Microbiology

A packaging signal-binding protein regulates the assembly checkpoint of integrative filamentous phages

1. Ting-Yu Yeh
2. Michael C. Feehley
3. Patrick J. Feehley
4. Vivian Y. Ooi
5. Yi-Yung Hung
6. Shao-Cheng Wang
7. Gregory P. Contreras

• Curated by eLife

  eLife assessment

  This valuable work describes a new protein factor that is required for filamentous phage assembly. Convincing evidence is provided for the binding of PSB15 to the packaging signal of the single-stranded DNA, Trx, and cardiolipin, and a mechanism for how the phage DNA is targeted to the assembly site in the bacterial inner membrane is presented. The work will be of interest to microbiologists.

Reviewed by eLife

Aspergillus dsRNA virus drives fungal fitness and pathogenicity in the mammalian host

1. Marina Campos Rocha
2. Vanda Lerer
3. John Adeoye
4. Hilla Hayby
5. Maria Laura Fabre
6. Amelia E. Barber
7. Neta Shlezinger

Reviewed by preLights

Detailing organelle division and segregation in Plasmodium falciparum

1. Julie M.J. Verhoef
2. Cas Boshoven
3. Felix Evers
4. Laura J. Akkerman
5. Barend C.A. Gijsbrechts
6. Marga van de Vegte-Bolmer
7. Geert-Jan van Gemert
8. Akhil B. Vaidya
9. Taco W.A. Kooij

Reviewed by Review Commons

Importin-7-dependent nuclear localization of the Flavivirus core protein is required for infectious virus production

1. Yumi Itoh
2. Makoto Tokunaga
3. Yoichi Miyamoto
4. Tatsuya Suzuki
5. Akira Takada
6. Akinori Ninomiya
7. Mami Matsuda
8. Yoshihiro Yoneda
9. Masahiro Oka
10. Ryosuke Suzuki
11. Yoshiharu Matsuura
12. Toru Okamoto

Reviewed by Review Commons

Conserved jumbo phage factors required for protein import into a phage nucleus

1. Claire Kokontis
2. Timothy A Klein
3. Sukrit Silas
4. Joseph Bondy-Denomy

Reviewed by Arcadia Science

Prophages express a type IV pilus component to provide anti-phage defence

1. Kristina M. Sztanko
2. P. Nathael Javorčík
3. Alexa D. Fitzpatrick
4. Tatiana Lenskaia
5. Karen L. Maxwell
6. Alan R. Davidson

Reviewed by Arcadia Science

Design of a new model yeast consortium for ecological studies of enological fermentation

1. Eléonore Pourcelot
2. Audrey Vigna
3. Thérèse Marlin
4. Virginie Galeote
5. Thibault Nidelet

Reviewed by Arcadia Science

Neutralizing gut-derived lipopolysaccharide as a novel therapeutic strategy for severe leptospirosis

1. Xufeng Xie
2. Xi Chen
3. Shilei Zhang
4. Jiuxi Liu
5. Wenlong Zhang
6. Yongguo Cao

• Curated by eLife

  eLife assessment

  The gut microbiota influences many infectious diseases; however, its role Leptospirosis remains unclear. In this fundamental work, Xie et al. use a hamster model to show that Leptospira infection leads to gut pathology, an altered gut microbiota, and increased translocation. A combined use of antibiotics and LPS neutralization prolonged survival, providing a potential new therapeutic approach. This study utilizes compelling methods to provide new insights into this emerging disease, which could be dissected further in future studies aimed at gaining mechanistic insight and assessing the translational relevance of these discoveries.

Reviewed by eLife

Discovery of the 1-naphthylamine biodegradation pathway reveals a broad-substrate-spectrum enzyme catalyzing 1-naphthylamine glutamylation

1. Shu-Ting Zhang
2. Shi-Kai Deng
3. Tao Li
4. Megan E Maloney
5. De-Feng Li
6. Jim C Spain
7. Ning-Yi Zhou

• Curated by eLife

  eLife assessment

  This important work identifies a p. aeruginosa strain and enzyme that can degrade 1-naphthylamine, a harmful industrial pollutant. Data resulting from in vivo and structural approaches are compelling, but additional mutagenesis would further test and establish the broad substrate specificity of NpaA1. With this additional data, this paper would be of high interest to biologists and enzymologists studying biodegradation of industrial pollutants.

Reviewed by eLife

Investigating Novel Streptomyces Bacteriophage Endolysins as Potential Antimicrobial Agents

1. Jindanuch Maneekul
2. Amanda Chiaha
3. Rachel Hughes
4. Faith Labry
5. Joshua Saito
6. Matthew Almendares
7. Brenda N. Banda
8. Leslie Lopez
9. Nyeomi McGaskey
10. Melizza Miranda
11. Jenil Rana
12. Brandon R. Zadeh
13. Lee E. Hughes

Reviewed by Arcadia Science