Microbiology

Detailing organelle division and segregation in Plasmodium falciparum

1. Julie M.J. Verhoef
2. Cas Boshoven
3. Felix Evers
4. Laura J. Akkerman
5. Barend C.A. Gijsbrechts
6. Marga van de Vegte-Bolmer
7. Geert-Jan van Gemert
8. Akhil B. Vaidya
9. Taco W.A. Kooij

Reviewed by Review Commons

Importin-7-dependent nuclear localization of the Flavivirus core protein is required for infectious virus production

1. Yumi Itoh
2. Makoto Tokunaga
3. Yoichi Miyamoto
4. Tatsuya Suzuki
5. Akira Takada
6. Akinori Ninomiya
7. Mami Matsuda
8. Yoshihiro Yoneda
9. Masahiro Oka
10. Ryosuke Suzuki
11. Yoshiharu Matsuura
12. Toru Okamoto

Reviewed by Review Commons

Conserved jumbo phage factors required for protein import into a phage nucleus

1. Claire Kokontis
2. Timothy A Klein
3. Sukrit Silas
4. Joseph Bondy-Denomy

Reviewed by Arcadia Science

Prophages express a type IV pilus component to provide anti-phage defence

1. Kristina M. Sztanko
2. P. Nathael Javorčík
3. Alexa D. Fitzpatrick
4. Tatiana Lenskaia
5. Karen L. Maxwell
6. Alan R. Davidson

Reviewed by Arcadia Science

Design of a new model yeast consortium for ecological studies of enological fermentation

1. Eléonore Pourcelot
2. Audrey Vigna
3. Thérèse Marlin
4. Virginie Galeote
5. Thibault Nidelet

Reviewed by Arcadia Science

Neutralizing gut-derived lipopolysaccharide as a novel therapeutic strategy for severe leptospirosis

1. Xufeng Xie
2. Xi Chen
3. Shilei Zhang
4. Jiuxi Liu
5. Wenlong Zhang
6. Yongguo Cao

• Curated by eLife

  eLife assessment

  The gut microbiota influences many infectious diseases; however, its role Leptospirosis remains unclear. In this fundamental work, Xie et al. use a hamster model to show that Leptospira infection leads to gut pathology, an altered gut microbiota, and increased translocation. A combined use of antibiotics and LPS neutralization prolonged survival, providing a potential new therapeutic approach. This study utilizes compelling methods to provide new insights into this emerging disease, which could be dissected further in future studies aimed at gaining mechanistic insight and assessing the translational relevance of these discoveries.

Reviewed by eLife

MX2 restricts HIV-1 and herpes simplex virus type 1 by forming cytoplasmic biomolecular condensates that mimic nuclear pore complexes

1. George D. Moschonas
2. Louis Delhaye
3. Robin Cooreman
4. Franziska Hüsers
5. Anayat Bhat
6. Delphine De Sutter
7. Eef Parthoens
8. Anne-Sophie Desmet
9. Aleksandra Maciejczuk
10. Hanna Grzesik
11. Saskia Lippens
12. Zeger Debyser
13. Beate Sodeik
14. Sven Eyckerman
15. Xavier Saelens

Reviewed by Rapid Reviews Infectious Diseases

Discovery of the 1-naphthylamine biodegradation pathway reveals a broad-substrate-spectrum enzyme catalyzing 1-naphthylamine glutamylation

1. Shu-Ting Zhang
2. Shi-Kai Deng
3. Tao Li
4. Megan E Maloney
5. De-Feng Li
6. Jim C Spain
7. Ning-Yi Zhou

• Curated by eLife

  eLife assessment

  This important work identifies a p. aeruginosa strain and enzyme that can degrade 1-naphthylamine, a harmful industrial pollutant. Data resulting from in vivo and structural approaches are compelling, but additional mutagenesis would further test and establish the broad substrate specificity of NpaA1. With this additional data, this paper would be of high interest to biologists and enzymologists studying biodegradation of industrial pollutants.

Reviewed by eLife

Investigating Novel Streptomyces Bacteriophage Endolysins as Potential Antimicrobial Agents

1. Jindanuch Maneekul
2. Amanda Chiaha
3. Rachel Hughes
4. Faith Labry
5. Joshua Saito
6. Matthew Almendares
7. Brenda N. Banda
8. Leslie Lopez
9. Nyeomi McGaskey
10. Melizza Miranda
11. Jenil Rana
12. Brandon R. Zadeh
13. Lee E. Hughes

Reviewed by Arcadia Science

A chemically induced attenuated strain of Candida albicans generates robust protective immune responses and prevents systemic candidiasis development

1. Swagata Bose
2. Satya Ranjan Sahu
3. Abinash Dutta
4. Narottam Acharya

• Curated by eLife

  eLife assessment

  This study presents a useful strategy in which the authors devised a simple method to attenuate Candida albicans and deliver a live whole-cell vaccine in a mouse model of systemic candidiasis. The reviewers are not convinced about the completeness of the study: the strength of the evidence is incomplete and could be augmented with additional experiments to more fully characterize vaccine efficacy and host immune responses.

Reviewed by eLife