Microbiology

Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

1. Fangyan Wang
2. Xiujie Liu
3. Furong Huang
4. Yan Zhou
5. Xinyu Wang
6. Zhengyang Song
7. Sisi Wang
8. Xiaoting Wang
9. Dibang Shi
10. Gaoyi Ruan
11. Xiawei Ji
12. Eryao Zhang
13. Zenglin Tan
14. Yuqing Ye
15. Chuang Wang
16. Jesse Zhu
17. Wantie Wang

• Curated by eLife

  eLife assessment

  This study presents a valuable finding on the impact of metformin-induced shifts in gut microbial community structure and metabolite levels for drug efficacy in a mouse model of liver injury. The current evidence supporting the claims of the authors is solid. This paper will be of broad interest to researchers across multiple disciplines, including the microbiome, liver disease, and pharmacology.

Reviewed by eLife

Camel milk affects serum metabolites by modulating the intestinal microflora

1. Haitao Yue
2. Jiaxue Zhang
3. Ruiqi Wang
4. Luyu Zhao
5. Yuxuan Kou
6. Runye Li
7. Zhengyang Yang
8. Yurong Qian
9. Xinhui Li
10. Xiao Wang
11. Pazilaiti Yasheng
12. Jieyi Wu
13. Xiangxiang Xing
14. Lei Xie
15. Hao Niu
16. Gangliang Chen
17. Jie Yang
18. Ying Liu
19. Tian Shi
20. Feng Gao

Reviewed by Review Commons

Targeted phage hunting to specific Klebsiella pneumoniae clinical isolates is an efficient antibiotic resistance and infection control strategy

1. Celia Ferriol-González
2. Robby Concha-Eloko
3. Mireia Bernabéu-Gimeno
4. Felipe Fernández-Cuenca
5. Javier E. Cañada-García
6. Silvia García-Cobos
7. Rafael Sanjuán
8. Pilar Domingo-Calap

Reviewed by PREreview

Temporal and spatial dynamics within the fungal microbiome of grape fermentation

1. Cristobal A. Onetto
2. Chris M. Ward
3. Steven Van Den Heuvel
4. Laura Hale
5. Kathleen Cuijvers
6. Anthony R. Borneman

Reviewed by Arcadia Science

RNase-mediated reprogramming of Yersinia virulence

1. Ines Meyer
2. Marcel Volk
3. Ileana Salto
4. Theresa Moesser
5. Anne-Sophie Herbrüggen
6. Manfred Rohde
7. Michael Beckstette
8. Ann Kathrin Heroven
9. Petra Dersch

Reviewed by PREreview

Secreted dengue virus NS1 from infection is predominantly dimeric and in complex with high-density lipoprotein

1. Bing Liang Alvin Chew
2. AN Qi Ngoh
3. Wint Wint Phoo
4. Kitti Wing Ki Chan
5. Zheng Ser
6. Nikhil K Tulsian
7. Shiao See Lim
8. Mei Jie Grace Weng
9. Satoru Watanabe
10. Milly M Choy
11. Jenny Low
12. Eng Eong Ooi
13. Christiane Ruedl
14. Radoslaw M Sobota
15. Subhash G Vasudevan
16. Dahai Luo

• Curated by eLife

  eLife assessment

  This potentially useful study aims to advance our understanding of the structure of the native form of a viral toxin secreted from infected cells. While some of the findings confirm previous reports, the new claims in this study are unfortunately only inadequately supported by the methods and analyses used. More rigorous approaches are needed to justify the main conclusion that the structure of the viral toxin derived from infected cells in this study is distinct from previously reported structures of recombinantly expressed versions of the toxin.

Reviewed by eLife

Quantification of sporozoite expelling by Anopheles mosquitoes infected with laboratory and naturally circulating P. falciparum gametocytes

1. Chiara Andolina
2. Wouter Graumans
3. Moussa Guelbeogo
4. Geert-Jan van Gemert
5. Jordache Ramijth
6. Soré Harouna
7. Zongo Soumanaba
8. Rianne Stoter
9. Marga Vegte-Bolmer
10. Martina Pangos
11. Photini Sinnis
12. Katharine Collins
13. Sarah G Staedke
14. Alfred B Tiono
15. Chris Drakeley
16. Kjerstin Lanke
17. Teun Bousema

• Curated by eLife

  eLife assessment

  This important study combines experimental infections with laboratory and field Plasmodium falciparum isolates to quantify the force of human malaria parasite transmission. By using compelling methodological approaches, the authors establish clear positive correlations between mosquito infection levels (as determined by oocyst numbers), sporozoite loads in salivary glands, and sporozoites expelled during feeding. The link between heterogenous infection levels in the mosquitoes and malaria transmission would be of interest to vector biologists, parasitologists, immunologists, and mathematical modellers.

Reviewed by eLife

Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics

1. William Stribling
2. Lindsey R. Hall
3. Aubrey Powell
4. Casey Harless
5. Melissa J. Martin
6. Brendan W. Corey
7. Erik Snesrud
8. Ana Ong
9. Rosslyn Maybank
10. Jason Stam
11. Katie Bartlett
12. Brendan T. Jones
13. Lan N. Preston
14. Katherine F. Lane
15. Bernadette Thompson
16. Lynn M. Young
17. Yoon I. Kwak
18. Alice E. Barsoumian
19. Ana-Elizabeth Markelz
20. John L. Kiley
21. Robert J. Cybulski
22. Jason W. Bennett
23. Patrick T. Mc Gann
24. Francois Lebreton

• Curated by eLife

  eLife assessment

  This important work presents an example of how genomic data can be used to improve understanding of an ongoing, long-term bacterial outbreak in a hospital with an application to multi-drug resistant Pseudomonas aeruginosa, and will be of interest to researchers concerned with the spread of drug-resistant bacteria in hospital settings. The convincing genomic analyses highlight the value of routine surveillance of patients and environmental sampling and show how such data can help in dating the origin of the outbreak and in characterising the epidemic lineages. These findings highlight the importance of understanding environmental factors contributing to the transmission of P. aeruginosa for guiding and tailoring infection control efforts; however, epidemiological information was limited and the sampling methodology was inconsistent, complicating interpretation of inferences about exact transmission routes.

Reviewed by eLife

A treasure trove of 1,034 actinomycete genomes

1. Tue Sparholt Jørgensen
2. Omkar Mohite
3. Eva B Sterndorff
4. Maria Alvarez-Arevalo
5. Kai Blin
6. Thomas J Booth
7. Pep Charusanti
8. David Faurdal
9. Troels Ø Hansen
10. Matin Nuhamunada
11. Anna-Sophie Mourched
12. Bernhard Ø Palsson
13. Tilmann Weber

Reviewed by Arcadia Science

Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes

1. Sarah Poirier
2. Fabrice Jean-Pierre

Reviewed by Arcadia Science