Microbiology

Multi-tiered actions of Legionella effectors to modulate host Rab10 dynamics

1. Tomoko Kubori
2. Kohei Arasaki
3. Hiromu Oide
4. Tomoe Kitao
5. Hiroki Nagai

• Curated by eLife

  eLife assessment

  This important study explores the interplay between Legionella Dot/Icm effectors that modulate ubiquitination of the host GTPase Rab10, which undergoes phosphoribosyl-ubiquitination by the SidE family of effectors, which in turn are required for Rab10 recruitment to the Legionella containing vacuole (LCV). The evidence supporting the claims of the authors is convincing. The study is not only relevant for the microbiology community, but will also be of interest to colleagues in the broader fields of membrane trafficking and general cell biology.

Reviewed by eLife

Widespread fungal-bacterial competition for magnesium enhances antibiotic resistance

1. Yu-Ying Phoebe Hsieh
2. Wanting Wendy Sun
3. Janet M. Young
4. Robin Cheung
5. Deborah A. Hogan
6. Ajai A. Dandekar
7. Harmit S. Malik

Reviewed by Review Commons

Warming and altered precipitation independently and interactively suppress alpine soil microbial growth in a decadal-long experiment

1. Yang Ruan
2. Ning Ling
3. Shengjing Jiang
4. Xin Jing
5. Jin-Sheng He
6. Qirong Shen
7. Zhibiao Nan

• Curated by eLife

  eLife assessment

  This important study addresses the long-term effect of warming and precipitation on microbial growth, as a proxy for understanding the impact of global warming. The evidence that warming and altered precipitation exhibit antagonistic effects on bacterial growth is compelling and advances our understanding of microbial dynamics affected by environmental factors. This study will interest microbial ecologists, microbiologists, and scientists generally concerned with climate change.

Reviewed by eLife

Giant genes are rare but implicated in cell wall degradation by predatory bacteria

1. Jacob West-Roberts
2. Luis Valentin-Alvarado
3. Susan Mullen
4. Rohan Sachdeva
5. Justin Smith
6. Laura A. Hug
7. Daniel S. Gregoire
8. Wentso Liu
9. Tzu-Yu Lin
10. Gabriel Husain
11. Yuki Amano
12. Lynn Ly
13. Jillian F. Banfield

Reviewed by PREreview

Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress

1. Magdalena Podkowik
2. Andrew I Perault
3. Gregory Putzel
4. Andrew Pountain
5. Jisun Kim
6. Ashley L DuMont
7. Erin E Zwack
8. Robert J Ulrich
9. Theodora K Karagounis
10. Chunyi Zhou
11. Andreas F Haag
12. Julia Shenderovich
13. Gregory A Wasserman
14. Junbeom Kwon
15. John Chen
16. Anthony R Richardson
17. Jeffrey N Weiser
18. Carla R Nowosad
19. Desmond S Lun
20. Dane Parker
21. Alejandro Pironti
22. Xilin Zhao
23. Karl Drlica
24. Itai Yanai
25. Victor J Torres
26. Bo Shopsin

• Curated by eLife

  eLife assessment

  This important study outlines how the agr quorum sensing system in Staphylococcus aureus confers long-lived protection against oxidative stress, thereby linking bacterial metabolism to virulence in this pathogen. While the findings, which are supported by solid data, seem at first glance to contradict earlier findings that show increased fitness of agr mutants under oxidative stress, the core conclusions of the study are well-substantiated. The topic of the paper holds broad relevance to microbiologists, especially those focusing on host-pathogen interactions and bacterial responses to ROS.

Reviewed by eLife

Alternative cell entry mechanisms for SARS-CoV-2 and multiple animal viruses

1. Ravi Ojha
2. Anmin Jiang
3. Elina Mäntylä
4. Naphak Modhira
5. Robert Witte
6. Arnaud Gaudin
7. Lisa De Zanetti
8. Rachel Gormal
9. Maija Vihinen-Ranta
10. Jason Mercer
11. Maarit Suomalainen
12. Urs F. Greber
13. Yohei Yamauchi
14. Pierre Yves-Lozach
15. Ari Helenius
16. Olli Vapalahti
17. Paul Young
18. Daniel Watterson
19. Frédéric A. Meunier
20. Merja Joensuu
21. Giuseppe Balistreri

Reviewed by Review Commons

Eukaryotic CD-NTase, STING, and viperin proteins evolved via domain shuffling, horizontal transfer, and ancient inheritance from prokaryotes

1. Edward M. Culbertson
2. Tera C. Levin

Reviewed by Review Commons

Interferon induced circRNAs escape herpesvirus host shutoff and suppress lytic infection

1. Sarah E Dremel
2. Takanobu Tagawa
3. Vishal N Koparde
4. Carmen Hernandez-Perez
5. Jesse H Arbuckle
6. Thomas M Kristie
7. Laurie T Krug
8. Joseph M Ziegelbauer

Reviewed by Review Commons

Complete Protection from SARS-CoV-2 Lung Infection in Mice Through Combined Intranasal Delivery of PIKfyve Kinase and TMPRSS2 Protease Inhibitors

1. Ravi Kant
2. Lauri Kareinen
3. Ravi Ojha
4. Tomas Strandin
5. Saber Hassan Saber
6. Angelina Lesnikova
7. Suvi Kuivanen
8. Tarja Sirnonen
9. Merja Joensuu
10. Olli Vapalahti
11. Tom Kirchhausen
12. Anja Kipar
13. Giuseppe Balistreri

Reviewed by Review Commons

PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes

1. Abdoulie O Touray
2. Rishi Rajesh
3. Tony Isebe
4. Tamara Sternlieb
5. Mira Loock
6. Oksana Kutova
7. Igor Cestari

Reviewed by eLife