Microbiology

Two newly cultivated eukaryotrophic flagellates represent distinct anaerobic lineages within Rhizaria

1. Yana Eglit
2. Maggie Lawton
3. Alastair G.B. Simpson
4. Ryan M.R. Gawryluk

Reviewed by Arcadia Science

Latent infection of an active giant endogenous virus in a unicellular green alga

1. Maria P. Erazo-Garcia
2. Uri Sheyn
3. Zachary K. Barth
4. Rory J. Craig
5. Petronella Wessman
6. Abdeali M. Jivaji
7. W. Keith Ray
8. Maria Svensson-Coelho
9. Charlie K. Cornwallis
10. Karin Rengefors
11. Corina P. D. Brussaard
12. Mohammad Moniruzzaman
13. Frank O. Aylward

Reviewed by Arcadia Science

Bam complex associated proteins in Escherichia coli are functionally linked to peptidoglycan biosynthesis, membrane fluidity and DNA replication

1. Jack A Bryant
2. Kara A Staunton
3. Hannah M Doherty
4. Micheal B Alao
5. Xuyu Ma
6. Joanna Morcinek-Orłowska
7. Emily CA Goodall
8. Jessica Gray
9. Mathew Milner
10. Jeffrey A Cole
11. Felicity de Cogan
12. Timothy J Knowles
13. Monika Glinkowska
14. Danesh Moradigaravand
15. Ian R Henderson
16. Manuel Banzhaf

• Curated by eLife

  eLife assessment

  This is a useful study that generated a rich inventory of genetic interactions with the potential to produce new insight into the molecular function of Bam-associated proteins. The interactions with genes of unknown function are of special interest as they may suggest experiments to find the functions of these genes. The overall data provided to support their conclusions is solid, but there is a major concern with known polar effects on certain mutations, which should be addressed by complementation.

Reviewed by eLife

Apoptotic caspases cleave DRP1 to promote mitochondrial fusion and anti-viral immune responses

1. Yujie Fang
2. Zihan Guan
3. Xiangtao Zhu
4. Zhenqiong Guan
5. Shufen Li
6. Ke Peng

• Curated by eLife

  eLife assessment

  This manuscript describes an unexpected role of cellular caspases in cleaving Drp1, a protein involved in mitochondrial fission, in virus-infected cells. Drp1 cleavage augments mitochondrial fission, reinforcing MAVS-dependent type-1 IFN response against multiple viruses. The findings presented in this manuscript are important and the strength of evidence is solid. Additional studies may allow for more robust mechanistic substantiation of the proposed model.

Reviewed by eLife

Drug-induced differential culturability in diverse strains of Mycobacterium tuberculosis

1. Valerie F. A. March
2. Nino Maghradze
3. Kakha Mchedlishvili
4. Teona Avaliani
5. Rusudan Aspindzelashvili
6. Zaza Avaliani
7. Maia Kipiani
8. Nestani Tukvadze
9. Levan Jugheli
10. Selim Bouaouina
11. Anna Doetsch
12. Galo A. Goig
13. Sebastien Gagneux
14. Sonia Borrell

Reviewed by PREreview