Microbiology

  1. Hybridization breaks species barriers in long-term coevolution of a cyanobacterial population

    1. Gabriel Birzu
    2. Harihara Subrahmaniam Muralidharan
    3. Danielle Goudeau
    4. Rex R. Malmstrom
    5. Daniel S. Fisher
    6. Devaki Bhaya

    • Curated by eLife

      eLife assessment

      This important study demonstrates widespread introgression between species of cyanobacteria in hot springs in Yellowstone National Park. Using single cell sequencing of hundreds of genomes, the authors provide one of the most convincing demonstrations to date of the importance of selection and hybridization in shaping polymorphism within a natural community. The strong enthusiasm for the paper is only dampened slightly by the methods not being described in the clearest possible manner.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  2. Emergent Antibiotic Persistence in Cross-Feeding Bacteria in Structured Habitats

    1. Xianyi Xiong
    2. Hans G. Othmer
    3. William R. Harcombe

    Reviewed by Arcadia Science

    4 evaluationsAppears in 1 listLatest version Latest activity

  3. A non-canonical Arp2/3 complex is essential for Plasmodium DNA segregation and transmission of malaria

    1. Franziska Hentzschel
    2. David Jewanski
    3. Yvonne Sokolowski
    4. Pratika Agarwal
    5. Anna Kraeft
    6. Kolja Hildenbrand
    7. Lilian P. Dorner
    8. Mirko Singer
    9. Friedrich Frischknecht
    10. Matthias Marti

    Reviewed by Arcadia Science

    12 evaluationsAppears in 1 listLatest version Latest activity

  4. SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression

    1. Marisa E. McGrath
    2. Yong Xue
    3. Louis Taylor
    4. Carly Dillen
    5. Jeremy Ardanuy
    6. Norberto Gonzalez-Juarbe
    7. Lauren Baracco
    8. Raymond Kim
    9. Rebecca Hart
    10. Nacyra Assad-Garcia
    11. Sanjay Vashee
    12. Matthew B. Frieman

    Reviewed by Rapid Reviews Infectious Diseases, PREreview

    6 evaluationsAppears in 2 listsLatest version Latest activity

  5. A synthetic peptide mimic kills Candida albicans and synergistically prevents infection

    1. Sebastian Schaefer
    2. Raghav Vij
    3. Jakob L. Sprague
    4. Sophie Austermeier
    5. Hue Dinh
    6. Peter R. Judzewitsch
    7. Sven Müller-Loennies
    8. Taynara Lopes Silva
    9. Eric Seemann
    10. Britta Qualmann
    11. Christian Hertweck
    12. Kirstin Scherlach
    13. Thomas Gutsmann
    14. Amy K. Cain
    15. Nathaniel Corrigan
    16. Mark S. Gresnigt
    17. Cyrille Boyer
    18. Megan D. Lenardon
    19. Sascha Brunke

    Reviewed by Rapid Reviews Infectious Diseases

    3 evaluationsAppears in 1 listLatest version Latest activity

  6. Transcriptional regulation of SARS-CoV-2 receptor ACE2 by SP1

    1. Hui Han
    2. Rong-Hua Luo
    3. Xin-Yan Long
    4. Li-Qiong Wang
    5. Qian Zhu
    6. Xin-Yue Tang
    7. Rui Zhu
    8. Yi-Cheng Ma
    9. Yong-Tang Zheng
    10. Cheng-Gang Zou

    • Curated by eLife

      eLife assessment

      This is a valuable report that describes that ACE2 expression is upregulated by SARS-CoV-2 infection via activation of transcription factor Sp1 and inhibition of HNF4α through the PI3K/AKT pathway. Inhibition of Sp1 reduces SARS-CoV-2 infection in vitro and in an animal model. This work is solid and will be of interest to those interested in ACE2 biology and its impact in COVID-19.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  7. Uncovering the Hidden Antibiotic Potential of Cannabis

    1. Maya A. Farha
    2. Omar M. El-Halfawy
    3. Robert T. Gale
    4. Craig R. MacNair
    5. Lindsey A. Carfrae
    6. Xiong Zhang
    7. Nicholas G. Jentsch
    8. Jakob Magolan
    9. Eric D. Brown

    Reviewed by PREreview

    2 evaluationsAppears in 1 listLatest version Latest activity

  8. A Chemical Reaction Similarity-Based Prediction Algorithm Identifies the Multiple Taxa Required to Catalyze an Entire Metabolic Pathway of Dietary Flavonoids

    1. Ebru Ece Gulsan
    2. Farrhin Nowshad
    3. Pomaikaimaikalani Yamaguchi
    4. Xiaokun Dong
    5. Arul Jayaraman
    6. Kyongbum Lee

    • Curated by eLife

      eLife assessment

      This paper reports useful findings regarding gut bacteria that metabolize dietary flavonoids, which can enhance, reduce, or otherwise alter the flavonoid bioactivities. With a newly developed bioinformatics tool, the authors predict bacterial species that can metabolize parts of the flavonoid tilianin. Formal proof of concept is missing, but if experimentally confirmed, the study will change the way we think about metabolism of flavonoids and would be of broad interest regarding gut bacterial metabolism. Most of the analyses are compelling, but others require further inquiry.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  9. Structure of a tripartite protein complex that targets toxins to the type VII secretion system

    1. Timothy A. Klein
    2. Prakhar Y. Shah
    3. Polyniki Gkragkopoulou
    4. Dirk W. Grebenc
    5. Youngchang Kim
    6. John C. Whitney

    Reviewed by Arcadia Science

    8 evaluationsAppears in 1 listLatest version Latest activity

  10. Divergent and diversified proteome content across a serially acquired plastid lineage

    1. Anna M. G. Novák Vanclová
    2. Charlotte Nef
    3. Adél Vancl
    4. Fuhai Liu
    5. Zoltán Füssy
    6. Chris Bowler
    7. Richard G. Dorrell

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity
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