Microbiology

  1. Epigenetic liquid biopsies reveal elevated vascular endothelial cell turnover and erythropoiesis in asymptomatic COVID-19 patients

    1. Roni Ben-Ami
    2. Netanel Loyfer
    3. Eden Cohen
    4. Gavriel Fialkoff
    5. Israa Sharkia
    6. Naama Bogot
    7. Danit Kochan
    8. George Kalak
    9. Amir Jarjoui
    10. Chen Chen-Shuali
    11. Hava Azulai
    12. Hezi Barhoum
    13. Nissim Arish
    14. Moshe M Greenberger
    15. David Vellema
    16. Ramzi Kurd
    17. Eli Ben Chetrit
    18. Davina Bohm
    19. Talya Wolak
    20. Ahmad Quteineh
    21. Gordon Cann
    22. Benjamin Glaser
    23. Nir Friedman
    24. Tommy Kaplan
    25. Ruth Shemer
    26. Ariel Rokach
    27. Yuval Dor

    Reviewed by Rapid Reviews Infectious Diseases

    3 evaluationsAppears in 1 listLatest version Latest activity

  2. Extracellular vesicles are the main contributor to the non-viral protected extracellular sequence space

    1. Dominik Lücking
    2. Coraline Mercier
    3. Tomas Alarcón-Schumacher
    4. Susanne Erdmann

    Reviewed by Arcadia Science

    24 evaluationsAppears in 1 listLatest version Latest activity

  3. Erythrocyte invasion-neutralising antibodies prevent Plasmodium falciparum RH5 from binding to basigin-containing membrane protein complexes

    1. Abhishek Jamwal
    2. Cristina F Constantin
    3. Stephan Hirschi
    4. Sebastian Henrich
    5. Wolfgang Bildl
    6. Bernd Fakler
    7. Simon J Draper
    8. Uwe Schulte
    9. Matthew K Higgins

    • Curated by eLife

      eLife assessment

      This elegantly performed and rigorous study generates new and conceptually important insights into the interaction between an essential malaria parasite invasion ligand (and vaccine candidate) called PfRH5, and its erythrocyte surface integral membrane receptor basigin. The authors provide compelling evidence based on rigorous biochemical assays that erythrocyte basigin is predominantly expressed in a complex with one of two distinct erythrocyte membrane proteins called PMCA and MCT1 and that PfRH5 binds to these complexes better than to isolated basigin. Certain invasion-inhibitory antibodies, that do not prevent binding of PfRH5 to isolated basigin, do in contrast prevent binding to the basigin complexes, explaining the mode of action of these previously enigmatic antibodies and providing valuable data towards the improved design of vaccines based on PfRH5.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  4. Evolution of a functionally intact but antigenically distinct DENV fusion loop

    1. Rita M Meganck
    2. Deanna Zhu
    3. Stephanie Dong
    4. Lisa J Snoderly-Foster
    5. Yago R Dalben
    6. Devina Thiono
    7. Laura J White
    8. Arivianda M DeSilva
    9. Ralph S Baric
    10. Longping V Tse

    • Curated by eLife

      eLife assessment

      This valuable study describes engineered dengue virus variants that can be used to dissect epitope specificities in polyclonal sera, and to design candidate vaccine antigens that dampen antibody responses against undesirable epitopes. While the major claims are supported by solid evidence, experiments to distinguish the impact on antibody binding from neutralizing activities would have strengthened the study. This work will be of interest to virologists and structural biologists working on antibody responses to flaviviruses.

    Reviewed by eLife

    7 evaluationsAppears in 1 listLatest version Latest activity

  5. Microbes with higher metabolic independence are enriched in human gut microbiomes under stress

    1. Iva Veseli
    2. Yiqun T. Chen
    3. Matthew S. Schechter
    4. Chiara Vanni
    5. Emily C. Fogarty
    6. Andrea R. Watson
    7. Bana A. Jabri
    8. Ran Blekhman
    9. Amy D. Willis
    10. Michael K. Yu
    11. Antonio Fernandez-Guerra
    12. Jessika Fussel
    13. A. Murat Eren

    • Curated by eLife

      eLife assessment

      This study describes an important bioinformatics tool for normalizing gene copy number from metagenomic assemblies. The tool is used in a meta-analysis of data from inflammatory bowel disease (IBD) patients and healthy controls. While some of the evidence for the power of the method is compelling, other evidence seems incomplete. The inclusion of additional computational and/or experimental validation would markedly strengthen the study. This paper will likely be of broad interest to researchers studying the role of complex microbial communities in host health and disease.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  6. Oral Immunization with rVSV Bivalent Vaccine Elicits Protective Immune Responses, Including ADCC, against Both SARS-CoV-2 and Influenza A Viruses

    1. Maggie Jing Ouyang
    2. Zhujun Ao
    3. Titus A. Olukitibi
    4. Peter Lawrynuik
    5. Christopher Shieh
    6. Sam K. P. Kung
    7. Keith R. Fowke
    8. Darwyn Kobasa
    9. Xiaojian Yao

    Reviewed by Rapid Reviews Infectious Diseases

    3 evaluationsAppears in 1 listLatest version Latest activity

  7. Computational exploration of the global microbiome for antibiotic discovery

    1. Célio Dias Santos-Júnior
    2. Marcelo Der Torossian Torres
    3. Yiqian Duan
    4. Álvaro Rodríguez del Río
    5. Thomas S.B. Schmidt
    6. Hui Chong
    7. Anthony Fullam
    8. Kuhn Michael
    9. Chengkai Zhu
    10. Amy Houseman
    11. Jelena Somborski
    12. Anna Vines
    13. Xing-Ming Zhao
    14. Peer Bork
    15. Jaime Huerta-Cepas
    16. Cesar de la Fuente-Nunez
    17. Luis Pedro Coelho

    Reviewed by Arcadia Science

    12 evaluationsAppears in 1 listLatest version Latest activity

  8. Metabolic diversity in commensal protists regulates intestinal immunity and trans-kingdom competition

    1. Elias R. Gerrick
    2. Soumaya Zlitni
    3. Patrick T. West
    4. Matthew M. Carter
    5. Claire M. Mechler
    6. Matthew R. Olm
    7. Elisa B. Caffrey
    8. Jessica A. Li
    9. Steven K. Higginbottom
    10. Christopher J. Severyn
    11. Frauke Kracke
    12. Alfred M. Spormann
    13. Justin L. Sonnenburg
    14. Ami S. Bhatt
    15. Michael R. Howitt

    Reviewed by Arcadia Science

    3 evaluationsAppears in 1 listLatest version Latest activity

  9. Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma

    1. Alex W Chan
    2. Malgorzata Broncel
    3. Eden Yifrach
    4. Nicole R Haseley
    5. Sundeep Chakladar
    6. Elena Andree
    7. Alice L Herneisen
    8. Emily Shortt
    9. Moritz Treeck
    10. Sebastian Lourido

    • Curated by eLife

      eLife assessment

      This important study in the protozoan parasite Toxoplasma gondii significantly advances our understanding of calcium signaling mediated by the kinase CDPK1 in this species. The authors' conclusions are supported by convincing evidence, with rigorous biochemical experiments and microscopy analysis. The work will be of broad interest to researchers in the fields of signal transduction and protozoan biology.

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity

  10. Non-invasive Analysis of Peptidoglycan from Living Animals

    1. Karl L. Ocius
    2. Sree H. Kolli
    3. Saadman S. Ahmad
    4. Jules M. Dressler
    5. Mahendra D. Chordia
    6. Brandon L. Jutras
    7. Melanie R. Rutkowski
    8. Marcos M. Pires

    Reviewed by Arcadia Science

    1 evaluationAppears in 1 listLatest version Latest activity
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