Microbiology

Reversion to sensitivity explains limited transmission of resistance in a hospital pathogen

1. Kevin C Tracy
2. Jordan McKaig
3. Clare Kinnear
4. Jess Millar
5. Aaron A King
6. Andrew F Read
7. Robert J Woods

• Curated by eLife

  eLife Assessment

  This important study, which will be of interest to those studying the evolution and maintenance of antibiotic resistance, addresses the hypothesis that antibiotic resistance arising de novo during treatment will carry a higher fitness cost and will revert to susceptibility more readily than resistance that has been transmitted between hosts. There are, however, concerns that the 'putatively transmitted isolates' in this study do not necessarily represent resistant isolates that have been transmitted between hosts. The support for the central claim of different patterns of reversion between isolates with de novo resistance and putatively transmitted resistant isolates is currently incomplete.

Reviewed by eLife

Trim7 does not have a role in the restriction of murine norovirus infection in vivo

1. Mridula Annaswamy Srinivas
2. Linley R. Pierce
3. Mikayla C. Olson
4. Shelly J. Roberston
5. Gail L. Sturdevant
6. Sonja M. Best
7. Robert C. Orchard

Reviewed by Arcadia Science

Mixed alkyl/aryl phosphonates identify metabolic serine hydrolases as antimalarial targets

1. John M. Bennett
2. Sunil K. Narwal
3. Stephanie Kabeche
4. Daniel Abegg
5. Vandana Thathy
6. Fiona Hackett
7. Tomas Yeo
8. Veronica L. Li
9. Ryan Muir
10. Franco Faucher
11. Scott Lovell
12. Michael J. Blackman
13. Alexander Adibekian
14. Ellen Yeh
15. David A. Fidock
16. Matthew Bogyo

Reviewed by preLights

Reduced gravity and muon flux absence affect Caenorhabditis elegans life history traits and viral infection

1. Ana Villena-Giménez
2. Victoria G. Castiglioni
3. Juan C. Muñoz-Sánchez
4. Esmeralda G. Legarda
5. Rubén González
6. Santiago F. Elena

Reviewed by Arcadia Science