberley D Seed

• Curated by eLife

  eLife assessment

  This valuable study reports on the structure and function of capsid size-determining external scaffolding protein encoded by a Vibrio phage satellite. The structural work is of high quality and the presented reconstructions are compelling. The paper offers a substantial advance in the field of phage and virus structure and assembly, with implications for understanding the evolution of phage satellites.

Reviewed by eLife, PREreview

Protein kinase PfPK2 mediated signalling is critical for host erythrocyte invasion by malaria parasite

1. Rahul Singh Rawat
2. Ankit Gupta
3. Neelam Antil
4. Sonika Bhatnagar
5. Monika Singh
6. Akanksha Rawat
7. T. S. Keshava Prasad
8. Pushkar Sharma

Reviewed by Review Commons

Agrobacteria deploy two classes of His-Me finger superfamily nuclease effectors exerting different antibacterial capacities against specific bacterial competitors

1. Mary Nia M. Santos
2. Katherine L. Pintor
3. Pei-Yu Hsieh
4. Yee-Wai Cheung
5. Li-Kang Sung
6. Yu-Ling Shih
7. Erh-Min Lai

Reviewed by Review Commons

A novel glideosome-associated protein S14 coordinates sporozoite gliding motility and infectivity in mosquito and mammalian hosts

1. Ankit Ghosh
2. Aastha Varshney
3. Sunil Kumar Narwal
4. Nirdosh
5. Sachin Gaurav
6. Roshni Gupta
7. Shakil Ahmed
8. Satish Mishra

Reviewed by Review Commons

Single-cell transcriptome analysis illuminating the characteristics of species-specific innate immune responses against viral infections

1. Hirofumi Aso
2. Jumpei Ito
3. Haruka Ozaki
4. Yukie Kashima
5. Yutaka Suzuki
6. Yoshio Koyanagi
7. Kei Sato

Reviewed by GigaScience

Interplay between acetylation and ubiquitination of imitation switch chromatin remodeler Isw1 confers multidrug resistance in Cryptococcus neoformans

1. Yang Meng
2. Zhuoran Li
3. Tianhang Jiang
4. Tianshu Sun
5. Yanjian Li
6. Xindi Gao
7. Hailong Li
8. Chenhao Suo
9. Chao Li
10. Sheng Yang
11. Tian Lan
12. Guojian Liao
13. Tong-Bao Liu
14. Ping Wang
15. Chen Ding

• Curated by eLife

  eLife assessment

  This study links chromatin remodeling with antifungal drug resistance in Cryptococcus neoformans. The work is important because it reveals a new facet of how drug resistance can emerge and associates. The work presented is well done but the story is incomplete since there are questions about methods and association that need to be addressed. Establishing a link between chromatin remodeling and antifungal resistance is a finding that would be of interest to infectious disease researchers, cell biologists, and drug developers.

Reviewed by eLife

Prolonged delays in human microbiota transmission after a controlled antibiotic perturbation

1. Katherine S. Xue
2. Sophie Jean Walton
3. Doran A. Goldman
4. Maike L. Morrison
5. Adrian J. Verster
6. Autumn B. Parrott
7. Feiqiao Brian Yu
8. Norma F. Neff
9. Noah A. Rosenberg
10. Benjamin D. Ross
11. Dmitri A. Petrov
12. Kerwyn Casey Huang
13. Benjamin H. Good
14. David A. Relman

Reviewed by Arcadia Science