Microbiology

Surface-mediated bacteriophage defense incurs fitness tradeoffs for interbacterial antagonism

1. Chia-En Tsai
2. Feng-Qi Wang
3. Chih-Wen Yang
4. Ling-Li Yang
5. Thao VP Nguyen
6. Yung-Chih Chen
7. Po-Yin Chen
8. Ing-Shouh Hwang
9. See-Yeun Ting

Reviewed by Review Commons

Organ structure and bacterial microbiogeography in a reproductive organ of the Hawaiian bobtail squid reveal dimensions of a defensive symbiosis

1. Derrick L. Kamp
2. Allison H. Kerwin
3. Sarah J. McAnulty
4. Spencer V. Nyholm

Reviewed by Arcadia Science

An unusual trafficking domain in MSRP6 defines a complex needed for Maurer’s clefts anchoring and maintenance in P. falciparum infected red blood cells

1. Alexandra Blancke Soares
2. Jan Stäcker
3. Svenja Schwald
4. Wieteke Hoijmakers
5. Nahla Galal Metwally
6. Jakob Cronshagen
7. Hanno Schoeler
8. Sven Flemming
9. Katharina Höhn
10. Ulrike Fröhlke
11. Paolo Mesén-Ramírez
12. Bärbel Bergmann
13. Melissa Khosh-Naucke
14. Iris Bruchhaus
15. Richárd Bártfai
16. Tobias Spielmann

• Curated by eLife

  eLife Assessment

  This study presents valuable data on the identification and function of a protein complex present at the Maurer's cleft organelles of Plasmodium falciparum-infected red blood cells. The evidence supporting the findings is solid, but would benefit from greater rigor in presentation and analysis.

Reviewed by eLife

Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites

1. Deborah Maus
2. Elyzana Putrianti
3. Tobias Hoffmann
4. Michael Laue
5. Frank Seeber
6. Martin Blume

• Curated by eLife

  eLife Assessment

  This valuable study utilizes a newly developed approach to culture T gondii bradyzoites in myotubes, and then takes advantage of the antiparasitic compound collection known as the Pathogen Box, to find compounds that target both tachyzoite and bradyzoite forms of the parasite. A set of compounds yielding patterns consistent with targeting the mitochondrial bc1 complex was explored further, with solid evidence for changes in ATP production in bradyzoites to support the conclusions about the importance of this complex. The paper will be interesting for parasitologists studying drug discovery of apicomplexan parasites.

Reviewed by eLife

A CRISPRi Library Screen in Group B Streptococcus Identifies Surface Immunogenic Protein (Sip) as a Mediator of Multiple Host Interactions

1. K Firestone
2. KP Gopalakrishna
3. LM Rogers
4. A Peters
5. JA Gaddy
6. C Nichols
7. MH Hall
8. HN Varela
9. SM Carlin
10. GH Hillebrand
11. EJ Giacobe
12. DM Aronoff
13. TA Hooven

Reviewed by Arcadia Science

Mapping the ultrastructural topology of the corynebacterial cell surface

1. Buse Isbilir
2. Anna Yeates
3. Vikram Alva
4. Tanmay A. M. Bharat

Reviewed by Review Commons

Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages

1. Marisa S Egan
2. Emily A O'Rourke
3. Shrawan Kumar Mageswaran
4. Biao Zuo
5. Inna Martynyuk
6. Tabitha Demissie
7. Emma N Hunter
8. Antonia R Bass
9. Yi-Wei Chang
10. Igor E Brodsky
11. Sunny Shin

• Curated by eLife

  eLife Assessment

  This paper provides fundamental insights into the control of Salmonella within human macrophages, with convincing evidence that Salmonella can replicate in the macrophage cytosol in the absence of inflammasome signaling. This paper, which improves our understanding of how the immune system fights bacterial infections, will be of broad interest to cell biologists, immunologists and microbiologists.

Reviewed by eLife

Combination of mitomycin C and low-dose metronidazole synergistically against Clostridioides difficile infection and recurrence prevention

1. Jun-Jia Gong
2. I-Hsiu Huang
3. Yuan-Pin Hung
4. Yi-Wei Chen
5. Yun-Chien Lin
6. Jenn-Wei Chen

Reviewed by Rapid Reviews Infectious Diseases

Birth of new protein folds and functions in the virome

1. Jason Nomburg
2. Nathan Price
3. Jennifer A. Doudna

Reviewed by Arcadia Science

Aminoglycoside tolerance in Vibrio cholerae engages translational reprogramming associated with queuosine tRNA modification

1. Louna Fruchard
2. Anamaria Babosan
3. Andre Carvalho
4. Manon Lang
5. Blaise Li
6. Magalie Duchateau
7. Quentin Giai Gianetto
8. Mariette Matondo
9. Frederic Bonhomme
10. Isabelle Hatin
11. Hugo Arbes
12. Céline Fabret
13. Enora Corler
14. Guillaume Sanchez
15. Virginie Marchand
16. Yuri Motorin
17. Olivier Namy
18. Valérie de Crécy-Lagard
19. Didier Mazel
20. Zeynep Baharoglu

• Curated by eLife

  eLife Assessment

  This study investigates the role of queuosine (Q) tRNA modification in aminoglycoside tolerance in Vibrio cholerae and presents convincing evidence to conclude that Q is essential for the efficient translation of TAT codons, although this depends on the context. The absence of Q reduces aminoglycoside tolerance potentially by reprogramming the translation of an oxidative stress response gene, rxsA. Overall, the findings point to an important mechanism whereby changes in Q modification levels control the decoding of mRNAs enriched in TAT codons under antibiotic stress.

Reviewed by eLife