Microbiology

An algicidal bacterium shapes the microbiome during outdoor diatom cultivation collapse

1. Naomi E. Gilbert
2. Jeffery A. Kimbrel
3. Ty J. Samo
4. Anthony J. Siccardi
5. Rhona K. Stuart
6. Xavier Mayali

Reviewed by Arcadia Science

DNA binding is rate-limiting for natural transformation

1. Taylor J. Ellison
2. Courtney K. Ellison

Reviewed by Arcadia Science

Laboratory horror stories: Poison in the agars

1. Mari K. Davidson
2. Reine U. Protacio
3. Dominique Helmlinger
4. Wayne P. Wahls

Reviewed by Arcadia Science

The bacterial microbiome of symbiotic and menthol-bleached polyps of long-term aquarium-reared Galaxea fascicularis

1. Giulia Puntin
2. Jane C. Y. Wong
3. Till Röthig
4. David M. Baker
5. Michael Sweet
6. Maren Ziegler

Reviewed by Arcadia Science

In vitro reconstitution reveals membrane clustering and RNA recruitment by the enteroviral AAA+ ATPase 2C

1. Kasturika Shankar
2. Marie N. Sorin
3. Himanshu Sharma
4. Oskar Skoglund
5. Selma Dahmane
6. Josy Ter Beek
7. Solomon Tesfalidet
8. Louise Nenzén
9. Lars-Anders Carlson

Reviewed by Review Commons

Global Release of Translational Repression Across Plasmodium’s Host-to-Vector Transmission Event

1. Kelly T. Rios
2. James P. McGee
3. Aswathy Sebastian
4. Robert L. Moritz
5. Marina Feric
6. Sabrina Absalon
7. Kristian E. Swearingen
8. Scott E. Lindner

Reviewed by Review Commons

Targeting plasmid-encoded proteins that contain immunoglobulin-like domains to combat antimicrobial resistance

1. Alejandro Prieto
2. Luïsa Miró
3. Yago Margolles
4. Manuel Bernabeu
5. David Salguero
6. Susana Merino
7. Joan Tomas
8. Juan Alberto Corbera
9. Anna Perez-Bosque
10. Mario Huttener
11. Luis Ángel Fernández
12. Antonio Juarez

• Curated by eLife

  eLife assessment

  This important and novel study addresses the challenge of antimicrobial resistance by targeting plasmid proteins that interfere with plasmid transfer as a strategy to limit the spread of antibiotic-resistance genes. The evidence presented and the integration of two approaches to tackle antimicrobial resistance is convincing. This work will interest those working on plasmid transfer and antimicrobial resistance.

Reviewed by eLife

Potential pandemic risk of circulating swine H1N2 influenza viruses

1. Valerie Le Sage
2. Nicole C. Rockey
3. Andrea J. French
4. Ryan McBride
5. Kevin R. McCarthy
6. Lora H. Rigatti
7. Meredith J. Shephard
8. Jennifer E. Jones
9. Sydney G. Walter
10. Joshua D. Doyle
11. Lingqing Xu
12. Dominique J. Barbeau
13. Shengyang Wang
14. Sheila A. Frizzell
15. Michael M. Myerburg
16. James C. Paulson
17. Anita K. McElroy
18. Tavis K. Anderson
19. Amy L. Vincent Baker
20. Seema S. Lakdawala

Reviewed by PREreview

In-silico docking platform with serine protease inhibitor (SERPIN) structures identifies host cysteine protease targets with significance for SARS-CoV-2

1. Joaquín J Rodriguez Galvan
2. Maren de Vries
3. Shiraz Belblidia
4. Ashley Fisher
5. Rachel A Prescott
6. Keaton M Crosse
7. Walter F. Mangel
8. Ralf Duerr
9. Meike Dittmann

Reviewed by Review Commons

Divergent downstream biosynthetic pathways are supported by L-cysteine synthases of Mycobacterium tuberculosis

1. Mehak Zahoor Khan
2. Debbie M Hunt
3. Biplab Singha
4. Yogita Kapoor
5. Nitesh Kumar Singh
6. D V Sai Prasad
7. Sriram Dharmarajan
8. Divya Tej Sowpati
9. Luiz Pedro S de Carvalho
10. Vinay Kumar Nandicoori

• Curated by eLife

  eLife assessment

  Sulphur atoms derived from cysteine are thought to play significant roles in maintaining redox homeostasis in Mycobacterium tuberculosis, which encounters stresses associated with immune cell interactions. In this valuable manuscript, the authors provide solid evidence that the genes encoding cysteine biosynthetic enzymes (cysM and cysK2) are required to maintain full viability of M. tuberculosis under in vitro stress conditions, macrophage infections, and within the lung tissues of mice. The manuscript presents transcriptomic and metabolomic evidence to support the hypothesis that CysM and CysK2 play distinct roles in maintaining cysteine-derived metabolite pools under stress conditions. The work will be of interest to microbiologists in general.

Reviewed by eLife