1. Acute targeted induction of gut-microbial metabolism affects host clock genes and nocturnal feeding

    This article has 9 authors:
    1. Giorgia Greter
    2. Claudia Moresi
    3. Stefanie Oswald
    4. Alice de Wouters d’Oplinter
    5. Daria Künzli
    6. Elisa Cappio Barazzone
    7. Jiayi Lan
    8. Emma Slack
    9. Markus Arnoldini
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Feeding, the circadian rhythm, and the gut microbiota are all intimately linked, motivating new approaches to identify causal relationships while minimizing confounding factors. The authors employ an innovative combination of the stool softener lactulose and a defined 3-member gut microbiota to acutely induce gut bacterial metabolism in mice during the daytime, resulting in changes in the ileal expression of clock genes and altered feeding behavior. Together, this study utilizes solid methods to provide important new insights into the role of gut microbiota in the circadian rhythm, setting the stage for follow-on studies aimed at better understanding the mechanisms responsible.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  2. Bam complex associated proteins in Escherichia coli are functionally linked to peptidoglycan biosynthesis, membrane fluidity and DNA replication

    This article has 16 authors:
    1. Jack A Bryant
    2. Kara A Staunton
    3. Hannah M Doherty
    4. Micheal B Alao
    5. Xuyu Ma
    6. Joanna Morcinek-Orłowska
    7. Emily CA Goodall
    8. Jessica Gray
    9. Mathew Milner
    10. Jeffrey A Cole
    11. Felicity de Cogan
    12. Timothy J Knowles
    13. Monika Glinkowska
    14. Danesh Moradigaravand
    15. Ian R Henderson
    16. Manuel Banzhaf
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is a useful study that generated a rich inventory of genetic interactions with the potential to produce new insight into the molecular function of Bam-associated proteins. The interactions with genes of unknown function are of special interest as they may suggest experiments to find the functions of these genes. The overall data provided to support their conclusions is solid, but there is a major concern with known polar effects on certain mutations, which should be addressed by complementation.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  3. Apoptotic caspases cleave DRP1 to promote mitochondrial fusion and anti-viral immune responses

    This article has 6 authors:
    1. Yujie Fang
    2. Zihan Guan
    3. Xiangtao Zhu
    4. Zhenqiong Guan
    5. Shufen Li
    6. Ke Peng
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript describes an unexpected role of cellular caspases in cleaving Drp1, a protein involved in mitochondrial fission, in virus-infected cells. Drp1 cleavage augments mitochondrial fission, reinforcing MAVS-dependent type-1 IFN response against multiple viruses. The findings presented in this manuscript are important and the strength of evidence is solid. Additional studies may allow for more robust mechanistic substantiation of the proposed model.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. Zika virus remodels and hijacks IGF2BP2 ribonucleoprotein complex to promote viral replication organelle biogenesis

    This article has 13 authors:
    1. Clément Mazeaud
    2. Stefan Pfister
    3. Jonathan E Owen
    4. Higor Sette Pereira
    5. Flavie Charbonneau
    6. Zachary E Robinson
    7. Anaïs Anton
    8. Cheyanne L Bemis
    9. Aïssatou Aïcha Sow
    10. Trushar R Patel
    11. Christopher J Neufeldt
    12. Pietro Scaturro
    13. Laurent Chatel-Chaix
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study combines multidisciplinary approaches to examine the role of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) as a potential novel host dependency factor for Zika virus. The main claims are supported by the data but remain incomplete. The evidence would be strengthened by improving the western blot analyses and adjusting the toning of their claims in relation to the role of IGF2BP2 for viral replication. With the experimental evidence strengthened, this work will be of interest to virologists working on flaviviruses.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  5. Drug-induced differential culturability in diverse strains of Mycobacterium tuberculosis

    This article has 14 authors:
    1. Valerie F. A. March
    2. Nino Maghradze
    3. Kakha Mchedlishvili
    4. Teona Avaliani
    5. Rusudan Aspindzelashvili
    6. Zaza Avaliani
    7. Maia Kipiani
    8. Nestani Tukvadze
    9. Levan Jugheli
    10. Selim Bouaouina
    11. Anna Doetsch
    12. Galo A. Goig
    13. Sebastien Gagneux
    14. Sonia Borrell

    Reviewed by PREreview

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  6. Evolution of Omicron lineage towards increased fitness in the upper respiratory tract in the absence of severe lung pathology

    This article has 17 authors:
    1. Arthur Wickenhagen
    2. Meaghan Flagg
    3. Julia R. Port
    4. Claude Kwe Yinda
    5. Kerry Goldin
    6. Shane Gallogly
    7. Jonathan E. Schulz
    8. Tessa Lutterman
    9. Brandi N. Williamson
    10. Franziska Kaiser
    11. Reshma K. Mukesh
    12. Sarah van Tol
    13. Brian Smith
    14. Neeltje van Doremalen
    15. Colin A. Russell
    16. Emmie de Wit
    17. Vincent J. Munster

    Reviewed by Rapid Reviews Infectious Diseases

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  7. The bat influenza A virus subtype H18N11 induces nanoscale MHCII clustering upon host cell attachment

    This article has 10 authors:
    1. Maria Kaukab Osman
    2. Jonathan Robert
    3. Lukas Broich
    4. Dennis Frank
    5. Robert Grosse
    6. Martin Schwemmle
    7. Antoni G. Wrobel
    8. Kevin Ciminski
    9. Christian Sieben
    10. Peter Reuther

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  8. The RND efflux pump EefABC is highly conserved within lineages of E. coli commonly associated with infection

    This article has 11 authors:
    1. Hannah L. Pugh
    2. Elizabeth M. Darby
    3. Leah Burgess
    4. Abigail L. Colclough
    5. Asti-Rochelle Meosa John
    6. Steven Dunn
    7. Christopher Connor
    8. Eoughin A. Perry
    9. Alan McNally
    10. Vassiliy N. Bavro
    11. Jessica M. A. Blair

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  9. The glycoprotein quality control factor Malectin promotes coronavirus replication and viral protein biogenesis

    This article has 2 authors:
    1. Jonathan P Davies
    2. Lars Plate
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is a valuable study that utilizes proteomic and genetic approaches to identify the glycoprotein quality control factor malectin as a pro-viral host protein involved in the replication of coronavirus. The evidence supporting this conclusion is solid, although additional insight into the mechanistic basis of malectin-mediated viral replication would further strengthen this study. This work will be of interest to cell biologists studying the molecular mechanisms of glycoprotein quality control and virologists studying the host-pathogen interactions.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  10. Architecture of genome-wide transcriptional regulatory network reveals dynamic functions and evolutionary trajectories in Pseudomonas syringae

    This article has 7 authors:
    1. Yue Sun
    2. Jingwei Li
    3. Jiadai Huang
    4. Shumin Li
    5. Youyue Li
    6. Beifang Lu
    7. Xin Deng
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This work advances our understanding of transcriptional regulation of virulence and metabolic pathways in plant pathogenic bacteria. Solid evidence for the claims is provided by computational analysis of newly generated data on the genome-wide binding of 170 transcription factors to their target genes, together with experimental validation of the biological functions of some of these transcription factors. The findings and resources from this study will be valuable to researchers in the fields of systems biology, bacteriology, and plant-microbe interactions.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
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